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Q9C510

- PPA6_ARATH

UniProt

Q9C510 - PPA6_ARATH

Protein

Purple acid phosphatase 6

Gene

PAP6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Cofactori

    Binds 1 iron ion per subunit.By similarity
    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi164 – 1641IronBy similarity
    Metal bindingi192 – 1921IronBy similarity
    Metal bindingi192 – 1921ZincBy similarity
    Metal bindingi195 – 1951IronBy similarity
    Metal bindingi229 – 2291ZincBy similarity
    Binding sitei229 – 2291SubstrateBy similarity
    Metal bindingi314 – 3141ZincBy similarity
    Active sitei324 – 3241Proton donorBy similarity
    Metal bindingi351 – 3511ZincBy similarity
    Metal bindingi353 – 3531IronBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: TAIR
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dephosphorylation Source: GOC

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Iron, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciARA:AT1G56360-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Purple acid phosphatase 6 (EC:3.1.3.2)
    Gene namesi
    Name:PAP6
    Ordered Locus Names:At1g56360
    ORF Names:F13N6.16, F14G9.2
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G56360.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 466446Purple acid phosphatase 6PRO_0000372811Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi367 – 3671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi424 – 4241N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9C510.
    PRIDEiQ9C510.

    Expressioni

    Tissue specificityi

    Specifically expressed in flowers.1 Publication

    Gene expression databases

    GenevestigatoriQ9C510.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C510.
    SMRiQ9C510. Positions 39-458.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni351 – 3533Substrate bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000238330.
    InParanoidiQ9C510.
    OMAiEPGTMTV.
    PhylomeDBiQ9C510.

    Family and domain databases

    Gene3Di2.60.40.380. 1 hit.
    3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR003961. Fibronectin_type3.
    IPR029052. Metallo-depent_PP-like.
    IPR008963. Purple_acid_Pase-like_N.
    IPR015914. Purple_acid_Pase_N.
    IPR025733. Purple_acid_PPase_C_dom.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    PF14008. Metallophos_C. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49363. SSF49363. 1 hit.
    SSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9C510-1 [UniParc]FASTAAdd to Basket

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    MKNLVIFAFL FLSITTVING GITSKFVRQA LPSIEMSLDT FPSPGGYNTP    50
    EQVHLTQGDH DGRGMIVSWV TPLNLAGSNV VTYWIATNGS DVKPAKKRAH 100
    ASTKSYRFYD YSSGFLHHAT IKGLEYDTKY IYEVGTDKSV RQFSFTTPPK 150
    IGPDVPYTFG IIGDLGQTYA SNETLYHYMS NPKGQAVLFA GDLSYADDHP 200
    NHDQRKWDTW GRFMEPCAAY QPFIFAAGNH EIDFVPNIGE PHAFKPYTHR 250
    YPNAYKASQS TSPLWYSVRR ASAHIIVLSS YSAYGKYTPQ YIWLEQELKN 300
    VNREETPWLI VIVHSPWYNS NNYHYMEGES MRVMFESWLV NSKVDLVLSG 350
    HVHAYERSER ISNIKYNITN GLSSPVKDPN APIYITIGDG GNIEGIANSF 400
    VDPQPSYSAY REASFGHAVL EIMNRTHAQY TWHRNQDNEP VAADSIMLHN 450
    RHFFPVEEIV SSNIRA 466
    Length:466
    Mass (Da):52,830
    Last modified:June 1, 2001 - v1
    Checksum:iC7743C328422F3FC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti174 – 1752TL → AS in AAW29947. (PubMed:16244908)Curated
    Sequence conflicti357 – 3571R → G in AAW29947. (PubMed:16244908)Curated
    Sequence conflicti442 – 4421A → T in AAW29947. (PubMed:16244908)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY842022 mRNA. Translation: AAW29947.1.
    AC058785 Genomic DNA. Translation: AAG51511.1.
    AC069159 Genomic DNA. Translation: AAG50924.1.
    CP002684 Genomic DNA. Translation: AEE33383.1.
    DQ446366 mRNA. Translation: ABE65716.1.
    BT026359 mRNA. Translation: ABH04466.1.
    PIRiF96605.
    RefSeqiNP_176033.1. NM_104516.1.
    UniGeneiAt.51194.

    Genome annotation databases

    EnsemblPlantsiAT1G56360.1; AT1G56360.1; AT1G56360.
    GeneIDi842090.
    KEGGiath:AT1G56360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY842022 mRNA. Translation: AAW29947.1 .
    AC058785 Genomic DNA. Translation: AAG51511.1 .
    AC069159 Genomic DNA. Translation: AAG50924.1 .
    CP002684 Genomic DNA. Translation: AEE33383.1 .
    DQ446366 mRNA. Translation: ABE65716.1 .
    BT026359 mRNA. Translation: ABH04466.1 .
    PIRi F96605.
    RefSeqi NP_176033.1. NM_104516.1.
    UniGenei At.51194.

    3D structure databases

    ProteinModelPortali Q9C510.
    SMRi Q9C510. Positions 39-458.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9C510.
    PRIDEi Q9C510.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G56360.1 ; AT1G56360.1 ; AT1G56360 .
    GeneIDi 842090.
    KEGGi ath:AT1G56360.

    Organism-specific databases

    TAIRi AT1G56360.

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000238330.
    InParanoidi Q9C510.
    OMAi EPGTMTV.
    PhylomeDBi Q9C510.

    Enzyme and pathway databases

    BioCyci ARA:AT1G56360-MONOMER.

    Gene expression databases

    Genevestigatori Q9C510.

    Family and domain databases

    Gene3Di 2.60.40.380. 1 hit.
    3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR003961. Fibronectin_type3.
    IPR029052. Metallo-depent_PP-like.
    IPR008963. Purple_acid_Pase-like_N.
    IPR015914. Purple_acid_Pase_N.
    IPR025733. Purple_acid_PPase_C_dom.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    PF14008. Metallophos_C. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49363. SSF49363. 1 hit.
    SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Expression patterns of purple acid phosphatase genes in Arabidopsis organs and functional analysis of AtPAP23 predominantly transcribed in flower."
      Zhu H., Qian W., Lu X., Li D., Liu X., Liu K., Wang D.
      Plant Mol. Biol. 59:581-594(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: cv. Columbia.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W., Redman J.C., Wu H.C., Utterback T., Town C.D.
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Arabidopsis ORF Clones."
      Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. "Purple acid phosphatases of Arabidopsis thaliana. Comparative analysis and differential regulation by phosphate deprivation."
      Li D., Zhu H., Liu K., Liu X., Leggewie G., Udvardi M., Wang D.
      J. Biol. Chem. 277:27772-27781(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiPPA6_ARATH
    AccessioniPrimary (citable) accession number: Q9C510
    Secondary accession number(s): Q5MAV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3