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Protein

Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3

Gene

SUVH3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi432Zinc 1By similarity1
Metal bindingi432Zinc 2By similarity1
Metal bindingi434Zinc 1By similarity1
Metal bindingi438Zinc 1By similarity1
Metal bindingi438Zinc 3By similarity1
Metal bindingi445Zinc 1By similarity1
Metal bindingi447Zinc 2By similarity1
Metal bindingi473Zinc 2By similarity1
Metal bindingi473Zinc 3By similarity1
Metal bindingi477Zinc 2By similarity1
Metal bindingi479Zinc 3By similarity1
Metal bindingi483Zinc 3By similarity1
Binding sitei540S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei542S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei592S-adenosyl-L-methioninePROSITE-ProRule annotation1
Metal bindingi598Zinc 4By similarity1
Metal bindingi657Zinc 4By similarity1
Metal bindingi659Zinc 4By similarity1
Metal bindingi664Zinc 4By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi108 – 120A.T hookAdd BLAST13

GO - Molecular functioni

GO - Biological processi

  • regulation of gene expression, epigenetic Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3 (EC:2.1.1.43)
Alternative name(s):
Histone H3-K9 methyltransferase 3
Short name:
H3-K9-HMTase 3
Protein SET DOMAIN GROUP 19
Suppressor of variegation 3-9 homolog protein 3
Short name:
Su(var)3-9 homolog protein 3
Gene namesi
Name:SUVH3
Synonyms:SDG19, SET19
Ordered Locus Names:At1g73100
ORF Names:F3N23.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G73100.

Subcellular locationi

GO - Cellular componenti

  • chromosome Source: TAIR
  • chromosome, centromeric region Source: UniProtKB-SubCell
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001860741 – 669Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3Add BLAST669

Proteomic databases

PaxDbiQ9C5P4.

Expressioni

Tissue specificityi

Expressed in leaves stems and flowers.1 Publication

Gene expression databases

GenevisibleiQ9C5P4. AT.

Interactioni

Protein-protein interaction databases

BioGridi28860. 4 interactors.
IntActiQ9C5P4. 2 interactors.
MINTiMINT-8068307.
STRINGi3702.AT1G73100.1.

Structurei

3D structure databases

ProteinModelPortaliQ9C5P4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini208 – 355YDGPROSITE-ProRule annotationAdd BLAST148
Domaini430 – 491Pre-SETPROSITE-ProRule annotationAdd BLAST62
Domaini494 – 638SETPROSITE-ProRule annotationAdd BLAST145
Domaini653 – 669Post-SETPROSITE-ProRule annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni504 – 506S-adenosyl-L-methionine bindingBy similarity3
Regioni595 – 596S-adenosyl-L-methionine bindingBy similarity2

Domaini

Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity.
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation
Contains 1 A.T hook DNA-binding domain.Curated
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 pre-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation
Contains 1 YDG domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
COG3440. LUCA.
HOGENOMiHOG000238382.
InParanoidiQ9C5P4.
KOiK11420.
OMAiNHYDKSI.
OrthoDBiEOG093605J1.
PhylomeDBiQ9C5P4.

Family and domain databases

Gene3Di2.30.280.10. 1 hit.
InterProiIPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C5P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGVPGFNTV PNPNHYDKSI VLDIKPLRSL KPVFPNGNQG PPFVGCPPFG
60 70 80 90 100
PSSSEYSSFF PFGAQQPTHD TPDLNQTQNT PIPSFVPPLR SYRTPTKTNG
110 120 130 140 150
PSSSSGTKRG VGRPKGTTSV KKKEKKTVAN EPNLDVQVVK KFSSDFDSGI
160 170 180 190 200
SAAEREDGNA YLVSSVLMRF DAVRRRLSQV EFTKSATSKA AGTLMSNGVR
210 220 230 240 250
TNMKKRVGTV PGIEVGDIFF SRIEMCLVGL HMQTMAGIDY IISKAGSDEE
260 270 280 290 300
SLATSIVSSG RYEGEAQDPE SLIYSGQGGN ADKNRQASDQ KLERGNLALE
310 320 330 340 350
NSLRKGNGVR VVRGEEDAAS KTGKIYIYDG LYSISESWVE KGKSGCNTFK
360 370 380 390 400
YKLVRQPGQP PAFGFWKSVQ KWKEGLTTRP GLILPDLTSG AESKPVSLVN
410 420 430 440 450
DVDEDKGPAY FTYTSSLKYS ETFKLTQPVI GCSCSGSCSP GNHNCSCIRK
460 470 480 490 500
NDGDLPYLNG VILVSRRPVI YECGPTCPCH ASCKNRVIQT GLKSRLEVFK
510 520 530 540 550
TRNRGWGLRS WDSLRAGSFI CEYAGEVKDN GNLRGNQEED AYVFDTSRVF
560 570 580 590 600
NSFKWNYEPE LVDEDPSTEV PEEFNLPSPL LISAKKFGNV ARFMNHSCSP
610 620 630 640 650
NVFWQPVIRE GNGESVIHIA FFAMRHIPPM AELTYDYGIS PTSEARDESL
660
LHGQRTCLCG SEQCRGSFG
Length:669
Mass (Da):73,439
Last modified:May 9, 2003 - v2
Checksum:i8878E000747FD1AB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti416S → P in AAK28968 (PubMed:11691919).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF344446 mRNA. Translation: AAK28968.1.
AC008017 Genomic DNA. Translation: AAD55657.1.
CP002684 Genomic DNA. Translation: AEE35414.1.
AY099620 mRNA. Translation: AAM20471.1.
BT002137 mRNA. Translation: AAN72148.1.
PIRiF96756.
RefSeqiNP_565056.1. NM_105968.3.
UniGeneiAt.11687.
At.43232.

Genome annotation databases

EnsemblPlantsiAT1G73100.1; AT1G73100.1; AT1G73100.
GeneIDi843641.
GrameneiAT1G73100.1; AT1G73100.1; AT1G73100.
KEGGiath:AT1G73100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF344446 mRNA. Translation: AAK28968.1.
AC008017 Genomic DNA. Translation: AAD55657.1.
CP002684 Genomic DNA. Translation: AEE35414.1.
AY099620 mRNA. Translation: AAM20471.1.
BT002137 mRNA. Translation: AAN72148.1.
PIRiF96756.
RefSeqiNP_565056.1. NM_105968.3.
UniGeneiAt.11687.
At.43232.

3D structure databases

ProteinModelPortaliQ9C5P4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi28860. 4 interactors.
IntActiQ9C5P4. 2 interactors.
MINTiMINT-8068307.
STRINGi3702.AT1G73100.1.

Proteomic databases

PaxDbiQ9C5P4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G73100.1; AT1G73100.1; AT1G73100.
GeneIDi843641.
GrameneiAT1G73100.1; AT1G73100.1; AT1G73100.
KEGGiath:AT1G73100.

Organism-specific databases

TAIRiAT1G73100.

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
COG3440. LUCA.
HOGENOMiHOG000238382.
InParanoidiQ9C5P4.
KOiK11420.
OMAiNHYDKSI.
OrthoDBiEOG093605J1.
PhylomeDBiQ9C5P4.

Miscellaneous databases

PROiQ9C5P4.

Gene expression databases

GenevisibleiQ9C5P4. AT.

Family and domain databases

Gene3Di2.30.280.10. 1 hit.
InterProiIPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUVH3_ARATH
AccessioniPrimary (citable) accession number: Q9C5P4
Secondary accession number(s): Q9SSL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 9, 2003
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.