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Q9C0K7

- STRAB_HUMAN

UniProt

Q9C0K7 - STRAB_HUMAN

Protein

STE20-related kinase adapter protein beta

Gene

STRADB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei89 – 891ATPPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 729ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. transferase activity, transferring phosphorus-containing groups Source: InterPro

    GO - Biological processi

    1. activation of protein kinase activity Source: UniProtKB
    2. cell cycle arrest Source: Reactome
    3. cell morphogenesis Source: Ensembl
    4. insulin receptor signaling pathway Source: Reactome
    5. JNK cascade Source: Ensembl
    6. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    7. protein export from nucleus Source: UniProtKB

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_21285. Regulation of AMPK activity via LKB1.
    SignaLinkiQ9C0K7.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    STE20-related kinase adapter protein beta
    Short name:
    STRAD beta
    Alternative name(s):
    Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein
    CALS-21
    ILP-interacting protein
    Pseudokinase ALS2CR2
    Gene namesi
    Name:STRADB
    Synonyms:ALS2CR2, ILPIP
    ORF Names:PRO1038
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:13205. STRADB.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24743.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 418418STE20-related kinase adapter protein betaPRO_0000085617Add
    BLAST

    Proteomic databases

    PaxDbiQ9C0K7.
    PRIDEiQ9C0K7.

    PTM databases

    PhosphoSiteiQ9C0K7.

    Expressioni

    Tissue specificityi

    Highly expressed in heart, skeletal muscle, testis, liver and colon.2 Publications

    Gene expression databases

    BgeeiQ9C0K7.
    CleanExiHS_STRADB.
    GenevestigatoriQ9C0K7.

    Organism-specific databases

    HPAiHPA026549.
    HPA028520.

    Interactioni

    Subunit structurei

    Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a complex with TAK1, TRAF6, TAB1 and TAB2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CAB39Q9Y3765EBI-306893,EBI-306905
    STK11Q158316EBI-306893,EBI-306838

    Protein-protein interaction databases

    BioGridi120668. 7 interactions.
    IntActiQ9C0K7. 5 interactions.
    MINTiMINT-7969373.
    STRINGi9606.ENSP00000194530.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C0K7.
    SMRiQ9C0K7. Positions 3-386.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini58 – 369312Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The protein kinase domain is predicted to be catalytically inactive.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000005157.
    HOVERGENiHBG055069.
    InParanoidiQ9C0K7.
    KOiK17532.
    OMAiCSTNVSH.
    PhylomeDBiQ9C0K7.
    TreeFamiTF319817.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9C0K7-1) [UniParc]FASTAAdd to Basket

    Also known as: ILPIP-alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLLDCFCTS RTQVESLRPE KQSETSIHQY LVDEPTLSWS RPSTRASEVL    50
    CSTNVSHYEL QVEIGRGFDN LTSVHLARHT PTGTLVTIKI TNLENCNEER 100
    LKALQKAVIL SHFFRHPNIT TYWTVFTVGS WLWVISPFMA YGSASQLLRT 150
    YFPEGMSETL IRNILFGAVR GLNYLHQNGC IHRSIKASHI LISGDGLVTL 200
    SGLSHLHSLV KHGQRHRAVY DFPQFSTSVQ PWLSPELLRQ DLHGYNVKSD 250
    IYSVGITACE LASGQVPFQD MHRTQMLLQK LKGPPYSPLD ISIFPQSESR 300
    MKNSQSGVDS GIGESVLVSS GTHTVNSDRL HTPSSKTFSP AFFSLVQLCL 350
    QQDPEKRPSA SSLLSHVFFK QMKEESQDSI LSLLPPAYNK PSISLPPVLP 400
    WTEPECDFPD EKDSYWEF 418
    Length:418
    Mass (Da):47,026
    Last modified:June 1, 2001 - v1
    Checksum:iA63ED6CCE1E18C96
    GO
    Isoform 2 (identifier: Q9C0K7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         372-377: MKEESQ → PYFEFL
         378-418: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:377
    Mass (Da):42,371
    Checksum:iC869F81FDED0839A
    GO
    Isoform 3 (identifier: Q9C0K7-3) [UniParc]FASTAAdd to Basket

    Also known as: ILPIP-beta

    The sequence of this isoform differs from the canonical sequence as follows:
         1-138: Missing.

    Show »
    Length:280
    Mass (Da):31,219
    Checksum:i9D433EAA77D5CF08
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti155 – 1551G → E in a metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_041335
    Natural varianti386 – 3861P → L.1 Publication
    Corresponds to variant rs35636836 [ dbSNP | Ensembl ].
    VAR_041336

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 138138Missing in isoform 3. 2 PublicationsVSP_016625Add
    BLAST
    Alternative sequencei372 – 3776MKEESQ → PYFEFL in isoform 2. 1 PublicationVSP_016623
    Alternative sequencei378 – 41841Missing in isoform 2. 1 PublicationVSP_016624Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB038950 mRNA. Translation: BAB32500.1.
    AY093697 mRNA. Translation: AAM19143.1.
    AF116618 mRNA. Translation: AAF71042.1.
    AK027637 mRNA. Translation: BAB55254.1.
    AC007282 Genomic DNA. Translation: AAY14692.1.
    BC008302 mRNA. Translation: AAH08302.1.
    BC090871 mRNA. Translation: AAH90871.1.
    CCDSiCCDS2348.1. [Q9C0K7-1]
    CCDS56161.1. [Q9C0K7-2]
    RefSeqiNP_001193793.1. NM_001206864.1. [Q9C0K7-2]
    NP_061041.2. NM_018571.5. [Q9C0K7-1]
    XP_005246727.1. XM_005246670.1. [Q9C0K7-3]
    UniGeneiHs.652338.

