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Protein

Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7

Gene

SUVH7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi458Zinc 1By similarity1
Metal bindingi458Zinc 2By similarity1
Metal bindingi461Zinc 1By similarity1
Metal bindingi466Zinc 1By similarity1
Metal bindingi466Zinc 3By similarity1
Metal bindingi471Zinc 1By similarity1
Metal bindingi473Zinc 2By similarity1
Metal bindingi498Zinc 2By similarity1
Metal bindingi498Zinc 3By similarity1
Metal bindingi502Zinc 2By similarity1
Metal bindingi504Zinc 3By similarity1
Metal bindingi508Zinc 3By similarity1
Binding sitei562S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei564S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei614S-adenosyl-L-methioninePROSITE-ProRule annotation1
Metal bindingi620Zinc 4By similarity1
Metal bindingi681Zinc 4By similarity1
Metal bindingi683Zinc 4By similarity1
Metal bindingi688Zinc 4By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi129 – 141A.T hookAdd BLAST13

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7 (EC:2.1.1.43)
Alternative name(s):
Histone H3-K9 methyltransferase 7
Short name:
H3-K9-HMTase 7
Protein SET DOMAIN GROUP 17
Suppressor of variegation 3-9 homolog protein 7
Short name:
Su(var)3-9 homolog protein 7
Gene namesi
Name:SUVH7
Synonyms:SDG17, SET17
Ordered Locus Names:At1g17770
ORF Names:F2H15.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G17770.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Chromosomecentromere By similarity

  • Note: Associates with centromeric constitutive heterochromatin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001860781 – 693Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7Add BLAST693

Proteomic databases

PaxDbiQ9C5P1.
PRIDEiQ9C5P1.

Expressioni

Gene expression databases

ExpressionAtlasiQ9C5P1. differential.
GenevisibleiQ9C5P1. AT.

Interactioni

Protein-protein interaction databases

BioGridi23594. 1 interactor.
STRINGi3702.AT1G17770.1.

Structurei

3D structure databases

ProteinModelPortaliQ9C5P1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini227 – 373YDGPROSITE-ProRule annotationAdd BLAST147
Domaini454 – 516Pre-SETPROSITE-ProRule annotationAdd BLAST63
Domaini519 – 660SETPROSITE-ProRule annotationAdd BLAST142
Domaini677 – 693Post-SETPROSITE-ProRule annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni529 – 531S-adenosyl-L-methionine bindingBy similarity3
Regioni617 – 618S-adenosyl-L-methionine bindingBy similarity2

Domaini

Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity.
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation
Contains 1 A.T hook DNA-binding domain.Curated
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 pre-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation
Contains 1 YDG domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
COG3440. LUCA.
HOGENOMiHOG000238382.
InParanoidiQ9C5P1.
KOiK11420.
OMAiQVSEFIN.
OrthoDBiEOG093613YB.
PhylomeDBiQ9C5P1.

Family and domain databases

Gene3Di2.30.280.10. 1 hit.
InterProiIPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C5P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKSIPIKAI PVACVRPDLV DDVTKNTSTI PTMVSPVLTN MPSATSPLLM
60 70 80 90 100
VPPLRTIWPS NKEWYDGDAG PSSTGPIKRE ASDNTNDTAH NTFAPPPEMV
110 120 130 140 150
IPLITIRPSD DSSNYSCDAG AGPSTGPVKR GRGRPKGSKN STPTEPKKPK
160 170 180 190 200
VYDPNSLKVT SRGNFDSEIT EAETETGNQE IVDSVMMRFD AVRRRLCQIN
210 220 230 240 250
HPEDILTTAS GNCTKMGVKT NTRRRIGAVP GIHVGDIFYY WGEMCLVGLH
260 270 280 290 300
KSNYGGIDFF TAAESAVEGH AAMCVVTAGQ YDGETEGLDT LIYSGQGGTD
310 320 330 340 350
VYGNARDQEM KGGNLALEAS VSKGNDVRVV RGVIHPHENN QKIYIYDGMY
360 370 380 390 400
LVSKFWTVTG KSGFKEFRFK LVRKPNQPPA YAIWKTVENL RNHDLIDSRQ
410 420 430 440 450
GFILEDLSFG AELLRVPLVN EVDEDDKTIP EDFDYIPSQC HSGMMTHEFH
460 470 480 490 500
FDRQSLGCQN CRHQPCMHQN CTCVQRNGDL LPYHNNILVC RKPLIYECGG
510 520 530 540 550
SCPCPDHCPT RLVQTGLKLH LEVFKTRNCG WGLRSWDPIR AGTFICEFAG
560 570 580 590 600
LRKTKEEVEE DDDYLFDTSK IYQRFRWNYE PELLLEDSWE QVSEFINLPT
610 620 630 640 650
QVLISAKEKG NVGRFMNHSC SPNVFWQPIE YENRGDVYLL IGLFAMKHIP
660 670 680 690
PMTELTYDYG VSCVERSEED EVLLYKGKKT CLCGSVKCRG SFT
Length:693
Mass (Da):77,632
Last modified:June 1, 2001 - v1
Checksum:iE03E22BC2863E2D7
GO

Sequence cautioni

The sequence AAF97258 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF344450 mRNA. Translation: AAK28972.1.
AC034106 Genomic DNA. Translation: AAF97258.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29634.1.
PIRiG86312.
RefSeqiNP_564036.1. NM_101640.1.
UniGeneiAt.15818.

Genome annotation databases

EnsemblPlantsiAT1G17770.1; AT1G17770.1; AT1G17770.
GeneIDi838355.
GrameneiAT1G17770.1; AT1G17770.1; AT1G17770.
KEGGiath:AT1G17770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF344450 mRNA. Translation: AAK28972.1.
AC034106 Genomic DNA. Translation: AAF97258.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29634.1.
PIRiG86312.
RefSeqiNP_564036.1. NM_101640.1.
UniGeneiAt.15818.

3D structure databases

ProteinModelPortaliQ9C5P1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23594. 1 interactor.
STRINGi3702.AT1G17770.1.

Proteomic databases

PaxDbiQ9C5P1.
PRIDEiQ9C5P1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G17770.1; AT1G17770.1; AT1G17770.
GeneIDi838355.
GrameneiAT1G17770.1; AT1G17770.1; AT1G17770.
KEGGiath:AT1G17770.

Organism-specific databases

TAIRiAT1G17770.

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
COG3440. LUCA.
HOGENOMiHOG000238382.
InParanoidiQ9C5P1.
KOiK11420.
OMAiQVSEFIN.
OrthoDBiEOG093613YB.
PhylomeDBiQ9C5P1.

Miscellaneous databases

PROiQ9C5P1.

Gene expression databases

ExpressionAtlasiQ9C5P1. differential.
GenevisibleiQ9C5P1. AT.

Family and domain databases

Gene3Di2.30.280.10. 1 hit.
InterProiIPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUVH7_ARATH
AccessioniPrimary (citable) accession number: Q9C5P1
Secondary accession number(s): Q9LMU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.