ID ARP3C_HUMAN Reviewed; 210 AA. AC Q9C0K3; Q5CZI4; DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 27-MAR-2024, entry version 143. DE RecName: Full=Actin-related protein 3C; DE AltName: Full=Actin-related protein 11; DE Flags: Precursor; GN Name=ACTR3C; Synonyms=ARP11; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE SPECIFICITY. RC TISSUE=Lung; RX PubMed=11162478; DOI=10.1006/bbrc.2000.4059; RA Shindo-Okada N., Shimizu K.; RT "Isolation of a novel actin-related gene expressed in low-metastatic PC-14 RT human lung adenocarcinoma."; RL Biochem. Biophys. Res. Commun. 280:61-67(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Fetal kidney; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). CC -!- FUNCTION: May play a role in the suppression of metastatic potential in CC lung adenoma carcinoma cells. {ECO:0000269|PubMed:11162478}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9C0K3-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9C0K3-2; Sequence=VSP_032218; CC -!- TISSUE SPECIFICITY: Expressed in kidney, stomach, spleen, bone marrow, CC uterus, testis, placenta, skeletal muscle, mammary gland, lung, fetal CC liver, and fetal kidney, but not detected in small intestine, brain, CC and thymus. Expressed in low-metastatic lung adenocarcinoma cells but CC not in high-metastatic ones. {ECO:0000269|PubMed:11162478}. CC -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB039791; BAB21501.1; -; mRNA. DR EMBL; BX640643; CAI56711.1; -; mRNA. DR CCDS; CCDS47744.1; -. [Q9C0K3-1] DR PIR; JC7580; JC7580. DR RefSeq; NP_001157930.1; NM_001164458.1. [Q9C0K3-1] DR RefSeq; NP_001157931.1; NM_001164459.1. [Q9C0K3-1] DR RefSeq; XP_011514808.1; XM_011516506.2. [Q9C0K3-1] DR RefSeq; XP_011514809.1; XM_011516507.2. [Q9C0K3-1] DR RefSeq; XP_011514810.1; XM_011516508.2. [Q9C0K3-1] DR RefSeq; XP_016868038.1; XM_017012549.1. DR AlphaFoldDB; Q9C0K3; -. DR SMR; Q9C0K3; -. DR BioGRID; 576126; 9. DR IntAct; Q9C0K3; 4. DR STRING; 9606.ENSP00000252071; -. DR GlyGen; Q9C0K3; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q9C0K3; -. DR PhosphoSitePlus; Q9C0K3; -. DR BioMuta; ACTR3C; -. DR DMDM; 74739414; -. DR jPOST; Q9C0K3; -. DR MassIVE; Q9C0K3; -. DR MaxQB; Q9C0K3; -. DR PaxDb; 9606-ENSP00000252071; -. DR PeptideAtlas; Q9C0K3; -. DR ProteomicsDB; 80071; -. [Q9C0K3-1] DR Pumba; Q9C0K3; -. DR Antibodypedia; 66353; 6 antibodies from 6 providers. DR DNASU; 653857; -. DR Ensembl; ENST00000252071.8; ENSP00000252071.4; ENSG00000106526.12. [Q9C0K3-1] DR Ensembl; ENST00000683684.1; ENSP00000507618.1; ENSG00000106526.12. [Q9C0K3-1] DR GeneID; 653857; -. DR KEGG; hsa:653857; -. DR MANE-Select; ENST00000683684.1; ENSP00000507618.1; NM_001164458.2; NP_001157930.1. DR UCSC; uc003wgu.3; human. [Q9C0K3-1] DR AGR; HGNC:37282; -. DR CTD; 653857; -. DR DisGeNET; 653857; -. DR GeneCards; ACTR3C; -. DR HGNC; HGNC:37282; ACTR3C. DR HPA; ENSG00000106526; Tissue enhanced (parathyroid). DR neXtProt; NX_Q9C0K3; -. DR OpenTargets; ENSG00000106526; -. DR PharmGKB; PA165617588; -. DR VEuPathDB; HostDB:ENSG00000106526; -. DR eggNOG; KOG0678; Eukaryota. DR GeneTree; ENSGT00940000158304; -. DR InParanoid; Q9C0K3; -. DR OMA; PRILECW; -. DR OrthoDB; 4014719at2759; -. DR PhylomeDB; Q9C0K3; -. DR TreeFam; TF300644; -. DR PathwayCommons; Q9C0K3; -. DR SignaLink; Q9C0K3; -. DR BioGRID-ORCS; 653857; 55 hits in 1078 CRISPR screens. DR ChiTaRS; ACTR3C; human. DR GenomeRNAi; 653857; -. DR Pharos; Q9C0K3; Tdark. DR PRO; PR:Q9C0K3; -. DR Proteomes; UP000005640; Chromosome 7. DR RNAct; Q9C0K3; Protein. DR Bgee; ENSG00000106526; Expressed in right lobe of liver and 108 other cell types or tissues. DR ExpressionAtlas; Q9C0K3; baseline and differential. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1. DR Gene3D; 3.30.420.40; -; 2. DR InterPro; IPR004000; Actin. DR InterPro; IPR043129; ATPase_NBD. DR PANTHER; PTHR11937; ACTIN; 1. DR PANTHER; PTHR11937:SF514; ACTIN-RELATED PROTEIN 3B-RELATED; 1. DR Pfam; PF00022; Actin; 1. DR SMART; SM00268; ACTIN; 1. DR SUPFAM; SSF53067; Actin-like ATPase domain; 1. DR Genevisible; Q9C0K3; HS. PE 2: Evidence at transcript level; KW Actin-binding; Alternative splicing; ATP-binding; Nucleotide-binding; KW Reference proteome; Signal. FT SIGNAL 1..21 FT /evidence="ECO:0000255" FT CHAIN 22..210 FT /note="Actin-related protein 3C" FT /id="PRO_0000324333" FT VAR_SEQ 1..163 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:17974005" FT /id="VSP_032218" FT CONFLICT 189 FT /note="M -> V (in Ref. 2; CAI56711)" FT /evidence="ECO:0000305" SQ SEQUENCE 210 AA; 23712 MW; AB94A33B440CD35B CRC64; MFESFNVPGL YIAVQAVLAL AASWTSRQVG ERTLTGIVID SGDGVTHVIP VAEGYVIGSC IKHIPIAGRD ITYFIQQLLR EREVGIPPEQ SLETAKAIKE KYCYICPDIV KEFAKYDVDP QKWIKQYTGI NAINQKKFVI DVGYERFLGP EIFFHPEFAN PDSMESISDV VDEVIQNCPI DVRRPLYKME QIPLSYPQGH GFHPLSPPFH //