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Q9C0J8

- WDR33_HUMAN

UniProt

Q9C0J8 - WDR33_HUMAN

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Protein
pre-mRNA 3' end processing protein WDR33
Gene
WDR33, WDC146
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.1 Publication

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. postreplication repair Source: UniProtKB
  3. spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing

Enzyme and pathway databases

SignaLinkiQ9C0J8.

Names & Taxonomyi

Protein namesi
Recommended name:
pre-mRNA 3' end processing protein WDR33
Alternative name(s):
WD repeat-containing protein 33
WD repeat-containing protein WDC146
Gene namesi
Name:WDR33
Synonyms:WDC146
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:25651. WDR33.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134943440.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 13361335pre-mRNA 3' end processing protein WDR33
PRO_0000051382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei7 – 71Phosphoserine3 Publications
Modified residuei46 – 461N6-acetyllysine1 Publication
Modified residuei1210 – 12101Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9C0J8.
PaxDbiQ9C0J8.
PRIDEiQ9C0J8.

PTM databases

PhosphoSiteiQ9C0J8.

Expressioni

Tissue specificityi

Most highly expressed in testis.1 Publication

Gene expression databases

ArrayExpressiQ9C0J8.
BgeeiQ9C0J8.
CleanExiHS_WDR33.
GenevestigatoriQ9C0J8.

Organism-specific databases

HPAiHPA026897.

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation specificity factor (CPSF) module of the pre-mRNA 3'-end processing complex. Interacts with CPSF3/CPSF73.1 Publication

Protein-protein interaction databases

BioGridi120620. 36 interactions.
IntActiQ9C0J8. 20 interactions.
MINTiMINT-1371235.
STRINGi9606.ENSP00000325377.

Structurei

3D structure databases

ProteinModelPortaliQ9C0J8.
SMRiQ9C0J8. Positions 122-434.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati117 – 15640WD 1
Add
BLAST
Repeati159 – 19840WD 2
Add
BLAST
Repeati200 – 23940WD 3
Add
BLAST
Repeati242 – 28342WD 4
Add
BLAST
Repeati286 – 32540WD 5
Add
BLAST
Repeati329 – 36941WD 6
Add
BLAST
Repeati373 – 41240WD 7
Add
BLAST
Domaini618 – 770153Collagen-like
Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.

Keywords - Domaini

Collagen, Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000126810.
HOVERGENiHBG062379.
InParanoidiQ9C0J8.
KOiK15542.
OMAiTVMEVKL.
OrthoDBiEOG7QG43G.
PhylomeDBiQ9C0J8.
TreeFamiTF317659.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR008160. Collagen.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00400. WD40. 6 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9C0J8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATEIGSPPR FFHMPRFQHQ APRQLFYKRP DFAQQQAMQQ LTFDGKRMRK     50
AVNRKTIDYN PSVIKYLENR IWQRDQRDMR AIQPDAGYYN DLVPPIGMLN 100
NPMNAVTTKF VRTSTNKVKC PVFVVRWTPE GRRLVTGASS GEFTLWNGLT 150
FNFETILQAH DSPVRAMTWS HNDMWMLTAD HGGYVKYWQS NMNNVKMFQA 200
HKEAIREASF SPTDNKFATC SDDGTVRIWD FLRCHEERIL RGHGADVKCV 250
DWHPTKGLVV SGSKDSQQPI KFWDPKTGQS LATLHAHKNT VMEVKLNLNG 300
NWLLTASRDH LCKLFDIRNL KEELQVFRGH KKEATAVAWH PVHEGLFASG 350
GSDGSLLFWH VGVEKEVGGM EMAHEGMIWS LAWHPLGHIL CSGSNDHTSK 400
FWTRNRPGDK MRDRYNLNLL PGMSEDGVEY DDLEPNSLAV IPGMGIPEQL 450
KLAMEQEQMG KDESNEIEMT IPGLDWGMEE VMQKDQKKVP QKKVPYAKPI 500
PAQFQQAWMQ NKVPIPAPNE VLNDRKEDIK LEEKKKTQAE IEQEMATLQY 550
TNPQLLEQLK IERLAQKQVE QIQPPPSSGT PLLGPQPFPG QGPMSQIPQG 600
FQQPHPSQQM PMNMAQMGPP GPQGQFRPPG PQGQMGPQGP PLHQGGGGPQ 650
GFMGPQGPQG PPQGLPRPQD MHGPQGMQRH PGPHGPLGPQ GPPGPQGSSG 700
PQGHMGPQGP PGPQGHIGPQ GPPGPQGHLG PQGPPGTQGM QGPPGPRGMQ 750
GPPHPHGIQG GPGSQGIQGP VSQGPLMGLN PRGMQGPPGP RENQGPAPQG 800
MIMGHPPQEM RGPHPPGGLL GHGPQEMRGP QEIRGMQGPP PQGSMLGPPQ 850
ELRGPPGSQS QQGPPQGSLG PPPQGGMQGP PGPQGQQNPA RGPHPSQGPI 900
PFQQQKTPLL GDGPRAPFNQ EGQSTGPPPL IPGLGQQGAQ GRIPPLNPGQ 950
GPGPNKGDSR GPPNHHMGPM SERRHEQSGG PEHGPERGPF RGGQDCRGPP 1000
DRRGPHPDFP DDFSRPDDFH PDKRFGHRLR EFEGRGGPLP QEEKWRRGGP 1050
GPPFPPDHRE FSEGDGRGAA RGPPGAWEGR RPGDERFPRD PEDPRFRGRR 1100
EESFRRGAPP RHEGRAPPRG RDGFPGPEDF GPEENFDASE EAARGRDLRG 1150
RGRGTPRGGR KGLLPTPDEF PRFEGGRKPD SWDGNREPGP GHEHFRDTPR 1200
PDHPPHDGHS PASRERSSSL QGMDMASLPP RKRPWHDGPG TSEHREMEAP 1250
GGPSEDRGGK GRGGPGPAQR VPKSGRSSSL DGEHHDGYHR DEPFGGPPGS 1300
GTPSRGGRSG SNWGRGSNMN SGPPRRGASR GGGRGR 1336
Length:1,336
Mass (Da):145,891
Last modified:October 14, 2008 - v2
Checksum:iDE45F510F93BB783
GO
Isoform 2 (identifier: Q9C0J8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-326: SFSPTDNKFA...IRNLKEELQV → RFIHNIPFSV...YFIPNKEFSL
     327-1336: Missing.

