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Q9C0K7

- STRAB_HUMAN

UniProt

Q9C0K7 - STRAB_HUMAN

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Protein

STE20-related kinase adapter protein beta

Gene
STRADB, ALS2CR2, ILPIP, PRO1038
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation By similarity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 729ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. transferase activity, transferring phosphorus-containing groups Source: InterPro

GO - Biological processi

  1. activation of protein kinase activity Source: UniProtKB
  2. cell cycle arrest Source: Reactome
  3. cell morphogenesis Source: Ensembl
  4. insulin receptor signaling pathway Source: Reactome
  5. JNK cascade Source: Ensembl
  6. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  7. protein export from nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_21285. Regulation of AMPK activity via LKB1.
SignaLinkiQ9C0K7.

Names & Taxonomyi

Protein namesi
Recommended name:
STE20-related kinase adapter protein beta
Short name:
STRAD beta
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein
CALS-21
ILP-interacting protein
Pseudokinase ALS2CR2
Gene namesi
Name:STRADB
Synonyms:ALS2CR2, ILPIP
ORF Names:PRO1038
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:13205. STRADB.

Subcellular locationi

Nucleus. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: Reactome
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24743.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418STE20-related kinase adapter protein betaPRO_0000085617Add
BLAST

Proteomic databases

PaxDbiQ9C0K7.
PRIDEiQ9C0K7.

PTM databases

PhosphoSiteiQ9C0K7.

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle, testis, liver and colon.2 Publications

Gene expression databases

BgeeiQ9C0K7.
CleanExiHS_STRADB.
GenevestigatoriQ9C0K7.

Organism-specific databases

HPAiHPA026549.
HPA028520.

Interactioni

Subunit structurei

Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a complex with TAK1, TRAF6, TAB1 and TAB2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CAB39Q9Y3765EBI-306893,EBI-306905
STK11Q158316EBI-306893,EBI-306838

Protein-protein interaction databases

BioGridi120668. 7 interactions.
IntActiQ9C0K7. 5 interactions.
MINTiMINT-7969373.
STRINGi9606.ENSP00000194530.

Structurei

3D structure databases

ProteinModelPortaliQ9C0K7.
SMRiQ9C0K7. Positions 3-386.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 369312Protein kinaseAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000005157.
HOVERGENiHBG055069.
InParanoidiQ9C0K7.
KOiK17532.
OMAiCSTNVSH.
PhylomeDBiQ9C0K7.
TreeFamiTF319817.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9C0K7-1) [UniParc]FASTAAdd to Basket

Also known as: ILPIP-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLLDCFCTS RTQVESLRPE KQSETSIHQY LVDEPTLSWS RPSTRASEVL    50
CSTNVSHYEL QVEIGRGFDN LTSVHLARHT PTGTLVTIKI TNLENCNEER 100
LKALQKAVIL SHFFRHPNIT TYWTVFTVGS WLWVISPFMA YGSASQLLRT 150
YFPEGMSETL IRNILFGAVR GLNYLHQNGC IHRSIKASHI LISGDGLVTL 200
SGLSHLHSLV KHGQRHRAVY DFPQFSTSVQ PWLSPELLRQ DLHGYNVKSD 250
IYSVGITACE LASGQVPFQD MHRTQMLLQK LKGPPYSPLD ISIFPQSESR 300
MKNSQSGVDS GIGESVLVSS GTHTVNSDRL HTPSSKTFSP AFFSLVQLCL 350
QQDPEKRPSA SSLLSHVFFK QMKEESQDSI LSLLPPAYNK PSISLPPVLP 400
WTEPECDFPD EKDSYWEF 418
Length:418
Mass (Da):47,026
Last modified:June 1, 2001 - v1
Checksum:iA63ED6CCE1E18C96
GO
Isoform 2 (identifier: Q9C0K7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     372-377: MKEESQ → PYFEFL
     378-418: Missing.

Note: No experimental confirmation available.

Show »
Length:377
Mass (Da):42,371
Checksum:iC869F81FDED0839A
GO
Isoform 3 (identifier: Q9C0K7-3) [UniParc]FASTAAdd to Basket

Also known as: ILPIP-beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Show »
Length:280
Mass (Da):31,219
Checksum:i9D433EAA77D5CF08
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti155 – 1551G → E in a metastatic melanoma sample; somatic mutation. 1 Publication
VAR_041335
Natural varianti386 – 3861P → L.1 Publication
Corresponds to variant rs35636836 [ dbSNP | Ensembl ].
VAR_041336

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 138138Missing in isoform 3. VSP_016625Add
BLAST
Alternative sequencei372 – 3776MKEESQ → PYFEFL in isoform 2. VSP_016623
Alternative sequencei378 – 41841Missing in isoform 2. VSP_016624Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB038950 mRNA. Translation: BAB32500.1.
AY093697 mRNA. Translation: AAM19143.1.
AF116618 mRNA. Translation: AAF71042.1.
AK027637 mRNA. Translation: BAB55254.1.
AC007282 Genomic DNA. Translation: AAY14692.1.
BC008302 mRNA. Translation: AAH08302.1.
BC090871 mRNA. Translation: AAH90871.1.
CCDSiCCDS2348.1. [Q9C0K7-1]
CCDS56161.1. [Q9C0K7-2]
RefSeqiNP_001193793.1. NM_001206864.1. [Q9C0K7-2]
NP_061041.2. NM_018571.5. [Q9C0K7-1]
XP_005246727.1. XM_005246670.1. [Q9C0K7-3]
UniGeneiHs.652338.

