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Q9C150

- PYRF_CANDC

UniProt

Q9C150 - PYRF_CANDC

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
URA3, CD36_81280
Organism
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Substrate By similarity
Active sitei95 – 951Proton donor By similarity
Binding sitei221 – 2211Substrate By similarity
Binding sitei239 – 2391Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
ORF Names:CD36_81280
OrganismiCandida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Taxonomic identifieri573826 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000002605: Chromosome 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Orotidine 5'-phosphate decarboxylasePRO_0000134648Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi573826.CD36_81280.

Structurei

3D structure databases

ProteinModelPortaliQ9C150.
SMRiQ9C150. Positions 7-269.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 633Substrate binding By similarity
Regioni93 – 10210Substrate binding By similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000213905.
KOiK01591.
OrthoDBiEOG7CVQ76.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C150-1 [UniParc]FASTAAdd to Basket

« Hide

MTVNTKTYSA RAETHASPVA QRLFRLMESK KTNLCASIDV DTTKEFLELI    50
DKLGPYVCLI KTHIDIINDF SYESTIEPLL ELSRKHQFMI FEDRKFADIG 100
NTVKKQYIGG VYKISSWADI TNAHGVTGNG VVEGLKQGAK ETTTDQEPRG 150
LLMLAELSSV GSLAYGEYSQ KTVEIAKSDK EFVIGFIAQR DMGGQEEGFD 200
WIIMTPGVGL DDKGDGLGQQ YRTVNEVVST GTDIIIVGRG LFGKGRDPEV 250
EGKRYRDAGW NAYLKKTGQL 270
Length:270
Mass (Da):29,921
Last modified:June 1, 2001 - v1
Checksum:i217D05C4926175D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ302032 Genomic DNA. Translation: CAC27824.1.
FM992690 Genomic DNA. Translation: CAX42658.1.
RefSeqiXP_002419073.1. XM_002419028.1.

Genome annotation databases

GeneIDi8047017.
KEGGicdu:CD36_81280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ302032 Genomic DNA. Translation: CAC27824.1 .
FM992690 Genomic DNA. Translation: CAX42658.1 .
RefSeqi XP_002419073.1. XM_002419028.1.

3D structure databases

ProteinModelPortali Q9C150.
SMRi Q9C150. Positions 7-269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 573826.CD36_81280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8047017.
KEGGi cdu:CD36_81280.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000213905.
KOi K01591.
OrthoDBi EOG7CVQ76.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isogenic strain construction and gene targeting in Candida dubliniensis."
    Staib P., Moran G.P., Sullivan D.J., Coleman D.C., Morschhauser J.
    J. Bacteriol. 183:2859-2865(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841.

Entry informationi

Entry nameiPYRF_CANDC
AccessioniPrimary (citable) accession number: Q9C150
Secondary accession number(s): B9WDA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: November 13, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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