Show »
Length:326
Mass (Da):38,294
Checksum:i1F1F704B877F7904
GO
Isoform 3 (identifier: Q9C0J8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     242-257: GHGADVKCVDWHPTKG → DTCFHHCRCYFLSVKR
     258-326: Missing.
     327-1336: Missing.

Note: No experimental confirmation available.

Show »
Length:257
Mass (Da):30,288
Checksum:i2235A458B412633E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331A → S.
Corresponds to variant rs11557686 [ dbSNP | Ensembl ].
VAR_046717
Natural varianti711 – 7111P → R.
Corresponds to variant rs12615078 [ dbSNP | Ensembl ].
VAR_053427

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei209 – 326118SFSPT…EELQV → RFIHNIPFSVVPIVMVKLFS KCILGAEMHGLCQFLGNFLH PINTIFFFVFTHSPFCWHLS EVVLSRYQPLQYVRDVLSAA FCTGFLFSFMINNVYTLFLF IIYCVRQEYFIPNKEFSL in isoform 2.
VSP_041333Add
BLAST
Alternative sequencei242 – 25716GHGAD…HPTKG → DTCFHHCRCYFLSVKR in isoform 3.
VSP_042684Add
BLAST
Alternative sequencei258 – 32669Missing in isoform 3.
VSP_042685Add
BLAST
Alternative sequencei327 – 13361010Missing in isoform 2 and isoform 3.
VSP_041334Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131T → A in BAD97039. 1 Publication
Sequence conflicti715 – 7151G → S in BAB32435. 1 Publication
Isoform 2 (identifier: Q9C0J8-2)
Sequence conflicti274 – 2741R → Q in BAD97039. 1 Publication
Sequence conflicti306 – 3061F → S in AAH05401. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB044749 mRNA. Translation: BAB32435.1.
AK002156 mRNA. Translation: BAA92113.1.
AK223319 mRNA. Translation: BAD97039.1.
AC006011 Genomic DNA. Translation: AAX82033.1.
CH471103 Genomic DNA. Translation: EAW95342.1.
CH471103 Genomic DNA. Translation: EAW95343.1.
BC005401 mRNA. Translation: AAH05401.1. Different termination.
BC013990 mRNA. Translation: AAH13990.1.
BC068484 mRNA. Translation: AAH68484.1.
AL834365 mRNA. Translation: CAH10688.1.
CCDSiCCDS2150.1. [Q9C0J8-1]
CCDS42746.1. [Q9C0J8-3]
CCDS46407.1. [Q9C0J8-2]
RefSeqiNP_001006623.1. NM_001006622.2. [Q9C0J8-2]
NP_001006624.1. NM_001006623.2. [Q9C0J8-3]
NP_060853.3. NM_018383.4. [Q9C0J8-1]
UniGeneiHs.554831.

