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Protein

Actin-related protein 3C

Gene

ACTR3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9C0K3.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 3C
Alternative name(s):
Actin-related protein 11
Gene namesi
Name:ACTR3C
Synonyms:ARP11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:37282. ACTR3C.

Subcellular locationi

GO - Cellular componenti

  • Arp2/3 protein complex Source: InterPro
  • extracellular exosome Source: UniProtKB

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000106526.
PharmGKBiPA165617588.

Polymorphism and mutation databases

BioMutaiACTR3C.
DMDMi74739414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000032433322 – 210Actin-related protein 3CAdd BLAST189

Proteomic databases

MaxQBiQ9C0K3.
PaxDbiQ9C0K3.
PeptideAtlasiQ9C0K3.
PRIDEiQ9C0K3.

PTM databases

iPTMnetiQ9C0K3.
PhosphoSitePlusiQ9C0K3.

Expressioni

Tissue specificityi

Expressed in kidney, stomach, spleen, bone marrow, uterus, testis, placenta, skeletal muscle, mammary gland, lung, fetal liver, and fetal kidney, but not detected in small intestine, brain, and thymus. Expressed in low-metastatic lung adenocarcinoma cells but not in high-metastatic ones.1 Publication

Gene expression databases

BgeeiENSG00000106526.
ExpressionAtlasiQ9C0K3. baseline and differential.
GenevisibleiQ9C0K3. HS.

Organism-specific databases

HPAiHPA055957.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi576126. 4 interactors.
STRINGi9606.ENSP00000252071.

Structurei

3D structure databases

ProteinModelPortaliQ9C0K3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0678. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00550000074695.
HOGENOMiHOG000034070.
HOVERGENiHBG075770.
InParanoidiQ9C0K3.
KOiK18584.
OMAiIMERFME.
PhylomeDBiQ9C0K3.
TreeFamiTF300644.

Family and domain databases

InterProiView protein in InterPro
IPR004000. Actin.
IPR015623. Arp3_met.
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF304. PTHR11937:SF304. 1 hit.
PfamiView protein in Pfam
PF00022. Actin. 1 hit.
SMARTiView protein in SMART
SM00268. ACTIN. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0K3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFESFNVPGL YIAVQAVLAL AASWTSRQVG ERTLTGIVID SGDGVTHVIP
60 70 80 90 100
VAEGYVIGSC IKHIPIAGRD ITYFIQQLLR EREVGIPPEQ SLETAKAIKE
110 120 130 140 150
KYCYICPDIV KEFAKYDVDP QKWIKQYTGI NAINQKKFVI DVGYERFLGP
160 170 180 190 200
EIFFHPEFAN PDSMESISDV VDEVIQNCPI DVRRPLYKME QIPLSYPQGH
210
GFHPLSPPFH
Length:210
Mass (Da):23,712
Last modified:June 1, 2001 - v1
Checksum:iAB94A33B440CD35B
GO
Isoform 2 (identifier: Q9C0K3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: Missing.

Note: No experimental confirmation available.
Show »
Length:47
Mass (Da):5,418
Checksum:iBFB88F46E446D136
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189M → V in CAI56711 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0322181 – 163Missing in isoform 2. 1 PublicationAdd BLAST163

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039791 mRNA. Translation: BAB21501.1.
BX640643 mRNA. Translation: CAI56711.1.
CCDSiCCDS47744.1. [Q9C0K3-1]
PIRiJC7580.
RefSeqiNP_001157930.1. NM_001164458.1. [Q9C0K3-1]
NP_001157931.1. NM_001164459.1. [Q9C0K3-1]
XP_011514808.1. XM_011516506.2. [Q9C0K3-1]
XP_011514809.1. XM_011516507.2. [Q9C0K3-1]
XP_011514810.1. XM_011516508.2. [Q9C0K3-1]
XP_016868038.1. XM_017012549.1. [Q9C0K3-1]
UniGeneiHs.664579.

Genome annotation databases

EnsembliENST00000252071; ENSP00000252071; ENSG00000106526. [Q9C0K3-1]
GeneIDi653857.
KEGGihsa:653857.
UCSCiuc003wgu.3. human. [Q9C0K3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARP3C_HUMAN
AccessioniPrimary (citable) accession number: Q9C0K3
Secondary accession number(s): Q5CZI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families