Q9C5P1 (SUVH7_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7
EC=2.1.1.43

Alternative name(s):
Histone H3-K9 methyltransferase 7
Short name=H3-K9-HMTase 7
Protein SET DOMAIN GROUP 17
Suppressor of variegation 3-9 homolog protein 7
Short name=Su(var)3-9 homolog protein 7

Gene names

Name:	SUVH7
Synonyms:	SDG17, SET17
Ordered Locus Names:	At1g17770
ORF Names:	F2H15.1

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	693 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus By similarity. Chromosome › centromere By similarity. Note: Associates with centromeric constitutive heterochromatin By similarity.
Domain	Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. Contains 1 A.T hook DNA-binding domain. Contains 1 post-SET domain. Contains 1 pre-SET domain. Contains 1 SET domain. Contains 1 YDG domain.
Sequence caution	The sequence AAF97258.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Centromere Chromosome Nucleus
Ligand	DNA-binding S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	chromosome, centromeric region Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 693	693	Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7		PRO_0000186078
Regions
	Domain	227 – 373	147	YDG
	Domain	454 – 516	63	Pre-SET
	Domain	518 – 664	147	SET
	Domain	677 – 693	17	Post-SET
	DNA binding	129 – 141	13	A.T hook

Sequences

	Sequence		Length	Mass (Da)
	Q9C5P1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: E03E22BC2863E2D7	FASTA	693	77,632
	10 20 30 40 50 60 MDKSIPIKAI PVACVRPDLV DDVTKNTSTI PTMVSPVLTN MPSATSPLLM VPPLRTIWPS 70 80 90 100 110 120 NKEWYDGDAG PSSTGPIKRE ASDNTNDTAH NTFAPPPEMV IPLITIRPSD DSSNYSCDAG 130 140 150 160 170 180 AGPSTGPVKR GRGRPKGSKN STPTEPKKPK VYDPNSLKVT SRGNFDSEIT EAETETGNQE 190 200 210 220 230 240 IVDSVMMRFD AVRRRLCQIN HPEDILTTAS GNCTKMGVKT NTRRRIGAVP GIHVGDIFYY 250 260 270 280 290 300 WGEMCLVGLH KSNYGGIDFF TAAESAVEGH AAMCVVTAGQ YDGETEGLDT LIYSGQGGTD 310 320 330 340 350 360 VYGNARDQEM KGGNLALEAS VSKGNDVRVV RGVIHPHENN QKIYIYDGMY LVSKFWTVTG 370 380 390 400 410 420 KSGFKEFRFK LVRKPNQPPA YAIWKTVENL RNHDLIDSRQ GFILEDLSFG AELLRVPLVN 430 440 450 460 470 480 EVDEDDKTIP EDFDYIPSQC HSGMMTHEFH FDRQSLGCQN CRHQPCMHQN CTCVQRNGDL 490 500 510 520 530 540 LPYHNNILVC RKPLIYECGG SCPCPDHCPT RLVQTGLKLH LEVFKTRNCG WGLRSWDPIR 550 560 570 580 590 600 AGTFICEFAG LRKTKEEVEE DDDYLFDTSK IYQRFRWNYE PELLLEDSWE QVSEFINLPT 610 620 630 640 650 660 QVLISAKEKG NVGRFMNHSC SPNVFWQPIE YENRGDVYLL IGLFAMKHIP PMTELTYDYG 670 680 690 VSCVERSEED EVLLYKGKKT CLCGSVKCRG SFT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes." Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B. Nucleic Acids Res. 29:4319-4333(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], NOMENCLATURE.
[2]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[4]	"Heterochromatin proteins and the control of heterochromatic gene silencing in Arabidopsis." Fischer A., Hofmann I., Naumann K., Reuter G. J. Plant Physiol. 163:358-368(2006) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF344450 mRNA. Translation: AAK28972.1. AC034106 Genomic DNA. Translation: AAF97258.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE29634.1.
IPI	IPI00542064.
PIR	G86312.
RefSeq	NP_564036.1. NM_101640.1.
UniGene	At.15818.
3D structure databases
ProteinModelPortal	Q9C5P1.
SMR	Q9C5P1. Positions 226-378, 403-691.
ModBase	Search...
Proteomic databases
PaxDb	Q9C5P1.
PRIDE	Q9C5P1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G17770.1; AT1G17770.1; AT1G17770.
GeneID	838355.
KEGG	ath:AT1G17770.
Organism-specific databases
TAIR	At1g17770.
Phylogenomic databases
eggNOG	COG3440.
HOGENOM	HOG000238382.
InParanoid	Q9C5P1.
KO	K11420.
OMA	QVSEFIN.
PhylomeDB	Q9C5P1.
ProtClustDB	CLSN2687844.
Gene expression databases
Genevestigator	Q9C5P1.
GermOnline	AT1G17770. Arabidopsis thaliana.
Family and domain databases
Gene3D	2.30.280.10. 1 hit.
InterPro	IPR017956. AT_hook_DNA-bd_motif. IPR025794. Hist-Lys_N-MeTrfase_plant. IPR003616. Post-SET_dom. IPR007728. Pre-SET_dom. IPR001214. SET_dom. IPR003105. SRA_YDG. [Graphical view]
Pfam	PF05033. Pre-SET. 1 hit. PF00856. SET. 1 hit. PF02182. YDG_SRA. 1 hit. [Graphical view]
SMART	SM00384. AT_hook. 1 hit. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. SM00466. SRA. 1 hit. [Graphical view]
PROSITE	PS50868. POST_SET. 1 hit. PS50867. PRE_SET. 1 hit. PS50280. SET. 1 hit. PS51015. YDG. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUVH7_ARATH

Accession

Primary (citable) accession number: Q9C5P1
Secondary accession number(s): Q9LMU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program