Genome annotation databases

EnsembliENST00000322313; ENSP00000325377; ENSG00000136709. [Q9C0J8-1]
ENST00000393006; ENSP00000376730; ENSG00000136709. [Q9C0J8-3]
ENST00000409658; ENSP00000387186; ENSG00000136709. [Q9C0J8-2]
GeneIDi55339.
KEGGihsa:55339.
UCSCiuc002tpg.2. human. [Q9C0J8-1]
uc002tph.2. human. [Q9C0J8-3]
uc002tpi.2. human. [Q9C0J8-2]

Polymorphism databases

DMDMi209572695.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB044749 mRNA. Translation: BAB32435.1 .
AK002156 mRNA. Translation: BAA92113.1 .
AK223319 mRNA. Translation: BAD97039.1 .
AC006011 Genomic DNA. Translation: AAX82033.1 .
CH471103 Genomic DNA. Translation: EAW95342.1 .
CH471103 Genomic DNA. Translation: EAW95343.1 .
BC005401 mRNA. Translation: AAH05401.1 . Different termination.
BC013990 mRNA. Translation: AAH13990.1 .
BC068484 mRNA. Translation: AAH68484.1 .
AL834365 mRNA. Translation: CAH10688.1 .
CCDSi CCDS2150.1. [Q9C0J8-1 ]
CCDS42746.1. [Q9C0J8-3 ]
CCDS46407.1. [Q9C0J8-2 ]
RefSeqi NP_001006623.1. NM_001006622.2. [Q9C0J8-2 ]
NP_001006624.1. NM_001006623.2. [Q9C0J8-3 ]
NP_060853.3. NM_018383.4. [Q9C0J8-1 ]
UniGenei Hs.554831.

3D structure databases

ProteinModelPortali Q9C0J8.
SMRi Q9C0J8. Positions 122-434.
ModBasei Search...

Protein-protein interaction databases

BioGridi 120620. 36 interactions.
IntActi Q9C0J8. 20 interactions.
MINTi MINT-1371235.
STRINGi 9606.ENSP00000325377.

PTM databases

PhosphoSitei Q9C0J8.

Polymorphism databases

DMDMi 209572695.

Proteomic databases

MaxQBi Q9C0J8.
PaxDbi Q9C0J8.
PRIDEi Q9C0J8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322313 ; ENSP00000325377 ; ENSG00000136709 . [Q9C0J8-1 ]
ENST00000393006 ; ENSP00000376730 ; ENSG00000136709 . [Q9C0J8-3 ]
ENST00000409658 ; ENSP00000387186 ; ENSG00000136709 . [Q9C0J8-2 ]
GeneIDi 55339.
KEGGi hsa:55339.
UCSCi uc002tpg.2. human. [Q9C0J8-1 ]
uc002tph.2. human. [Q9C0J8-3 ]
uc002tpi.2. human. [Q9C0J8-2 ]

Organism-specific databases

CTDi 55339.
GeneCardsi GC02M128458.
HGNCi HGNC:25651. WDR33.
HPAi HPA026897.
neXtProti NX_Q9C0J8.
PharmGKBi PA134943440.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000126810.
HOVERGENi HBG062379.
InParanoidi Q9C0J8.
KOi K15542.
OMAi TVMEVKL.
OrthoDBi EOG7QG43G.
PhylomeDBi Q9C0J8.
TreeFami TF317659.

Enzyme and pathway databases

SignaLinki Q9C0J8.

Miscellaneous databases

ChiTaRSi WDR33. human.
GeneWikii WDR33.
GenomeRNAii 55339.
NextBioi 59651.
PROi Q9C0J8.

Gene expression databases

ArrayExpressi Q9C0J8.
Bgeei Q9C0J8.
CleanExi HS_WDR33.
Genevestigatori Q9C0J8.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR008160. Collagen.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF01391. Collagen. 2 hits.
PF00400. WD40. 6 hits.
[Graphical view ]
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel WD40 repeat protein, WDC146, highly expressed during spermatogenesis in a stage-specific manner."
    Ito S., Sakai A., Nomura T., Miki Y., Ouchida M., Sasaki J., Shimizu K.
    Biochem. Biophys. Res. Commun. 280:656-663(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Small intestine.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain, Pancreas and Placenta.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1187-1336 (ISOFORM 1).
    Tissue: Melanoma.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1210, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Molecular architecture of the human pre-mRNA 3' processing complex."
    Shi Y., Di Giammartino D.C., Taylor D., Sarkeshik A., Rice W.J., Yates J.R. III, Frank J., Manley J.L.
    Mol. Cell 33:365-376(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE 3' PRE-MRNA END PROCESSING COMPLEX, SUBCELLULAR LOCATION, INTERACTION WITH CPSF3.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-46, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7 AND SER-1210, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWDR33_HUMAN
AccessioniPrimary (citable) accession number: Q9C0J8
Secondary accession number(s): Q05DP8
, Q53FG9, Q587J1, Q69YF7, Q6NUQ0, Q9NUL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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