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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

rnr-2

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi146Iron 1PROSITE-ProRule annotation1
Metal bindingi177Iron 1PROSITE-ProRule annotation1
Metal bindingi177Iron 2By similarity1
Metal bindingi180Iron 1PROSITE-ProRule annotation1
Active sitei184PROSITE-ProRule annotation1
Metal bindingi240Iron 2By similarity1
Metal bindingi274Iron 2By similarity1
Metal bindingi277Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:rnr-2
Synonyms:rnr2
ORF Names:NCU07887
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 3, Linkage Group III

Organism-specific databases

EuPathDBiFungiDB:NCU07887.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904621 – 410Ribonucleoside-diphosphate reductase small chainAdd BLAST410

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9C167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000255975.
InParanoidiQ9C167.
KOiK10808.
OMAiTHKAHRR.
OrthoDBiEOG092C3G06.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR030475. RNR_small_AS.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVQTSPSKQ VTSGIQNLNM DSPAKKLDFG ATDKENKPFD EDLAKLEAEI
60 70 80 90 100
DAEHNANKKA AEAKKMAPTL KPEEANEPLL TENPQRFVLF PIKYHEIWQM
110 120 130 140 150
YKKAEASFWT AEEIDLSKDL HDWNNRLNDD EKFFISHILA FFAASDGIVN
160 170 180 190 200
ENLVERFSGE VQIPEARCFY GFQIMMENIH SETYSLLIDT YIKEPSQRTY
210 220 230 240 250
LFNAIDTIPC IRKKADWALR WITDKSSTFA QRLVAFAAVE GIFFSGAFAS
260 270 280 290 300
IFWLKKRGLM PGLTFSNELI SRDEGLHTDF ACLLFSHLNN RPSKQLIQEI
310 320 330 340 350
IVDAVRIEQE FLTEALPCAL LGMNADLMKQ YIEFVADRLL VALGNEKIYR
360 370 380 390 400
STNPFDFMEN ISLGGKTNFF EKRVGDYQKA GVMNSTKKAD ADAEVAKNEN
410
GGDFTFDEDF
Length:410
Mass (Da):46,698
Last modified:December 1, 2001 - v2
Checksum:iFAC2314C4959BE8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY027867 Genomic DNA. Translation: AAK14804.2.
CM002238 Genomic DNA. Translation: EAA33584.1.
RefSeqiXP_962820.1. XM_957727.3.

Genome annotation databases

EnsemblFungiiEAA33584; EAA33584; NCU07887.
GeneIDi3878959.
KEGGincr:NCU07887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY027867 Genomic DNA. Translation: AAK14804.2.
CM002238 Genomic DNA. Translation: EAA33584.1.
RefSeqiXP_962820.1. XM_957727.3.

3D structure databases

ProteinModelPortaliQ9C167.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA33584; EAA33584; NCU07887.
GeneIDi3878959.
KEGGincr:NCU07887.

Organism-specific databases

EuPathDBiFungiDB:NCU07887.

Phylogenomic databases

HOGENOMiHOG000255975.
InParanoidiQ9C167.
KOiK10808.
OMAiTHKAHRR.
OrthoDBiEOG092C3G06.

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR030475. RNR_small_AS.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIR2_NEUCR
AccessioniPrimary (citable) accession number: Q9C167
Secondary accession number(s): Q7RVY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.