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Q9C0J8

- WDR33_HUMAN

UniProt

Q9C0J8 - WDR33_HUMAN

Protein

pre-mRNA 3' end processing protein WDR33

Gene

WDR33

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.1 Publication

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. postreplication repair Source: UniProtKB
    3. spermatogenesis Source: UniProtKB

    Keywords - Biological processi

    mRNA processing

    Enzyme and pathway databases

    SignaLinkiQ9C0J8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    pre-mRNA 3' end processing protein WDR33
    Alternative name(s):
    WD repeat-containing protein 33
    WD repeat-containing protein WDC146
    Gene namesi
    Name:WDR33
    Synonyms:WDC146
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:25651. WDR33.

    Subcellular locationi

    Nucleus 2 Publications

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134943440.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 13361335pre-mRNA 3' end processing protein WDR33PRO_0000051382Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications
    Modified residuei7 – 71Phosphoserine3 Publications
    Modified residuei46 – 461N6-acetyllysine1 Publication
    Modified residuei1210 – 12101Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9C0J8.
    PaxDbiQ9C0J8.
    PRIDEiQ9C0J8.

    PTM databases

    PhosphoSiteiQ9C0J8.

    Expressioni

    Tissue specificityi

    Most highly expressed in testis.1 Publication

    Gene expression databases

    ArrayExpressiQ9C0J8.
    BgeeiQ9C0J8.
    CleanExiHS_WDR33.
    GenevestigatoriQ9C0J8.

    Organism-specific databases

    HPAiHPA026897.

    Interactioni

    Subunit structurei

    Component of the cleavage and polyadenylation specificity factor (CPSF) module of the pre-mRNA 3'-end processing complex. Interacts with CPSF3/CPSF73.1 Publication

    Protein-protein interaction databases

    BioGridi120620. 36 interactions.
    IntActiQ9C0J8. 20 interactions.
    MINTiMINT-1371235.
    STRINGi9606.ENSP00000325377.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C0J8.
    SMRiQ9C0J8. Positions 122-434.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati117 – 15640WD 1Add
    BLAST
    Repeati159 – 19840WD 2Add
    BLAST
    Repeati200 – 23940WD 3Add
    BLAST
    Repeati242 – 28342WD 4Add
    BLAST
    Repeati286 – 32540WD 5Add
    BLAST
    Repeati329 – 36941WD 6Add
    BLAST
    Repeati373 – 41240WD 7Add
    BLAST
    Domaini618 – 770153Collagen-likeAdd
    BLAST

    Sequence similaritiesi

    Contains 1 collagen-like domain.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Collagen, Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000126810.
    HOVERGENiHBG062379.
    InParanoidiQ9C0J8.
    KOiK15542.
    OMAiTVMEVKL.
    OrthoDBiEOG7QG43G.
    PhylomeDBiQ9C0J8.
    TreeFamiTF317659.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR008160. Collagen.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF01391. Collagen. 2 hits.
    PF00400. WD40. 6 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9C0J8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATEIGSPPR FFHMPRFQHQ APRQLFYKRP DFAQQQAMQQ LTFDGKRMRK     50
    AVNRKTIDYN PSVIKYLENR IWQRDQRDMR AIQPDAGYYN DLVPPIGMLN 100
    NPMNAVTTKF VRTSTNKVKC PVFVVRWTPE GRRLVTGASS GEFTLWNGLT 150
    FNFETILQAH DSPVRAMTWS HNDMWMLTAD HGGYVKYWQS NMNNVKMFQA 200
    HKEAIREASF SPTDNKFATC SDDGTVRIWD FLRCHEERIL RGHGADVKCV 250
    DWHPTKGLVV SGSKDSQQPI KFWDPKTGQS LATLHAHKNT VMEVKLNLNG 300
    NWLLTASRDH LCKLFDIRNL KEELQVFRGH KKEATAVAWH PVHEGLFASG 350
    GSDGSLLFWH VGVEKEVGGM EMAHEGMIWS LAWHPLGHIL CSGSNDHTSK 400
    FWTRNRPGDK MRDRYNLNLL PGMSEDGVEY DDLEPNSLAV IPGMGIPEQL 450
    KLAMEQEQMG KDESNEIEMT IPGLDWGMEE VMQKDQKKVP QKKVPYAKPI 500
    PAQFQQAWMQ NKVPIPAPNE VLNDRKEDIK LEEKKKTQAE IEQEMATLQY 550
    TNPQLLEQLK IERLAQKQVE QIQPPPSSGT PLLGPQPFPG QGPMSQIPQG 600
    FQQPHPSQQM PMNMAQMGPP GPQGQFRPPG PQGQMGPQGP PLHQGGGGPQ 650
    GFMGPQGPQG PPQGLPRPQD MHGPQGMQRH PGPHGPLGPQ GPPGPQGSSG 700
    PQGHMGPQGP PGPQGHIGPQ GPPGPQGHLG PQGPPGTQGM QGPPGPRGMQ 750
    GPPHPHGIQG GPGSQGIQGP VSQGPLMGLN PRGMQGPPGP RENQGPAPQG 800
    MIMGHPPQEM RGPHPPGGLL GHGPQEMRGP QEIRGMQGPP PQGSMLGPPQ 850
    ELRGPPGSQS QQGPPQGSLG PPPQGGMQGP PGPQGQQNPA RGPHPSQGPI 900
    PFQQQKTPLL GDGPRAPFNQ EGQSTGPPPL IPGLGQQGAQ GRIPPLNPGQ 950
    GPGPNKGDSR GPPNHHMGPM SERRHEQSGG PEHGPERGPF RGGQDCRGPP 1000
    DRRGPHPDFP DDFSRPDDFH PDKRFGHRLR EFEGRGGPLP QEEKWRRGGP 1050
    GPPFPPDHRE FSEGDGRGAA RGPPGAWEGR RPGDERFPRD PEDPRFRGRR 1100
    EESFRRGAPP RHEGRAPPRG RDGFPGPEDF GPEENFDASE EAARGRDLRG 1150
    RGRGTPRGGR KGLLPTPDEF PRFEGGRKPD SWDGNREPGP GHEHFRDTPR 1200
    PDHPPHDGHS PASRERSSSL QGMDMASLPP RKRPWHDGPG TSEHREMEAP 1250
    GGPSEDRGGK GRGGPGPAQR VPKSGRSSSL DGEHHDGYHR DEPFGGPPGS 1300
    GTPSRGGRSG SNWGRGSNMN SGPPRRGASR GGGRGR 1336
    Length:1,336
    Mass (Da):145,891
    Last modified:October 14, 2008 - v2
    Checksum:iDE45F510F93BB783
    GO
    Isoform 2 (identifier: Q9C0J8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         209-326: SFSPTDNKFA...IRNLKEELQV → RFIHNIPFSV...YFIPNKEFSL
         327-1336: Missing.

