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Q9C150 (PYRF_CANDC) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
ORF Names:CD36_81280
OrganismCandida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast) [Complete proteome]
Taxonomic identifier573826 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Orotidine 5'-phosphate decarboxylase
PRO_0000134648

Regions

Region61 – 633Substrate binding By similarity
Region93 – 10210Substrate binding By similarity

Sites

Active site951Proton donor By similarity
Binding site391Substrate By similarity
Binding site2211Substrate By similarity
Binding site2391Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9C150 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 217D05C4926175D9

FASTA27029,921
        10         20         30         40         50         60 
MTVNTKTYSA RAETHASPVA QRLFRLMESK KTNLCASIDV DTTKEFLELI DKLGPYVCLI 

        70         80         90        100        110        120 
KTHIDIINDF SYESTIEPLL ELSRKHQFMI FEDRKFADIG NTVKKQYIGG VYKISSWADI 

       130        140        150        160        170        180 
TNAHGVTGNG VVEGLKQGAK ETTTDQEPRG LLMLAELSSV GSLAYGEYSQ KTVEIAKSDK 

       190        200        210        220        230        240 
EFVIGFIAQR DMGGQEEGFD WIIMTPGVGL DDKGDGLGQQ YRTVNEVVST GTDIIIVGRG 

       250        260        270 
LFGKGRDPEV EGKRYRDAGW NAYLKKTGQL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ302032 Genomic DNA. Translation: CAC27824.1.
FM992690 Genomic DNA. Translation: CAX42658.1.
RefSeqXP_002419073.1. XM_002419028.1.

3D structure databases

ProteinModelPortalQ9C150.
SMRQ9C150. Positions 7-269.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING573826.CD36_81280.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8047017.
KEGGcdu:CD36_81280.

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000213905.
KOK01591.
OrthoDBEOG7CVQ76.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_CANDC
AccessionPrimary (citable) accession number: Q9C150
Secondary accession number(s): B9WDA6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: November 13, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways