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Q9C124

- ACEA_PICPA

UniProt

Q9C124 - ACEA_PICPA

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Protein
Isocitrate lyase
Gene
ICL1
Organism
Komagataella pastoris (Yeast) (Pichia pastoris)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate = succinate + glyoxylate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei213 – 2131 By similarity

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Gene namesi
Name:ICL1
OrganismiKomagataella pastoris (Yeast) (Pichia pastoris)
Taxonomic identifieri4922 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKomagataella

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Isocitrate lyase
PRO_0000068797Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9C124.
SMRiQ9C124. Positions 10-531.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C124-1 [UniParc]FASTAAdd to Basket

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MSGPYTKIDL DKEEQDFQNQ IKEIEEWWSQ PRWAKTKRIY NAEDIAKRRS    50
SLSSVPASNQ QAQKLFKLLG EHAKNETASF TFGALDPIHI TQMAKYLDTI 100
YVSGWQCSST ASTSNEPSPD LADYPMDTVP NKVERLILRR QLFHDRKQRE 150
ERLSVSKQER AKLPYTDFLR PIIADADTGH GGITAIIKLT KMFIERGAAG 200
IHIEDQAPGT KKCGHMAGKV LVPVQEHINR LVAIRTSADL FQSDLIAVAR 250
TDSEAATLLT STIDKRDHYF VIGATNPDIP DLIDVLTEAE LQGKYGAELS 300
QLEADWSKKA GLKLYHEAVF EAIDKSSSVK DKQAAKDKFS AKVGPLTGTS 350
HKEAAKLAKE ILGEEVFFDW EAPKVREGYY RYQGGTECAI MRARAYSPYA 400
DLVWMESKVP DYQEAVDFAK GVKTFTQTNW LAYNLSPSFN WNKAMSPDEQ 450
ETYIKRLGKL GYNWQFITLA VLHTTALAVD NFSRDYQKIG MKAYGQQVQA 500
KEIEDGIEIV KHQKWSGAEY IDGLLKLTTG GLSSTAAMGA GVTEDQFKDH 550
Length:550
Mass (Da):61,744
Last modified:June 1, 2001 - v1
Checksum:i4DBE4BB5543CB6BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ272040 Genomic DNA. Translation: CAC34630.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ272040 Genomic DNA. Translation: CAC34630.1 .

3D structure databases

ProteinModelPortali Q9C124.
SMRi Q9C124. Positions 10-531.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .

Family and domain databases

Gene3Di 3.20.20.60. 2 hits.
InterProi IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfami PF00463. ICL. 1 hit.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of the ICL gene from Pichia pastoris."
    Menendez J.D.D.J., Valdes I., Cabrera N.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BKM 90.

Entry informationi

Entry nameiACEA_PICPA
AccessioniPrimary (citable) accession number: Q9C124
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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