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Protein

RuvB-like helicase 1

Gene

rvb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 788ATPBy similarity

GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: PomBase
  • DNA repair Source: UniProtKB-KW
  • histone exchange Source: PomBase
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RuvB-like helicase 1 (EC:3.6.4.12)
Gene namesi
Name:rvb1
ORF Names:SPAPB8E5.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAPB8E5.09.
PomBaseiSPAPB8E5.09. rvb1.

Subcellular locationi

GO - Cellular componenti

  • ASTRA complex Source: PomBase
  • cytosol Source: PomBase
  • Ino80 complex Source: PomBase
  • nucleus Source: PomBase
  • Swr1 complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456RuvB-like helicase 1PRO_0000165658Add
BLAST

Proteomic databases

MaxQBiQ9C0X6.
PRIDEiQ9C0X6.

Interactioni

Subunit structurei

May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi279655. 11 interactions.
IntActiQ9C0X6. 2 interactions.
MINTiMINT-8210858.

Structurei

3D structure databases

ProteinModelPortaliQ9C0X6.
SMRiQ9C0X6. Positions 12-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.Curated

Phylogenomic databases

HOGENOMiHOG000190885.
InParanoidiQ9C0X6.
KOiK04499.
OMAiTPVAHNA.
OrthoDBiEOG7FBRT0.
PhylomeDBiQ9C0X6.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR027238. RuvB-like.
IPR010339. TIP49_C.
[Graphical view]
PANTHERiPTHR11093. PTHR11093. 1 hit.
PfamiPF06068. TIP49. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9C0X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQISEVKGN GRDNRITTHS HIKGLGLKED GTCESVGGGF IGQEKAREAC
60 70 80 90 100
GIITDLIKSK KFGGKGVLFA GGAGTGKTAL ALAIAQELGP KVPFCPMVGS
110 120 130 140 150
EVYSSEIKKT EALMENFRRA IGLRVKETKE VYEGEVTEMV PEEAENPLGG
160 170 180 190 200
YGKTISHVLL GLKTHKGTKQ LKLDPSIYES LQREQVSTGD VIYIEANTGA
210 220 230 240 250
VKRVGRSDAY ATEFDLEAEE YVPMPKGEVH KRKEIVQDVT LHDLDIANAR
260 270 280 290 300
PQGGQDIMSM MGQLMKPKKT EITDKLRGEI NKVVNKYIEQ GIAELIPGVL
310 320 330 340 350
FIDEVHMLDI ECFTYLNQAL ESTISPIVIF ASNRGICTIR GTEDIQAPHG
360 370 380 390 400
IPTDLLDRLL IVRTLPYSES EIRSILQIRA KVENIILTDE CLDKLAQEGS
410 420 430 440 450
RTSLRYVIQL LTPVSIIASL HGNKEIGVQD IEECNDLFLD ARRSAQVVKS

SSGFLQ
Length:456
Mass (Da):50,052
Last modified:June 1, 2001 - v1
Checksum:iBE9CE98F3705536F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAC37428.1.
RefSeqiNP_594783.1. NM_001020211.2.

Genome annotation databases

EnsemblFungiiSPAPB8E5.09.1; SPAPB8E5.09.1:pep; SPAPB8E5.09.
GeneIDi2543227.
KEGGispo:SPAPB8E5.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAC37428.1.
RefSeqiNP_594783.1. NM_001020211.2.

3D structure databases

ProteinModelPortaliQ9C0X6.
SMRiQ9C0X6. Positions 12-448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279655. 11 interactions.
IntActiQ9C0X6. 2 interactions.
MINTiMINT-8210858.

Proteomic databases

MaxQBiQ9C0X6.
PRIDEiQ9C0X6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAPB8E5.09.1; SPAPB8E5.09.1:pep; SPAPB8E5.09.
GeneIDi2543227.
KEGGispo:SPAPB8E5.09.

Organism-specific databases

EuPathDBiFungiDB:SPAPB8E5.09.
PomBaseiSPAPB8E5.09. rvb1.

Phylogenomic databases

HOGENOMiHOG000190885.
InParanoidiQ9C0X6.
KOiK04499.
OMAiTPVAHNA.
OrthoDBiEOG7FBRT0.
PhylomeDBiQ9C0X6.

Miscellaneous databases

PROiQ9C0X6.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR027238. RuvB-like.
IPR010339. TIP49_C.
[Graphical view]
PANTHERiPTHR11093. PTHR11093. 1 hit.
PfamiPF06068. TIP49. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiRUVB1_SCHPO
AccessioniPrimary (citable) accession number: Q9C0X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.