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Q9C0Y9

- SPEB3_SCHPO

UniProt

Q9C0Y9 - SPEB3_SCHPO

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Protein

Putative agmatinase 3

Gene

SPAPB24D3.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Agmatine + H2O = putrescine + urea.

Cofactori

Mn2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi198 – 1981Manganese 1PROSITE-ProRule annotation
Metal bindingi222 – 2221Manganese 1PROSITE-ProRule annotation
Metal bindingi222 – 2221Manganese 2PROSITE-ProRule annotation
Metal bindingi224 – 2241Manganese 2PROSITE-ProRule annotation
Metal bindingi226 – 2261Manganese 1PROSITE-ProRule annotation
Metal bindingi319 – 3191Manganese 1PROSITE-ProRule annotation
Metal bindingi319 – 3191Manganese 2PROSITE-ProRule annotation
Metal bindingi321 – 3211Manganese 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. agmatinase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. urea metabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_241380. Agmatine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative agmatinase 3 (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase 3
Short name:
AUH 3
Gene namesi
ORF Names:SPAPB24D3.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAPB24D3.03.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 408387Putative agmatinase 3PRO_0000311760Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi279984. 6 interactions.
STRINGi4896.SPAPB24D3.03-1.

Structurei

3D structure databases

ProteinModelPortaliQ9C0Y9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000204320.
InParanoidiQ9C0Y9.
OrthoDBiEOG718KPD.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9C0Y9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSVEWFTWG VFLLLSGFGE AGRMGLGFQE KNPVFVKEKQ SPFYAVPSNY
60 70 80 90 100
EEVEFSSIVE PMYSGIATFG RLENVECLSK RSEDFDIAFI GMPFDTGTSY
110 120 130 140 150
RPGARFGPSS LREGSRRINT KYGAVNVPLE INPFKSWAKL VDCGDIPVTT
160 170 180 190 200
YDILKAMDQL ESAYFQLIAR KPSSFTDHDG FAKNDTVLPR VLSLGGDHTI
210 220 230 240 250
VLPILRALHR VYGQPISVIH FDSHLDTWAP GLIGDGDEAD GINHGSYFYF
260 270 280 290 300
ASQEGIMSKD ANIHAGIRTP ISSFSDYDDD VDCGFKIIEA REIDDLGIDG
310 320 330 340 350
IVKKIRDRVG DNLVYLSIDI DVLDPAFAPA TGTPETGGWS SREMRAILRG
360 370 380 390 400
LQGLKFVGAD LVEVAPAYDV AEITSLAGAQ LLFDIVSMMV KYPLVKEADL

SRYMPIHK
Length:408
Mass (Da):45,085
Last modified:June 13, 2012 - v2
Checksum:i3BB0F4614304C536
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAC36899.2.
RefSeqiNP_593990.2. NM_001019416.2.

Genome annotation databases

EnsemblFungiiSPAPB24D3.03.1; SPAPB24D3.03.1:pep; SPAPB24D3.03.
GeneIDi2543569.
KEGGispo:SPAPB24D3.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAC36899.2 .
RefSeqi NP_593990.2. NM_001019416.2.

3D structure databases

ProteinModelPortali Q9C0Y9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279984. 6 interactions.
STRINGi 4896.SPAPB24D3.03-1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAPB24D3.03.1 ; SPAPB24D3.03.1:pep ; SPAPB24D3.03 .
GeneIDi 2543569.
KEGGi spo:SPAPB24D3.03.

Organism-specific databases

PomBasei SPAPB24D3.03.

Phylogenomic databases

eggNOGi COG0010.
HOGENOMi HOG000204320.
InParanoidi Q9C0Y9.
OrthoDBi EOG718KPD.

Enzyme and pathway databases

Reactomei REACT_241380. Agmatine biosynthesis.

Miscellaneous databases

NextBioi 20804576.

Family and domain databases

Gene3Di 3.40.800.10. 1 hit.
InterProi IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view ]
PANTHERi PTHR11358. PTHR11358. 1 hit.
Pfami PF00491. Arginase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036979. Arginase. 1 hit.
PRINTSi PR00116. ARGINASE.
PROSITEi PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comparative functional genomics of the fission yeasts."
    Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
    , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
    Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.

Entry informationi

Entry nameiSPEB3_SCHPO
AccessioniPrimary (citable) accession number: Q9C0Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 13, 2012
Last modified: November 26, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3