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Protein

Thrombospondin type-1 domain-containing protein 7B

Gene

THSD7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-HSA-5083635. Defective B3GALTL causes Peters-plus syndrome (PpS).
R-HSA-5173214. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin type-1 domain-containing protein 7B
Gene namesi
Name:THSD7B
Synonyms:KIAA1679
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29348. THSD7B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 15571526ExtracellularSequence analysisAdd
BLAST
Transmembranei1558 – 157821HelicalSequence analysisAdd
BLAST
Topological domaini1579 – 160830CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi118574152.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 16081577Thrombospondin type-1 domain-containing protein 7BPRO_0000260251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence analysis
Disulfide bondi411 ↔ 477PROSITE-ProRule annotation
Disulfide bondi431 ↔ 481PROSITE-ProRule annotation
Disulfide bondi442 ↔ 466PROSITE-ProRule annotation
Disulfide bondi602 ↔ 643PROSITE-ProRule annotation
Disulfide bondi613 ↔ 617PROSITE-ProRule annotation
Disulfide bondi655 ↔ 660PROSITE-ProRule annotation
Glycosylationi683 – 6831N-linked (GlcNAc...)Sequence analysis
Disulfide bondi738 ↔ 779PROSITE-ProRule annotation
Disulfide bondi749 ↔ 753PROSITE-ProRule annotation
Glycosylationi757 – 7571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi789 ↔ 795PROSITE-ProRule annotation
Glycosylationi842 – 8421N-linked (GlcNAc...)Sequence analysis
Disulfide bondi872 ↔ 907PROSITE-ProRule annotation
Disulfide bondi883 ↔ 887PROSITE-ProRule annotation
Disulfide bondi921 ↔ 923PROSITE-ProRule annotation
Glycosylationi933 – 9331N-linked (GlcNAc...)Sequence analysis
Disulfide bondi937 ↔ 993PROSITE-ProRule annotation
Disulfide bondi959 ↔ 997PROSITE-ProRule annotation
Disulfide bondi970 ↔ 983PROSITE-ProRule annotation
Disulfide bondi1001 ↔ 1038PROSITE-ProRule annotation
Disulfide bondi1012 ↔ 1016PROSITE-ProRule annotation
Disulfide bondi1122 ↔ 1126PROSITE-ProRule annotation
Glycosylationi1188 – 11881N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1250 ↔ 1288PROSITE-ProRule annotation
Disulfide bondi1261 ↔ 1265PROSITE-ProRule annotation
Disulfide bondi1298 ↔ 1303PROSITE-ProRule annotation
Glycosylationi1310 – 13101N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1373 ↔ 1417PROSITE-ProRule annotation
Disulfide bondi1384 ↔ 1388PROSITE-ProRule annotation
Disulfide bondi1427 ↔ 1432PROSITE-ProRule annotation
Glycosylationi1458 – 14581N-linked (GlcNAc...)Sequence analysis
Glycosylationi1526 – 15261N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9C0I4.
PaxDbiQ9C0I4.
PeptideAtlasiQ9C0I4.
PRIDEiQ9C0I4.

PTM databases

iPTMnetiQ9C0I4.
PhosphoSiteiQ9C0I4.

Expressioni

Gene expression databases

BgeeiENSG00000144229.
CleanExiHS_THSD7B.
ExpressionAtlasiQ9C0I4. baseline and differential.
GenevisibleiQ9C0I4. HS.

Organism-specific databases

HPAiHPA051416.

Interactioni

Protein-protein interaction databases

IntActiQ9C0I4. 1 interaction.
STRINGi9606.ENSP00000272643.

Structurei

3D structure databases

ProteinModelPortaliQ9C0I4.
SMRiQ9C0I4. Positions 42-70, 109-274, 340-369, 482-839, 872-897, 999-1056, 1058-1178, 1188-1217, 1249-1433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 9859TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini102 – 17776TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini179 – 23355TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini336 – 39257TSP type-1 4PROSITE-ProRule annotationAdd
BLAST
Domaini399 – 48284TSP type-1 5PROSITE-ProRule annotationAdd
BLAST
Domaini484 – 54360TSP type-1 6PROSITE-ProRule annotationAdd
BLAST
Domaini601 – 66161TSP type-1 7PROSITE-ProRule annotationAdd
BLAST
Domaini662 – 73574TSP type-1 8PROSITE-ProRule annotationAdd
BLAST
Domaini737 – 79660TSP type-1 9PROSITE-ProRule annotationAdd
BLAST
Domaini797 – 86973TSP type-1 10PROSITE-ProRule annotationAdd
BLAST
Domaini871 – 92454TSP type-1 11PROSITE-ProRule annotationAdd
BLAST
Domaini925 – 99874TSP type-1 12PROSITE-ProRule annotationAdd
BLAST
Domaini1000 – 1127128TSP type-1 13PROSITE-ProRule annotationAdd
BLAST
Domaini1129 – 118355TSP type-1 14PROSITE-ProRule annotationAdd
BLAST
Domaini1184 – 124764TSP type-1 15PROSITE-ProRule annotationAdd
BLAST
Domaini1249 – 130456TSP type-1 16PROSITE-ProRule annotationAdd
BLAST
Domaini1305 – 137066TSP type-1 17PROSITE-ProRule annotationAdd
BLAST
Domaini1372 – 143362TSP type-1 18PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi584 – 5896Poly-Pro

Sequence similaritiesi

Contains 18 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3538. Eukaryota.
ENOG410XR0P. LUCA.
HOGENOMiHOG000154569.
HOVERGENiHBG094038.
InParanoidiQ9C0I4.
OrthoDBiEOG091G00BM.
PhylomeDBiQ9C0I4.
TreeFamiTF329791.

Family and domain databases

InterProiIPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00090. TSP_1. 8 hits.
[Graphical view]
SMARTiSM00209. TSP1. 16 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 12 hits.
PROSITEiPS50092. TSP1. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9C0I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPKSNLTVT CWVWRSMRKL FLLLSLLLSH AAHLEGKKDN QFIWKTGPWG
60 70 80 90 100
RCTGDCGPGG VQSRAVWCFH VDGWTSHLSN CGESNRPPKE RSCFRVCDWH
110 120 130 140 150
SDLFQWEVSD WHHCVLVPYA RGEVKPRTAE CVTAQHGLQH RMVRCIQKLN
160 170 180 190 200
RTVVANEICE HFALQPPTEQ ACLIPCPRDC VVSEFLPWSN CSKGCGKKLQ
210 220 230 240 250
HRTRAVIAPP LFGGLQCPNL TESRACDAPI SCPLGEEEYT FSLKVGPWSK
260 270 280 290 300
CRLPHLKEIN PSGRTVLDFN SDSNERVTFK HQSYKAHHHS KSWAIEIGYQ
310 320 330 340 350
TRQVSCTRSD GQNAMLSLCL QDSFPLTVQS CIMPKDCETS QWSSWSPCSK
360 370 380 390 400
TCRSGSLLPG FRSRSRNVKH MAIGGGKECP ELLEKEACIV EGELLQQCPR
410 420 430 440 450
YSWRTSEWKE CQVSLLLEQQ DPHWHVTGPV CGGGIQTREV YCAQSVPAAA
460 470 480 490 500
ALRAKEVSRP VEKALCVGPA PLPSQLCNIP CSTDCIVSSW SAWGLCIHEN
510 520 530 540 550
CHDPQGKKGF RTRQRHVLME STGPAGHCPH LVESVPCEDP MCYRWLASEG
560 570 580 590 600
ICFPDHGKCG LGHRILKAVC QNDRGEDVSG SLCPVPPPPE RKSCEIPCRM
610 620 630 640 650
DCVLSEWTEW SSCSQSCSNK NSDGKQTRSR TILALAGEGG KPCPPSQALQ
660 670 680 690 700
EHRLCNDHSC MQLHWETSPW GPCSEDTLVT ALNATIGWNG EATCGVGIQT
710 720 730 740 750
RRVFCVKSHV GQVMTKRCPD STRPETVRPC FLPCKKDCIV TAFSEWTPCP
760 770 780 790 800
RMCQAGNATV KQSRYRIIIQ EAANGGQECP DTLYEERECE DVSLCPVYRW
810 820 830 840 850
KPQKWSPCIL VPESVWQGIT GSSEACGKGL QTRAVSCISD DNRSAEMMEC
860 870 880 890 900
LKQTNGMPLL VQECTVPCRE DCTFTAWSKF TPCSTNCEAT KSRRRQLTGK
910 920 930 940 950
SRKKEKCQDS DLYPLVETEL CPCDEFISQP YGNWSDCILP EGRREPHRGL
960 970 980 990 1000
RVQADSKECG EGLRFRAVAC SDKNGRPVDP SFCSSSGYIQ EKCVIPCPFD
1010 1020 1030 1040 1050
CKLSDWSSWG SCSSSCGIGV RIRSKWLKEK PYNGGRPCPK LDLKNQAQVH
1060 1070 1080 1090 1100
EAVPCYSECN QYSWVVEHWS SCKINNELRS LRCGGGTQSR KIRCVNTADG
1110 1120 1130 1140 1150
EGGAVDSNLC NQDEIPPETQ SCSLMCPNEC VMSEWGLWSK CPQSCDPHTM
1160 1170 1180 1190 1200
QRRTRHLLRP SLNSRTCAED SQVQPCLLNE NCFQFQYNLT EWSTCQLSEN
1210 1220 1230 1240 1250
APCGQGVRTR LLSCVCSDGK PVSMDQCEQH NLEKPQRMSI PCLVECVVNC
1260 1270 1280 1290 1300
QLSGWTAWTE CSQTCGHGGR MSRTRFIIMP TQGEGRPCPT ELTQEKTCPV
1310 1320 1330 1340 1350
TPCYSWVLGN WSACKLEGGD CGEGVQIRSL SCMVHSGSIS HAAGRVEDAL
1360 1370 1380 1390 1400
CGEMPFQDSI LKQLCSVPCP GDCHLTEWSE WSTCELTCID GRSFETVGRQ
1410 1420 1430 1440 1450
SRSRTFIIQS FENQDSCPQQ VLETRPCTGG KCYHYTWKAS LWNNNERTVW
1460 1470 1480 1490 1500
CQRSDGVNVT GGCSPQARPA AIRQCIPACR KPFSYCTQGG VCGCEKGYTE
1510 1520 1530 1540 1550
IMKSNGFLDY CMKVPGSEDK KADVKNLSGK NRPVNSKIHD IFKGWSLQPL
1560 1570 1580 1590 1600
DPDGRVKIWV YGVSGGAFLI MIFLIFTSYL VCKKPKPHQS TPPQQKPLTL

