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Q9C5P1 (SUVH7_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7

EC=2.1.1.43
Alternative name(s):
Histone H3-K9 methyltransferase 7
Short name=H3-K9-HMTase 7
Protein SET DOMAIN GROUP 17
Suppressor of variegation 3-9 homolog protein 7
Short name=Su(var)3-9 homolog protein 7
Gene names
Name:SUVH7
Synonyms:SDG17, SET17
Ordered Locus Names:At1g17770
ORF Names:F2H15.1
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length693 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosomecentromere By similarity. Note: Associates with centromeric constitutive heterochromatin By similarity.

Domain

Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity.

In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.

Contains 1 A.T hook DNA-binding domain.

Contains 1 post-SET domain.

Contains 1 pre-SET domain.

Contains 1 SET domain.

Contains 1 YDG domain.

Sequence caution

The sequence AAF97258.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 693693Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7
PRO_0000186078

Regions

Domain227 – 373147YDG
Domain454 – 51663Pre-SET
Domain519 – 660142SET
Domain677 – 69317Post-SET
DNA binding129 – 14113A.T hook
Region529 – 5313S-adenosyl-L-methionine binding By similarity
Region617 – 6182S-adenosyl-L-methionine binding By similarity

Sites

Metal binding4581Zinc 1 By similarity
Metal binding4581Zinc 2 By similarity
Metal binding4611Zinc 1 By similarity
Metal binding4661Zinc 1 By similarity
Metal binding4661Zinc 3 By similarity
Metal binding4711Zinc 1 By similarity
Metal binding4731Zinc 2 By similarity
Metal binding4981Zinc 2 By similarity
Metal binding4981Zinc 3 By similarity
Metal binding5021Zinc 2 By similarity
Metal binding5041Zinc 3 By similarity
Metal binding5081Zinc 3 By similarity
Metal binding6201Zinc 4 By similarity
Metal binding6811Zinc 4 By similarity
Metal binding6831Zinc 4 By similarity
Metal binding6881Zinc 4 By similarity
Binding site5621S-adenosyl-L-methionine By similarity
Binding site5641S-adenosyl-L-methionine By similarity
Binding site6141S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9C5P1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: E03E22BC2863E2D7

FASTA69377,632
        10         20         30         40         50         60 
MDKSIPIKAI PVACVRPDLV DDVTKNTSTI PTMVSPVLTN MPSATSPLLM VPPLRTIWPS 

        70         80         90        100        110        120 
NKEWYDGDAG PSSTGPIKRE ASDNTNDTAH NTFAPPPEMV IPLITIRPSD DSSNYSCDAG 

       130        140        150        160        170        180 
AGPSTGPVKR GRGRPKGSKN STPTEPKKPK VYDPNSLKVT SRGNFDSEIT EAETETGNQE 

       190        200        210        220        230        240 
IVDSVMMRFD AVRRRLCQIN HPEDILTTAS GNCTKMGVKT NTRRRIGAVP GIHVGDIFYY 

       250        260        270        280        290        300 
WGEMCLVGLH KSNYGGIDFF TAAESAVEGH AAMCVVTAGQ YDGETEGLDT LIYSGQGGTD 

       310        320        330        340        350        360 
VYGNARDQEM KGGNLALEAS VSKGNDVRVV RGVIHPHENN QKIYIYDGMY LVSKFWTVTG 

       370        380        390        400        410        420 
KSGFKEFRFK LVRKPNQPPA YAIWKTVENL RNHDLIDSRQ GFILEDLSFG AELLRVPLVN 

       430        440        450        460        470        480 
EVDEDDKTIP EDFDYIPSQC HSGMMTHEFH FDRQSLGCQN CRHQPCMHQN CTCVQRNGDL 

       490        500        510        520        530        540 
LPYHNNILVC RKPLIYECGG SCPCPDHCPT RLVQTGLKLH LEVFKTRNCG WGLRSWDPIR 

       550        560        570        580        590        600 
AGTFICEFAG LRKTKEEVEE DDDYLFDTSK IYQRFRWNYE PELLLEDSWE QVSEFINLPT 

       610        620        630        640        650        660 
QVLISAKEKG NVGRFMNHSC SPNVFWQPIE YENRGDVYLL IGLFAMKHIP PMTELTYDYG 

       670        680        690 
VSCVERSEED EVLLYKGKKT CLCGSVKCRG SFT 

« Hide

References

« Hide 'large scale' references
[1]"The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes."
Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B.
Nucleic Acids Res. 29:4319-4333(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], NOMENCLATURE.
[2]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Heterochromatin proteins and the control of heterochromatic gene silencing in Arabidopsis."
Fischer A., Hofmann I., Naumann K., Reuter G.
J. Plant Physiol. 163:358-368(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF344450 mRNA. Translation: AAK28972.1.
AC034106 Genomic DNA. Translation: AAF97258.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29634.1.
PIRG86312.
RefSeqNP_564036.1. NM_101640.1.
UniGeneAt.15818.

3D structure databases

ProteinModelPortalQ9C5P1.
SMRQ9C5P1. Positions 175-691.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid23594. 1 interaction.

Proteomic databases

PaxDbQ9C5P1.
PRIDEQ9C5P1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G17770.1; AT1G17770.1; AT1G17770.
GeneID838355.
KEGGath:AT1G17770.

Organism-specific databases

TAIRAT1G17770.

Phylogenomic databases

eggNOGCOG3440.
HOGENOMHOG000238382.
InParanoidQ9C5P1.
KOK11420.
OMAQVSEFIN.
PhylomeDBQ9C5P1.

Enzyme and pathway databases

BioCycARA:AT1G17770-MONOMER.

Gene expression databases

GenevestigatorQ9C5P1.

Family and domain databases

Gene3D2.30.280.10. 1 hit.
InterProIPR017956. AT_hook_DNA-bd_motif.
IPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view]
PfamPF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTSM00384. AT_hook. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view]
SUPFAMSSF88697. SSF88697. 1 hit.
PROSITEPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUVH7_ARATH
AccessionPrimary (citable) accession number: Q9C5P1
Secondary accession number(s): Q9LMU9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names