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Q9C510

- PPA6_ARATH

UniProt

Q9C510 - PPA6_ARATH

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Protein

Purple acid phosphatase 6

Gene

PAP6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Binds 1 iron ion per subunit.By similarity
Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi164 – 1641IronBy similarity
Metal bindingi192 – 1921IronBy similarity
Metal bindingi192 – 1921ZincBy similarity
Metal bindingi195 – 1951IronBy similarity
Metal bindingi229 – 2291ZincBy similarity
Binding sitei229 – 2291SubstrateBy similarity
Metal bindingi314 – 3141ZincBy similarity
Active sitei324 – 3241Proton donorBy similarity
Metal bindingi351 – 3511ZincBy similarity
Metal bindingi353 – 3531IronBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: TAIR
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dephosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G56360-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Purple acid phosphatase 6 (EC:3.1.3.2)
Gene namesi
Name:PAP6
Ordered Locus Names:At1g56360
ORF Names:F13N6.16, F14G9.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G56360.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 466446Purple acid phosphatase 6PRO_0000372811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi367 – 3671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi424 – 4241N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9C510.
PRIDEiQ9C510.

Expressioni

Tissue specificityi

Specifically expressed in flowers.1 Publication

Gene expression databases

GenevestigatoriQ9C510.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9C510.
SMRiQ9C510. Positions 39-458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni351 – 3533Substrate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000238330.
InParanoidiQ9C510.
OMAiEPGTMTV.
PhylomeDBiQ9C510.

Family and domain databases

Gene3Di2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR003961. Fibronectin_type3.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9C510-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNLVIFAFL FLSITTVING GITSKFVRQA LPSIEMSLDT FPSPGGYNTP
60 70 80 90 100
EQVHLTQGDH DGRGMIVSWV TPLNLAGSNV VTYWIATNGS DVKPAKKRAH
110 120 130 140 150
ASTKSYRFYD YSSGFLHHAT IKGLEYDTKY IYEVGTDKSV RQFSFTTPPK
160 170 180 190 200
IGPDVPYTFG IIGDLGQTYA SNETLYHYMS NPKGQAVLFA GDLSYADDHP
210 220 230 240 250
NHDQRKWDTW GRFMEPCAAY QPFIFAAGNH EIDFVPNIGE PHAFKPYTHR
260 270 280 290 300
YPNAYKASQS TSPLWYSVRR ASAHIIVLSS YSAYGKYTPQ YIWLEQELKN
310 320 330 340 350
VNREETPWLI VIVHSPWYNS NNYHYMEGES MRVMFESWLV NSKVDLVLSG
360 370 380 390 400
HVHAYERSER ISNIKYNITN GLSSPVKDPN APIYITIGDG GNIEGIANSF
410 420 430 440 450
VDPQPSYSAY REASFGHAVL EIMNRTHAQY TWHRNQDNEP VAADSIMLHN
460
RHFFPVEEIV SSNIRA
Length:466
Mass (Da):52,830
Last modified:June 1, 2001 - v1
Checksum:iC7743C328422F3FC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1752TL → AS in AAW29947. (PubMed:16244908)Curated
Sequence conflicti357 – 3571R → G in AAW29947. (PubMed:16244908)Curated
Sequence conflicti442 – 4421A → T in AAW29947. (PubMed:16244908)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY842022 mRNA. Translation: AAW29947.1.
AC058785 Genomic DNA. Translation: AAG51511.1.
AC069159 Genomic DNA. Translation: AAG50924.1.
CP002684 Genomic DNA. Translation: AEE33383.1.
DQ446366 mRNA. Translation: ABE65716.1.
BT026359 mRNA. Translation: ABH04466.1.
PIRiF96605.
RefSeqiNP_176033.1. NM_104516.1.
UniGeneiAt.51194.

Genome annotation databases

EnsemblPlantsiAT1G56360.1; AT1G56360.1; AT1G56360.
GeneIDi842090.
KEGGiath:AT1G56360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY842022 mRNA. Translation: AAW29947.1 .
AC058785 Genomic DNA. Translation: AAG51511.1 .
AC069159 Genomic DNA. Translation: AAG50924.1 .
CP002684 Genomic DNA. Translation: AEE33383.1 .
DQ446366 mRNA. Translation: ABE65716.1 .
BT026359 mRNA. Translation: ABH04466.1 .
PIRi F96605.
RefSeqi NP_176033.1. NM_104516.1.
UniGenei At.51194.

3D structure databases

ProteinModelPortali Q9C510.
SMRi Q9C510. Positions 39-458.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9C510.
PRIDEi Q9C510.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G56360.1 ; AT1G56360.1 ; AT1G56360 .
GeneIDi 842090.
KEGGi ath:AT1G56360.

Organism-specific databases

TAIRi AT1G56360.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000238330.
InParanoidi Q9C510.
OMAi EPGTMTV.
PhylomeDBi Q9C510.

Enzyme and pathway databases

BioCyci ARA:AT1G56360-MONOMER.

Gene expression databases

Genevestigatori Q9C510.

Family and domain databases

Gene3Di 2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR003961. Fibronectin_type3.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression patterns of purple acid phosphatase genes in Arabidopsis organs and functional analysis of AtPAP23 predominantly transcribed in flower."
    Zhu H., Qian W., Lu X., Li D., Liu X., Liu K., Wang D.
    Plant Mol. Biol. 59:581-594(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W., Redman J.C., Wu H.C., Utterback T., Town C.D.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Arabidopsis ORF Clones."
    Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Purple acid phosphatases of Arabidopsis thaliana. Comparative analysis and differential regulation by phosphate deprivation."
    Li D., Zhu H., Liu K., Liu X., Leggewie G., Udvardi M., Wang D.
    J. Biol. Chem. 277:27772-27781(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiPPA6_ARATH
AccessioniPrimary (citable) accession number: Q9C510
Secondary accession number(s): Q5MAV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3