Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aquaporin AqpM

Gene

aqpM

Organism
Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi1.A.8.13.2. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin AqpM
Gene namesi
Name:aqpM
Ordered Locus Names:MTBMA_c05510
OrganismiMethanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri79929 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000000345 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 55ExtracellularSequence analysisAdd BLAST23
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 103CytoplasmicSequence analysisAdd BLAST27
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 145ExtracellularSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 172CytoplasmicSequence analysis6
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 217ExtracellularSequence analysisAdd BLAST24
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 246CytoplasmicSequence analysis8

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000640061 – 246Aquaporin AqpMAdd BLAST246

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi79929.MTBMA_c05510.

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 33Combined sources30
Turni46 – 51Combined sources6
Helixi52 – 73Combined sources22
Turni74 – 76Combined sources3
Helixi83 – 91Combined sources9
Helixi97 – 99Combined sources3
Helixi100 – 122Combined sources23
Helixi125 – 128Combined sources4
Helixi131 – 133Combined sources3
Helixi143 – 164Combined sources22
Helixi175 – 194Combined sources20
Helixi200 – 214Combined sources15
Helixi219 – 223Combined sources5
Helixi224 – 243Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EVUX-ray2.30A1-246[»]
2F2BX-ray1.68A1-246[»]
ProteinModelPortaliQ9C4Z5.
SMRiQ9C4Z5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9C4Z5.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi82 – 84NPA 13
Motifi199 – 201NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG04431. Archaea.
COG0580. LUCA.
HOGENOMiHOG000288286.
KOiK02440.
OMAiNIFFECA.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C4Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSLTKRCIA EFIGTFILVF FGAGSAAVTL MIASGGTSPN PFNIGIGLLG
60 70 80 90 100
GLGDWVAIGL AFGFAIAASI YALGNISGCH INPAVTIGLW SVKKFPGREV
110 120 130 140 150
VPYIIAQLLG AAFGSFIFLQ CAGIGAATVG GLGATAPFPG ISYWQAMLAE
160 170 180 190 200
VVGTFLLMIT IMGIAVDERA PKGFAGIIIG LTVAGIITTL GNISGSSLNP
210 220 230 240
ARTFGPYLND MIFAGTNLWN YYPIYVIGPI VGAVLAALTY QYLTSE
Length:246
Mass (Da):25,357
Last modified:November 30, 2010 - v4
Checksum:iB6A31126A66257D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti217N → D no nucleotide entry (Ref. 2) Curated1
Sequence conflicti223P → S no nucleotide entry (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055880 Genomic DNA. Translation: BAB32660.1.
CP001710 Genomic DNA. Translation: ADL58146.1.
RefSeqiWP_013295370.1. NC_014408.1.

Genome annotation databases

EnsemblBacteriaiADL58146; ADL58146; MTBMA_c05510.
GeneIDi9704259.
KEGGimmg:MTBMA_c05510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055880 Genomic DNA. Translation: BAB32660.1.
CP001710 Genomic DNA. Translation: ADL58146.1.
RefSeqiWP_013295370.1. NC_014408.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EVUX-ray2.30A1-246[»]
2F2BX-ray1.68A1-246[»]
ProteinModelPortaliQ9C4Z5.
SMRiQ9C4Z5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi79929.MTBMA_c05510.

Protein family/group databases

TCDBi1.A.8.13.2. the major intrinsic protein (mip) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADL58146; ADL58146; MTBMA_c05510.
GeneIDi9704259.
KEGGimmg:MTBMA_c05510.

Phylogenomic databases

eggNOGiarCOG04431. Archaea.
COG0580. LUCA.
HOGENOMiHOG000288286.
KOiK02440.
OMAiNIFFECA.

Miscellaneous databases

EvolutionaryTraceiQ9C4Z5.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAQPM_METTM
AccessioniPrimary (citable) accession number: Q9C4Z5
Secondary accession number(s): D9PV98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 93 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.