Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoinositide phosphatase SAC7

Gene

SAC7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphoinositide phosphatase that preferentially hydrolyzes PtdIns4P. Regulates the accumulation of PtdIns4P on membrane compartments at the tips of growing root hairs leading to proper root hair development.3 Publications

GO - Molecular functioni

  • phosphatidylinositol-4-phosphate phosphatase activity Source: TAIR

GO - Biological processi

  • response to wounding Source: UniProtKB
  • root hair cell tip growth Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciARA:AT3G51460-MONOMER.
BRENDAi3.1.3.66. 399.
3.1.3.B4. 399.
ReactomeiR-ATH-1483248. Synthesis of PIPs at the ER membrane.
R-ATH-1660514. Synthesis of PIPs at the Golgi membrane.
R-ATH-1660516. Synthesis of PIPs at the early endosome membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phosphatase SAC7 (EC:3.1.3.-)
Short name:
AtSAC7
Alternative name(s):
Protein ROOT HAIR DEFECTIVE 4
Protein SUPPRESSOR OF ACTIN 1C
Short name:
AtSAC1c
Protein SUPPRESSOR OF ACTIN 7
SAC domain protein 7
SAC1-like protein AtSAC1c
Gene namesi
Name:SAC7
Synonyms:RHD4, SAC1C
Ordered Locus Names:At3g51460
ORF Names:F26O13.100
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G51460.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei528 – 548HelicalSequence analysisAdd BLAST21
Transmembranei559 – 579HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: TAIR
  • plasma membrane of cell tip Source: TAIR
  • plasmodesma Source: TAIR
  • pollen tube tip Source: TAIR
  • root hair tip Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Short, bulged and branched root hairs. Accumulates elevated levels of PtdIns4P in roots.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004219731 – 597Phosphoinositide phosphatase SAC7Add BLAST597

Proteomic databases

PaxDbiQ9C5G5.
PRIDEiQ9C5G5.

PTM databases

iPTMnetiQ9C5G5.

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Inductioni

By wounding.1 Publication

Gene expression databases

GenevisibleiQ9C5G5. AT.

Interactioni

Protein-protein interaction databases

BioGridi9627. 1 interactor.
STRINGi3702.AT3G51460.1.

Structurei

3D structure databases

ProteinModelPortaliQ9C5G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 458SACPROSITE-ProRule annotationAdd BLAST329

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi393 – 404Phosphatase catalytic coreAdd BLAST12

Domaini

The phosphatase catalytic core motif (or RXNCXDCLDRTN motif) from the SAC domain is found in metal-independent protein phosphatases and inositol polyphosphate phosphatases.By similarity

Sequence similaritiesi

Contains 1 SAC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1889. Eukaryota.
COG5329. LUCA.
HOGENOMiHOG000189112.
InParanoidiQ9C5G5.
OMAiINQCVIN.
OrthoDBiEOG0936054J.
PhylomeDBiQ9C5G5.

Family and domain databases

InterProiIPR030069. SAC6/7/8.
IPR002013. SAC_dom.
[Graphical view]
PANTHERiPTHR11200:SF120. PTHR11200:SF120. 1 hit.
PfamiPF02383. Syja_N. 1 hit.
[Graphical view]
PROSITEiPS50275. SAC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C5G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METVDSRNKL HSRLRLWEFP DQYIIEPADG SGSSCLDISR VDASMKLIDQ
60 70 80 90 100
VPESNSVRVP KIRSIFGVVG MLKLLAGSYL VVVTESERVG SFLGHPIFKV
110 120 130 140 150
TTLKVLPCDH SLKNSPEEQK KMETEFSKLL SVAEKTTGLY FSYEVNLTLS
160 170 180 190 200
SQRLHEMGDE SKSLPLWRQA EPRFLWNNYM LEVLIDNKLD QFLLPVIQGS
210 220 230 240 250
FNSFETAIGR DIVDITLIAR RCTRRNGTRM WRRGADLDGY VANFVETEQI
260 270 280 290 300
VQMNGYTSSF VQVRGSMPFM WEQVVDLTYK PKFEIVQPEE AKRIAERHFL
310 320 330 340 350
DLRKKYGSVL AVDLVNKQGG EGRLCEKYAT VMQHITGDDI RYLHFDFHQI
360 370 380 390 400
CGHIHFERLS ILYEQIEGFL EKNGYFLLNE KGEKMKEQLG VVRSNCIDCL
410 420 430 440 450
DRTNVTQSMI GRKMLEVQLK RIGVFGAEET ISSHLNFDEH YKILWANHGD
460 470 480 490 500
EISIQYSGTP ALKGDFVRYG HRTAHGVLKD GWSSLRRYYL NNFADGTKQD
510 520 530 540 550
AIDLLQGHYI VAVSRDMAPV PQKGGLEAVA NFPVALFVVL MSFWFATMSL
560 570 580 590
KQTGSDYKHK HLFFSLLWTG ICVGMAALVR ANGRIFCNRP RLHKPRG
Length:597
Mass (Da):68,237
Last modified:June 1, 2001 - v1
Checksum:i18C62357E3BD53DA
GO

