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Q9C1J2 (PYRF_PICPA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
OrganismKomagataella pastoris (Yeast) (Pichia pastoris)
Taxonomic identifier4922 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKomagataella

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Orotidine 5'-phosphate decarboxylase
PRO_0000134674

Regions

Region58 – 603Substrate binding By similarity
Region90 – 9910Substrate binding By similarity

Sites

Active site921Proton donor By similarity
Binding site361Substrate By similarity
Binding site2161Substrate By similarity
Binding site2341Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9C1J2 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 4BFAC8CE526BAFB8

FASTA26329,146
        10         20         30         40         50         60 
MARSYAERAN THQSPVARRL FALMEQKQSN LCASVDVRTT KELLELLDKL GPFICLAKTH 

        70         80         90        100        110        120 
IDIIDDFTYD GTILPLLELS KKHKFLIFED RKFADIGNTV KHQYQGGVYK IAQWADITNA 

       130        140        150        160        170        180 
HGVIGSGIVK GLKEAATETT DQPRGLLMLA ELSSKGSIAH GKYTEETVEI AKSDKEFVIG 

       190        200        210        220        230        240 
FIAQNSMGGQ DEGFDWIIMT PGVGLDDTGD ALGQQYRTVS QVFSTGTDII IVGRGLFGKG 

       250        260 
RDPLKEGERY RKAGWEAYQN ILR 

« Hide

References

[1]"New selectable marker/auxotrophic host strain combinations for molecular genetic manipulation of Pichia pastoris."
Lin Cereghino G.P., Lin Cereghino J., Sunga A.J., Johnson M.A., Lim M., Gleeson M.A.G., Cregg J.M.
Gene 263:159-169(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF321098 Genomic DNA. Translation: AAK06768.1.

3D structure databases

ProteinModelPortalQ9C1J2.
SMRQ9C1J2. Positions 4-258.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_PICPA
AccessionPrimary (citable) accession number: Q9C1J2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: October 16, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways