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Protein

Sphingosine-1-phosphate lyase

Gene

DPL1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. May play a minor role in maintenance of sphingolipid metabolism during normal plant development and growth, but be required for maintaining sphingoid long chain bases (LCB) and their phosphorylated derivatives (LCB-P) levels when sphingolipid metabolism is perturbed. May play a role in dehydration stress.2 Publications

Catalytic activityi

Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.2 Publications

Cofactori

Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

  • carboxylic acid metabolic process Source: InterPro
  • sphingolipid catabolic process Source: TAIR

Keywordsi

Molecular functionLyase
Biological processLipid metabolism, Sphingolipid metabolism, Stress response
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciARA:AT1G27980-MONOMER
MetaCyc:AT1G27980-MONOMER
BRENDAi4.1.2.27 399
ReactomeiR-ATH-1660661 Sphingolipid de novo biosynthesis
UniPathwayiUPA00222

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine-1-phosphate lyase (EC:4.1.2.27)
Short name:
AtSPL1
Short name:
S1PL
Short name:
SP-lyase
Short name:
SPL
Alternative name(s):
Dihydrosphingosine phosphate lyase 1
Short name:
AtDPL1
Sphingosine-1-phosphate aldolase
Gene namesi
Name:DPL1
Ordered Locus Names:At1g27980
ORF Names:F13K9.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G27980
TAIRilocus:2010524 AT1G27980

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29LumenalSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini51 – 544CytoplasmicSequence analysisAdd BLAST494

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth conditions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001470171 – 544Sphingosine-1-phosphate lyaseAdd BLAST544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei349N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ9C509
PRIDEiQ9C509

Expressioni

Tissue specificityi

Expressed in the peripheral parts of leaves and the bases of trichomes.1 Publication

Gene expression databases

ExpressionAtlasiQ9C509 baseline and differential
GenevisibleiQ9C509 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G27980.1

Structurei

3D structure databases

ProteinModelPortaliQ9C509
SMRiQ9C509
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1383 Eukaryota
COG0076 LUCA
HOGENOMiHOG000190693
InParanoidiQ9C509
KOiK01634
OMAiDPHKMGL
OrthoDBiEOG093607D0
PhylomeDBiQ9C509

Family and domain databases

Gene3Di3.40.640.101 hit
3.90.1150.101 hit
InterProiView protein in InterPro
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C509-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSFSYSSMK SMLIQARGSL NSRLSEFEPL VLLLVPLVSL FLAQIIGSVF
60 70 80 90 100
GVVHEKGLKA CLIGFIMGLL KMIPGVQNYI DAEKQKVVDQ LQSGSSSKKK
110 120 130 140 150
NKTEVLPVKG LGVEVLEKME NEKRNDAIWQ GKCSGTVYIG GAESEGHFSL
160 170 180 190 200
INQACSMFAH TNPLHIDVFQ SVVRFESEVV AMTAALLGSK ETASGGQICG
210 220 230 240 250
NMTSGGTESI VLAVKSSRDY MKYKKGITRP EMIIPESGHS AYDKAAQYFK
260 270 280 290 300
IKLWRVPVDK DFRADVKATR RHINRNTIMI VGSAPGFPHG IIDPIEELGQ
310 320 330 340 350
LALSYGICFH VDLCLGGFVL PFARKLGYQI PPFDFSVQGV TSISVDVHKY
360 370 380 390 400
GLAPKGTSTV LYRNHEIRKH QFVAVTEWSG GLYVSPTIAG SRPGSLVAGA
410 420 430 440 450
WAAMMSLGEE GYLQNTSKIM EASKRLEEGV REIHELFVIG KPDMTIVAFG
460 470 480 490 500
SKALDIFEVN DIMSSKGWHL NALQRPNSIH ICITLQHVPV VDDFLRDLRE
510 520 530 540
AVETVKANPG PITGGLAPIY GAAGKMPDRG MVNELLVSFM DSQY
Length:544
Mass (Da):59,478
Last modified:June 1, 2001 - v1
Checksum:iCC5C9952C2317248
GO

Sequence cautioni

The sequence AAM62669 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB175035 mRNA Translation: BAD13416.1
AC069471 Genomic DNA Translation: AAG51494.1
CP002684 Genomic DNA Translation: AEE30898.1
AF360166 mRNA Translation: AAK25876.1
AY113914 mRNA Translation: AAM44962.1
AY085442 mRNA Translation: AAM62669.1 Different initiation.
PIRiC86405
RefSeqiNP_174119.1, NM_102563.4
UniGeneiAt.17690
At.66881

Genome annotation databases

EnsemblPlantsiAT1G27980.1; AT1G27980.1; AT1G27980
GeneIDi839691
GrameneiAT1G27980.1; AT1G27980.1; AT1G27980
KEGGiath:AT1G27980

Similar proteinsi

Entry informationi

Entry nameiSGPL_ARATH
AccessioniPrimary (citable) accession number: Q9C509
Secondary accession number(s): Q549V9, Q8LEF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome