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Q9C5P4

- SUVH3_ARATH

UniProt

Q9C5P4 - SUVH3_ARATH

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Protein
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3
Gene
SUVH3, SDG19, SET19, At1g73100, F3N23.30
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi432 – 4321Zinc 1 By similarity
Metal bindingi432 – 4321Zinc 2 By similarity
Metal bindingi434 – 4341Zinc 1 By similarity
Metal bindingi438 – 4381Zinc 1 By similarity
Metal bindingi438 – 4381Zinc 3 By similarity
Metal bindingi445 – 4451Zinc 1 By similarity
Metal bindingi447 – 4471Zinc 2 By similarity
Metal bindingi473 – 4731Zinc 2 By similarity
Metal bindingi473 – 4731Zinc 3 By similarity
Metal bindingi477 – 4771Zinc 2 By similarity
Metal bindingi479 – 4791Zinc 3 By similarity
Metal bindingi483 – 4831Zinc 3 By similarity
Binding sitei540 – 5401S-adenosyl-L-methionine By similarity
Binding sitei542 – 5421S-adenosyl-L-methionine By similarity
Binding sitei592 – 5921S-adenosyl-L-methionine By similarity
Metal bindingi598 – 5981Zinc 4 By similarity
Metal bindingi657 – 6571Zinc 4 By similarity
Metal bindingi659 – 6591Zinc 4 By similarity
Metal bindingi664 – 6641Zinc 4 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi108 – 12013A.T hook
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. histone methyltransferase activity Source: TAIR
  3. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of gene expression, epigenetic Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G73100-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3 (EC:2.1.1.43)
Alternative name(s):
Histone H3-K9 methyltransferase 3
Short name:
H3-K9-HMTase 3
Protein SET DOMAIN GROUP 19
Suppressor of variegation 3-9 homolog protein 3
Short name:
Su(var)3-9 homolog protein 3
Gene namesi
Name:SUVH3
Synonyms:SDG19, SET19
Ordered Locus Names:At1g73100
ORF Names:F3N23.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G73100.

Subcellular locationi

Nucleus. Chromosomecentromere
Note: Associates with centromeric constitutive heterochromatin.1 Publication

GO - Cellular componenti

  1. chromosome Source: TAIR
  2. chromosome, centromeric region Source: UniProtKB-SubCell
  3. nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3
PRO_0000186074Add
BLAST

Proteomic databases

PaxDbiQ9C5P4.
PRIDEiQ9C5P4.

Expressioni

Tissue specificityi

Expressed in leaves stems and flowers.1 Publication

Gene expression databases

GenevestigatoriQ9C5P4.

Interactioni

Protein-protein interaction databases

BioGridi28860. 3 interactions.
IntActiQ9C5P4. 2 interactions.
MINTiMINT-8068307.
STRINGi3702.AT1G73100.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9C5P4.
SMRiQ9C5P4. Positions 155-666.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini208 – 355148YDG
Add
BLAST
Domaini430 – 49162Pre-SET
Add
BLAST
Domaini494 – 638145SET
Add
BLAST
Domaini653 – 66917Post-SET
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni504 – 5063S-adenosyl-L-methionine binding By similarity
Regioni595 – 5962S-adenosyl-L-methionine binding By similarity

Domaini

Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity.
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster By similarity.

Sequence similaritiesi

Contains 1 post-SET domain.
Contains 1 pre-SET domain.
Contains 1 SET domain.
Contains 1 YDG domain.

Phylogenomic databases

eggNOGiCOG3440.
HOGENOMiHOG000238382.
InParanoidiQ9C5P4.
KOiK11420.
OMAiIHIAFFA.
PhylomeDBiQ9C5P4.

Family and domain databases

Gene3Di2.30.280.10. 1 hit.
InterProiIPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR003606. Pre-SET_Zn-bd_sub.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C5P4-1 [UniParc]FASTAAdd to Basket

« Hide

MQGVPGFNTV PNPNHYDKSI VLDIKPLRSL KPVFPNGNQG PPFVGCPPFG    50
PSSSEYSSFF PFGAQQPTHD TPDLNQTQNT PIPSFVPPLR SYRTPTKTNG 100
PSSSSGTKRG VGRPKGTTSV KKKEKKTVAN EPNLDVQVVK KFSSDFDSGI 150
SAAEREDGNA YLVSSVLMRF DAVRRRLSQV EFTKSATSKA AGTLMSNGVR 200
TNMKKRVGTV PGIEVGDIFF SRIEMCLVGL HMQTMAGIDY IISKAGSDEE 250
SLATSIVSSG RYEGEAQDPE SLIYSGQGGN ADKNRQASDQ KLERGNLALE 300
NSLRKGNGVR VVRGEEDAAS KTGKIYIYDG LYSISESWVE KGKSGCNTFK 350
YKLVRQPGQP PAFGFWKSVQ KWKEGLTTRP GLILPDLTSG AESKPVSLVN 400
DVDEDKGPAY FTYTSSLKYS ETFKLTQPVI GCSCSGSCSP GNHNCSCIRK 450
NDGDLPYLNG VILVSRRPVI YECGPTCPCH ASCKNRVIQT GLKSRLEVFK 500
TRNRGWGLRS WDSLRAGSFI CEYAGEVKDN GNLRGNQEED AYVFDTSRVF 550
NSFKWNYEPE LVDEDPSTEV PEEFNLPSPL LISAKKFGNV ARFMNHSCSP 600
NVFWQPVIRE GNGESVIHIA FFAMRHIPPM AELTYDYGIS PTSEARDESL 650
LHGQRTCLCG SEQCRGSFG 669
Length:669
Mass (Da):73,439
Last modified:May 9, 2003 - v2
Checksum:i8878E000747FD1AB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti416 – 4161S → P in AAK28968. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF344446 mRNA. Translation: AAK28968.1.
AC008017 Genomic DNA. Translation: AAD55657.1.
CP002684 Genomic DNA. Translation: AEE35414.1.
AY099620 mRNA. Translation: AAM20471.1.
BT002137 mRNA. Translation: AAN72148.1.
PIRiF96756.
RefSeqiNP_565056.1. NM_105968.3.
UniGeneiAt.11687.
At.43232.

Genome annotation databases

EnsemblPlantsiAT1G73100.1; AT1G73100.1; AT1G73100.
GeneIDi843641.
KEGGiath:AT1G73100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF344446 mRNA. Translation: AAK28968.1 .
AC008017 Genomic DNA. Translation: AAD55657.1 .
CP002684 Genomic DNA. Translation: AEE35414.1 .
AY099620 mRNA. Translation: AAM20471.1 .
BT002137 mRNA. Translation: AAN72148.1 .
PIRi F96756.
RefSeqi NP_565056.1. NM_105968.3.
UniGenei At.11687.
At.43232.

3D structure databases

ProteinModelPortali Q9C5P4.
SMRi Q9C5P4. Positions 155-666.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 28860. 3 interactions.
IntActi Q9C5P4. 2 interactions.
MINTi MINT-8068307.
STRINGi 3702.AT1G73100.1-P.

Proteomic databases

PaxDbi Q9C5P4.
PRIDEi Q9C5P4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G73100.1 ; AT1G73100.1 ; AT1G73100 .
GeneIDi 843641.
KEGGi ath:AT1G73100.

Organism-specific databases

TAIRi AT1G73100.

Phylogenomic databases

eggNOGi COG3440.
HOGENOMi HOG000238382.
InParanoidi Q9C5P4.
KOi K11420.
OMAi IHIAFFA.
PhylomeDBi Q9C5P4.

Enzyme and pathway databases

BioCyci ARA:AT1G73100-MONOMER.

Gene expression databases

Genevestigatori Q9C5P4.

Family and domain databases

Gene3Di 2.30.280.10. 1 hit.
InterProi IPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR003606. Pre-SET_Zn-bd_sub.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view ]
Pfami PF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view ]
SUPFAMi SSF88697. SSF88697. 1 hit.
PROSITEi PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes."
    Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B.
    Nucleic Acids Res. 29:4319-4333(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, NOMENCLATURE, TISSUE SPECIFICITY.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Heterochromatin proteins and the control of heterochromatic gene silencing in Arabidopsis."
    Fischer A., Hofmann I., Naumann K., Reuter G.
    J. Plant Physiol. 163:358-368(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiSUVH3_ARATH
AccessioniPrimary (citable) accession number: Q9C5P4
Secondary accession number(s): Q9SSL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 9, 2003
Last modified: June 11, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi