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Q9C167

- RIR2_NEUCR

UniProt

Q9C167 - RIR2_NEUCR

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Protein
Ribonucleoside-diphosphate reductase small chain
Gene
rnr-2, rnr2, NCU07887
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi146 – 1461Iron 1 By similarity
Metal bindingi177 – 1771Iron 1 By similarity
Metal bindingi177 – 1771Iron 2 By similarity
Metal bindingi180 – 1801Iron 1 By similarity
Active sitei184 – 1841 By similarity
Metal bindingi240 – 2401Iron 2 By similarity
Metal bindingi274 – 2741Iron 2 By similarity
Metal bindingi277 – 2771Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
  2. deoxyribonucleoside diphosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:rnr-2
Synonyms:rnr2
ORF Names:NCU07887
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 3, Linkage Group III

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Ribonucleoside-diphosphate reductase small chain
PRO_0000190462Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit By similarity.

Protein-protein interaction databases

STRINGi5141.NCU07887.1.

Structurei

3D structure databases

ProteinModelPortaliQ9C167.
SMRiQ9C167. Positions 32-360.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
HOGENOMiHOG000255975.
KOiK10808.
OMAiGVMNSTK.
OrthoDBiEOG7T1RMH.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C167-1 [UniParc]FASTAAdd to Basket

« Hide

MSVQTSPSKQ VTSGIQNLNM DSPAKKLDFG ATDKENKPFD EDLAKLEAEI    50
DAEHNANKKA AEAKKMAPTL KPEEANEPLL TENPQRFVLF PIKYHEIWQM 100
YKKAEASFWT AEEIDLSKDL HDWNNRLNDD EKFFISHILA FFAASDGIVN 150
ENLVERFSGE VQIPEARCFY GFQIMMENIH SETYSLLIDT YIKEPSQRTY 200
LFNAIDTIPC IRKKADWALR WITDKSSTFA QRLVAFAAVE GIFFSGAFAS 250
IFWLKKRGLM PGLTFSNELI SRDEGLHTDF ACLLFSHLNN RPSKQLIQEI 300
IVDAVRIEQE FLTEALPCAL LGMNADLMKQ YIEFVADRLL VALGNEKIYR 350
STNPFDFMEN ISLGGKTNFF EKRVGDYQKA GVMNSTKKAD ADAEVAKNEN 400
GGDFTFDEDF 410
Length:410
Mass (Da):46,698
Last modified:December 1, 2001 - v2
Checksum:iFAC2314C4959BE8E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY027867 Genomic DNA. Translation: AAK14804.2.
CM002238 Genomic DNA. Translation: EAA33584.1.
RefSeqiXP_962820.1. XM_957727.2.
UniGeneiNcr.16250.

Genome annotation databases

EnsemblFungiiEFNCRT00000007516; EFNCRP00000007506; EFNCRG00000007504.
GeneIDi3878959.
KEGGincr:NCU07887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY027867 Genomic DNA. Translation: AAK14804.2 .
CM002238 Genomic DNA. Translation: EAA33584.1 .
RefSeqi XP_962820.1. XM_957727.2.
UniGenei Ncr.16250.

3D structure databases

ProteinModelPortali Q9C167.
SMRi Q9C167. Positions 32-360.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU07887.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000007516 ; EFNCRP00000007506 ; EFNCRG00000007504 .
GeneIDi 3878959.
KEGGi ncr:NCU07887.

Phylogenomic databases

eggNOGi COG0208.
HOGENOMi HOG000255975.
KOi K10808.
OMAi GVMNSTK.
OrthoDBi EOG7T1RMH.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Suppressor of un-24 temperature sensitive mutation."
    Kotierk M., Smith M.L.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FGSC 1131.
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiRIR2_NEUCR
AccessioniPrimary (citable) accession number: Q9C167
Secondary accession number(s): Q7RVY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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