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Protein

Vacuolar protein sorting-associated protein vps5

Gene

vps5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for efficient sporulation target of PtdIns3P in vesicle transport required for onset of the forespore membrane formation.1 Publication
Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor pep1/vps10. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The vps29-vps26-vps35 subcomplex may be involved in cargo selection.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei244 – 2441Phosphatidylinositol 3-phosphateBy similarity
Binding sitei270 – 2701Phosphatidylinositol 3-phosphateBy similarity
Binding sitei284 – 2841Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

  • ascospore-type prospore membrane assembly Source: PomBase
  • intracellular protein transport Source: PomBase
  • retrograde transport, endosome to Golgi Source: PomBase
  • vesicle-mediated transport Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Protein transport, Sporulation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein vps5
Gene namesi
Name:vps5
ORF Names:SPCPJ732.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCPJ732.01.
PomBaseiSPCPJ732.01. vps5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • endosome Source: PomBase
  • Golgi apparatus Source: UniProtKB-SubCell
  • prospore membrane Source: PomBase
  • retromer complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Vacuolar protein sorting-associated protein vps5PRO_0000213803Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551Phosphothreonine1 Publication
Modified residuei332 – 3321Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9C0U7.

PTM databases

iPTMnetiQ9C0U7.

Interactioni

Subunit structurei

Component of the retromer complex which consists of vps29, vps26, vps35, vps5 and vps17.By similarity

Protein-protein interaction databases

BioGridi276113. 143 interactions.
MINTiMINT-4701803.

Structurei

3D structure databases

ProteinModelPortaliQ9C0U7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini200 – 317118PXPROSITE-ProRule annotationAdd
BLAST

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ9C0U7.
KOiK17917.
OMAiIRYVESA.
OrthoDBiEOG73JM44.
PhylomeDBiQ9C0U7.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR015404. Vps5_C.
[Graphical view]
PfamiPF00787. PX. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C0U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGHNIYEED DAFNPFADSV SPLNPPKTDQ EPSAEGVEEE SPNVQASPPK
60 70 80 90 100
THIYTSPRKR SVNLKSLPFE TLTLDSAPLG PLQFSDAPSM APENNRLEVG
110 120 130 140 150
LNTKINPLKG SSPALNADFS ANKPWISEVN SFSPSPIGAT ENPTIPNSEQ
160 170 180 190 200
TVDTLDAASS SAPNFTHTVS SASSQKQGST SLTDTENQKA HPAAAPQSLT
210 220 230 240 250
PFYIQVHDPH TVKEITKSHT VYSVSTRLEE HNQPSVSNVT VQRRYNDFAF
260 270 280 290 300
LYQLLSNNHP GCIIPPIPEK QVVGRFDDEF IEQRRAALEV MLRKISAHPV
310 320 330 340 350
LRDDYSFKLF LEAETFDPRM THRTTLIESS SSPLRSGPST SGLLDSFTSA
360 370 380 390 400
FHTSGSSKFS EQDPILIEAK DTLDSLETQL KSVYHALLLS IDQRIQFASA
410 420 430 440 450
IHDFGEAVGN LSLVDLEPTL SSKFDGLSQL QVELRFVQER KVAQDNLTLG
460 470 480 490 500
TTLEEYIRYV ESAKNAFTTR QKLWQTWQSS VQAVSRAKTQ LEKCKKQAKS
510 520 530 540 550
QQKSLPYLEE QYEKYRAKAA DLEKEFSEST TLLKRDLSSL TTSRVDDLKA
560 570
SVETWLESAI ESQKEIIERW ESFLDQ
Length:576
Mass (Da):64,230
Last modified:June 1, 2001 - v1
Checksum:iD8CC2B20CA3D09AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAC34987.1.
RefSeqiNP_587929.1. NM_001022920.2.

Genome annotation databases

EnsemblFungiiSPCPJ732.01.1; SPCPJ732.01.1:pep; SPCPJ732.01.
GeneIDi2539552.
KEGGispo:SPCPJ732.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAC34987.1.
RefSeqiNP_587929.1. NM_001022920.2.

3D structure databases

ProteinModelPortaliQ9C0U7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276113. 143 interactions.
MINTiMINT-4701803.

PTM databases

iPTMnetiQ9C0U7.

Proteomic databases

MaxQBiQ9C0U7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCPJ732.01.1; SPCPJ732.01.1:pep; SPCPJ732.01.
GeneIDi2539552.
KEGGispo:SPCPJ732.01.

Organism-specific databases

EuPathDBiFungiDB:SPCPJ732.01.
PomBaseiSPCPJ732.01. vps5.

Phylogenomic databases

InParanoidiQ9C0U7.
KOiK17917.
OMAiIRYVESA.
OrthoDBiEOG73JM44.
PhylomeDBiQ9C0U7.

Miscellaneous databases

NextBioi20800712.
PROiQ9C0U7.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR015404. Vps5_C.
[Graphical view]
PfamiPF00787. PX. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Sorting nexin homologues are targets of phosphatidylinositol 3-phosphate in sporulation of Schizosaccharomyces pombe."
    Koga T., Onishi M., Nakamura Y., Hirata A., Nakamura T., Shimoda C., Iwaki T., Takegawa K., Fukui Y.
    Genes Cells 9:561-574(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  3. Cited for: FUNCTION.
  4. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-55 AND SER-332, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiVPS5_SCHPO
AccessioniPrimary (citable) accession number: Q9C0U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.