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Q9C100

- PMT2_SCHPO

UniProt

Q9C100 - PMT2_SCHPO

Protein

Dolichyl-phosphate-mannose--protein mannosyltransferase 2

Gene

ogm2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.1 Publication

    Catalytic activityi

    Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

    Pathwayi

    GO - Molecular functioni

    1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: PomBase

    GO - Biological processi

    1. protein O-linked mannosylation Source: GOC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.109. 5615.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT39. Glycosyltransferase Family 39.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dolichyl-phosphate-mannose--protein mannosyltransferase 2 (EC:2.4.1.109)
    Gene namesi
    Name:ogm2
    Synonyms:oma2
    ORF Names:SPAPB1E7.09
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAPB1E7.09.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication. Nucleus membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. dolichyl-phosphate-mannose-protein mannosyltransferase complex Source: PomBase
    2. endomembrane system Source: PomBase
    3. endoplasmic reticulum Source: PomBase
    4. endoplasmic reticulum membrane Source: PomBase
    5. integral component of membrane Source: UniProtKB-KW
    6. nuclear membrane Source: PomBase

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 739739Dolichyl-phosphate-mannose--protein mannosyltransferase 2PRO_0000237686Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9C100.

    Interactioni

    Protein-protein interaction databases

    BioGridi280071. 2 interactions.
    MINTiMINT-4702145.
    STRINGi4896.SPAPB1E7.09-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C100.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei54 – 7421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei285 – 30521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei602 – 62221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei639 – 65921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei692 – 71221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini332 – 38655MIR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini399 – 45557MIR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini463 – 52159MIR 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyltransferase 39 family.Curated
    Contains 3 MIR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1928.
    HOGENOMiHOG000157526.
    KOiK00728.
    OMAiWLCISRF.
    OrthoDBiEOG7BP89X.
    PhylomeDBiQ9C100.

    Family and domain databases

    InterProiIPR027005. GlyclTrfase_39_like.
    IPR003342. Glyco_trans_39.
    IPR016093. MIR_motif.
    [Graphical view]
    PANTHERiPTHR10050. PTHR10050. 1 hit.
    PfamiPF02815. MIR. 1 hit.
    PF02366. PMT. 1 hit.
    [Graphical view]
    SMARTiSM00472. MIR. 3 hits.
    [Graphical view]
    SUPFAMiSSF82109. SSF82109. 1 hit.
    PROSITEiPS50919. MIR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9C100-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYEQLHAQS GQLRQRFPSK HSEIEDEVAN EKEELKDATK SALGEVKTNK    50
    KYYILGYFLV PLLLTVIAGF VRVWKIADSN VVIWDEAHFG KFASYYLKHE 100
    FYFDVHPPLG KMLNAVAGKL VGYDGSFDFS SGATYPEDLN YKFMRLWNAA 150
    FGTLCIPLVY FTALNFNYSF LAATLCTLMV ALDNHLATIS RFILLDSMLL 200
    FFIISTFFCL SRYHVYHKAP FTFYWFKWLF LTGVCIGCVC SVKLVGLFIT 250
    AVVGLYTVDE LWCLLNDKRV TWKAYAGHWI ARVCLLIFLP ILIYAFTFWI 300
    QFAVLYRSGP GDAQMPSLFQ ARLEGSPLTK NPIDLMYGSK FTLKSRNPTG 350
    ALLHSHVQTY PEGSEQQQVT GYHHKDGNNE WMFVPTHGVA YNYEENDPMN 400
    PILNGSVVRL IHPFTNRNLH THKIPAPLNK RMYEVSGYGL GDVGDEKDYW 450
    IVNILYDTAH RDAYNVRSLS TVFQLYNPVV GCYLSSSSSS LPSWGFGQIE 500
    MYCDPDPDPS NTDTQWNVEE HINPRLPEGS INDYPSSFWS DFLHLNRAML 550
    RANNGLIPDE DKLDALRSEA YQWPFLLATL RMCGWGDNQI KYLLVGNPVA 600
    YWFATSSLIV FALFVVGAVL AWRRRVLRWS QEACDTFHYA GIYPFLGWFF 650
    NYLPYYIMGR VLYVHHYEPS YALSTFTAAF VVDWFTKKMP KIVRVVVFIS 700
    LYAIIAGVFI YFKDVTFGMH GPASDFHRLR WLNSWNVHD 739
    Length:739
    Mass (Da):85,037
    Last modified:June 1, 2001 - v1
    Checksum:iF0F0BBD35D889252
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAC36926.1.
    RefSeqiNP_594135.1. NM_001019559.2.

    Genome annotation databases

    EnsemblFungiiSPAPB1E7.09.1; SPAPB1E7.09.1:pep; SPAPB1E7.09.
    GeneIDi2543657.
    KEGGispo:SPAPB1E7.09.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAC36926.1 .
    RefSeqi NP_594135.1. NM_001019559.2.

    3D structure databases

    ProteinModelPortali Q9C100.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 280071. 2 interactions.
    MINTi MINT-4702145.
    STRINGi 4896.SPAPB1E7.09-1.

    Protein family/group databases

    CAZyi GT39. Glycosyltransferase Family 39.

    Proteomic databases

    MaxQBi Q9C100.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAPB1E7.09.1 ; SPAPB1E7.09.1:pep ; SPAPB1E7.09 .
    GeneIDi 2543657.
    KEGGi spo:SPAPB1E7.09.

    Organism-specific databases

    PomBasei SPAPB1E7.09.

    Phylogenomic databases

    eggNOGi COG1928.
    HOGENOMi HOG000157526.
    KOi K00728.
    OMAi WLCISRF.
    OrthoDBi EOG7BP89X.
    PhylomeDBi Q9C100.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    BRENDAi 2.4.1.109. 5615.

    Miscellaneous databases

    NextBioi 20804663.
    PROi Q9C100.

    Family and domain databases

    InterProi IPR027005. GlyclTrfase_39_like.
    IPR003342. Glyco_trans_39.
    IPR016093. MIR_motif.
    [Graphical view ]
    PANTHERi PTHR10050. PTHR10050. 1 hit.
    Pfami PF02815. MIR. 1 hit.
    PF02366. PMT. 1 hit.
    [Graphical view ]
    SMARTi SM00472. MIR. 3 hits.
    [Graphical view ]
    SUPFAMi SSF82109. SSF82109. 1 hit.
    PROSITEi PS50919. MIR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Characterization of O-mannosyltransferase family in Schizosaccharomyces pombe."
      Tanaka N., Fujita Y., Suzuki S., Morishita M., Giga-Hama Y., Shimoda C., Takegawa K.
      Biochem. Biophys. Res. Commun. 330:813-820(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiPMT2_SCHPO
    AccessioniPrimary (citable) accession number: Q9C100
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3