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Q9C0K3

- ARP3C_HUMAN

UniProt

Q9C0K3 - ARP3C_HUMAN

Protein

Actin-related protein 3C

Gene

ACTR3C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.1 Publication

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    Keywords - Ligandi

    Actin-binding, ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ9C0K3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Actin-related protein 3C
    Alternative name(s):
    Actin-related protein 11
    Gene namesi
    Name:ACTR3C
    Synonyms:ARP11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:37282. ACTR3C.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165617588.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 210189Actin-related protein 3CPRO_0000324333Add
    BLAST

    Proteomic databases

    MaxQBiQ9C0K3.
    PaxDbiQ9C0K3.
    PRIDEiQ9C0K3.

    PTM databases

    PhosphoSiteiQ9C0K3.

    Expressioni

    Tissue specificityi

    Expressed in kidney, stomach, spleen, bone marrow, uterus, testis, placenta, skeletal muscle, mammary gland, lung, fetal liver, and fetal kidney, but not detected in small intestine, brain, and thymus. Expressed in low-metastatic lung adenocarcinoma cells but not in high-metastatic ones.1 Publication

    Gene expression databases

    ArrayExpressiQ9C0K3.
    BgeeiQ9C0K3.
    GenevestigatoriQ9C0K3.

    Organism-specific databases

    HPAiHPA055957.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000252071.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C0K3.
    SMRiQ9C0K3. Positions 1-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the actin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5277.
    HOGENOMiHOG000034070.
    HOVERGENiHBG075770.
    InParanoidiQ9C0K3.
    OMAiHIFPNIV.
    PhylomeDBiQ9C0K3.
    TreeFamiTF300644.

    Family and domain databases

    InterProiIPR004000. Actin-related.
    [Graphical view]
    PANTHERiPTHR11937. PTHR11937. 1 hit.
    PfamiPF00022. Actin. 1 hit.
    [Graphical view]
    SMARTiSM00268. ACTIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9C0K3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFESFNVPGL YIAVQAVLAL AASWTSRQVG ERTLTGIVID SGDGVTHVIP    50
    VAEGYVIGSC IKHIPIAGRD ITYFIQQLLR EREVGIPPEQ SLETAKAIKE 100
    KYCYICPDIV KEFAKYDVDP QKWIKQYTGI NAINQKKFVI DVGYERFLGP 150
    EIFFHPEFAN PDSMESISDV VDEVIQNCPI DVRRPLYKME QIPLSYPQGH 200
    GFHPLSPPFH 210
    Length:210
    Mass (Da):23,712
    Last modified:June 1, 2001 - v1
    Checksum:iAB94A33B440CD35B
    GO
    Isoform 2 (identifier: Q9C0K3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-163: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:47
    Mass (Da):5,418
    Checksum:iBFB88F46E446D136
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti189 – 1891M → V in CAI56711. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 163163Missing in isoform 2. 1 PublicationVSP_032218Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039791 mRNA. Translation: BAB21501.1.
    BX640643 mRNA. Translation: CAI56711.1.
    CCDSiCCDS47744.1. [Q9C0K3-1]
    PIRiJC7580.
    RefSeqiNP_001157930.1. NM_001164458.1. [Q9C0K3-1]
    NP_001157931.1. NM_001164459.1. [Q9C0K3-1]
    UniGeneiHs.664579.

    Genome annotation databases

    EnsembliENST00000252071; ENSP00000252071; ENSG00000106526. [Q9C0K3-1]
    ENST00000539352; ENSP00000440990; ENSG00000106526. [Q9C0K3-1]
    GeneIDi653857.
    KEGGihsa:653857.
    UCSCiuc003wgu.2. human. [Q9C0K3-1]

    Polymorphism databases

    DMDMi74739414.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039791 mRNA. Translation: BAB21501.1 .
    BX640643 mRNA. Translation: CAI56711.1 .
    CCDSi CCDS47744.1. [Q9C0K3-1 ]
    PIRi JC7580.
    RefSeqi NP_001157930.1. NM_001164458.1. [Q9C0K3-1 ]
    NP_001157931.1. NM_001164459.1. [Q9C0K3-1 ]
    UniGenei Hs.664579.

    3D structure databases

    ProteinModelPortali Q9C0K3.
    SMRi Q9C0K3. Positions 1-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000252071.

    PTM databases

    PhosphoSitei Q9C0K3.

    Polymorphism databases

    DMDMi 74739414.

    Proteomic databases

    MaxQBi Q9C0K3.
    PaxDbi Q9C0K3.
    PRIDEi Q9C0K3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252071 ; ENSP00000252071 ; ENSG00000106526 . [Q9C0K3-1 ]
    ENST00000539352 ; ENSP00000440990 ; ENSG00000106526 . [Q9C0K3-1 ]
    GeneIDi 653857.
    KEGGi hsa:653857.
    UCSCi uc003wgu.2. human. [Q9C0K3-1 ]

    Organism-specific databases

    CTDi 653857.
    GeneCardsi GC07M149942.
    H-InvDB HIX0041149.
    HIX0201521.
    HGNCi HGNC:37282. ACTR3C.
    HPAi HPA055957.
    neXtProti NX_Q9C0K3.
    PharmGKBi PA165617588.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5277.
    HOGENOMi HOG000034070.
    HOVERGENi HBG075770.
    InParanoidi Q9C0K3.
    OMAi HIFPNIV.
    PhylomeDBi Q9C0K3.
    TreeFami TF300644.

    Enzyme and pathway databases

    SignaLinki Q9C0K3.

    Miscellaneous databases

    ChiTaRSi ACTR3C. human.
    GenomeRNAii 653857.
    NextBioi 123684.
    PROi Q9C0K3.

    Gene expression databases

    ArrayExpressi Q9C0K3.
    Bgeei Q9C0K3.
    Genevestigatori Q9C0K3.

    Family and domain databases

    InterProi IPR004000. Actin-related.
    [Graphical view ]
    PANTHERi PTHR11937. PTHR11937. 1 hit.
    Pfami PF00022. Actin. 1 hit.
    [Graphical view ]
    SMARTi SM00268. ACTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma."
      Shindo-Okada N., Shimizu K.
      Biochem. Biophys. Res. Commun. 280:61-67(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
      Tissue: Lung.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Fetal kidney.

    Entry informationi

    Entry nameiARP3C_HUMAN
    AccessioniPrimary (citable) accession number: Q9C0K3
    Secondary accession number(s): Q5CZI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3