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Q9C0K3 (ARP3C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Actin-related protein 3C
Alternative name(s):
Actin-related protein 11
Gene names
Name:ACTR3C
Synonyms:ARP11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells. Ref.1

Tissue specificity

Expressed in kidney, stomach, spleen, bone marrow, uterus, testis, placenta, skeletal muscle, mammary gland, lung, fetal liver, and fetal kidney, but not detected in small intestine, brain, and thymus. Expressed in low-metastatic lung adenocarcinoma cells but not in high-metastatic ones. Ref.1

Sequence similarities

Belongs to the actin family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainSignal
   LigandActin-binding
ATP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9C0K3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9C0K3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 210189Actin-related protein 3C
PRO_0000324333

Natural variations

Alternative sequence1 – 163163Missing in isoform 2.
VSP_032218

Experimental info

Sequence conflict1891M → V in CAI56711. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: AB94A33B440CD35B

FASTA21023,712
        10         20         30         40         50         60 
MFESFNVPGL YIAVQAVLAL AASWTSRQVG ERTLTGIVID SGDGVTHVIP VAEGYVIGSC 

        70         80         90        100        110        120 
IKHIPIAGRD ITYFIQQLLR EREVGIPPEQ SLETAKAIKE KYCYICPDIV KEFAKYDVDP 

       130        140        150        160        170        180 
QKWIKQYTGI NAINQKKFVI DVGYERFLGP EIFFHPEFAN PDSMESISDV VDEVIQNCPI 

       190        200        210 
DVRRPLYKME QIPLSYPQGH GFHPLSPPFH 

« Hide

Isoform 2 [UniParc].

Checksum: BFB88F46E446D136
Show »

FASTA475,418

References

« Hide 'large scale' references
[1]"Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma."
Shindo-Okada N., Shimizu K.
Biochem. Biophys. Res. Commun. 280:61-67(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
Tissue: Lung.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Fetal kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB039791 mRNA. Translation: BAB21501.1.
BX640643 mRNA. Translation: CAI56711.1.
CCDSCCDS47744.1. [Q9C0K3-1]
PIRJC7580.
RefSeqNP_001157930.1. NM_001164458.1. [Q9C0K3-1]
NP_001157931.1. NM_001164459.1. [Q9C0K3-1]
UniGeneHs.664579.

3D structure databases

ProteinModelPortalQ9C0K3.
SMRQ9C0K3. Positions 1-188.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000252071.

PTM databases

PhosphoSiteQ9C0K3.

Polymorphism databases

DMDM74739414.

Proteomic databases

MaxQBQ9C0K3.
PaxDbQ9C0K3.
PRIDEQ9C0K3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000252071; ENSP00000252071; ENSG00000106526. [Q9C0K3-1]
ENST00000539352; ENSP00000440990; ENSG00000106526. [Q9C0K3-1]
GeneID653857.
KEGGhsa:653857.
UCSCuc003wgu.2. human. [Q9C0K3-1]

Organism-specific databases

CTD653857.
GeneCardsGC07M149942.
H-InvDBHIX0041149.
HIX0201521.
HGNCHGNC:37282. ACTR3C.
HPAHPA055957.
neXtProtNX_Q9C0K3.
PharmGKBPA165617588.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5277.
HOGENOMHOG000034070.
HOVERGENHBG075770.
InParanoidQ9C0K3.
OMAHIFPNIV.
PhylomeDBQ9C0K3.
TreeFamTF300644.

Enzyme and pathway databases

SignaLinkQ9C0K3.

Gene expression databases

ArrayExpressQ9C0K3.
BgeeQ9C0K3.
GenevestigatorQ9C0K3.

Family and domain databases

InterProIPR004000. Actin-related.
[Graphical view]
PANTHERPTHR11937. PTHR11937. 1 hit.
PfamPF00022. Actin. 1 hit.
[Graphical view]
SMARTSM00268. ACTIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSACTR3C. human.
GenomeRNAi653857.
NextBio123684.
PROQ9C0K3.

Entry information

Entry nameARP3C_HUMAN
AccessionPrimary (citable) accession number: Q9C0K3
Secondary accession number(s): Q5CZI4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM