Q9C566 (CYP40_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP40
Short name=PPIase CYP40
EC=5.2.1.8

Alternative name(s):
Cyclophilin of 40 kDa
Short name=Cyclophilin-40
Protein SQUINT
Rotamase CYP40

Gene names

Name:	CYP40
Synonyms:	SQN
Ordered Locus Names:	At2g15790
ORF Names:	F19G14.21

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in promoting the expression of the juvenile phase of vegetative development, and, to a lower extent, in regulating the positioning of floral buds, floral morphogenesis and the expression of HSPs. Ref.1
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation	Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase By similarity.
Subcellular location	Cytoplasm Probable.
Tissue specificity	Expressed at low levels in seedlings, leaves and flowers. Ref.1
Sequence similarities	Belongs to the cyclophilin-type PPIase family. Contains 1 PPIase cyclophilin-type domain. Contains 2 TPR repeats.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat TPR repeat
Ligand	Cyclosporin
Molecular function	Chaperone Isomerase Rotamase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	floral meristem determinacy Inferred from genetic interaction. Source: TAIR protein folding Inferred from electronic annotation. Source: UniProtKB-KW vegetative phase change Inferred from mutant phenotype Ref.1. Source: TAIR
Cellular component	cytosol Inferred from direct assay. Source: TAIR
Molecular function	peptide binding Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Peptidyl-prolyl cis-trans isomerase CYP40		PRO_0000064138
Regions
	Domain	7 – 172	166	PPIase cyclophilin-type
	Repeat	212 – 245	34	TPR 1
	Repeat	298 – 331	34	TPR 2

Sequences

	Sequence		Length	Mass (Da)
	Q9C566 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: BF3D1FE56DE7FD57	FASTA	361	40,607
	10 20 30 40 50 60 MGRSKCFMDI SIGGELEGRI VIELYDDVVP KTAENFRLLC TGEKGLGPNT GVPLHYKGNR 70 80 90 100 110 120 FHRVIKGFMI QGGDISANDG TGGESIYGLK FDDENFELKH ERKGMLSMAN SGPNTNGSQF 130 140 150 160 170 180 FITTTRTSHL DGKHVVFGRV TKGMGVVRSI EHVSIEEQSC PSQDVVIHDC GEIPEGADDG 190 200 210 220 230 240 ICDFFKDGDV YPDWPIDLNE SPAELSWWME TVDFVKAHGN EHFKKQDYKM ALRKYRKALR 250 260 270 280 290 300 YLDICWEKEG IDEETSTALR KTKSQIFTNS AACKLKFGDA KGALLDTEFA MRDEDNNVKA 310 320 330 340 350 360 LFRQGQAYMA LNNVDAAAES LEKALQFEPN DAGIKKEYAA VMKKIAFRDN EEKKQYRKMF V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Regulation of vegetative phase change in Arabidopsis thaliana by cyclophilin 40." Berardini T.Z., Bollman K., Sun H., Poethig R.S. Science 291:2405-2407(2001) [PubMed: 11264535] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Strain: cv. Columbia.
[2]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[4]	"The Arabidopsis cyclophilin gene family." Romano P.G.N., Horton P., Gray J.E. Plant Physiol. 134:1268-1282(2004) [PubMed: 15051864] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY026065 mRNA. Translation: AAK02067.1. AC006438 Genomic DNA. Translation: AAD41985.2. CP002685 Genomic DNA. Translation: AEC06438.1.
IPI	IPI00520185.
PIR	D84533.
RefSeq	NP_565381.1. NM_127141.3.
UniGene	At.13863.
3D structure databases
ProteinModelPortal	Q9C566.
SMR	Q9C566. Positions 1-356.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9C566.
Proteomic databases
PRIDE	Q9C566.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT2G15790.1; AT2G15790.1; AT2G15790.
GeneID	816074.
GenomeReviews	Gene locus AT2G15790 in contig CT485783_GR.
KEGG	ath:AT2G15790.
NMPDR	fig|3702.1.peg.8581.
Organism-specific databases
TAIR	At2g15790.
Phylogenomic databases
GeneTree	EPGT00070000029031.
HOGENOM	HBG610621.
InParanoid	Q9C566.
OMA	KGMGVVK.
PhylomeDB	Q9C566.
ProtClustDB	CLSN2688145.
Gene expression databases
ArrayExpress	Q9C566.
Genevestigator	Q9C566.
GermOnline	AT2G15790. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. IPR020892. Cyclophilin-type_PPIase_CS. IPR023114. Elongated_TPR_rpt_dom. IPR013026. TPR-contain. IPR011990. TPR-like_helical. IPR013105. TPR_2. IPR019734. TPR_repeat. [Graphical view]
Gene3D	G3DSA:1.10.150.160. Elongated_TPR_rpt_dom. 1 hit. G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit. G3DSA:1.25.40.10. TPR-like_helical. 1 hit.
KO	K05864.
Pfam	PF00160. Pro_isomerase. 1 hit. PF07719. TPR_2. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. PS50005. TPR. 2 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYP40_ARATH

Accession

Primary (citable) accession number: Q9C566
Secondary accession number(s): Q9XIL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program