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Q9C167

- RIR2_NEUCR

UniProt

Q9C167 - RIR2_NEUCR

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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

rnr-2

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi146 – 1461Iron 1PROSITE-ProRule annotation
Metal bindingi177 – 1771Iron 1PROSITE-ProRule annotation
Metal bindingi177 – 1771Iron 2By similarity
Metal bindingi180 – 1801Iron 1PROSITE-ProRule annotation
Active sitei184 – 1841PROSITE-ProRule annotation
Metal bindingi240 – 2401Iron 2By similarity
Metal bindingi274 – 2741Iron 2By similarity
Metal bindingi277 – 2771Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:rnr-2
Synonyms:rnr2
ORF Names:NCU07887
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 3, Linkage Group III

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Ribonucleoside-diphosphate reductase small chainPRO_0000190462Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.By similarity

Protein-protein interaction databases

STRINGi5141.NCU07887.1.

Structurei

3D structure databases

ProteinModelPortaliQ9C167.
SMRiQ9C167. Positions 32-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
HOGENOMiHOG000255975.
InParanoidiQ9C167.
KOiK10808.
OMAiGVMNSTK.
OrthoDBiEOG7T1RMH.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C167-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVQTSPSKQ VTSGIQNLNM DSPAKKLDFG ATDKENKPFD EDLAKLEAEI
60 70 80 90 100
DAEHNANKKA AEAKKMAPTL KPEEANEPLL TENPQRFVLF PIKYHEIWQM
110 120 130 140 150
YKKAEASFWT AEEIDLSKDL HDWNNRLNDD EKFFISHILA FFAASDGIVN
160 170 180 190 200
ENLVERFSGE VQIPEARCFY GFQIMMENIH SETYSLLIDT YIKEPSQRTY
210 220 230 240 250
LFNAIDTIPC IRKKADWALR WITDKSSTFA QRLVAFAAVE GIFFSGAFAS
260 270 280 290 300
IFWLKKRGLM PGLTFSNELI SRDEGLHTDF ACLLFSHLNN RPSKQLIQEI
310 320 330 340 350
IVDAVRIEQE FLTEALPCAL LGMNADLMKQ YIEFVADRLL VALGNEKIYR
360 370 380 390 400
STNPFDFMEN ISLGGKTNFF EKRVGDYQKA GVMNSTKKAD ADAEVAKNEN
410
GGDFTFDEDF
Length:410
Mass (Da):46,698
Last modified:December 1, 2001 - v2
Checksum:iFAC2314C4959BE8E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY027867 Genomic DNA. Translation: AAK14804.2.
CM002238 Genomic DNA. Translation: EAA33584.1.
RefSeqiXP_962820.1. XM_957727.2.
UniGeneiNcr.16250.

Genome annotation databases

EnsemblFungiiEFNCRT00000007516; EFNCRP00000007506; EFNCRG00000007504.
GeneIDi3878959.
KEGGincr:NCU07887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY027867 Genomic DNA. Translation: AAK14804.2 .
CM002238 Genomic DNA. Translation: EAA33584.1 .
RefSeqi XP_962820.1. XM_957727.2.
UniGenei Ncr.16250.

3D structure databases

ProteinModelPortali Q9C167.
SMRi Q9C167. Positions 32-360.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU07887.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000007516 ; EFNCRP00000007506 ; EFNCRG00000007504 .
GeneIDi 3878959.
KEGGi ncr:NCU07887.

Phylogenomic databases

eggNOGi COG0208.
HOGENOMi HOG000255975.
InParanoidi Q9C167.
KOi K10808.
OMAi GVMNSTK.
OrthoDBi EOG7T1RMH.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Suppressor of un-24 temperature sensitive mutation."
    Kotierk M., Smith M.L.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FGSC 1131.
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiRIR2_NEUCR
AccessioniPrimary (citable) accession number: Q9C167
Secondary accession number(s): Q7RVY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3