    Genome annotation databases

    EnsembliENST00000194530; ENSP00000194530; ENSG00000082146. [Q9C0K7-1]
    ENST00000392249; ENSP00000376080; ENSG00000082146. [Q9C0K7-2]
    GeneIDi55437.
    KEGGihsa:55437.
    UCSCiuc002uyd.4. human. [Q9C0K7-1]
    uc021vvb.1. human. [Q9C0K7-2]

    Polymorphism databases

    DMDMi74762722.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB038950 mRNA. Translation: BAB32500.1 .
    AY093697 mRNA. Translation: AAM19143.1 .
    AF116618 mRNA. Translation: AAF71042.1 .
    AK027637 mRNA. Translation: BAB55254.1 .
    AC007282 Genomic DNA. Translation: AAY14692.1 .
    BC008302 mRNA. Translation: AAH08302.1 .
    BC090871 mRNA. Translation: AAH90871.1 .
    CCDSi CCDS2348.1. [Q9C0K7-1 ]
    CCDS56161.1. [Q9C0K7-2 ]
    RefSeqi NP_001193793.1. NM_001206864.1. [Q9C0K7-2 ]
    NP_061041.2. NM_018571.5. [Q9C0K7-1 ]
    XP_005246727.1. XM_005246670.1. [Q9C0K7-3 ]
    UniGenei Hs.652338.

    3D structure databases

    ProteinModelPortali Q9C0K7.
    SMRi Q9C0K7. Positions 3-386.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120668. 7 interactions.
    IntActi Q9C0K7. 5 interactions.
    MINTi MINT-7969373.
    STRINGi 9606.ENSP00000194530.

    PTM databases

    PhosphoSitei Q9C0K7.

    Polymorphism databases

    DMDMi 74762722.

    Proteomic databases

    PaxDbi Q9C0K7.
    PRIDEi Q9C0K7.

    Protocols and materials databases

    DNASUi 55437.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000194530 ; ENSP00000194530 ; ENSG00000082146 . [Q9C0K7-1 ]
    ENST00000392249 ; ENSP00000376080 ; ENSG00000082146 . [Q9C0K7-2 ]
    GeneIDi 55437.
    KEGGi hsa:55437.
    UCSCi uc002uyd.4. human. [Q9C0K7-1 ]
    uc021vvb.1. human. [Q9C0K7-2 ]

    Organism-specific databases

    CTDi 55437.
    GeneCardsi GC02P202252.
    HGNCi HGNC:13205. STRADB.
    HPAi HPA026549.
    HPA028520.
    MIMi 607333. gene.
    neXtProti NX_Q9C0K7.
    PharmGKBi PA24743.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000005157.
    HOVERGENi HBG055069.
    InParanoidi Q9C0K7.
    KOi K17532.
    OMAi CSTNVSH.
    PhylomeDBi Q9C0K7.
    TreeFami TF319817.

    Enzyme and pathway databases

    Reactomei REACT_21285. Regulation of AMPK activity via LKB1.
    SignaLinki Q9C0K7.

    Miscellaneous databases

    GeneWikii ALS2CR2.
    GenomeRNAii 55437.
    NextBioi 59838.
    PROi Q9C0K7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9C0K7.
    CleanExi HS_STRADB.
    Genevestigatori Q9C0K7.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2."
      Hadano S., Yanagisawa Y., Skaug J., Fichter K., Nasir J., Martindale D., Koop B.F., Scherer S.W., Nicholson D.W., Rouleau G.A., Ikeda J.-E., Hayden M.R.
      Genomics 71:200-213(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis."
      Sanna M.G., Da Silva Correia J., Luo Y., Chuang B., Paulson L.M., Nguyen B., Deveraux Q.L., Ulevitch R.J.
      J. Biol. Chem. 277:30454-30462(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), TISSUE SPECIFICITY, INTERACTION WITH BIRC4.
    3. "Functional prediction of the coding sequences of 121 new genes deduced by analysis of cDNA clones from human fetal liver."
      Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J., Liu M., He F.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Fetal liver.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta.
    7. "MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm."
      Boudeau J., Baas A.F., Deak M., Morrice N.A., Kieloch A., Schutkowski M., Prescott A.R., Clevers H.C., Alessi D.R.
      EMBO J. 22:5102-5114(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH STK11/LKB1 AND CAB39.
    8. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-155 AND LEU-386.

    Entry informationi

    Entry nameiSTRAB_HUMAN
    AccessioniPrimary (citable) accession number: Q9C0K7
    Secondary accession number(s): Q5BKY7, Q9P1L0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3