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Q9C167

- RIR2_NEUCR

UniProt

Q9C167 - RIR2_NEUCR

Protein

Ribonucleoside-diphosphate reductase small chain

Gene

rnr-2

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi146 – 1461Iron 1PROSITE-ProRule annotation
    Metal bindingi177 – 1771Iron 1PROSITE-ProRule annotation
    Metal bindingi177 – 1771Iron 2By similarity
    Metal bindingi180 – 1801Iron 1PROSITE-ProRule annotation
    Active sitei184 – 1841PROSITE-ProRule annotation
    Metal bindingi240 – 2401Iron 2By similarity
    Metal bindingi274 – 2741Iron 2By similarity
    Metal bindingi277 – 2771Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:rnr-2
    Synonyms:rnr2
    ORF Names:NCU07887
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 3, Linkage Group III

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 410410Ribonucleoside-diphosphate reductase small chainPRO_0000190462Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large and a small subunit.By similarity

    Protein-protein interaction databases

    STRINGi5141.NCU07887.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C167.
    SMRiQ9C167. Positions 32-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0208.
    HOGENOMiHOG000255975.
    KOiK10808.
    OMAiGVMNSTK.
    OrthoDBiEOG7T1RMH.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9C167-1 [UniParc]FASTAAdd to Basket

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    MSVQTSPSKQ VTSGIQNLNM DSPAKKLDFG ATDKENKPFD EDLAKLEAEI    50
    DAEHNANKKA AEAKKMAPTL KPEEANEPLL TENPQRFVLF PIKYHEIWQM 100
    YKKAEASFWT AEEIDLSKDL HDWNNRLNDD EKFFISHILA FFAASDGIVN 150
    ENLVERFSGE VQIPEARCFY GFQIMMENIH SETYSLLIDT YIKEPSQRTY 200
    LFNAIDTIPC IRKKADWALR WITDKSSTFA QRLVAFAAVE GIFFSGAFAS 250
    IFWLKKRGLM PGLTFSNELI SRDEGLHTDF ACLLFSHLNN RPSKQLIQEI 300
    IVDAVRIEQE FLTEALPCAL LGMNADLMKQ YIEFVADRLL VALGNEKIYR 350
    STNPFDFMEN ISLGGKTNFF EKRVGDYQKA GVMNSTKKAD ADAEVAKNEN 400
    GGDFTFDEDF 410
    Length:410
    Mass (Da):46,698
    Last modified:December 1, 2001 - v2
    Checksum:iFAC2314C4959BE8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY027867 Genomic DNA. Translation: AAK14804.2.
    CM002238 Genomic DNA. Translation: EAA33584.1.
    RefSeqiXP_962820.1. XM_957727.2.
    UniGeneiNcr.16250.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000007516; EFNCRP00000007506; EFNCRG00000007504.
    GeneIDi3878959.
    KEGGincr:NCU07887.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY027867 Genomic DNA. Translation: AAK14804.2 .
    CM002238 Genomic DNA. Translation: EAA33584.1 .
    RefSeqi XP_962820.1. XM_957727.2.
    UniGenei Ncr.16250.

    3D structure databases

    ProteinModelPortali Q9C167.
    SMRi Q9C167. Positions 32-360.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU07887.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000007516 ; EFNCRP00000007506 ; EFNCRG00000007504 .
    GeneIDi 3878959.
    KEGGi ncr:NCU07887.

    Phylogenomic databases

    eggNOGi COG0208.
    HOGENOMi HOG000255975.
    KOi K10808.
    OMAi GVMNSTK.
    OrthoDBi EOG7T1RMH.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Suppressor of un-24 temperature sensitive mutation."
      Kotierk M., Smith M.L.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FGSC 1131.
    2. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiRIR2_NEUCR
    AccessioniPrimary (citable) accession number: Q9C167
    Secondary accession number(s): Q7RVY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 30, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3