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Protein

Phosphoinositide phosphatase SAC7

Gene

SAC7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Phosphoinositide phosphatase that preferentially hydrolyzes PtdIns4P. Regulates the accumulation of PtdIns4P on membrane compartments at the tips of growing root hairs leading to proper root hair development.3 Publications

GO - Molecular functioni

  • phosphatidylinositol-4-phosphate phosphatase activity Source: TAIR

GO - Biological processi

  • response to wounding Source: UniProtKB
  • root hair cell tip growth Source: TAIR

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciARA:AT3G51460-MONOMER
BRENDAi3.1.3.66 399
3.1.3.B4 399
ReactomeiR-ATH-1483248 Synthesis of PIPs at the ER membrane
R-ATH-1660514 Synthesis of PIPs at the Golgi membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phosphatase SAC7 (EC:3.1.3.-)
Short name:
AtSAC7
Alternative name(s):
Protein ROOT HAIR DEFECTIVE 4
Protein SUPPRESSOR OF ACTIN 1C
Short name:
AtSAC1c
Protein SUPPRESSOR OF ACTIN 7
SAC domain protein 7
SAC1-like protein AtSAC1c
Gene namesi
Name:SAC7
Synonyms:RHD4, SAC1C
Ordered Locus Names:At3g51460
ORF Names:F26O13.100
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G51460
TAIRilocus:2081780 AT3G51460

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei528 – 548HelicalSequence analysisAdd BLAST21
Transmembranei559 – 579HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Short, bulged and branched root hairs. Accumulates elevated levels of PtdIns4P in roots.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004219731 – 597Phosphoinositide phosphatase SAC7Add BLAST597

Proteomic databases

PaxDbiQ9C5G5
PRIDEiQ9C5G5

PTM databases

iPTMnetiQ9C5G5

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Inductioni

By wounding.1 Publication

Gene expression databases

ExpressionAtlasiQ9C5G5 baseline and differential
GenevisibleiQ9C5G5 AT

Interactioni

Protein-protein interaction databases

BioGridi9627, 1 interactor
STRINGi3702.AT3G51460.1

Structurei

3D structure databases

ProteinModelPortaliQ9C5G5
SMRiQ9C5G5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 458SACPROSITE-ProRule annotationAdd BLAST329

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi393 – 404Phosphatase catalytic coreAdd BLAST12

Domaini

The phosphatase catalytic core motif (or RXNCXDCLDRTN motif) from the SAC domain is found in metal-independent protein phosphatases and inositol polyphosphate phosphatases.By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1889 Eukaryota
COG5329 LUCA
HOGENOMiHOG000189112
InParanoidiQ9C5G5
KOiK21797
OMAiMLFWGAM
OrthoDBiEOG0936054J
PhylomeDBiQ9C5G5

Family and domain databases

InterProiView protein in InterPro
IPR030069 SAC6/7/8
IPR002013 SAC_dom
PANTHERiPTHR11200:SF254 PTHR11200:SF254, 1 hit
PfamiView protein in Pfam
PF02383 Syja_N, 1 hit
PROSITEiView protein in PROSITE
PS50275 SAC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C5G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METVDSRNKL HSRLRLWEFP DQYIIEPADG SGSSCLDISR VDASMKLIDQ
60 70 80 90 100
VPESNSVRVP KIRSIFGVVG MLKLLAGSYL VVVTESERVG SFLGHPIFKV
110 120 130 140 150
TTLKVLPCDH SLKNSPEEQK KMETEFSKLL SVAEKTTGLY FSYEVNLTLS
160 170 180 190 200
SQRLHEMGDE SKSLPLWRQA EPRFLWNNYM LEVLIDNKLD QFLLPVIQGS
210 220 230 240 250
FNSFETAIGR DIVDITLIAR RCTRRNGTRM WRRGADLDGY VANFVETEQI
260 270 280 290 300
VQMNGYTSSF VQVRGSMPFM WEQVVDLTYK PKFEIVQPEE AKRIAERHFL
310 320 330 340 350
DLRKKYGSVL AVDLVNKQGG EGRLCEKYAT VMQHITGDDI RYLHFDFHQI
360 370 380 390 400
CGHIHFERLS ILYEQIEGFL EKNGYFLLNE KGEKMKEQLG VVRSNCIDCL
410 420 430 440 450
DRTNVTQSMI GRKMLEVQLK RIGVFGAEET ISSHLNFDEH YKILWANHGD
460 470 480 490 500
EISIQYSGTP ALKGDFVRYG HRTAHGVLKD GWSSLRRYYL NNFADGTKQD
510 520 530 540 550
AIDLLQGHYI VAVSRDMAPV PQKGGLEAVA NFPVALFVVL MSFWFATMSL
560 570 580 590
KQTGSDYKHK HLFFSLLWTG ICVGMAALVR ANGRIFCNRP RLHKPRG
Length:597
Mass (Da):68,237
Last modified:June 1, 2001 - v1
Checksum:i18C62357E3BD53DA
GO

Sequence cautioni

The sequence CAB63010 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF266459 mRNA Translation: AAP41368.1
AY227250 mRNA Translation: AAP49840.1
AL133452 Genomic DNA Translation: CAB63010.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE78795.1
AF360267 mRNA Translation: AAK25977.1
AY040078 mRNA Translation: AAK64136.1
AK229963 mRNA Translation: BAF01789.1
PIRiT45777
RefSeqiNP_190714.2, NM_115005.5
UniGeneiAt.22192

Genome annotation databases

EnsemblPlantsiAT3G51460.1; AT3G51460.1; AT3G51460
GeneIDi824309
GrameneiAT3G51460.1; AT3G51460.1; AT3G51460
KEGGiath:AT3G51460

Similar proteinsi

Entry informationi

Entry nameiSAC7_ARATH
AccessioniPrimary (citable) accession number: Q9C5G5
Secondary accession number(s): Q0WM67, Q9SD03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health