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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391SubstrateBy similarity
Active sitei95 – 951Proton donorPROSITE-ProRule annotation
Binding sitei221 – 2211SubstrateBy similarity
Binding sitei239 – 2391SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
ORF Names:CD36_81280
OrganismiCandida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Taxonomic identifieri573826 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000002605 Componenti: Chromosome 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Orotidine 5'-phosphate decarboxylasePRO_0000134648Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi573826.CD36_81280.

Structurei

3D structure databases

ProteinModelPortaliQ9C150.
SMRiQ9C150. Positions 7-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 633Substrate bindingBy similarity
Regioni93 – 10210Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000213905.
KOiK01591.
OrthoDBiEOG7CVQ76.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C150-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVNTKTYSA RAETHASPVA QRLFRLMESK KTNLCASIDV DTTKEFLELI
60 70 80 90 100
DKLGPYVCLI KTHIDIINDF SYESTIEPLL ELSRKHQFMI FEDRKFADIG
110 120 130 140 150
NTVKKQYIGG VYKISSWADI TNAHGVTGNG VVEGLKQGAK ETTTDQEPRG
160 170 180 190 200
LLMLAELSSV GSLAYGEYSQ KTVEIAKSDK EFVIGFIAQR DMGGQEEGFD
210 220 230 240 250
WIIMTPGVGL DDKGDGLGQQ YRTVNEVVST GTDIIIVGRG LFGKGRDPEV
260 270
EGKRYRDAGW NAYLKKTGQL
Length:270
Mass (Da):29,921
Last modified:June 1, 2001 - v1
Checksum:i217D05C4926175D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302032 Genomic DNA. Translation: CAC27824.1.
FM992690 Genomic DNA. Translation: CAX42658.1.
RefSeqiXP_002419073.1. XM_002419028.1.

Genome annotation databases

GeneIDi8047017.
KEGGicdu:CD36_81280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302032 Genomic DNA. Translation: CAC27824.1.
FM992690 Genomic DNA. Translation: CAX42658.1.
RefSeqiXP_002419073.1. XM_002419028.1.

3D structure databases

ProteinModelPortaliQ9C150.
SMRiQ9C150. Positions 7-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi573826.CD36_81280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8047017.
KEGGicdu:CD36_81280.

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000213905.
KOiK01591.
OrthoDBiEOG7CVQ76.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isogenic strain construction and gene targeting in Candida dubliniensis."
    Staib P., Moran G.P., Sullivan D.J., Coleman D.C., Morschhauser J.
    J. Bacteriol. 183:2859-2865(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841.

Entry informationi

Entry nameiPYRF_CANDC
AccessioniPrimary (citable) accession number: Q9C150
Secondary accession number(s): B9WDA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.