Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9C5P1

- SUVH7_ARATH

UniProt

Q9C5P1 - SUVH7_ARATH

Protein

Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7

Gene

SUVH7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi458 – 4581Zinc 1By similarity
    Metal bindingi458 – 4581Zinc 2By similarity
    Metal bindingi461 – 4611Zinc 1By similarity
    Metal bindingi466 – 4661Zinc 1By similarity
    Metal bindingi466 – 4661Zinc 3By similarity
    Metal bindingi471 – 4711Zinc 1By similarity
    Metal bindingi473 – 4731Zinc 2By similarity
    Metal bindingi498 – 4981Zinc 2By similarity
    Metal bindingi498 – 4981Zinc 3By similarity
    Metal bindingi502 – 5021Zinc 2By similarity
    Metal bindingi504 – 5041Zinc 3By similarity
    Metal bindingi508 – 5081Zinc 3By similarity
    Binding sitei562 – 5621S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei564 – 5641S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei614 – 6141S-adenosyl-L-methioninePROSITE-ProRule annotation
    Metal bindingi620 – 6201Zinc 4By similarity
    Metal bindingi681 – 6811Zinc 4By similarity
    Metal bindingi683 – 6831Zinc 4By similarity
    Metal bindingi688 – 6881Zinc 4By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi129 – 14113A.T hookAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
    3. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Transferase

    Keywords - Ligandi

    DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

    Enzyme and pathway databases

    BioCyciARA:AT1G17770-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7 (EC:2.1.1.43)
    Alternative name(s):
    Histone H3-K9 methyltransferase 7
    Short name:
    H3-K9-HMTase 7
    Protein SET DOMAIN GROUP 17
    Suppressor of variegation 3-9 homolog protein 7
    Short name:
    Su(var)3-9 homolog protein 7
    Gene namesi
    Name:SUVH7
    Synonyms:SDG17, SET17
    Ordered Locus Names:At1g17770
    ORF Names:F2H15.1
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G17770.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Chromosomecentromere By similarity
    Note: Associates with centromeric constitutive heterochromatin.By similarity

    GO - Cellular componenti

    1. chromosome, centromeric region Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 693693Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7PRO_0000186078Add
    BLAST

    Proteomic databases

    PaxDbiQ9C5P1.
    PRIDEiQ9C5P1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9C5P1.

    Interactioni

    Protein-protein interaction databases

    BioGridi23594. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C5P1.
    SMRiQ9C5P1. Positions 175-691.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini227 – 373147YDGPROSITE-ProRule annotationAdd
    BLAST
    Domaini454 – 51663Pre-SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini519 – 660142SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini677 – 69317Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni529 – 5313S-adenosyl-L-methionine bindingBy similarity
    Regioni617 – 6182S-adenosyl-L-methionine bindingBy similarity

    Domaini

    Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity.
    In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation
    Contains 1 A.T hook DNA-binding domain.Curated
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 pre-SET domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation
    Contains 1 YDG domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG3440.
    HOGENOMiHOG000238382.
    InParanoidiQ9C5P1.
    KOiK11420.
    OMAiQVSEFIN.
    PhylomeDBiQ9C5P1.

    Family and domain databases

    Gene3Di2.30.280.10. 1 hit.
    InterProiIPR017956. AT_hook_DNA-bd_motif.
    IPR025794. Hist-Lys_N-MeTrfase_plant.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR015947. PUA-like_domain.
    IPR001214. SET_dom.
    IPR003105. SRA_YDG.
    [Graphical view]
    PfamiPF05033. Pre-SET. 1 hit.
    PF02182. SAD_SRA. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00384. AT_hook. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    SM00466. SRA. 1 hit.
    [Graphical view]
    SUPFAMiSSF88697. SSF88697. 1 hit.
    PROSITEiPS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS51575. SAM_MT43_SUVAR39_2. 1 hit.
    PS50280. SET. 1 hit.
    PS51015. YDG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9C5P1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKSIPIKAI PVACVRPDLV DDVTKNTSTI PTMVSPVLTN MPSATSPLLM    50
    VPPLRTIWPS NKEWYDGDAG PSSTGPIKRE ASDNTNDTAH NTFAPPPEMV 100
    IPLITIRPSD DSSNYSCDAG AGPSTGPVKR GRGRPKGSKN STPTEPKKPK 150
    VYDPNSLKVT SRGNFDSEIT EAETETGNQE IVDSVMMRFD AVRRRLCQIN 200
    HPEDILTTAS GNCTKMGVKT NTRRRIGAVP GIHVGDIFYY WGEMCLVGLH 250
    KSNYGGIDFF TAAESAVEGH AAMCVVTAGQ YDGETEGLDT LIYSGQGGTD 300
    VYGNARDQEM KGGNLALEAS VSKGNDVRVV RGVIHPHENN QKIYIYDGMY 350
    LVSKFWTVTG KSGFKEFRFK LVRKPNQPPA YAIWKTVENL RNHDLIDSRQ 400
    GFILEDLSFG AELLRVPLVN EVDEDDKTIP EDFDYIPSQC HSGMMTHEFH 450
    FDRQSLGCQN CRHQPCMHQN CTCVQRNGDL LPYHNNILVC RKPLIYECGG 500
    SCPCPDHCPT RLVQTGLKLH LEVFKTRNCG WGLRSWDPIR AGTFICEFAG 550
    LRKTKEEVEE DDDYLFDTSK IYQRFRWNYE PELLLEDSWE QVSEFINLPT 600
    QVLISAKEKG NVGRFMNHSC SPNVFWQPIE YENRGDVYLL IGLFAMKHIP 650
    PMTELTYDYG VSCVERSEED EVLLYKGKKT CLCGSVKCRG SFT 693
    Length:693
    Mass (Da):77,632
    Last modified:June 1, 2001 - v1
    Checksum:iE03E22BC2863E2D7
    GO

    Sequence cautioni

    The sequence AAF97258.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF344450 mRNA. Translation: AAK28972.1.
    AC034106 Genomic DNA. Translation: AAF97258.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE29634.1.
    PIRiG86312.
    RefSeqiNP_564036.1. NM_101640.1.
    UniGeneiAt.15818.

    Genome annotation databases

    EnsemblPlantsiAT1G17770.1; AT1G17770.1; AT1G17770.
    GeneIDi838355.
    KEGGiath:AT1G17770.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF344450 mRNA. Translation: AAK28972.1 .
    AC034106 Genomic DNA. Translation: AAF97258.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE29634.1 .
    PIRi G86312.
    RefSeqi NP_564036.1. NM_101640.1.
    UniGenei At.15818.

    3D structure databases

    ProteinModelPortali Q9C5P1.
    SMRi Q9C5P1. Positions 175-691.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 23594. 1 interaction.

    Proteomic databases

    PaxDbi Q9C5P1.
    PRIDEi Q9C5P1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G17770.1 ; AT1G17770.1 ; AT1G17770 .
    GeneIDi 838355.
    KEGGi ath:AT1G17770.

    Organism-specific databases

    TAIRi AT1G17770.

    Phylogenomic databases

    eggNOGi COG3440.
    HOGENOMi HOG000238382.
    InParanoidi Q9C5P1.
    KOi K11420.
    OMAi QVSEFIN.
    PhylomeDBi Q9C5P1.

    Enzyme and pathway databases

    BioCyci ARA:AT1G17770-MONOMER.

    Gene expression databases

    Genevestigatori Q9C5P1.

    Family and domain databases

    Gene3Di 2.30.280.10. 1 hit.
    InterProi IPR017956. AT_hook_DNA-bd_motif.
    IPR025794. Hist-Lys_N-MeTrfase_plant.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR015947. PUA-like_domain.
    IPR001214. SET_dom.
    IPR003105. SRA_YDG.
    [Graphical view ]
    Pfami PF05033. Pre-SET. 1 hit.
    PF02182. SAD_SRA. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00384. AT_hook. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    SM00466. SRA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF88697. SSF88697. 1 hit.
    PROSITEi PS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS51575. SAM_MT43_SUVAR39_2. 1 hit.
    PS50280. SET. 1 hit.
    PS51015. YDG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes."
      Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B.
      Nucleic Acids Res. 29:4319-4333(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], NOMENCLATURE.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Heterochromatin proteins and the control of heterochromatic gene silencing in Arabidopsis."
      Fischer A., Hofmann I., Naumann K., Reuter G.
      J. Plant Physiol. 163:358-368(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiSUVH7_ARATH
    AccessioniPrimary (citable) accession number: Q9C5P1
    Secondary accession number(s): Q9LMU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3