Sequence cautioni

The sequence CAB63010 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF266459 mRNA. Translation: AAP41368.1.
AY227250 mRNA. Translation: AAP49840.1.
AL133452 Genomic DNA. Translation: CAB63010.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE78795.1.
AF360267 mRNA. Translation: AAK25977.1.
AY040078 mRNA. Translation: AAK64136.1.
AK229963 mRNA. Translation: BAF01789.1.
PIRiT45777.
RefSeqiNP_190714.2. NM_115005.5.
UniGeneiAt.22192.

Genome annotation databases

EnsemblPlantsiAT3G51460.1; AT3G51460.1; AT3G51460.
GeneIDi824309.
GrameneiAT3G51460.1; AT3G51460.1; AT3G51460.
KEGGiath:AT3G51460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF266459 mRNA. Translation: AAP41368.1.
AY227250 mRNA. Translation: AAP49840.1.
AL133452 Genomic DNA. Translation: CAB63010.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE78795.1.
AF360267 mRNA. Translation: AAK25977.1.
AY040078 mRNA. Translation: AAK64136.1.
AK229963 mRNA. Translation: BAF01789.1.
PIRiT45777.
RefSeqiNP_190714.2. NM_115005.5.
UniGeneiAt.22192.

3D structure databases

ProteinModelPortaliQ9C5G5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi9627. 1 interactor.
STRINGi3702.AT3G51460.1.

PTM databases

iPTMnetiQ9C5G5.

Proteomic databases

PaxDbiQ9C5G5.
PRIDEiQ9C5G5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G51460.1; AT3G51460.1; AT3G51460.
GeneIDi824309.
GrameneiAT3G51460.1; AT3G51460.1; AT3G51460.
KEGGiath:AT3G51460.

Organism-specific databases

TAIRiAT3G51460.

Phylogenomic databases

eggNOGiKOG1889. Eukaryota.
COG5329. LUCA.
HOGENOMiHOG000189112.
InParanoidiQ9C5G5.
OMAiINQCVIN.
OrthoDBiEOG0936054J.
PhylomeDBiQ9C5G5.

Enzyme and pathway databases

BioCyciARA:AT3G51460-MONOMER.
BRENDAi3.1.3.66. 399.
3.1.3.B4. 399.
ReactomeiR-ATH-1483248. Synthesis of PIPs at the ER membrane.
R-ATH-1660514. Synthesis of PIPs at the Golgi membrane.
R-ATH-1660516. Synthesis of PIPs at the early endosome membrane.

Miscellaneous databases

PROiQ9C5G5.

Gene expression databases

GenevisibleiQ9C5G5. AT.

Family and domain databases

InterProiIPR030069. SAC6/7/8.
IPR002013. SAC_dom.
[Graphical view]
PANTHERiPTHR11200:SF120. PTHR11200:SF120. 1 hit.
PfamiPF02383. Syja_N. 1 hit.
[Graphical view]
PROSITEiPS50275. SAC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAC7_ARATH
AccessioniPrimary (citable) accession number: Q9C5G5
Secondary accession number(s): Q0WM67, Q9SD03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.