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Q9C500 (WPP2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
WPP domain-containing protein 2
Alternative name(s):
MFP1 attachment factor 2
Gene names
Name:WPP2
Synonyms:MAF2
Ordered Locus Names:At1g47200
ORF Names:F2G19.18, F8G22.9
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates the mitotic activity in roots. Plays a role with HSP70-1 in facilitating WIT1 nuclear envelope targeting. Ref.5 Ref.10

Subunit structure

Binds to FPP proteins By similarity. Interacts with WAP, WIP1, WIP2 and WIP3 through its WPP domain. Interacts with WIT1 and HSP70-1. Ref.6 Ref.7 Ref.8 Ref.10

Subcellular location

Nucleus envelope. Cytoplasm. Nucleus. Golgi apparatus By similarity. Note: Associated to the nuclear envelope (NE) in undifferentiated cells of the root tip. Associated with the outer NE and the nuclear pores in interphase cells and with the immature cell plate during cytokinesis. In differentiated cells, localized in both cytoplasm and nucleus. Accumulate in speckles of the cytoplasm belonging to the Golgi apparatus By similarity. Appears at the NE as cells reenter the cell cycle during dedifferentiation. Ref.5

Tissue specificity

Expressed in roots, stems, leaves and flowers. Ref.5

Domain

The WPP domain is required for the nuclear envelope localization By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 180180WPP domain-containing protein 2
PRO_0000347192

Regions

Region44 – 147104WPP

Amino acid modifications

Modified residue1731Phosphoserine Ref.9

Experimental info

Sequence conflict1721A → G in AAM62902. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9C500 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: F71F090976FA3826

FASTA18019,134
        10         20         30         40         50         60 
MAETAETINT TISSPPPESE SSTTISAMTD PTSQEAASKD TDLTKEAESE KKPGGISLRI 

        70         80         90        100        110        120 
WPPTQKTRDA VLNRLIETLS TESILSKRYG TLKSDDATTV AKLIEEEAYG VASNAVSSDD 

       130        140        150        160        170        180 
DGIKILELYS KEISKRMLES VKARSNASVG NGSVEDANTD ASEVSKDDAG PASEEEKSEA 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Full-length cDNA from Arabidopsis thaliana."
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Arabidopsis WPP-domain proteins are developmentally associated with the nuclear envelope and promote cell division."
Patel S., Rose A., Meulia T., Dixit R., Cyr R.J., Meier I.
Plant Cell 16:3260-3273(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[6]"The plant nuclear envelope protein MAF1 has an additional location at the Golgi and binds to a novel Golgi-associated coiled-coil protein."
Patel S., Brkljacic J., Gindullis F., Rose A., Meier I.
Planta 222:1028-1040(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH WAP.
[7]"Anchorage of plant RanGAP to the nuclear envelope involves novel nuclear-pore-associated proteins."
Xu X.M., Meulia T., Meier I.
Curr. Biol. 17:1157-1163(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH WIP1; WIP2 AND WIP3.
[8]"Two distinct interacting classes of nuclear envelope-associated coiled-coil proteins are required for the tissue-specific nuclear envelope targeting of Arabidopsis RanGAP."
Zhao Q., Brkljacic J., Meier I.
Plant Cell 20:1639-1651(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH WIT1.
[9]"Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks."
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A., Grossmann J., Gruissem W., Baginsky S.
Plant Physiol. 150:889-903(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1."
Brkljacic J., Zhao Q., Meier I.
Plant Physiol. 151:142-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH WIT1 AND HSP70-1, FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC079677 Genomic DNA. Translation: AAG52640.1.
AC083835 Genomic DNA. Translation: AAG50616.1.
CP002684 Genomic DNA. Translation: AEE32136.1.
AY072148 mRNA. Translation: AAL59970.1.
AY096476 mRNA. Translation: AAM20116.1.
AY085683 mRNA. Translation: AAM62902.1.
PIRF96512.
RefSeqNP_564498.1. NM_103613.2.
UniGeneAt.17221.

3D structure databases

ProteinModelPortalQ9C500.
SMRQ9C500. Positions 57-142.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid26348. 3 interactions.
IntActQ9C500. 6 interactions.

Proteomic databases

PaxDbQ9C500.
PRIDEQ9C500.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G47200.1; AT1G47200.1; AT1G47200.
GeneID841123.
KEGGath:AT1G47200.

Organism-specific databases

TAIRAT1G47200.

Phylogenomic databases

eggNOGNOG262975.
HOGENOMHOG000239842.
InParanoidQ9C500.
OMASAMTDPT.
PhylomeDBQ9C500.
ProtClustDBCLSN2686648.

Gene expression databases

GenevestigatorQ9C500.

Family and domain databases

InterProIPR025265. WPP_dom.
[Graphical view]
PfamPF13943. WPP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameWPP2_ARATH
AccessionPrimary (citable) accession number: Q9C500
Secondary accession number(s): Q8LE13
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 1, 2001
Last modified: March 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names