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Protein

Purple acid phosphatase 6

Gene

PAP6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi164IronBy similarity1
Metal bindingi192IronBy similarity1
Metal bindingi192ZincBy similarity1
Metal bindingi195IronBy similarity1
Metal bindingi229ZincBy similarity1
Binding sitei229SubstrateBy similarity1
Metal bindingi314ZincBy similarity1
Active sitei324Proton donorBy similarity1
Metal bindingi351ZincBy similarity1
Metal bindingi353IronBy similarity1

GO - Molecular functioni

  • acid phosphatase activity Source: TAIR
  • metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G56360-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Purple acid phosphatase 6 (EC:3.1.3.2)
Gene namesi
Name:PAP6
Ordered Locus Names:At1g56360
ORF Names:F13N6.16, F14G9.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G56360.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000037281121 – 466Purple acid phosphatase 6Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1
Glycosylationi172N-linked (GlcNAc...)Sequence analysis1
Glycosylationi367N-linked (GlcNAc...)Sequence analysis1
Glycosylationi424N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9C510.

Expressioni

Tissue specificityi

Specifically expressed in flowers.1 Publication

Gene expression databases

GenevisibleiQ9C510. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT1G56360.1.

Structurei

3D structure databases

ProteinModelPortaliQ9C510.
SMRiQ9C510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni351 – 353Substrate bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1378. Eukaryota.
COG1409. LUCA.
HOGENOMiHOG000238330.
InParanoidiQ9C510.
OMAiYWIATNG.
OrthoDBiEOG09360APJ.
PhylomeDBiQ9C510.

Family and domain databases

Gene3Di2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
PF16656. Pur_ac_phosph_N. 1 hit.
[Graphical view]
SUPFAMiSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9C510-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNLVIFAFL FLSITTVING GITSKFVRQA LPSIEMSLDT FPSPGGYNTP
60 70 80 90 100
EQVHLTQGDH DGRGMIVSWV TPLNLAGSNV VTYWIATNGS DVKPAKKRAH
110 120 130 140 150
ASTKSYRFYD YSSGFLHHAT IKGLEYDTKY IYEVGTDKSV RQFSFTTPPK
160 170 180 190 200
IGPDVPYTFG IIGDLGQTYA SNETLYHYMS NPKGQAVLFA GDLSYADDHP
210 220 230 240 250
NHDQRKWDTW GRFMEPCAAY QPFIFAAGNH EIDFVPNIGE PHAFKPYTHR
260 270 280 290 300
YPNAYKASQS TSPLWYSVRR ASAHIIVLSS YSAYGKYTPQ YIWLEQELKN
310 320 330 340 350
VNREETPWLI VIVHSPWYNS NNYHYMEGES MRVMFESWLV NSKVDLVLSG
360 370 380 390 400
HVHAYERSER ISNIKYNITN GLSSPVKDPN APIYITIGDG GNIEGIANSF
410 420 430 440 450
VDPQPSYSAY REASFGHAVL EIMNRTHAQY TWHRNQDNEP VAADSIMLHN
460
RHFFPVEEIV SSNIRA
Length:466
Mass (Da):52,830
Last modified:June 1, 2001 - v1
Checksum:iC7743C328422F3FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174 – 175TL → AS in AAW29947 (PubMed:16244908).Curated2
Sequence conflicti357R → G in AAW29947 (PubMed:16244908).Curated1
Sequence conflicti442A → T in AAW29947 (PubMed:16244908).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY842022 mRNA. Translation: AAW29947.1.
AC058785 Genomic DNA. Translation: AAG51511.1.
AC069159 Genomic DNA. Translation: AAG50924.1.
CP002684 Genomic DNA. Translation: AEE33383.1.
DQ446366 mRNA. Translation: ABE65716.1.
BT026359 mRNA. Translation: ABH04466.1.
PIRiF96605.
RefSeqiNP_176033.1. NM_104516.1.
UniGeneiAt.51194.

Genome annotation databases

EnsemblPlantsiAT1G56360.1; AT1G56360.1; AT1G56360.
GeneIDi842090.
GrameneiAT1G56360.1; AT1G56360.1; AT1G56360.
KEGGiath:AT1G56360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY842022 mRNA. Translation: AAW29947.1.
AC058785 Genomic DNA. Translation: AAG51511.1.
AC069159 Genomic DNA. Translation: AAG50924.1.
CP002684 Genomic DNA. Translation: AEE33383.1.
DQ446366 mRNA. Translation: ABE65716.1.
BT026359 mRNA. Translation: ABH04466.1.
PIRiF96605.
RefSeqiNP_176033.1. NM_104516.1.
UniGeneiAt.51194.

3D structure databases

ProteinModelPortaliQ9C510.
SMRiQ9C510.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G56360.1.

Proteomic databases

PaxDbiQ9C510.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G56360.1; AT1G56360.1; AT1G56360.
GeneIDi842090.
GrameneiAT1G56360.1; AT1G56360.1; AT1G56360.
KEGGiath:AT1G56360.

Organism-specific databases

TAIRiAT1G56360.

Phylogenomic databases

eggNOGiKOG1378. Eukaryota.
COG1409. LUCA.
HOGENOMiHOG000238330.
InParanoidiQ9C510.
OMAiYWIATNG.
OrthoDBiEOG09360APJ.
PhylomeDBiQ9C510.

Enzyme and pathway databases

BioCyciARA:AT1G56360-MONOMER.

Miscellaneous databases

PROiQ9C510.

Gene expression databases

GenevisibleiQ9C510. AT.

Family and domain databases

Gene3Di2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
PF16656. Pur_ac_phosph_N. 1 hit.
[Graphical view]
SUPFAMiSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPPA6_ARATH
AccessioniPrimary (citable) accession number: Q9C510
Secondary accession number(s): Q5MAV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.