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Protein

Vacuolar protein sorting-associated protein vps5

Gene

vps5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for efficient sporulation target of PtdIns3P in vesicle transport required for onset of the forespore membrane formation.1 Publication
Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor pep1/vps10. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The vps29-vps26-vps35 subcomplex may be involved in cargo selection.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei244Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei270Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei284Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • ascospore-type prospore membrane assembly Source: PomBase
  • endocytosis Source: GO_Central
  • intracellular protein transport Source: PomBase
  • protein retention in Golgi apparatus Source: GO_Central
  • retrograde transport, endosome to Golgi Source: PomBase
  • vesicle-mediated transport Source: PomBase
  • vesicle organization Source: GO_Central

Keywordsi

Biological processProtein transport, Sporulation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein vps5
Gene namesi
Name:vps5
ORF Names:SPCPJ732.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCPJ732.01
PomBaseiSPCPJ732.01 vps5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138031 – 576Vacuolar protein sorting-associated protein vps5Add BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55Phosphothreonine1 Publication1
Modified residuei332Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9C0U7
PaxDbiQ9C0U7
PRIDEiQ9C0U7

PTM databases

iPTMnetiQ9C0U7

Interactioni

Subunit structurei

Component of the retromer complex which consists of vps29, vps26, vps35, vps5 and vps17.By similarity

Protein-protein interaction databases

BioGridi276113, 143 interactors
STRINGi4896.SPCPJ732.01.1

Structurei

3D structure databases

ProteinModelPortaliQ9C0U7
SMRiQ9C0U7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini200 – 317PXPROSITE-ProRule annotationAdd BLAST118

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

InParanoidiQ9C0U7
KOiK17917
OMAiFLMQLDA
OrthoDBiEOG092C41VU
PhylomeDBiQ9C0U7

Family and domain databases

CDDicd07627 BAR_Vps5p, 1 hit
cd06861 PX_Vps5p, 1 hit
Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR035803 BAR_Vps5
IPR001683 Phox
IPR036871 PX_dom_sf
IPR037868 PX_Vps5
IPR015404 Vps5_C
PfamiView protein in Pfam
PF00787 PX, 1 hit
PF09325 Vps5, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C0U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGHNIYEED DAFNPFADSV SPLNPPKTDQ EPSAEGVEEE SPNVQASPPK
60 70 80 90 100
THIYTSPRKR SVNLKSLPFE TLTLDSAPLG PLQFSDAPSM APENNRLEVG
110 120 130 140 150
LNTKINPLKG SSPALNADFS ANKPWISEVN SFSPSPIGAT ENPTIPNSEQ
160 170 180 190 200
TVDTLDAASS SAPNFTHTVS SASSQKQGST SLTDTENQKA HPAAAPQSLT
210 220 230 240 250
PFYIQVHDPH TVKEITKSHT VYSVSTRLEE HNQPSVSNVT VQRRYNDFAF
260 270 280 290 300
LYQLLSNNHP GCIIPPIPEK QVVGRFDDEF IEQRRAALEV MLRKISAHPV
310 320 330 340 350
LRDDYSFKLF LEAETFDPRM THRTTLIESS SSPLRSGPST SGLLDSFTSA
360 370 380 390 400
FHTSGSSKFS EQDPILIEAK DTLDSLETQL KSVYHALLLS IDQRIQFASA
410 420 430 440 450
IHDFGEAVGN LSLVDLEPTL SSKFDGLSQL QVELRFVQER KVAQDNLTLG
460 470 480 490 500
TTLEEYIRYV ESAKNAFTTR QKLWQTWQSS VQAVSRAKTQ LEKCKKQAKS
510 520 530 540 550
QQKSLPYLEE QYEKYRAKAA DLEKEFSEST TLLKRDLSSL TTSRVDDLKA
560 570
SVETWLESAI ESQKEIIERW ESFLDQ
Length:576
Mass (Da):64,230
Last modified:June 1, 2001 - v1
Checksum:iD8CC2B20CA3D09AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAC34987.1
RefSeqiNP_587929.1, NM_001022920.2

Genome annotation databases

EnsemblFungiiSPCPJ732.01.1; SPCPJ732.01.1:pep; SPCPJ732.01
GeneIDi2539552
KEGGispo:SPCPJ732.01

Similar proteinsi

Entry informationi

Entry nameiVPS5_SCHPO
AccessioniPrimary (citable) accession number: Q9C0U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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