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Protein

Purple acid phosphatase 6

Gene

PAP6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi164IronBy similarity1
Metal bindingi192IronBy similarity1
Metal bindingi192ZincBy similarity1
Metal bindingi195IronBy similarity1
Metal bindingi229ZincBy similarity1
Binding sitei229SubstrateBy similarity1
Metal bindingi314ZincBy similarity1
Active sitei324Proton donorBy similarity1
Metal bindingi351ZincBy similarity1
Metal bindingi353IronBy similarity1

GO - Molecular functioni

  • acid phosphatase activity Source: TAIR
  • metal ion binding Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G56360-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Purple acid phosphatase 6 (EC:3.1.3.2)
Gene namesi
Name:PAP6
Ordered Locus Names:At1g56360
ORF Names:F13N6.16, F14G9.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G56360
TAIRilocus:2010753 AT1G56360

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000037281121 – 466Purple acid phosphatase 6Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi367N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi424N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9C510

Expressioni

Tissue specificityi

Specifically expressed in flowers.1 Publication

Gene expression databases

ExpressionAtlasiQ9C510 baseline and differential
GenevisibleiQ9C510 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT1G56360.1

Structurei

3D structure databases

ProteinModelPortaliQ9C510
SMRiQ9C510
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni351 – 353Substrate bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1378 Eukaryota
COG1409 LUCA
HOGENOMiHOG000238330
InParanoidiQ9C510
KOiK22390
OMAiGAGCHSH
OrthoDBiEOG09360APJ
PhylomeDBiQ9C510

Family and domain databases

Gene3Di2.60.40.380, 1 hit
3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR008963 Purple_acid_Pase-like_N
IPR015914 Purple_acid_Pase_N
IPR025733 Purple_acid_PPase_C_dom
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF14008 Metallophos_C, 1 hit
PF16656 Pur_ac_phosph_N, 1 hit
SUPFAMiSSF49363 SSF49363, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9C510-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNLVIFAFL FLSITTVING GITSKFVRQA LPSIEMSLDT FPSPGGYNTP
60 70 80 90 100
EQVHLTQGDH DGRGMIVSWV TPLNLAGSNV VTYWIATNGS DVKPAKKRAH
110 120 130 140 150
ASTKSYRFYD YSSGFLHHAT IKGLEYDTKY IYEVGTDKSV RQFSFTTPPK
160 170 180 190 200
IGPDVPYTFG IIGDLGQTYA SNETLYHYMS NPKGQAVLFA GDLSYADDHP
210 220 230 240 250
NHDQRKWDTW GRFMEPCAAY QPFIFAAGNH EIDFVPNIGE PHAFKPYTHR
260 270 280 290 300
YPNAYKASQS TSPLWYSVRR ASAHIIVLSS YSAYGKYTPQ YIWLEQELKN
310 320 330 340 350
VNREETPWLI VIVHSPWYNS NNYHYMEGES MRVMFESWLV NSKVDLVLSG
360 370 380 390 400
HVHAYERSER ISNIKYNITN GLSSPVKDPN APIYITIGDG GNIEGIANSF
410 420 430 440 450
VDPQPSYSAY REASFGHAVL EIMNRTHAQY TWHRNQDNEP VAADSIMLHN
460
RHFFPVEEIV SSNIRA
Length:466
Mass (Da):52,830
Last modified:June 1, 2001 - v1
Checksum:iC7743C328422F3FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174 – 175TL → AS in AAW29947 (PubMed:16244908).Curated2
Sequence conflicti357R → G in AAW29947 (PubMed:16244908).Curated1
Sequence conflicti442A → T in AAW29947 (PubMed:16244908).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY842022 mRNA Translation: AAW29947.1
AC058785 Genomic DNA Translation: AAG51511.1
AC069159 Genomic DNA Translation: AAG50924.1
CP002684 Genomic DNA Translation: AEE33383.1
DQ446366 mRNA Translation: ABE65716.1
BT026359 mRNA Translation: ABH04466.1
PIRiF96605
RefSeqiNP_176033.1, NM_104516.1
UniGeneiAt.51194

Genome annotation databases

EnsemblPlantsiAT1G56360.1; AT1G56360.1; AT1G56360
GeneIDi842090
GrameneiAT1G56360.1; AT1G56360.1; AT1G56360
KEGGiath:AT1G56360

Similar proteinsi

Entry informationi

Entry nameiPPA6_ARATH
AccessioniPrimary (citable) accession number: Q9C510
Secondary accession number(s): Q5MAV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health