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Q9C1J2

- PYRF_PICPA

UniProt

Q9C1J2 - PYRF_PICPA

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Komagataella pastoris (Yeast) (Pichia pastoris)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361SubstrateBy similarity
Active sitei92 – 921Proton donorPROSITE-ProRule annotation
Binding sitei216 – 2161SubstrateBy similarity
Binding sitei234 – 2341SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
OrganismiKomagataella pastoris (Yeast) (Pichia pastoris)
Taxonomic identifieri4922 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Orotidine 5'-phosphate decarboxylasePRO_0000134674Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9C1J2.
SMRiQ9C1J2. Positions 4-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 603Substrate bindingBy similarity
Regioni90 – 9910Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C1J2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARSYAERAN THQSPVARRL FALMEQKQSN LCASVDVRTT KELLELLDKL
60 70 80 90 100
GPFICLAKTH IDIIDDFTYD GTILPLLELS KKHKFLIFED RKFADIGNTV
110 120 130 140 150
KHQYQGGVYK IAQWADITNA HGVIGSGIVK GLKEAATETT DQPRGLLMLA
160 170 180 190 200
ELSSKGSIAH GKYTEETVEI AKSDKEFVIG FIAQNSMGGQ DEGFDWIIMT
210 220 230 240 250
PGVGLDDTGD ALGQQYRTVS QVFSTGTDII IVGRGLFGKG RDPLKEGERY
260
RKAGWEAYQN ILR
Length:263
Mass (Da):29,146
Last modified:June 1, 2001 - v1
Checksum:i4BFAC8CE526BAFB8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF321098 Genomic DNA. Translation: AAK06768.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF321098 Genomic DNA. Translation: AAK06768.1 .

3D structure databases

ProteinModelPortali Q9C1J2.
SMRi Q9C1J2. Positions 4-258.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "New selectable marker/auxotrophic host strain combinations for molecular genetic manipulation of Pichia pastoris."
    Lin Cereghino G.P., Lin Cereghino J., Sunga A.J., Johnson M.A., Lim M., Gleeson M.A.G., Cregg J.M.
    Gene 263:159-169(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPYRF_PICPA
AccessioniPrimary (citable) accession number: Q9C1J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3