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Q9C5P1

- SUVH7_ARATH

UniProt

Q9C5P1 - SUVH7_ARATH

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Protein

Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7

Gene

SUVH7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi458 – 4581Zinc 1By similarity
Metal bindingi458 – 4581Zinc 2By similarity
Metal bindingi461 – 4611Zinc 1By similarity
Metal bindingi466 – 4661Zinc 1By similarity
Metal bindingi466 – 4661Zinc 3By similarity
Metal bindingi471 – 4711Zinc 1By similarity
Metal bindingi473 – 4731Zinc 2By similarity
Metal bindingi498 – 4981Zinc 2By similarity
Metal bindingi498 – 4981Zinc 3By similarity
Metal bindingi502 – 5021Zinc 2By similarity
Metal bindingi504 – 5041Zinc 3By similarity
Metal bindingi508 – 5081Zinc 3By similarity
Binding sitei562 – 5621S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei564 – 5641S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei614 – 6141S-adenosyl-L-methioninePROSITE-ProRule annotation
Metal bindingi620 – 6201Zinc 4By similarity
Metal bindingi681 – 6811Zinc 4By similarity
Metal bindingi683 – 6831Zinc 4By similarity
Metal bindingi688 – 6881Zinc 4By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi129 – 14113A.T hookAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G17770-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7 (EC:2.1.1.43)
Alternative name(s):
Histone H3-K9 methyltransferase 7
Short name:
H3-K9-HMTase 7
Protein SET DOMAIN GROUP 17
Suppressor of variegation 3-9 homolog protein 7
Short name:
Su(var)3-9 homolog protein 7
Gene namesi
Name:SUVH7
Synonyms:SDG17, SET17
Ordered Locus Names:At1g17770
ORF Names:F2H15.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G17770.

Subcellular locationi

Nucleus PROSITE-ProRule annotation. Chromosomecentromere By similarity
Note: Associates with centromeric constitutive heterochromatin.By similarity

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7PRO_0000186078Add
BLAST

Proteomic databases

PaxDbiQ9C5P1.
PRIDEiQ9C5P1.

Expressioni

Gene expression databases

GenevestigatoriQ9C5P1.

Interactioni

Protein-protein interaction databases

BioGridi23594. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9C5P1.
SMRiQ9C5P1. Positions 223-691.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini227 – 373147YDGPROSITE-ProRule annotationAdd
BLAST
Domaini454 – 51663Pre-SETPROSITE-ProRule annotationAdd
BLAST
Domaini519 – 660142SETPROSITE-ProRule annotationAdd
BLAST
Domaini677 – 69317Post-SETPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni529 – 5313S-adenosyl-L-methionine bindingBy similarity
Regioni617 – 6182S-adenosyl-L-methionine bindingBy similarity

Domaini

Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity.
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation
Contains 1 A.T hook DNA-binding domain.Curated
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 pre-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation
Contains 1 YDG domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG3440.
HOGENOMiHOG000238382.
InParanoidiQ9C5P1.
KOiK11420.
OMAiQVSEFIN.
PhylomeDBiQ9C5P1.

Family and domain databases

Gene3Di2.30.280.10. 1 hit.
InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00384. AT_hook. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C5P1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKSIPIKAI PVACVRPDLV DDVTKNTSTI PTMVSPVLTN MPSATSPLLM
60 70 80 90 100
VPPLRTIWPS NKEWYDGDAG PSSTGPIKRE ASDNTNDTAH NTFAPPPEMV
110 120 130 140 150
IPLITIRPSD DSSNYSCDAG AGPSTGPVKR GRGRPKGSKN STPTEPKKPK
160 170 180 190 200
VYDPNSLKVT SRGNFDSEIT EAETETGNQE IVDSVMMRFD AVRRRLCQIN
210 220 230 240 250
HPEDILTTAS GNCTKMGVKT NTRRRIGAVP GIHVGDIFYY WGEMCLVGLH
260 270 280 290 300
KSNYGGIDFF TAAESAVEGH AAMCVVTAGQ YDGETEGLDT LIYSGQGGTD
310 320 330 340 350
VYGNARDQEM KGGNLALEAS VSKGNDVRVV RGVIHPHENN QKIYIYDGMY
360 370 380 390 400
LVSKFWTVTG KSGFKEFRFK LVRKPNQPPA YAIWKTVENL RNHDLIDSRQ
410 420 430 440 450
GFILEDLSFG AELLRVPLVN EVDEDDKTIP EDFDYIPSQC HSGMMTHEFH
460 470 480 490 500
FDRQSLGCQN CRHQPCMHQN CTCVQRNGDL LPYHNNILVC RKPLIYECGG
510 520 530 540 550
SCPCPDHCPT RLVQTGLKLH LEVFKTRNCG WGLRSWDPIR AGTFICEFAG
560 570 580 590 600
LRKTKEEVEE DDDYLFDTSK IYQRFRWNYE PELLLEDSWE QVSEFINLPT
610 620 630 640 650
QVLISAKEKG NVGRFMNHSC SPNVFWQPIE YENRGDVYLL IGLFAMKHIP
660 670 680 690
PMTELTYDYG VSCVERSEED EVLLYKGKKT CLCGSVKCRG SFT
Length:693
Mass (Da):77,632
Last modified:June 1, 2001 - v1
Checksum:iE03E22BC2863E2D7
GO

Sequence cautioni

The sequence AAF97258.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF344450 mRNA. Translation: AAK28972.1.
AC034106 Genomic DNA. Translation: AAF97258.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29634.1.
PIRiG86312.
RefSeqiNP_564036.1. NM_101640.1.
UniGeneiAt.15818.

Genome annotation databases

EnsemblPlantsiAT1G17770.1; AT1G17770.1; AT1G17770.
GeneIDi838355.
KEGGiath:AT1G17770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF344450 mRNA. Translation: AAK28972.1 .
AC034106 Genomic DNA. Translation: AAF97258.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE29634.1 .
PIRi G86312.
RefSeqi NP_564036.1. NM_101640.1.
UniGenei At.15818.

3D structure databases

ProteinModelPortali Q9C5P1.
SMRi Q9C5P1. Positions 223-691.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 23594. 1 interaction.

Proteomic databases

PaxDbi Q9C5P1.
PRIDEi Q9C5P1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G17770.1 ; AT1G17770.1 ; AT1G17770 .
GeneIDi 838355.
KEGGi ath:AT1G17770.

Organism-specific databases

TAIRi AT1G17770.

Phylogenomic databases

eggNOGi COG3440.
HOGENOMi HOG000238382.
InParanoidi Q9C5P1.
KOi K11420.
OMAi QVSEFIN.
PhylomeDBi Q9C5P1.

Enzyme and pathway databases

BioCyci ARA:AT1G17770-MONOMER.

Gene expression databases

Genevestigatori Q9C5P1.

Family and domain databases

Gene3Di 2.30.280.10. 1 hit.
InterProi IPR017956. AT_hook_DNA-bd_motif.
IPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view ]
Pfami PF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00384. AT_hook. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view ]
SUPFAMi SSF88697. SSF88697. 1 hit.
PROSITEi PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes."
    Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B.
    Nucleic Acids Res. 29:4319-4333(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], NOMENCLATURE.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Heterochromatin proteins and the control of heterochromatic gene silencing in Arabidopsis."
    Fischer A., Hofmann I., Naumann K., Reuter G.
    J. Plant Physiol. 163:358-368(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiSUVH7_ARATH
AccessioniPrimary (citable) accession number: Q9C5P1
Secondary accession number(s): Q9LMU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3