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Protein

Lupeol synthase 1

Gene

LUP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multifunctional enzyme that converts oxidosqualene to lupeol and 3,20-dihydroxylupane. Minor production of beta-amyrin, germanicol, taraxasterol and psi-taraxasterol.2 Publications

Catalytic activityi

Lupan-3-beta,20-diol = (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O.
(3S)-2,3-epoxy-2,3-dihydrosqualene = lupeol.

GO - Molecular functioni

  • beta-amyrin synthase activity Source: TAIR
  • lupan-3beta,20-diol synthase activity Source: UniProtKB-EC
  • lupeol synthase activity Source: TAIR

Keywordsi

Molecular functionIsomerase, Lyase

Enzyme and pathway databases

BioCyciARA:GQT-1793-MONOMER
BRENDAi4.2.1.128 399
5.4.99.41 399
ReactomeiR-ATH-191273 Cholesterol biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Lupeol synthase 1 (EC:4.2.1.128, EC:5.4.99.41)
Short name:
AtLUP1
Alternative name(s):
Lupan-3-beta,20-diol synthase
Gene namesi
Name:LUP1
Ordered Locus Names:At1g78970
ORF Names:YUP8H12R.28, YUP8H12R.42
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G78970
TAIRilocus:2207310 AT1G78970

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003661311 – 757Lupeol synthase 1Add BLAST757

Proteomic databases

PaxDbiQ9C5M3

Expressioni

Gene expression databases

ExpressionAtlasiQ9C5M3 baseline and differential
GenevisibleiQ9C5M3 AT

Interactioni

Protein-protein interaction databases

BioGridi29456, 2 interactors
STRINGi3702.AT1G78970.1

Structurei

3D structure databases

ProteinModelPortaliQ9C5M3
SMRiQ9C5M3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati149 – 190PFTB 1Add BLAST42
Repeati589 – 629PFTB 2Add BLAST41
Repeati638 – 679PFTB 3Add BLAST42

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0497 Eukaryota
COG1657 LUCA
HOGENOMiHOG000234317
InParanoidiQ9C5M3
KOiK15816
OMAiEFMANTM
OrthoDBiEOG0936031Q
PhylomeDBiQ9C5M3

Family and domain databases

CDDicd02892 SQCY_1, 1 hit
InterProiView protein in InterPro
IPR032696 SQ_cyclase_C
IPR032697 SQ_cyclase_N
IPR018333 Squalene_cyclase
IPR002365 Terpene_synthase_CS
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF13243 SQHop_cyclase_C, 1 hit
PF13249 SQHop_cyclase_N, 1 hit
SUPFAMiSSF48239 SSF48239, 2 hits
TIGRFAMsiTIGR01787 squalene_cyclas, 1 hit
PROSITEiView protein in PROSITE
PS01074 TERPENE_SYNTHASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C5M3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKLKIGKGN GEDPHLFSSN NFVGRQTWKF DHKAGSPEER AAVEEARRGF
60 70 80 90 100
LDNRFRVKGC SDLLWRMQFL REKKFEQGIP QLKATNIEEI TYETTTNALR
110 120 130 140 150
RGVRYFTALQ ASDGHWPGEI TGPLFFLPPL IFCLYITGHL EEVFDAEHRK
160 170 180 190 200
EMLRHIYCHQ NEDGGWGLHI ESKSVMFCTV LNYICLRMLG ENPEQDACKR
210 220 230 240 250
ARQWILDRGG VIFIPSWGKF WLSILGVYDW SGTNPTPPEL LMLPSFLPIH
260 270 280 290 300
PGKILCYSRM VSIPMSYLYG KRFVGPITPL ILLLREELYL EPYEEINWKK
310 320 330 340 350
SRRLYAKEDM YYAHPLVQDL LSDTLQNFVE PLLTRWPLNK LVREKALQLT
360 370 380 390 400
MKHIHYEDEN SHYITIGCVE KVLCMLACWV ENPNGDYFKK HLARIPDYMW
410 420 430 440 450
VAEDGMKMQS FGCQLWDTGF AIQALLASNL PDETDDALKR GHNYIKASQV
460 470 480 490 500
RENPSGDFRS MYRHISKGAW TFSDRDHGWQ VSDCTAEALK CCLLLSMMSA
510 520 530 540 550
DIVGQKIDDE QLYDSVNLLL SLQSGNGGVN AWEPSRAYKW LELLNPTEFM
560 570 580 590 600
ANTMVEREFV ECTSSVIQAL DLFRKLYPDH RKKEINRSIE KAVQFIQDNQ
610 620 630 640 650
TPDGSWYGNW GVCFIYATWF ALGGLAAAGE TYNDCLAMRN GVHFLLTTQR
660 670 680 690 700
DDGGWGESYL SCSEQRYIPS EGERSNLVQT SWAMMALIHT GQAERDLIPL
710 720 730 740 750
HRAAKLIINS QLENGDFPQQ EIVGAFMNTC MLHYATYRNT FPLWALAEYR

KVVFIVN
Length:757
Mass (Da):87,352
Last modified:June 1, 2001 - v1
Checksum:i98C1C0C30D7975D5
GO

Sequence cautioni

The sequence AAC17055 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti466S → W in AAB94341 (PubMed:11247608).Curated1
Sequence conflicti503V → G in AAD05032 (PubMed:9883589).Curated1
Sequence conflicti698I → T in AAD05032 (PubMed:9883589).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49919 mRNA Translation: AAD05032.1
U87266 mRNA Translation: AAB94341.1
AC002986 Genomic DNA Translation: AAC17055.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE36186.1
CP002684 Genomic DNA Translation: AEE36187.1
CP002684 Genomic DNA Translation: ANM58606.1
AF360147 mRNA Translation: AAK25857.1
AY052358 mRNA Translation: AAK96549.1
AY142678 mRNA Translation: AAN13216.1
PIRiT01058
RefSeqiNP_001321029.1, NM_001334865.1
NP_178018.1, NM_106546.3
NP_849903.1, NM_179572.2
UniGeneiAt.19007

Genome annotation databases

EnsemblPlantsiAT1G78970.1; AT1G78970.1; AT1G78970
AT1G78970.2; AT1G78970.2; AT1G78970
AT1G78970.3; AT1G78970.3; AT1G78970
GeneIDi844237
GrameneiAT1G78970.1; AT1G78970.1; AT1G78970
AT1G78970.2; AT1G78970.2; AT1G78970
AT1G78970.3; AT1G78970.3; AT1G78970
KEGGiath:AT1G78970

Similar proteinsi

Entry informationi

Entry nameiLUP1_ARATH
AccessioniPrimary (citable) accession number: Q9C5M3
Secondary accession number(s): O49985, O64551, P92977
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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