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Q9C167 (RIR2_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:rnr-2
Synonyms:rnr2
ORF Names:NCU07887
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small subunit By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 410410Ribonucleoside-diphosphate reductase small chain
PRO_0000190462

Sites

Active site1841 By similarity
Metal binding1461Iron 1 By similarity
Metal binding1771Iron 1 By similarity
Metal binding1771Iron 2 By similarity
Metal binding1801Iron 1 By similarity
Metal binding2401Iron 2 By similarity
Metal binding2741Iron 2 By similarity
Metal binding2771Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9C167 [UniParc].

Last modified December 1, 2001. Version 2.
Checksum: FAC2314C4959BE8E

FASTA41046,698
        10         20         30         40         50         60 
MSVQTSPSKQ VTSGIQNLNM DSPAKKLDFG ATDKENKPFD EDLAKLEAEI DAEHNANKKA 

        70         80         90        100        110        120 
AEAKKMAPTL KPEEANEPLL TENPQRFVLF PIKYHEIWQM YKKAEASFWT AEEIDLSKDL 

       130        140        150        160        170        180 
HDWNNRLNDD EKFFISHILA FFAASDGIVN ENLVERFSGE VQIPEARCFY GFQIMMENIH 

       190        200        210        220        230        240 
SETYSLLIDT YIKEPSQRTY LFNAIDTIPC IRKKADWALR WITDKSSTFA QRLVAFAAVE 

       250        260        270        280        290        300 
GIFFSGAFAS IFWLKKRGLM PGLTFSNELI SRDEGLHTDF ACLLFSHLNN RPSKQLIQEI 

       310        320        330        340        350        360 
IVDAVRIEQE FLTEALPCAL LGMNADLMKQ YIEFVADRLL VALGNEKIYR STNPFDFMEN 

       370        380        390        400        410 
ISLGGKTNFF EKRVGDYQKA GVMNSTKKAD ADAEVAKNEN GGDFTFDEDF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY027867 Genomic DNA. Translation: AAK14804.2.
CM002238 Genomic DNA. Translation: EAA33584.1.
RefSeqXP_962820.1. XM_957727.2.
UniGeneNcr.16250.

3D structure databases

ProteinModelPortalQ9C167.
SMRQ9C167. Positions 32-360.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU07887.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000007516; EFNCRP00000007506; EFNCRG00000007504.
GeneID3878959.
KEGGncr:NCU07887.

Phylogenomic databases

eggNOGCOG0208.
HOGENOMHOG000255975.
KOK10808.
OMAGVMNSTK.
OrthoDBEOG7T1RMH.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_NEUCR
AccessionPrimary (citable) accession number: Q9C167
Secondary accession number(s): Q7RVY4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways