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Protein

WRKY transcription factor 6

Gene

WRKY6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor involved in the control of processes related to senescence and pathogen defense (PubMed:12000796). Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (PubMed:12000796). Activates the transcription of the SIRK gene and represses its own expression and that of the WRKY42 genes (PubMed:12000796). Modulates phosphate homeostasis and Pi translocation by regulating PHO1 expression (PubMed:25733771).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi306 – 372WRKYPROSITE-ProRule annotationAdd BLAST67

GO - Molecular functioni

  • DNA binding transcription factor activity Source: TAIR
  • sequence-specific DNA binding Source: InterPro
  • transcription regulatory region DNA binding Source: TAIR

GO - Biological processi

  • cellular response to boron-containing substance deprivation Source: TAIR
  • cellular response to phosphate starvation Source: TAIR
  • ethylene-activated signaling pathway Source: UniProtKB-KW
  • negative regulation of transcription, DNA-templated Source: TAIR
  • response to chitin Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processEthylene signaling pathway, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
WRKY transcription factor 61 Publication
Alternative name(s):
WRKY DNA-binding protein 61 Publication
Short name:
AtWRKY61 Publication
Gene namesi
Name:WRKY61 Publication
Ordered Locus Names:At1g62300Imported
ORF Names:F19K23.22Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G62300
TAIRilocus:2018052 AT1G62300

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi278K → E: Abolishes nuclear localization. 1 Publication1
Mutagenesisi296 – 297RK → AA: No effect on nuclear localization. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001336481 – 553WRKY transcription factor 6Add BLAST553

Proteomic databases

PaxDbiQ9C519
PRIDEiQ9C519

PTM databases

iPTMnetiQ9C519

Expressioni

Tissue specificityi

Roots, leaves, shoots, flowers and siliques.

Inductioni

By salicylic acid, ethylene, jasmonic acid, pathogens, wounding and strongly during leaf senescence.2 Publications

Gene expression databases

ExpressionAtlasiQ9C519 baseline and differential
GenevisibleiQ9C519 AT

Interactioni

Protein-protein interaction databases

BioGridi27748, 4 interactors
IntActiQ9C519, 9 interactors
STRINGi3702.AT1G62300.1

Structurei

3D structure databases

ProteinModelPortaliQ9C519
SMRiQ9C519
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the WRKY group II-b family.Curated

Phylogenomic databases

eggNOGiENOG410IENH Eukaryota
ENOG410YDVM LUCA
HOGENOMiHOG000241202
InParanoidiQ9C519
OMAiANMRKAR
OrthoDBiEOG09360C4S
PhylomeDBiQ9C519

Family and domain databases

Gene3Di2.20.25.80, 1 hit
InterProiView protein in InterPro
IPR003657 WRKY_dom
IPR036576 WRKY_dom_sf
PfamiView protein in Pfam
PF03106 WRKY, 1 hit
SMARTiView protein in SMART
SM00774 WRKY, 1 hit
SUPFAMiSSF118290 SSF118290, 1 hit
PROSITEiView protein in PROSITE
PS50811 WRKY, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRGWSGLTL DSSSLDLLNP NRISHKNHRR FSNPLAMSRI DEEDDQKTRI
60 70 80 90 100
STNGSEFRFP VSLSGIRDRE DEDFSSGVAG DNDREVPGEV DFFSDKKSRV
110 120 130 140 150
CREDDEGFRV KKEEQDDRTD VNTGLNLRTT GNTKSDESMI DDGESSEMED
160 170 180 190 200
KRAKNELVKL QDELKKMTMD NQKLRELLTQ VSNSYTSLQM HLVSLMQQQQ
210 220 230 240 250
QQNNKVIEAA EKPEETIVPR QFIDLGPTRA VGEAEDVSNS SSEDRTRSGG
260 270 280 290 300
SSAAERRSNG KRLGREESPE TESNKIQKVN STTPTTFDQT AEATMRKARV
310 320 330 340 350
SVRARSEAPM ISDGCQWRKY GQKMAKGNPC PRAYYRCTMA TGCPVRKQVQ
360 370 380 390 400
RCAEDRSILI TTYEGNHNHP LPPAAVAMAS TTTAAANMLL SGSMSSHDGM
410 420 430 440 450
MNPTNLLARA VLPCSTSMAT ISASAPFPTV TLDLTHSPPP PNGSNPSSSA
460 470 480 490 500
ATNNNHNSLM QRPQQQQQQM TNLPPGMLPH VIGQALYNQS KFSGLQFSGG
510 520 530 540 550
SPSTAAFSQS HAVADTITAL TADPNFTAAL AAVISSMING TNHHDGEGNN

KNQ
Length:553
Mass (Da):60,593
Last modified:June 1, 2001 - v1
Checksum:i9C75C89E4F16F297
GO

Sequence cautioni

The sequence AAB60774 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331713 Genomic DNA Translation: AAK01128.1
AF331712 mRNA Translation: AAK01127.1
AC000375 Genomic DNA Translation: AAB60774.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE33948.1
AF224702 mRNA Translation: AAK28312.1
PIRiF96649
RefSeqiNP_564792.1, NM_104910.3
UniGeneiAt.25260

Genome annotation databases

EnsemblPlantsiAT1G62300.1; AT1G62300.1; AT1G62300
GeneIDi842527
GrameneiAT1G62300.1; AT1G62300.1; AT1G62300
KEGGiath:AT1G62300

Similar proteinsi

Entry informationi

Entry nameiWRKY6_ARATH
AccessioniPrimary (citable) accession number: Q9C519
Secondary accession number(s): O04594, Q9C5T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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