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Q9C500

- WPP2_ARATH

UniProt

Q9C500 - WPP2_ARATH

Protein

WPP domain-containing protein 2

Gene

WPP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Regulates the mitotic activity in roots. Plays a role with HSP70-1 in facilitating WIT1 nuclear envelope targeting.2 Publications

    GO - Biological processi

    1. lateral root development Source: TAIR
    2. mitotic nuclear division Source: TAIR

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WPP domain-containing protein 2
    Alternative name(s):
    MFP1 attachment factor 2
    Gene namesi
    Name:WPP2
    Synonyms:MAF2
    Ordered Locus Names:At1g47200
    ORF Names:F2G19.18, F8G22.9
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G47200.

    Subcellular locationi

    Nucleus envelope 1 Publication. Cytoplasm 1 Publication. Nucleus 1 Publication. Golgi apparatus By similarity
    Note: Associated to the nuclear envelope (NE) in undifferentiated cells of the root tip. Associated with the outer NE and the nuclear pores in interphase cells and with the immature cell plate during cytokinesis. In differentiated cells, localized in both cytoplasm and nucleus. Accumulate in speckles of the cytoplasm belonging to the Golgi apparatus By similarity. Appears at the NE as cells reenter the cell cycle during dedifferentiation.By similarity

    GO - Cellular componenti

    1. cytosol Source: TAIR
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. nuclear outer membrane Source: TAIR
    4. plasma membrane Source: TAIR

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 180180WPP domain-containing protein 2PRO_0000347192Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei173 – 1731Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9C500.
    PRIDEiQ9C500.

    Expressioni

    Tissue specificityi

    Expressed in roots, stems, leaves and flowers.1 Publication

    Gene expression databases

    GenevestigatoriQ9C500.

    Interactioni

    Subunit structurei

    Binds to FPP proteins By similarity. Interacts with WAP, WIP1, WIP2 and WIP3 through its WPP domain. Interacts with WIT1 and HSP70-1.By similarity4 Publications

    Protein-protein interaction databases

    BioGridi26348. 3 interactions.
    IntActiQ9C500. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C500.
    SMRiQ9C500. Positions 57-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni44 – 147104WPPAdd
    BLAST

    Domaini

    The WPP domain is required for the nuclear envelope localization.By similarity

    Phylogenomic databases

    eggNOGiNOG262975.
    HOGENOMiHOG000239842.
    InParanoidiQ9C500.
    OMAiSAMTDPT.
    PhylomeDBiQ9C500.

    Family and domain databases

    InterProiIPR025265. WPP_dom.
    [Graphical view]
    PfamiPF13943. WPP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9C500-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAETAETINT TISSPPPESE SSTTISAMTD PTSQEAASKD TDLTKEAESE    50
    KKPGGISLRI WPPTQKTRDA VLNRLIETLS TESILSKRYG TLKSDDATTV 100
    AKLIEEEAYG VASNAVSSDD DGIKILELYS KEISKRMLES VKARSNASVG 150
    NGSVEDANTD ASEVSKDDAG PASEEEKSEA 180
    Length:180
    Mass (Da):19,134
    Last modified:June 1, 2001 - v1
    Checksum:iF71F090976FA3826
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti172 – 1721A → G in AAM62902. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC079677 Genomic DNA. Translation: AAG52640.1.
    AC083835 Genomic DNA. Translation: AAG50616.1.
    CP002684 Genomic DNA. Translation: AEE32136.1.
    AY072148 mRNA. Translation: AAL59970.1.
    AY096476 mRNA. Translation: AAM20116.1.
    AY085683 mRNA. Translation: AAM62902.1.
    PIRiF96512.
    RefSeqiNP_564498.1. NM_103613.2.
    UniGeneiAt.17221.

    Genome annotation databases

    EnsemblPlantsiAT1G47200.1; AT1G47200.1; AT1G47200.
    GeneIDi841123.
    KEGGiath:AT1G47200.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC079677 Genomic DNA. Translation: AAG52640.1 .
    AC083835 Genomic DNA. Translation: AAG50616.1 .
    CP002684 Genomic DNA. Translation: AEE32136.1 .
    AY072148 mRNA. Translation: AAL59970.1 .
    AY096476 mRNA. Translation: AAM20116.1 .
    AY085683 mRNA. Translation: AAM62902.1 .
    PIRi F96512.
    RefSeqi NP_564498.1. NM_103613.2.
    UniGenei At.17221.

    3D structure databases

    ProteinModelPortali Q9C500.
    SMRi Q9C500. Positions 57-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 26348. 3 interactions.
    IntActi Q9C500. 6 interactions.

    Proteomic databases

    PaxDbi Q9C500.
    PRIDEi Q9C500.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G47200.1 ; AT1G47200.1 ; AT1G47200 .
    GeneIDi 841123.
    KEGGi ath:AT1G47200.

    Organism-specific databases

    TAIRi AT1G47200.

    Phylogenomic databases

    eggNOGi NOG262975.
    HOGENOMi HOG000239842.
    InParanoidi Q9C500.
    OMAi SAMTDPT.
    PhylomeDBi Q9C500.

    Gene expression databases

    Genevestigatori Q9C500.

    Family and domain databases

    InterProi IPR025265. WPP_dom.
    [Graphical view ]
    Pfami PF13943. WPP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Arabidopsis WPP-domain proteins are developmentally associated with the nuclear envelope and promote cell division."
      Patel S., Rose A., Meulia T., Dixit R., Cyr R.J., Meier I.
      Plant Cell 16:3260-3273(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    6. "The plant nuclear envelope protein MAF1 has an additional location at the Golgi and binds to a novel Golgi-associated coiled-coil protein."
      Patel S., Brkljacic J., Gindullis F., Rose A., Meier I.
      Planta 222:1028-1040(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH WAP.
    7. "Anchorage of plant RanGAP to the nuclear envelope involves novel nuclear-pore-associated proteins."
      Xu X.M., Meulia T., Meier I.
      Curr. Biol. 17:1157-1163(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH WIP1; WIP2 AND WIP3.
    8. "Two distinct interacting classes of nuclear envelope-associated coiled-coil proteins are required for the tissue-specific nuclear envelope targeting of Arabidopsis RanGAP."
      Zhao Q., Brkljacic J., Meier I.
      Plant Cell 20:1639-1651(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH WIT1.
    9. "Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks."
      Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A., Grossmann J., Gruissem W., Baginsky S.
      Plant Physiol. 150:889-903(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1."
      Brkljacic J., Zhao Q., Meier I.
      Plant Physiol. 151:142-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH WIT1 AND HSP70-1, FUNCTION.

    Entry informationi

    Entry nameiWPP2_ARATH
    AccessioniPrimary (citable) accession number: Q9C500
    Secondary accession number(s): Q8LE13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names

    External Data

    Dasty 3