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Q9C124 (ACEA_PICPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate lyase

Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
Gene names
Name:ICL1
OrganismKomagataella pastoris (Yeast) (Pichia pastoris)
Taxonomic identifier4922 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKomagataella

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentPeroxisome
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Isocitrate lyase
PRO_0000068797

Sites

Active site2131 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9C124 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 4DBE4BB5543CB6BD

FASTA55061,744
        10         20         30         40         50         60 
MSGPYTKIDL DKEEQDFQNQ IKEIEEWWSQ PRWAKTKRIY NAEDIAKRRS SLSSVPASNQ 

        70         80         90        100        110        120 
QAQKLFKLLG EHAKNETASF TFGALDPIHI TQMAKYLDTI YVSGWQCSST ASTSNEPSPD 

       130        140        150        160        170        180 
LADYPMDTVP NKVERLILRR QLFHDRKQRE ERLSVSKQER AKLPYTDFLR PIIADADTGH 

       190        200        210        220        230        240 
GGITAIIKLT KMFIERGAAG IHIEDQAPGT KKCGHMAGKV LVPVQEHINR LVAIRTSADL 

       250        260        270        280        290        300 
FQSDLIAVAR TDSEAATLLT STIDKRDHYF VIGATNPDIP DLIDVLTEAE LQGKYGAELS 

       310        320        330        340        350        360 
QLEADWSKKA GLKLYHEAVF EAIDKSSSVK DKQAAKDKFS AKVGPLTGTS HKEAAKLAKE 

       370        380        390        400        410        420 
ILGEEVFFDW EAPKVREGYY RYQGGTECAI MRARAYSPYA DLVWMESKVP DYQEAVDFAK 

       430        440        450        460        470        480 
GVKTFTQTNW LAYNLSPSFN WNKAMSPDEQ ETYIKRLGKL GYNWQFITLA VLHTTALAVD 

       490        500        510        520        530        540 
NFSRDYQKIG MKAYGQQVQA KEIEDGIEIV KHQKWSGAEY IDGLLKLTTG GLSSTAAMGA 

       550 
GVTEDQFKDH 

« Hide

References

[1]"Isolation and characterization of the ICL gene from Pichia pastoris."
Menendez J.D.D.J., Valdes I., Cabrera N.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BKM 90.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ272040 Genomic DNA. Translation: CAC34630.1.

3D structure databases

ProteinModelPortalQ9C124.
SMRQ9C124. Positions 10-531.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. SSF51621. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_PICPA
AccessionPrimary (citable) accession number: Q9C124
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways