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Q9C500

- WPP2_ARATH

UniProt

Q9C500 - WPP2_ARATH

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Protein

WPP domain-containing protein 2

Gene

WPP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulates the mitotic activity in roots. Plays a role with HSP70-1 in facilitating WIT1 nuclear envelope targeting.2 Publications

GO - Biological processi

  1. lateral root development Source: TAIR
  2. mitotic nuclear division Source: TAIR
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
WPP domain-containing protein 2
Alternative name(s):
MFP1 attachment factor 2
Gene namesi
Name:WPP2
Synonyms:MAF2
Ordered Locus Names:At1g47200
ORF Names:F2G19.18, F8G22.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G47200.

Subcellular locationi

Nucleus envelope 1 Publication. Cytoplasm 1 Publication. Nucleus 1 Publication. Golgi apparatus By similarity
Note: Associated to the nuclear envelope (NE) in undifferentiated cells of the root tip. Associated with the outer NE and the nuclear pores in interphase cells and with the immature cell plate during cytokinesis. In differentiated cells, localized in both cytoplasm and nucleus. Accumulate in speckles of the cytoplasm belonging to the Golgi apparatus (By similarity). Appears at the NE as cells reenter the cell cycle during dedifferentiation.By similarity

GO - Cellular componenti

  1. cytosol Source: TAIR
  2. Golgi apparatus Source: UniProtKB-KW
  3. nuclear outer membrane Source: TAIR
  4. plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180WPP domain-containing protein 2PRO_0000347192Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei173 – 1731Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9C500.
PRIDEiQ9C500.

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves and flowers.1 Publication

Gene expression databases

GenevestigatoriQ9C500.

Interactioni

Subunit structurei

Binds to FPP proteins (By similarity). Interacts with WAP, WIP1, WIP2 and WIP3 through its WPP domain. Interacts with WIT1 and HSP70-1.By similarity4 Publications

Protein-protein interaction databases

BioGridi26348. 3 interactions.
IntActiQ9C500. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9C500.
SMRiQ9C500. Positions 57-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni44 – 147104WPPAdd
BLAST

Domaini

The WPP domain is required for the nuclear envelope localization.By similarity

Phylogenomic databases

eggNOGiNOG262975.
HOGENOMiHOG000239842.
InParanoidiQ9C500.
OMAiSAMTDPT.
PhylomeDBiQ9C500.

Family and domain databases

InterProiIPR025265. WPP_dom.
[Graphical view]
PfamiPF13943. WPP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C500 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAETAETINT TISSPPPESE SSTTISAMTD PTSQEAASKD TDLTKEAESE
60 70 80 90 100
KKPGGISLRI WPPTQKTRDA VLNRLIETLS TESILSKRYG TLKSDDATTV
110 120 130 140 150
AKLIEEEAYG VASNAVSSDD DGIKILELYS KEISKRMLES VKARSNASVG
160 170 180
NGSVEDANTD ASEVSKDDAG PASEEEKSEA
Length:180
Mass (Da):19,134
Last modified:June 1, 2001 - v1
Checksum:iF71F090976FA3826
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti172 – 1721A → G in AAM62902. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC079677 Genomic DNA. Translation: AAG52640.1.
AC083835 Genomic DNA. Translation: AAG50616.1.
CP002684 Genomic DNA. Translation: AEE32136.1.
AY072148 mRNA. Translation: AAL59970.1.
AY096476 mRNA. Translation: AAM20116.1.
AY085683 mRNA. Translation: AAM62902.1.
PIRiF96512.
RefSeqiNP_564498.1. NM_103613.2.
UniGeneiAt.17221.

Genome annotation databases

EnsemblPlantsiAT1G47200.1; AT1G47200.1; AT1G47200.
GeneIDi841123.
KEGGiath:AT1G47200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC079677 Genomic DNA. Translation: AAG52640.1 .
AC083835 Genomic DNA. Translation: AAG50616.1 .
CP002684 Genomic DNA. Translation: AEE32136.1 .
AY072148 mRNA. Translation: AAL59970.1 .
AY096476 mRNA. Translation: AAM20116.1 .
AY085683 mRNA. Translation: AAM62902.1 .
PIRi F96512.
RefSeqi NP_564498.1. NM_103613.2.
UniGenei At.17221.

3D structure databases

ProteinModelPortali Q9C500.
SMRi Q9C500. Positions 57-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 26348. 3 interactions.
IntActi Q9C500. 6 interactions.

Proteomic databases

PaxDbi Q9C500.
PRIDEi Q9C500.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G47200.1 ; AT1G47200.1 ; AT1G47200 .
GeneIDi 841123.
KEGGi ath:AT1G47200.

Organism-specific databases

TAIRi AT1G47200.

Phylogenomic databases

eggNOGi NOG262975.
HOGENOMi HOG000239842.
InParanoidi Q9C500.
OMAi SAMTDPT.
PhylomeDBi Q9C500.

Gene expression databases

Genevestigatori Q9C500.

Family and domain databases

InterProi IPR025265. WPP_dom.
[Graphical view ]
Pfami PF13943. WPP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Arabidopsis WPP-domain proteins are developmentally associated with the nuclear envelope and promote cell division."
    Patel S., Rose A., Meulia T., Dixit R., Cyr R.J., Meier I.
    Plant Cell 16:3260-3273(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  6. "The plant nuclear envelope protein MAF1 has an additional location at the Golgi and binds to a novel Golgi-associated coiled-coil protein."
    Patel S., Brkljacic J., Gindullis F., Rose A., Meier I.
    Planta 222:1028-1040(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WAP.
  7. "Anchorage of plant RanGAP to the nuclear envelope involves novel nuclear-pore-associated proteins."
    Xu X.M., Meulia T., Meier I.
    Curr. Biol. 17:1157-1163(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WIP1; WIP2 AND WIP3.
  8. "Two distinct interacting classes of nuclear envelope-associated coiled-coil proteins are required for the tissue-specific nuclear envelope targeting of Arabidopsis RanGAP."
    Zhao Q., Brkljacic J., Meier I.
    Plant Cell 20:1639-1651(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WIT1.
  9. "Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks."
    Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A., Grossmann J., Gruissem W., Baginsky S.
    Plant Physiol. 150:889-903(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1."
    Brkljacic J., Zhao Q., Meier I.
    Plant Physiol. 151:142-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WIT1 AND HSP70-1, FUNCTION.

Entry informationi

Entry nameiWPP2_ARATH
AccessioniPrimary (citable) accession number: Q9C500
Secondary accession number(s): Q8LE13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names

External Data

Dasty 3