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Q9C131 (PYRF_PARBR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
OrganismParacoccidioides brasiliensis
Taxonomic identifier121759 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Orotidine 5'-phosphate decarboxylase
PRO_0000134667

Regions

Region62 – 643Substrate binding By similarity
Region93 – 10210Substrate binding By similarity

Sites

Active site951Proton donor By similarity
Binding site401Substrate By similarity
Binding site2351Substrate By similarity
Binding site2531Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9C131 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 5B0951F325883DCE

FASTA28531,064
        10         20         30         40         50         60 
MSSQSHIPYA VRASRHSNPL ARQLFQIAEE KKSNVVVSAD VTTSKELLDL ADRLGPYITV 

        70         80         90        100        110        120 
LKTHIDILTD LSPTTLTSLK SLASKHRFLL FEDRKFVDIG STVQKQYHGG SLRISEWAHI 

       130        140        150        160        170        180 
VNCAMLAGPG IVDALAQTAS TPEFRSVYAN EVEGGRALLI LAEMTSKGSM ATGAYTQLSV 

       190        200        210        220        230        240 
EAARRHRAFV LGFVATRALN DVLPVSTVDG DEEDFVVFTT GVSLSASGDA LGQQYQTPTS 

       250        260        270        280 
AVERGADFII SGRGIYAAED PLEAVLRYRE EGWKAYLERV KGWKA 

« Hide

References

[1]"Isolation and cloning of the URA3 gene of Paracoccidioides brasiliensis."
Reinoso C., Fermignan E.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 32071 / IVIC Pb73 / C81.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ133782 Genomic DNA. Translation: CAC34740.1.

3D structure databases

ProteinModelPortalQ9C131.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA4.1.1.23. 6937.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_PARBR
AccessionPrimary (citable) accession number: Q9C131
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: October 16, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways