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Protein

RuvB-like helicase 1

Gene

rvb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 78ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

  • ATP-dependent chromatin remodeling Source: PomBase
  • box C/D snoRNP assembly Source: GO_Central
  • chromatin remodeling Source: PomBase
  • DNA repair Source: UniProtKB-KW
  • histone acetylation Source: GO_Central
  • histone exchange Source: PomBase
  • regulation of nucleosome density Source: PomBase
  • regulation of transcription by RNA polymerase II Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Chromatin regulator, Helicase, Hydrolase
Biological processDNA damage, DNA repair, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RuvB-like helicase 1 (EC:3.6.4.12)
Gene namesi
Name:rvb1
ORF Names:SPAPB8E5.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAPB8E5.09
PomBaseiSPAPB8E5.09 rvb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001656581 – 456RuvB-like helicase 1Add BLAST456

Proteomic databases

MaxQBiQ9C0X6
PaxDbiQ9C0X6
PRIDEiQ9C0X6

PTM databases

iPTMnetiQ9C0X6

Interactioni

Subunit structurei

May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi279655, 11 interactors
IntActiQ9C0X6, 2 interactors
MINTiQ9C0X6
STRINGi4896.SPAPB8E5.09.1

Structurei

3D structure databases

ProteinModelPortaliQ9C0X6
SMRiQ9C0X6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.Curated

Phylogenomic databases

HOGENOMiHOG000190885
InParanoidiQ9C0X6
KOiK04499
OMAiDVHKRKE
OrthoDBiEOG092C2Z17
PhylomeDBiQ9C0X6

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR027238 RuvB-like
IPR037938 RUVBL1
IPR010339 TIP49_C
PANTHERiPTHR11093 PTHR11093, 1 hit
PTHR11093:SF6 PTHR11093:SF6, 1 hit
PfamiView protein in Pfam
PF06068 TIP49, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

Sequencei

Sequence statusi: Complete.

Q9C0X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQISEVKGN GRDNRITTHS HIKGLGLKED GTCESVGGGF IGQEKAREAC
60 70 80 90 100
GIITDLIKSK KFGGKGVLFA GGAGTGKTAL ALAIAQELGP KVPFCPMVGS
110 120 130 140 150
EVYSSEIKKT EALMENFRRA IGLRVKETKE VYEGEVTEMV PEEAENPLGG
160 170 180 190 200
YGKTISHVLL GLKTHKGTKQ LKLDPSIYES LQREQVSTGD VIYIEANTGA
210 220 230 240 250
VKRVGRSDAY ATEFDLEAEE YVPMPKGEVH KRKEIVQDVT LHDLDIANAR
260 270 280 290 300
PQGGQDIMSM MGQLMKPKKT EITDKLRGEI NKVVNKYIEQ GIAELIPGVL
310 320 330 340 350
FIDEVHMLDI ECFTYLNQAL ESTISPIVIF ASNRGICTIR GTEDIQAPHG
360 370 380 390 400
IPTDLLDRLL IVRTLPYSES EIRSILQIRA KVENIILTDE CLDKLAQEGS
410 420 430 440 450
RTSLRYVIQL LTPVSIIASL HGNKEIGVQD IEECNDLFLD ARRSAQVVKS

SSGFLQ
Length:456
Mass (Da):50,052
Last modified:June 1, 2001 - v1
Checksum:iBE9CE98F3705536F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAC37428.1
RefSeqiNP_594783.1, NM_001020211.2

Genome annotation databases

EnsemblFungiiSPAPB8E5.09.1; SPAPB8E5.09.1:pep; SPAPB8E5.09
GeneIDi2543227
KEGGispo:SPAPB8E5.09

Similar proteinsi

Entry informationi

Entry nameiRUVB1_SCHPO
AccessioniPrimary (citable) accession number: Q9C0X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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