Q9C141 (DMAW2_CLAPU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tryptophan dimethylallyltransferase 2
EC=2.5.1.34

Alternative name(s):
4-dimethylallyltryptophan synthase 2
All-trans-hexaprenyl-diphosphate synthase 2
L-tryptophan dimethylallyl transferase 2
Short name=DMATS 2

Gene names

Name:	dmaW2
Synonyms:	cpd2

Organism

Claviceps purpurea (Ergot fungus) (Sphacelia purpurea)

Taxonomic identifier

5111 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Clavicipitaceae › Claviceps

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the first step of ergot alkaloid biosynthesis. Ergot alkaloids, which are produced by endophyte fungi, can enhance plant host fitness, but also cause livestock toxicosis to host plants By similarity.
Catalytic activity	Dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan.
Pathway	Alkaloid biosynthesis; ergot alkaloid biosynthesis.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the tryptophan dimethylallyltransferase family.

Ontologies

Keywords
Biological process	Alkaloid metabolism
Molecular function	Transferase
Gene Ontology (GO)
Biological process	alkaloid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	tryptophan dimethylallyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Tryptophan dimethylallyltransferase 2		PRO_0000181365

Sequences

	Sequence		Length	Mass (Da)
	Q9C141 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 1ED9FE8900810E59	FASTA	448	51,521
	10 20 30 40 50 60 MSTAKDPGNG VYEILSLIFD FPSNEQRLWW HSTAPMFAAM LDNAGYSVHD QYRHLSIFKT 70 80 90 100 110 120 HIIPFLGVYP TKGQERWLSI LTRCGLPLEL SLNCTDSVVR YAYEPINEMT GTEKDPSNTL 130 140 150 160 170 180 PIIGSVQKLA QIQAGIDLEW FSYFKDELTL DESESAILQD TELVKEQIKT QNKLALDLKE 190 200 210 220 230 240 SQFALKVYFY PHLKSIATGN STHFLIFDSV FKLSQKHDSI QPAFQALCDY VSRRNDSSEV 250 260 270 280 290 300 DQHRALHARL LSCDLIDPAK SRVKIYLQEQ TVSLPAMEDL WTLGGRRVDA STMDGLDMLR 310 320 330 340 350 360 ELWSLLKVPT GHLEYPKGYM ELGEIPNEQL PSLVNYTLHR NDPMPEPQVY FTVFGMNDAE 370 380 390 400 410 420 ISNALTIFLQ RHGFADMAKK YRVFLQDSYP YHDFESLNYL HSLVSFSYRR NKPYLSVYLH 430 440 TFETGRWPVV ADSPISFDAY RRCDLSTK

References

[1]	"Molecular analysis of dimethyl-allyl-tryptophan-synthase-genes." Arntz C., Tudzynski P. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: T5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ312753 Genomic DNA. Translation: CAC37396.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR017795. Aromatic_prenylTrfase_DMATS. IPR012148. Trp_dimethylallyltransferase. IPR017796. Trp_dimethylallylTrfase_sub. [Graphical view]
Pfam	PF11991. Trp_DMAT. 1 hit. [Graphical view]
PIRSF	PIRSF000509. Trp_DMAT. 1 hit.
TIGRFAMs	TIGR03429. Arom_pren_DMATS. 1 hit. TIGR03430. Trp_dimet_allyl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DMAW2_CLAPU

Accession

Primary (citable) accession number: Q9C141

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	June 1, 2001
Last modified:	October 19, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program