Genome annotation databases

EnsembliENST00000194530; ENSP00000194530; ENSG00000082146. [Q9C0K7-1]
ENST00000392249; ENSP00000376080; ENSG00000082146. [Q9C0K7-2]
GeneIDi55437.
KEGGihsa:55437.
UCSCiuc002uyd.4. human. [Q9C0K7-1]
uc021vvb.1. human. [Q9C0K7-2]

Polymorphism databases

DMDMi74762722.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB038950 mRNA. Translation: BAB32500.1 .
AY093697 mRNA. Translation: AAM19143.1 .
AF116618 mRNA. Translation: AAF71042.1 .
AK027637 mRNA. Translation: BAB55254.1 .
AC007282 Genomic DNA. Translation: AAY14692.1 .
BC008302 mRNA. Translation: AAH08302.1 .
BC090871 mRNA. Translation: AAH90871.1 .
CCDSi CCDS2348.1. [Q9C0K7-1 ]
CCDS56161.1. [Q9C0K7-2 ]
RefSeqi NP_001193793.1. NM_001206864.1. [Q9C0K7-2 ]
NP_061041.2. NM_018571.5. [Q9C0K7-1 ]
XP_005246727.1. XM_005246670.1. [Q9C0K7-3 ]
UniGenei Hs.652338.

3D structure databases

ProteinModelPortali Q9C0K7.
SMRi Q9C0K7. Positions 3-386.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120668. 7 interactions.
IntActi Q9C0K7. 5 interactions.
MINTi MINT-7969373.
STRINGi 9606.ENSP00000194530.

PTM databases

PhosphoSitei Q9C0K7.

Polymorphism databases

DMDMi 74762722.

Proteomic databases

PaxDbi Q9C0K7.
PRIDEi Q9C0K7.

Protocols and materials databases

DNASUi 55437.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000194530 ; ENSP00000194530 ; ENSG00000082146 . [Q9C0K7-1 ]
ENST00000392249 ; ENSP00000376080 ; ENSG00000082146 . [Q9C0K7-2 ]
GeneIDi 55437.
KEGGi hsa:55437.
UCSCi uc002uyd.4. human. [Q9C0K7-1 ]
uc021vvb.1. human. [Q9C0K7-2 ]

Organism-specific databases

CTDi 55437.
GeneCardsi GC02P202252.
HGNCi HGNC:13205. STRADB.
HPAi HPA026549.
HPA028520.
MIMi 607333. gene.
neXtProti NX_Q9C0K7.
PharmGKBi PA24743.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000005157.
HOVERGENi HBG055069.
InParanoidi Q9C0K7.
KOi K17532.
OMAi CSTNVSH.
PhylomeDBi Q9C0K7.
TreeFami TF319817.

Enzyme and pathway databases

Reactomei REACT_21285. Regulation of AMPK activity via LKB1.
SignaLinki Q9C0K7.

Miscellaneous databases

GeneWikii ALS2CR2.
GenomeRNAii 55437.
NextBioi 59838.
PROi Q9C0K7.
SOURCEi Search...

Gene expression databases

Bgeei Q9C0K7.
CleanExi HS_STRADB.
Genevestigatori Q9C0K7.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2."
    Hadano S., Yanagisawa Y., Skaug J., Fichter K., Nasir J., Martindale D., Koop B.F., Scherer S.W., Nicholson D.W., Rouleau G.A., Ikeda J.-E., Hayden M.R.
    Genomics 71:200-213(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis."
    Sanna M.G., Da Silva Correia J., Luo Y., Chuang B., Paulson L.M., Nguyen B., Deveraux Q.L., Ulevitch R.J.
    J. Biol. Chem. 277:30454-30462(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), TISSUE SPECIFICITY, INTERACTION WITH BIRC4.
  3. "Functional prediction of the coding sequences of 121 new genes deduced by analysis of cDNA clones from human fetal liver."
    Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J., Liu M., He F.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Fetal liver.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  7. "MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm."
    Boudeau J., Baas A.F., Deak M., Morrice N.A., Kieloch A., Schutkowski M., Prescott A.R., Clevers H.C., Alessi D.R.
    EMBO J. 22:5102-5114(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH STK11/LKB1 AND CAB39.
  8. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-155 AND LEU-386.

Entry informationi

Entry nameiSTRAB_HUMAN
AccessioniPrimary (citable) accession number: Q9C0K7
Secondary accession number(s): Q5BKY7, Q9P1L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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