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Reviewed, UniProtKB/Swiss-Prot Q9C1X2 (YN53_SCHPO)

Last modified January 19, 2010. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Putative D-lactate dehydrogenase C713.03, mitochondrial
    EC=1.1.2.4
Gene names
ORF Names: SPBC713.03
OrganismSchizosaccharomyces pombe (Fission yeast) [Complete proteome]
Taxonomic identifier4896 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

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Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

(R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.

Cofactor

FAD Potential.

Subcellular location

Mitochondrion matrix Ref.2.

Sequence similarities

Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

Contains 1 FAD-binding PCMH-type domain.

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Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlactate metabolic process

Inferred by curator. Source: GeneDB_SPombe

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionD-lactate dehydrogenase (cytochrome) activity

Inferred from electronic annotation. Source: EC

FAD binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 526Putative D-lactate dehydrogenase C713.03, mitochondrialPRO_0000317236

Regions

Domain93 – 272180FAD-binding PCMH-type

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Sequences

Sequence LengthMass (Da)Tools
Q9C1X2-1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 00FAF5ABA81EBC11

FASTA52658,473
        10         20         30         40         50         60 
MHSLQCRRVI PFGKLSLSLH APRNALRFVH KPAFTFESYK SLHRDPKYAK LSEQDVQVFK 

        70         80         90        100        110        120 
SIIGKDGSLI DGLDKSTDPA DLDAFNIDWM NKYRGKTQLA LKPKTTQQVS EILKYCNQKK 

       130        140        150        160        170        180 
LAVVPQGGNT GLVGGSVPVF DEIVLNLGLM NQIHTFDEIS GVITLDSGVI LENADNFLAE 

       190        200        210        220        230        240 
KGYMFPLDLG AKGSCQVGGC AATAAGGLRL LRYGSLHGSI LGMEAVLPDG TILDNLVTLR 

       250        260        270        280        290        300 
KDNTGLDIKQ LFIGSEGYLG VITKLSVICP KRPSSTNVAF FGVPSYENVL KAFSETRSHL 

       310        320        330        340        350        360 
TEILSAFELM DNTSQTLVDK YSGTQRPLED EHPFYVLVET QGSNKEHDEQ KITALVEDLL 

       370        380        390        400        410        420 
EKEIISDGVL AQDESQLRVL WERREGITEC LAKAGSGVYK YDVSLPLPVL YDLVNDTKKR 

       430        440        450        460        470        480 
LIEFNLLDDT PEHPVIDVVG FGHMGDGNLH LNIAVRQFDK RVEKCLEPWV YEWVSRHRGS 

       490        500        510        520 
ISAEHGLGLL KKPFVGYSKS KEMIHLMKTL KNVFDPNGIM LPYKYV

« Hide

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References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 38366 / 972.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329671 Genomic DNA. Translation: CAC22604.1.
RefSeqNP_595342.1.

3D structure databases

SMRQ9C1X2. Positions 49-524.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9C1X2.

Genome annotation databases

GeneID2541151.
KEGGspo:SPBC713.03.
NMPDRfig|4896.1.peg.1208.

Organism-specific databases

GeneDB_SpombeSPBC713.03.

Phylogenomic databases

eggNOGfuNOG04802.
HOGENOMHBG553036.
OMAYSKPPEA.
OrthoDBEOG93N8VT.
PhylomeDBQ9C1X2.

Enzyme and pathway databases

BRENDA1.1.2.4. 653.

Gene expression databases

ArrayExpressQ9C1X2.

Family and domain databases

InterProIPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR016164. FAD-linked_Oxase-like_C.
IPR004113. FAD-linked_oxidase_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
Gene3DG3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
PfamPF02913. FAD-oxidase_C. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameYN53_SCHPO
AccessionPrimary (citable) accession number: Q9C1X2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2001
Last modified: January 19, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents