Q9C0N4 (SODC_CRYGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Cu-Zn]
EC=1.15.1.1

Gene names

Name:

SOD1

Organism

Cryptococcus gattii (Filobasidiella gattii) (Cryptococcus bacillisporus)

Taxonomic identifier

552467 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Tremellaceae › Filobasidiella › Filobasidiella/Cryptococcus neoformans species complex

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 154	153	Superoxide dismutase [Cu-Zn]		PRO_0000164117
Sites
	Metal binding	47	1	Copper By similarity
	Metal binding	49	1	Copper By similarity
	Metal binding	64	1	Copper By similarity
	Metal binding	64	1	Zinc By similarity
	Metal binding	72	1	Zinc By similarity
	Metal binding	81	1	Zinc By similarity
	Metal binding	84	1	Zinc By similarity
	Metal binding	121	1	Copper By similarity
Amino acid modifications
	Disulfide bond	58 ↔ 147		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9C0N4 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: CA4C2B4BA8F43FE4	FASTA	154	15,637
	10 20 30 40 50 60 MVKAVAVLKG DSPVTGVITF TQEKEGAPVT VSGDIKNLDA NAERGFHVHE FGDNTNGCTS 70 80 90 100 110 120 AGPHFNPHGK NHGAPSDSER HVGDLGNVKT DGNGVASVNI SDKSLSLFGP YSIIGRTIVV 130 140 150 HAGTDDFGKG GNAESLKTGN AGARAACGVI GISN

References

[1]

"Molecular cloning, phylogenetic analysis and three-dimensional modeling of Cu,Zn superoxide dismutase (CnSOD1) from three varieties of Cryptococcus neoformans." Chaturvedi S., Hamilton A.J., Hobby P., Zhu G., Lowry C.V., Chaturvedi V. Gene 268:41-51(2001) [PubMed: 11368899] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: NYS 155B and wm 780-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF248049 mRNA. Translation: AAK31918.1. AF248050 Genomic DNA. Translation: AAK31919.1. AF248051 Genomic DNA. Translation: AAK31920.1.
3D structure databases
ProteinModelPortal	Q9C0N4.
SMR	Q9C0N4. Positions 2-154.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR024134. SOD_Cu/Zn_/chaperones. IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn_dom. [Graphical view]
Gene3D	G3DSA:2.60.40.200. SOD_Cu_Zn. 1 hit.
PANTHER	PTHR10003. SOD_Cu_Zn. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
PRINTS	PR00068. CUZNDISMTASE.
SUPFAM	SSF49329. SOD_Cu_Zn. 1 hit.
PROSITE	PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODC_CRYGA

Accession

Primary (citable) accession number: Q9C0N4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	January 23, 2007
Last modified:	July 27, 2011
This is version 53 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program