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Q9C4Z5

- AQPM_METTM

UniProt

Q9C4Z5 - AQPM_METTM

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Protein

Aquaporin AqpM

Gene

aqpM

Organism
Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux.

GO - Molecular functioni

  1. transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciMMAR79929:GH5J-554-MONOMER.

Protein family/group databases

TCDBi1.A.8.13.2. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin AqpM
Gene namesi
Name:aqpM
Ordered Locus Names:MTBMA_c05510
OrganismiMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri79929 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000000345: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Topological domaini33 – 5523ExtracellularSequence AnalysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence AnalysisAdd
BLAST
Topological domaini77 – 10327CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence AnalysisAdd
BLAST
Topological domaini125 – 14521ExtracellularSequence AnalysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence AnalysisAdd
BLAST
Topological domaini167 – 1726CytoplasmicSequence Analysis
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Topological domaini194 – 21724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence AnalysisAdd
BLAST
Topological domaini239 – 2468CytoplasmicSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Aquaporin AqpMPRO_0000064006Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1
246
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 3330Combined sources
Turni46 – 516Combined sources
Helixi52 – 7322Combined sources
Turni74 – 763Combined sources
Helixi83 – 919Combined sources
Helixi97 – 993Combined sources
Helixi100 – 12223Combined sources
Helixi125 – 1284Combined sources
Helixi131 – 1333Combined sources
Helixi143 – 16422Combined sources
Helixi175 – 19420Combined sources
Helixi200 – 21415Combined sources
Helixi219 – 2235Combined sources
Helixi224 – 24320Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EVUX-ray2.30A1-246[»]
2F2BX-ray1.68A1-246[»]
ProteinModelPortaliQ9C4Z5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9C4Z5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi82 – 843NPA 1
Motifi199 – 2013NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000288286.
KOiK02440.
OMAiIYVIGPI.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C4Z5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSLTKRCIA EFIGTFILVF FGAGSAAVTL MIASGGTSPN PFNIGIGLLG
60 70 80 90 100
GLGDWVAIGL AFGFAIAASI YALGNISGCH INPAVTIGLW SVKKFPGREV
110 120 130 140 150
VPYIIAQLLG AAFGSFIFLQ CAGIGAATVG GLGATAPFPG ISYWQAMLAE
160 170 180 190 200
VVGTFLLMIT IMGIAVDERA PKGFAGIIIG LTVAGIITTL GNISGSSLNP
210 220 230 240
ARTFGPYLND MIFAGTNLWN YYPIYVIGPI VGAVLAALTY QYLTSE
Length:246
Mass (Da):25,357
Last modified:November 30, 2010 - v4
Checksum:iB6A31126A66257D6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti217 – 2171N → D no nucleotide entry 1 PublicationCurated
Sequence conflicti223 – 2231P → S no nucleotide entry 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055880 Genomic DNA. Translation: BAB32660.1.
CP001710 Genomic DNA. Translation: ADL58146.1.
RefSeqiYP_003849459.1. NC_014408.1.

Genome annotation databases

EnsemblBacteriaiADL58146; ADL58146; MTBMA_c05510.
GeneIDi9704259.
KEGGimmg:MTBMA_c05510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055880 Genomic DNA. Translation: BAB32660.1 .
CP001710 Genomic DNA. Translation: ADL58146.1 .
RefSeqi YP_003849459.1. NC_014408.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EVU X-ray 2.30 A 1-246 [» ]
2F2B X-ray 1.68 A 1-246 [» ]
ProteinModelPortali Q9C4Z5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 1.A.8.13.2. the major intrinsic protein (mip) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL58146 ; ADL58146 ; MTBMA_c05510 .
GeneIDi 9704259.
KEGGi mmg:MTBMA_c05510.

Phylogenomic databases

HOGENOMi HOG000288286.
KOi K02440.
OMAi IYVIGPI.

Enzyme and pathway databases

BioCyci MMAR79929:GH5J-554-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9C4Z5.

Family and domain databases

Gene3Di 1.20.1080.10. 1 hit.
InterProi IPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view ]
PANTHERi PTHR19139. PTHR19139. 1 hit.
Pfami PF00230. MIP. 1 hit.
[Graphical view ]
PRINTSi PR00783. MINTRINSICP.
SUPFAMi SSF81338. SSF81338. 1 hit.
TIGRFAMsi TIGR00861. MIP. 1 hit.
PROSITEi PS00221. MIP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rapid amplification of a water channel-like gene and its flanking sequences from the Methanothermobacter marburgensis genome using a single primer PCR strategy."
    Ding X., Kitagawa Y.
    J. Biosci. Bioeng. 92:488-491(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
  2. Kozono D., Ding X., Iwasaki I., Meng X., Kamagata Y., Agre P., Kitagawa Y.
    Submitted (JUL-2004) to UniProtKB
    Cited for: SEQUENCE REVISION TO 51; 217 AND 223.
  3. "Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
    Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
    J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
  4. "Functional expression and characterization of an archaeal aquaporin. AqpM from Methanothermobacter marburgensis."
    Kozono D., Ding X., Iwasaki I., Meng X., Kamagata Y., Agre P., Kitagawa Y.
    J. Biol. Chem. 278:10649-10656(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

Entry informationi

Entry nameiAQPM_METTM
AccessioniPrimary (citable) accession number: Q9C4Z5
Secondary accession number(s): D9PV98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: November 30, 2010
Last modified: November 26, 2014
This is version 87 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3