    Show »
    Length:326
    Mass (Da):38,294
    Checksum:i1F1F704B877F7904
    GO
    Isoform 3 (identifier: Q9C0J8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         242-257: GHGADVKCVDWHPTKG → DTCFHHCRCYFLSVKR
         258-326: Missing.
         327-1336: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:257
    Mass (Da):30,288
    Checksum:i2235A458B412633E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti113 – 1131T → A in BAD97039. 1 PublicationCurated
    Sequence conflicti715 – 7151G → S in BAB32435. (PubMed:11162572)Curated
    Isoform 2 (identifier: Q9C0J8-2)
    Sequence conflicti274 – 2741R → Q in BAD97039. 1 PublicationCurated
    Sequence conflicti306 – 3061F → S in AAH05401. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti33 – 331A → S.
    Corresponds to variant rs11557686 [ dbSNP | Ensembl ].
    VAR_046717
    Natural varianti711 – 7111P → R.
    Corresponds to variant rs12615078 [ dbSNP | Ensembl ].
    VAR_053427

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei209 – 326118SFSPT…EELQV → RFIHNIPFSVVPIVMVKLFS KCILGAEMHGLCQFLGNFLH PINTIFFFVFTHSPFCWHLS EVVLSRYQPLQYVRDVLSAA FCTGFLFSFMINNVYTLFLF IIYCVRQEYFIPNKEFSL in isoform 2. 3 PublicationsVSP_041333Add
    BLAST
    Alternative sequencei242 – 25716GHGAD…HPTKG → DTCFHHCRCYFLSVKR in isoform 3. 1 PublicationVSP_042684Add
    BLAST
    Alternative sequencei258 – 32669Missing in isoform 3. 1 PublicationVSP_042685Add
    BLAST
    Alternative sequencei327 – 13361010Missing in isoform 2 and isoform 3. 3 PublicationsVSP_041334Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB044749 mRNA. Translation: BAB32435.1.
    AK002156 mRNA. Translation: BAA92113.1.
    AK223319 mRNA. Translation: BAD97039.1.
    AC006011 Genomic DNA. Translation: AAX82033.1.
    CH471103 Genomic DNA. Translation: EAW95342.1.
    CH471103 Genomic DNA. Translation: EAW95343.1.
    BC005401 mRNA. Translation: AAH05401.1. Different termination.
    BC013990 mRNA. Translation: AAH13990.1.
    BC068484 mRNA. Translation: AAH68484.1.
    AL834365 mRNA. Translation: CAH10688.1.
    CCDSiCCDS2150.1. [Q9C0J8-1]
    CCDS42746.1. [Q9C0J8-3]
    CCDS46407.1. [Q9C0J8-2]
    RefSeqiNP_001006623.1. NM_001006622.2. [Q9C0J8-2]
    NP_001006624.1. NM_001006623.2. [Q9C0J8-3]
    NP_060853.3. NM_018383.4. [Q9C0J8-1]
    UniGeneiHs.554831.