AYDGDLDM
Length:1,608
Mass (Da):179,402
Last modified:November 28, 2006 - v2
Checksum:i66D147D6E5B883AA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti503 – 5031D → E in BAB21770 (PubMed:11214970).Curated
Sequence conflicti1503 – 15031K → R in BAB21770 (PubMed:11214970).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010873 Genomic DNA. No translation available.
AC012000 Genomic DNA. No translation available.
AB051466 mRNA. Translation: BAB21770.1.
UniGeneiHs.68533.

Genome annotation databases

EnsembliENST00000272643; ENSP00000272643; ENSG00000144229.
UCSCiuc061ocl.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010873 Genomic DNA. No translation available.
AC012000 Genomic DNA. No translation available.
AB051466 mRNA. Translation: BAB21770.1.
UniGeneiHs.68533.

3D structure databases

ProteinModelPortaliQ9C0I4.
SMRiQ9C0I4. Positions 42-70, 109-274, 340-369, 482-839, 872-897, 999-1056, 1058-1178, 1188-1217, 1249-1433.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9C0I4. 1 interaction.
STRINGi9606.ENSP00000272643.

PTM databases

iPTMnetiQ9C0I4.
PhosphoSiteiQ9C0I4.

Polymorphism and mutation databases

DMDMi118574152.

Proteomic databases

EPDiQ9C0I4.
PaxDbiQ9C0I4.
PeptideAtlasiQ9C0I4.
PRIDEiQ9C0I4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272643; ENSP00000272643; ENSG00000144229.
UCSCiuc061ocl.1. human.

Organism-specific databases

GeneCardsiTHSD7B.
H-InvDBHIX0018369.
HGNCiHGNC:29348. THSD7B.
HPAiHPA051416.
neXtProtiNX_Q9C0I4.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3538. Eukaryota.
ENOG410XR0P. LUCA.
HOGENOMiHOG000154569.
HOVERGENiHBG094038.
InParanoidiQ9C0I4.
OrthoDBiEOG091G00BM.
PhylomeDBiQ9C0I4.
TreeFamiTF329791.

Enzyme and pathway databases

ReactomeiR-HSA-5083635. Defective B3GALTL causes Peters-plus syndrome (PpS).
R-HSA-5173214. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

ChiTaRSiTHSD7B. human.
PROiQ9C0I4.

Gene expression databases

BgeeiENSG00000144229.
CleanExiHS_THSD7B.
ExpressionAtlasiQ9C0I4. baseline and differential.
GenevisibleiQ9C0I4. HS.

Family and domain databases

InterProiIPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00090. TSP_1. 8 hits.
[Graphical view]
SMARTiSM00209. TSP1. 16 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 12 hits.
PROSITEiPS50092. TSP1. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHS7B_HUMAN
AccessioniPrimary (citable) accession number: Q9C0I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: September 7, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.