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Q9C0W1 (NRK1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinamide riboside kinase
Short name=NRK
Short name=NmR-K
EC=2.7.1.22
Alternative name(s):
Nicotinic acid riboside kinase
EC=2.7.1.n4
Ribosylnicotinamide kinase
Short name=RNK
Ribosylnicotinic acid kinase
Gene names
Name:nrk1
ORF Names:SPBP22H7.06, pi025
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN) By similarity.

Catalytic activity

ATP + N-ribosylnicotinamide = ADP + nicotinamide ribonucleotide.

ATP + D-ribosylnicotinate = ADP + nicotinate D-ribonucleotide.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis.

Sequence similarities

Belongs to the uridine kinase family. NRK subfamily.

Sequence caution

The sequence BAA21404.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 230230Nicotinamide riboside kinase
PRO_0000215897

Regions

Nucleotide binding12 – 209ATP By similarity

Sites

Active site381Proton acceptor By similarity
Metal binding191Magnesium By similarity
Metal binding381Magnesium By similarity
Binding site571Substrate By similarity
Binding site1531ATP By similarity
Binding site1541Substrate By similarity
Binding site1571ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9C0W1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 4F7D6E727482D5EB

FASTA23026,264
        10         20         30         40         50         60 
MTRKTIIVGV SGASCSGKST LCQLLHAIFE GSSLVHEDDF YKTDAEIPVK NGIADWDCQE 

        70         80         90        100        110        120 
SLNLDAFLEN LHYIRDHGVL PTHLRNRENK NVAPEALIEY ADIIKEFKAP AIPTLEQHLV 

       130        140        150        160        170        180 
FVDGFMMYVN EDLINAFDIR LMLVTDFDTL KRRREARTGY ITLEGFWQDP PHYFENYVWP 

       190        200        210        220        230 
GYVHGHSHLF VNGDVTGKLL DKRIQLSPSS KMSVRDNVQW AINSILNALQ

« Hide

References

[1]"A 38 kb segment containing the cdc2 gene from the left arm of fission yeast chromosome II: sequence analysis and characterization of the genomic DNA and cDNAs encoded on the segment."
Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K., Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y., Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.
Yeast 16:71-80(2000) [PubMed: 10620777] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB004535 Genomic DNA. Translation: BAA21404.1. Sequence problems.
CU329671 Genomic DNA. Translation: CAC37374.1.
RefSeqNP_595603.1. NM_001021498.1.

3D structure databases

ProteinModelPortalQ9C0W1.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9C0W1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBP22H7.06.1; SPBP22H7.06.1:pep; SPBP22H7.06.
GeneID2541315.
GenomeReviewsGene locus nrk1 in contig CU329671_GR.
KEGGspo:SPBP22H7.06.
NMPDRfig|4896.1.peg.1469.

Organism-specific databases

GeneDB_SpombeSPBP22H7.06.

Phylogenomic databases

eggNOGfuNOG09257.
GeneTreeEFGT00050000001062.
HOGENOMHBG397986.
OMAIVYPAYL.
OrthoDBEOG4BGD5P.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-003638-MONOMER.

Gene expression databases

ArrayExpressQ9C0W1.

Family and domain databases

KOK10524.
ProtoNetSearch...

Entry information

Entry nameNRK1_SCHPO
AccessionPrimary (citable) accession number: Q9C0W1
Secondary accession number(s): O13616
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: December 14, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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