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Q9C0K3

- ARP3C_HUMAN

UniProt

Q9C0K3 - ARP3C_HUMAN

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Protein
Actin-related protein 3C
Gene
ACTR3C, ARP11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.1 Publication

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9C0K3.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 3C
Alternative name(s):
Actin-related protein 11
Gene namesi
Name:ACTR3C
Synonyms:ARP11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:37282. ACTR3C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165617588.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 210189Actin-related protein 3C
PRO_0000324333Add
BLAST

Proteomic databases

MaxQBiQ9C0K3.
PaxDbiQ9C0K3.
PRIDEiQ9C0K3.

PTM databases

PhosphoSiteiQ9C0K3.

Expressioni

Tissue specificityi

Expressed in kidney, stomach, spleen, bone marrow, uterus, testis, placenta, skeletal muscle, mammary gland, lung, fetal liver, and fetal kidney, but not detected in small intestine, brain, and thymus. Expressed in low-metastatic lung adenocarcinoma cells but not in high-metastatic ones.1 Publication

Gene expression databases

ArrayExpressiQ9C0K3.
BgeeiQ9C0K3.
GenevestigatoriQ9C0K3.

Organism-specific databases

HPAiHPA055957.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000252071.

Structurei

3D structure databases

ProteinModelPortaliQ9C0K3.
SMRiQ9C0K3. Positions 1-188.

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5277.
HOGENOMiHOG000034070.
HOVERGENiHBG075770.
InParanoidiQ9C0K3.
OMAiHIFPNIV.
PhylomeDBiQ9C0K3.
TreeFamiTF300644.

Family and domain databases

InterProiIPR004000. Actin-related.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9C0K3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFESFNVPGL YIAVQAVLAL AASWTSRQVG ERTLTGIVID SGDGVTHVIP    50
VAEGYVIGSC IKHIPIAGRD ITYFIQQLLR EREVGIPPEQ SLETAKAIKE 100
KYCYICPDIV KEFAKYDVDP QKWIKQYTGI NAINQKKFVI DVGYERFLGP 150
EIFFHPEFAN PDSMESISDV VDEVIQNCPI DVRRPLYKME QIPLSYPQGH 200
GFHPLSPPFH 210
Length:210
Mass (Da):23,712
Last modified:June 1, 2001 - v1
Checksum:iAB94A33B440CD35B
GO
Isoform 2 (identifier: Q9C0K3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: Missing.

Note: No experimental confirmation available.

Show »
Length:47
Mass (Da):5,418
Checksum:iBFB88F46E446D136
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 163163Missing in isoform 2.
VSP_032218Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti189 – 1891M → V in CAI56711. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB039791 mRNA. Translation: BAB21501.1.
BX640643 mRNA. Translation: CAI56711.1.
CCDSiCCDS47744.1. [Q9C0K3-1]
PIRiJC7580.
RefSeqiNP_001157930.1. NM_001164458.1. [Q9C0K3-1]
NP_001157931.1. NM_001164459.1. [Q9C0K3-1]
UniGeneiHs.664579.

Genome annotation databases

EnsembliENST00000252071; ENSP00000252071; ENSG00000106526. [Q9C0K3-1]
ENST00000539352; ENSP00000440990; ENSG00000106526. [Q9C0K3-1]
GeneIDi653857.
KEGGihsa:653857.
UCSCiuc003wgu.2. human. [Q9C0K3-1]

Polymorphism databases

DMDMi74739414.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB039791 mRNA. Translation: BAB21501.1 .
BX640643 mRNA. Translation: CAI56711.1 .
CCDSi CCDS47744.1. [Q9C0K3-1 ]
PIRi JC7580.
RefSeqi NP_001157930.1. NM_001164458.1. [Q9C0K3-1 ]
NP_001157931.1. NM_001164459.1. [Q9C0K3-1 ]
UniGenei Hs.664579.

3D structure databases

ProteinModelPortali Q9C0K3.
SMRi Q9C0K3. Positions 1-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000252071.

PTM databases

PhosphoSitei Q9C0K3.

Polymorphism databases

DMDMi 74739414.

Proteomic databases

MaxQBi Q9C0K3.
PaxDbi Q9C0K3.
PRIDEi Q9C0K3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252071 ; ENSP00000252071 ; ENSG00000106526 . [Q9C0K3-1 ]
ENST00000539352 ; ENSP00000440990 ; ENSG00000106526 . [Q9C0K3-1 ]
GeneIDi 653857.
KEGGi hsa:653857.
UCSCi uc003wgu.2. human. [Q9C0K3-1 ]

Organism-specific databases

CTDi 653857.
GeneCardsi GC07M149942.
H-InvDB HIX0041149.
HIX0201521.
HGNCi HGNC:37282. ACTR3C.
HPAi HPA055957.
neXtProti NX_Q9C0K3.
PharmGKBi PA165617588.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5277.
HOGENOMi HOG000034070.
HOVERGENi HBG075770.
InParanoidi Q9C0K3.
OMAi HIFPNIV.
PhylomeDBi Q9C0K3.
TreeFami TF300644.

Enzyme and pathway databases

SignaLinki Q9C0K3.

Miscellaneous databases

ChiTaRSi ACTR3C. human.
GenomeRNAii 653857.
NextBioi 123684.
PROi Q9C0K3.

Gene expression databases

ArrayExpressi Q9C0K3.
Bgeei Q9C0K3.
Genevestigatori Q9C0K3.

Family and domain databases

InterProi IPR004000. Actin-related.
[Graphical view ]
PANTHERi PTHR11937. PTHR11937. 1 hit.
Pfami PF00022. Actin. 1 hit.
[Graphical view ]
SMARTi SM00268. ACTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma."
    Shindo-Okada N., Shimizu K.
    Biochem. Biophys. Res. Commun. 280:61-67(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal kidney.

Entry informationi

Entry nameiARP3C_HUMAN
AccessioniPrimary (citable) accession number: Q9C0K3
Secondary accession number(s): Q5CZI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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