Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Actin-related protein 3C

Gene

ACTR3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9C0K3.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 3C
Alternative name(s):
Actin-related protein 11
Gene namesi
Name:ACTR3C
Synonyms:ARP11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:37282. ACTR3C.

Subcellular locationi

GO - Cellular componenti

  • Arp2/3 protein complex Source: InterPro
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165617588.

Polymorphism and mutation databases

BioMutaiACTR3C.
DMDMi74739414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 210189Actin-related protein 3CPRO_0000324333Add
BLAST

Proteomic databases

MaxQBiQ9C0K3.
PaxDbiQ9C0K3.
PRIDEiQ9C0K3.

PTM databases

PhosphoSiteiQ9C0K3.

Expressioni

Tissue specificityi

Expressed in kidney, stomach, spleen, bone marrow, uterus, testis, placenta, skeletal muscle, mammary gland, lung, fetal liver, and fetal kidney, but not detected in small intestine, brain, and thymus. Expressed in low-metastatic lung adenocarcinoma cells but not in high-metastatic ones.1 Publication

Gene expression databases

BgeeiQ9C0K3.
ExpressionAtlasiQ9C0K3. baseline and differential.
GenevisibleiQ9C0K3. HS.

Organism-specific databases

HPAiHPA055957.

Interactioni

Protein-protein interaction databases

BioGridi576126. 1 interaction.
STRINGi9606.ENSP00000252071.

Structurei

3D structure databases

ProteinModelPortaliQ9C0K3.
SMRiQ9C0K3. Positions 1-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5277.
GeneTreeiENSGT00550000074695.
HOGENOMiHOG000034070.
HOVERGENiHBG075770.
InParanoidiQ9C0K3.
KOiK18584.
OMAiHIFPNIV.
PhylomeDBiQ9C0K3.
TreeFamiTF300644.

Family and domain databases

InterProiIPR004000. Actin.
IPR015623. Arp3.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF170. PTHR11937:SF170. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0K3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFESFNVPGL YIAVQAVLAL AASWTSRQVG ERTLTGIVID SGDGVTHVIP
60 70 80 90 100
VAEGYVIGSC IKHIPIAGRD ITYFIQQLLR EREVGIPPEQ SLETAKAIKE
110 120 130 140 150
KYCYICPDIV KEFAKYDVDP QKWIKQYTGI NAINQKKFVI DVGYERFLGP
160 170 180 190 200
EIFFHPEFAN PDSMESISDV VDEVIQNCPI DVRRPLYKME QIPLSYPQGH
210
GFHPLSPPFH
Length:210
Mass (Da):23,712
Last modified:June 1, 2001 - v1
Checksum:iAB94A33B440CD35B
GO
Isoform 2 (identifier: Q9C0K3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: Missing.

Note: No experimental confirmation available.
Show »
Length:47
Mass (Da):5,418
Checksum:iBFB88F46E446D136
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti189 – 1891M → V in CAI56711 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 163163Missing in isoform 2. 1 PublicationVSP_032218Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039791 mRNA. Translation: BAB21501.1.
BX640643 mRNA. Translation: CAI56711.1.
CCDSiCCDS47744.1. [Q9C0K3-1]
PIRiJC7580.
RefSeqiNP_001157930.1. NM_001164458.1. [Q9C0K3-1]
NP_001157931.1. NM_001164459.1. [Q9C0K3-1]
XP_011514808.1. XM_011516506.1. [Q9C0K3-1]
XP_011514809.1. XM_011516507.1. [Q9C0K3-1]
XP_011514810.1. XM_011516508.1. [Q9C0K3-1]
UniGeneiHs.664579.

Genome annotation databases

EnsembliENST00000252071; ENSP00000252071; ENSG00000106526.
GeneIDi653857.
KEGGihsa:653857.
UCSCiuc003wgu.2. human. [Q9C0K3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039791 mRNA. Translation: BAB21501.1.
BX640643 mRNA. Translation: CAI56711.1.
CCDSiCCDS47744.1. [Q9C0K3-1]
PIRiJC7580.
RefSeqiNP_001157930.1. NM_001164458.1. [Q9C0K3-1]
NP_001157931.1. NM_001164459.1. [Q9C0K3-1]
XP_011514808.1. XM_011516506.1. [Q9C0K3-1]
XP_011514809.1. XM_011516507.1. [Q9C0K3-1]
XP_011514810.1. XM_011516508.1. [Q9C0K3-1]
UniGeneiHs.664579.

3D structure databases

ProteinModelPortaliQ9C0K3.
SMRiQ9C0K3. Positions 1-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi576126. 1 interaction.
STRINGi9606.ENSP00000252071.

PTM databases

PhosphoSiteiQ9C0K3.

Polymorphism and mutation databases

BioMutaiACTR3C.
DMDMi74739414.

Proteomic databases

MaxQBiQ9C0K3.
PaxDbiQ9C0K3.
PRIDEiQ9C0K3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252071; ENSP00000252071; ENSG00000106526.
GeneIDi653857.
KEGGihsa:653857.
UCSCiuc003wgu.2. human. [Q9C0K3-1]

Organism-specific databases

CTDi653857.
GeneCardsiGC07M149942.
H-InvDBHIX0041149.
HIX0201521.
HGNCiHGNC:37282. ACTR3C.
HPAiHPA055957.
neXtProtiNX_Q9C0K3.
PharmGKBiPA165617588.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5277.
GeneTreeiENSGT00550000074695.
HOGENOMiHOG000034070.
HOVERGENiHBG075770.
InParanoidiQ9C0K3.
KOiK18584.
OMAiHIFPNIV.
PhylomeDBiQ9C0K3.
TreeFamiTF300644.

Enzyme and pathway databases

SignaLinkiQ9C0K3.

Miscellaneous databases

ChiTaRSiACTR3C. human.
GenomeRNAii653857.
NextBioi123684.
PROiQ9C0K3.

Gene expression databases

BgeeiQ9C0K3.
ExpressionAtlasiQ9C0K3. baseline and differential.
GenevisibleiQ9C0K3. HS.

Family and domain databases

InterProiIPR004000. Actin.
IPR015623. Arp3.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF170. PTHR11937:SF170. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma."
    Shindo-Okada N., Shimizu K.
    Biochem. Biophys. Res. Commun. 280:61-67(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal kidney.

Entry informationi

Entry nameiARP3C_HUMAN
AccessioniPrimary (citable) accession number: Q9C0K3
Secondary accession number(s): Q5CZI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.