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Protein

Inner kinetochore subunit mis15

Gene

mis15

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (PubMed:16079914, PubMed:16855021). Has a role in the formation and/or maintenance of specialized chromatin at the centromere (PubMed:15369671, PubMed:15897182).4 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • CENP-A containing chromatin organization Source: PomBase
  • kinetochore assembly Source: InterPro
  • mitotic sister chromatid segregation Source: PomBase

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Inner kinetochore subunit mis15
Alternative name(s):
CENP-N homolog
Constitutive centromere-associated network protein mis15
Sim4 complex subunit mis15
Gene namesi
Name:mis15
ORF Names:pi022, SPBP22H7.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP22H7.09c
PomBaseiSPBP22H7.09c mis15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001167741 – 409Inner kinetochore subunit mis15Add BLAST409

Proteomic databases

MaxQBiQ9C0W0
PaxDbiQ9C0W0
PRIDEiQ9C0W0

Interactioni

Subunit structurei

Component of the inner kinetochore constitutive centromere-associated network (CCAN) (also known as central kinetochore Sim4 complex in fission yeast), which is composed of at least cnl2, cnp3, cnp20, fta1, fta2, fta3, fta4, fta6, fta7, mal2, mhf1, mhf2, mis6, mis15, mis17, sim4 and wip1 (PubMed:16079914, PubMed:16855021, PubMed:21445296). Interacts with mis6 and mis17 (PubMed:15369671).4 Publications

Protein-protein interaction databases

BioGridi277833, 9 interactors
IntActiQ9C0W0, 2 interactors
STRINGi4896.SPBP22H7.09c.1

Family & Domainsi

Sequence similaritiesi

Belongs to the CENP-N/CHL4 family.Curated

Phylogenomic databases

InParanoidiQ9C0W0
KOiK11551
OMAiDWRHGIT
OrthoDBiEOG092C39J1
PhylomeDBiQ9C0W0

Family and domain databases

InterProiView protein in InterPro
IPR007902 Chl4/mis15/CENP-N
PANTHERiPTHR12309:SF12 PTHR12309:SF12, 1 hit
PfamiView protein in Pfam
PF05238 CENP-N, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C0W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTELSSNIR IKHDKKIQKL LNRFPRDFLV KLCVEWIQKQ TYPPNAKDIN
60 70 80 90 100
LEDMLDDEEW NPEAFYKNVP KSMLKRSIIH RMLVYDWPNG FYLGQIAQLE
110 120 130 140 150
ILALAHGFVS MRWTASKVHH SAEKTVLPNP LVFLELLKSE LESIFVYHTY
160 170 180 190 200
ISRHETLPIT FIRLVLWDSK RPTALHTYPS SKQIFYLGLM DDSDVLLHNI
210 220 230 240 250
FLRNDVCHSL FLQCLSRLLY RLKAGSALRP IDLVSKNLTT FCTNVGVNKE
260 270 280 290 300
ANALGAWQIY AKNLVDRSPL DTRPILSDDN SSLIADSTQN CEKHREMAIQ
310 320 330 340 350
RRFGDTHSQV LDKLLITLDH DYIEKSTEKD KVLEENVESY NPTEQRPLVV
360 370 380 390 400
MQLRGQHILE GLKDICRQDA LDPFTMPSYL TGETGLSILY VRDGLVLQRQ

ESLGQQEIN
Length:409
Mass (Da):47,394
Last modified:March 23, 2010 - v3
Checksum:i60938B407FB66897
GO

Sequence cautioni

The sequence BAA21401 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA21401 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004535 Genomic DNA Translation: BAA21401.1 Sequence problems.
CU329671 Genomic DNA Translation: CAM11335.2
RefSeqiXP_001713131.2, XM_001713079.2

Genome annotation databases

EnsemblFungiiSPBP22H7.09c.1; SPBP22H7.09c.1:pep; SPBP22H7.09c
KEGGispo:SPBP22H7.09c

Entry informationi

Entry nameiCENPN_SCHPO
AccessioniPrimary (citable) accession number: Q9C0W0
Secondary accession number(s): A1IU53, O13613
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 23, 2010
Last modified: April 25, 2018
This is version 108 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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