    Genome annotation databases

    EnsembliENST00000322313; ENSP00000325377; ENSG00000136709. [Q9C0J8-1]
    ENST00000393006; ENSP00000376730; ENSG00000136709. [Q9C0J8-3]
    ENST00000409658; ENSP00000387186; ENSG00000136709. [Q9C0J8-2]
    GeneIDi55339.
    KEGGihsa:55339.
    UCSCiuc002tpg.2. human. [Q9C0J8-1]
    uc002tph.2. human. [Q9C0J8-3]
    uc002tpi.2. human. [Q9C0J8-2]

    Polymorphism databases

    DMDMi209572695.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB044749 mRNA. Translation: BAB32435.1 .
    AK002156 mRNA. Translation: BAA92113.1 .
    AK223319 mRNA. Translation: BAD97039.1 .
    AC006011 Genomic DNA. Translation: AAX82033.1 .
    CH471103 Genomic DNA. Translation: EAW95342.1 .
    CH471103 Genomic DNA. Translation: EAW95343.1 .
    BC005401 mRNA. Translation: AAH05401.1 . Different termination.
    BC013990 mRNA. Translation: AAH13990.1 .
    BC068484 mRNA. Translation: AAH68484.1 .
    AL834365 mRNA. Translation: CAH10688.1 .
    CCDSi CCDS2150.1. [Q9C0J8-1 ]
    CCDS42746.1. [Q9C0J8-3 ]
    CCDS46407.1. [Q9C0J8-2 ]
    RefSeqi NP_001006623.1. NM_001006622.2. [Q9C0J8-2 ]
    NP_001006624.1. NM_001006623.2. [Q9C0J8-3 ]
    NP_060853.3. NM_018383.4. [Q9C0J8-1 ]
    UniGenei Hs.554831.

    3D structure databases

    ProteinModelPortali Q9C0J8.
    SMRi Q9C0J8. Positions 122-434.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120620. 36 interactions.
    IntActi Q9C0J8. 20 interactions.
    MINTi MINT-1371235.
    STRINGi 9606.ENSP00000325377.

    PTM databases

    PhosphoSitei Q9C0J8.

    Polymorphism databases

    DMDMi 209572695.

    Proteomic databases

    MaxQBi Q9C0J8.
    PaxDbi Q9C0J8.
    PRIDEi Q9C0J8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322313 ; ENSP00000325377 ; ENSG00000136709 . [Q9C0J8-1 ]
    ENST00000393006 ; ENSP00000376730 ; ENSG00000136709 . [Q9C0J8-3 ]
    ENST00000409658 ; ENSP00000387186 ; ENSG00000136709 . [Q9C0J8-2 ]
    GeneIDi 55339.
    KEGGi hsa:55339.
    UCSCi uc002tpg.2. human. [Q9C0J8-1 ]
    uc002tph.2. human. [Q9C0J8-3 ]
    uc002tpi.2. human. [Q9C0J8-2 ]

    Organism-specific databases

    CTDi 55339.
    GeneCardsi GC02M128458.
    HGNCi HGNC:25651. WDR33.
    HPAi HPA026897.
    neXtProti NX_Q9C0J8.
    PharmGKBi PA134943440.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000126810.
    HOVERGENi HBG062379.
    InParanoidi Q9C0J8.
    KOi K15542.
    OMAi TVMEVKL.
    OrthoDBi EOG7QG43G.
    PhylomeDBi Q9C0J8.
    TreeFami TF317659.

    Enzyme and pathway databases

    SignaLinki Q9C0J8.

    Miscellaneous databases

    ChiTaRSi WDR33. human.
    GeneWikii WDR33.
    GenomeRNAii 55339.
    NextBioi 59651.
    PROi Q9C0J8.

    Gene expression databases

    ArrayExpressi Q9C0J8.
    Bgeei Q9C0J8.
    CleanExi HS_WDR33.
    Genevestigatori Q9C0J8.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR008160. Collagen.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF01391. Collagen. 2 hits.
    PF00400. WD40. 6 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel WD40 repeat protein, WDC146, highly expressed during spermatogenesis in a stage-specific manner."
      Ito S., Sakai A., Nomura T., Miki Y., Ouchida M., Sasaki J., Shimizu K.
      Biochem. Biophys. Res. Commun. 280:656-663(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Small intestine.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Brain, Pancreas and Placenta.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1187-1336 (ISOFORM 1).
      Tissue: Melanoma.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1210, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Molecular architecture of the human pre-mRNA 3' processing complex."
      Shi Y., Di Giammartino D.C., Taylor D., Sarkeshik A., Rice W.J., Yates J.R. III, Frank J., Manley J.L.
      Mol. Cell 33:365-376(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE 3' PRE-MRNA END PROCESSING COMPLEX, SUBCELLULAR LOCATION, INTERACTION WITH CPSF3.
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-46, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7 AND SER-1210, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiWDR33_HUMAN
    AccessioniPrimary (citable) accession number: Q9C0J8
    Secondary accession number(s): Q05DP8
    , Q53FG9, Q587J1, Q69YF7, Q6NUQ0, Q9NUL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2002
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3