Q9C0K3 (ARP3C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin-related protein 3C

Alternative name(s):
Actin-related protein 11

Gene names

Name:	ACTR3C
Synonyms:	ARP11

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells. Ref.1
Tissue specificity	Expressed in kidney, stomach, spleen, bone marrow, uterus, testis, placenta, skeletal muscle, mammary gland, lung, fetal liver, and fetal kidney, but not detected in small intestine, brain, and thymus. Expressed in low-metastatic lung adenocarcinoma cells but not in high-metastatic ones. Ref.1
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Signal
Ligand	ATP-binding Actin-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of actin filament polymerization Inferred from electronic annotation. Source: InterPro
Cellular component	cytoskeleton Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW actin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9C0K3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9C0K3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 210	189	Actin-related protein 3C		PRO_0000324333
Amino acid modifications
	Modified residue	102	1	Phosphotyrosine By similarity
Natural variations
	Alternative sequence	1 – 163	163	Missing in isoform 2.		VSP_032218
Experimental info
	Sequence conflict	189	1	M → V in CAI56711. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: AB94A33B440CD35B	FASTA	210	23,712
	10 20 30 40 50 60 MFESFNVPGL YIAVQAVLAL AASWTSRQVG ERTLTGIVID SGDGVTHVIP VAEGYVIGSC 70 80 90 100 110 120 IKHIPIAGRD ITYFIQQLLR EREVGIPPEQ SLETAKAIKE KYCYICPDIV KEFAKYDVDP 130 140 150 160 170 180 QKWIKQYTGI NAINQKKFVI DVGYERFLGP EIFFHPEFAN PDSMESISDV VDEVIQNCPI 190 200 210 DVRRPLYKME QIPLSYPQGH GFHPLSPPFH
	Isoform 2 [UniParc]. Checksum: BFB88F46E446D136	FASTA	47	5,418
	10 20 30 40 MESISDVVDE VIQNCPIDVR RPLYKMEQIP LSYPQGHGFH PLSPPFH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma." Shindo-Okada N., Shimizu K. Biochem. Biophys. Res. Commun. 280:61-67(2001) [PubMed: 11162478] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Lung.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Fetal kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB039791 mRNA. Translation: BAB21501.1. BX640643 mRNA. Translation: CAI56711.1.
IPI	IPI00946655. IPI00947074.
PIR	JC7580.
RefSeq	NP_001157930.1. NM_001164458.1. NP_001157931.1. NM_001164459.1.
UniGene	Hs.664579.
3D structure databases
HSSP	HSSP built from PDB template 1K8K based on UniProtKB P61157.
ProteinModelPortal	Q9C0K3.
SMR	Q9C0K3. Positions 1-188.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9C0K3.
Polymorphism databases
DMDM	74739414.
Proteomic databases
PRIDE	Q9C0K3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000252071; ENSP00000252071; ENSG00000106526.
GeneID	653857.
KEGG	hsa:653857.
UCSC	uc003wgu.1. human.
Organism-specific databases
CTD	653857.
GeneCards	GC07M149942.
H-InvDB	HIX0025262. HIX0201521.
HGNC	HGNC:37282. ACTR3C.
neXtProt	NX_Q9C0K3.
PharmGKB	PA165617588.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10282.
GeneTree	ENSGT00550000074695.
HOVERGEN	HBG075770.
InParanoid	Q9C0K3.
OMA	EFAKYDM.
PhylomeDB	Q9C0K3.
Gene expression databases
ArrayExpress	Q9C0K3.
Bgee	Q9C0K3.
Genevestigator	Q9C0K3.
Family and domain databases
InterPro	IPR004000. Actin-like. IPR015623. Arp3. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit. PTHR11937:SF31. Arp3. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00432. ACTINS_2. False negative. PS01132. ACTINS_ACT_LIKE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARP3C_HUMAN

Accession

Primary (citable) accession number: Q9C0K3
Secondary accession number(s): Q5CZI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.