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Protein

DNA ligase 3

Gene

adl1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei433 – 4331N6-AMP-lysine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: PomBase
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: InterPro
  4. DNA replication Source: UniProtKB-KW
  5. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 3 (EC:6.5.1.1)
Alternative name(s):
DNA ligase III
Polydeoxyribonucleotide synthase [ATP] 3
Gene namesi
Name:adl1
Synonyms:lig3
ORF Names:SPBC713.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC713.06.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 774774DNA ligase 3PRO_0000372334Add
BLAST

Interactioni

Protein-protein interaction databases

MINTiMINT-4702364.
STRINGi4896.SPBC713.06-1.

Structurei

3D structure databases

ProteinModelPortaliQ9C1W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.Curated

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036006.
InParanoidiQ9C1W9.
KOiK10747.
OMAiFIMEGEV.
OrthoDBiEOG7TXKRG.
PhylomeDBiQ9C1W9.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR000014. PAS.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C1W9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPKKRMKNG SSLKSTSKKG EKSRNIITIQ DLFSKREAQL TDTPNKLLTD
60 70 80 90 100
HDQSASDYAY ALKLQQLFDS ENQATAPEKL PKDVIIPEEE YHTDTFNVVK
110 120 130 140 150
ESNDKPKENL VTSEECKASF FSTDSVNKDS TIDYDALQKD PLTYVKSCRA
160 170 180 190 200
RFVSKDTKSF SYSSLANTFS LISSTKSRIR IVTLLTNFLL TLLYADPDSL
210 220 230 240 250
IATVWLCTNS IAPNFYGKNL GVGPAMYSKA LKEVCGITAS ALKNLWNKYG
260 270 280 290 300
DPGDVAFEAK VSVRTLSRPE PLTIKKVYST LLKIADSNGN GAQNRKLELT
310 320 330 340 350
KFLLISSNAE EVRYIGRSIM QNLRIGAVQN TMLASLSKAF FIFDNQNEIF
360 370 380 390 400
NFNSDSLQQQ FRQGEEIVKQ SFFQVPDYNI LVATLLREGI ENLKDNMSIR
410 420 430 440 450
PGIPVKPMLG SITKNLQHML ERLTDHNFSC EFKYDGQRAQ IHCDRLGNIK
460 470 480 490 500
IFSRHLEEIT GRFPDVIEVA QLALKHSCDF IIEGELVAID KSNGQILDFQ
510 520 530 540 550
KLSTRERKKV TVADITIDVC VFVFDIMFCD GKSCLQMPLI ERRRMFFEHF
560 570 580 590 600
NLIPNRFQFV SSLETNEEQS IQEFFSLAIT NKCEGLMVKV LNGTNSKFPS
610 620 630 640 650
TYEPDKRGEG WIKVKQDYDD EFESLDLVPI GAWYGNGRKA GWFSPILLAV
660 670 680 690 700
YNPDTGAYEA VCKCMSGFSD QFYKELTQKY SLESGNSSLK PIYNFCETGK
710 720 730 740 750
VTPQIYFAPQ EVWEIKGAQI TSSPAYKAAL GLIQDDRGLS IRFPRFIRVR
760 770
SDKGPEDAST NSILADMYMK QLNT
Length:774
Mass (Da):87,587
Last modified:June 1, 2001 - v1
Checksum:i9D69F9EA510F78FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAC22607.1.
RefSeqiNP_595345.1. NM_001021253.2.

Genome annotation databases

EnsemblFungiiSPBC713.06.1; SPBC713.06.1:pep; SPBC713.06.
GeneIDi2541111.
KEGGispo:SPBC713.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAC22607.1.
RefSeqiNP_595345.1. NM_001021253.2.

3D structure databases

ProteinModelPortaliQ9C1W9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4702364.
STRINGi4896.SPBC713.06-1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC713.06.1; SPBC713.06.1:pep; SPBC713.06.
GeneIDi2541111.
KEGGispo:SPBC713.06.

Organism-specific databases

PomBaseiSPBC713.06.

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036006.
InParanoidiQ9C1W9.
KOiK10747.
OMAiFIMEGEV.
OrthoDBiEOG7TXKRG.
PhylomeDBiQ9C1W9.

Miscellaneous databases

NextBioi20802224.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR000014. PAS.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDNLI3_SCHPO
AccessioniPrimary (citable) accession number: Q9C1W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.