Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SRC kinase signaling inhibitor 1

Gene

SRCIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.3 Publications

GO - Molecular functioni

  • protein domain specific binding Source: Ensembl
  • protein kinase binding Source: UniProtKB

GO - Biological processi

  • exocytosis Source: UniProtKB-KW
  • negative regulation of protein secretion Source: Ensembl
  • negative regulation of protein tyrosine kinase activity Source: UniProtKB
  • positive regulation of protein tyrosine kinase activity Source: UniProtKB
  • regulation of cell migration Source: UniProtKB
  • regulation of dendritic spine morphogenesis Source: UniProtKB
  • substrate adhesion-dependent cell spreading Source: UniProtKB

Keywordsi

Biological processExocytosis

Enzyme and pathway databases

SIGNORiQ9C0H9.

Names & Taxonomyi

Protein namesi
Recommended name:
SRC kinase signaling inhibitor 1
Alternative name(s):
SNAP-25-interacting protein
Short name:
SNIP
p130Cas-associated protein
p140Cap
Gene namesi
Name:SRCIN1
Synonyms:KIAA1684, P140
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000277363.4.
HGNCiHGNC:29506. SRCIN1.
MIMi610786. gene.
neXtProtiNX_Q9C0H9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi80725.
OpenTargetsiENSG00000277363.
PharmGKBiPA165432823.

Chemistry databases

ChEMBLiCHEMBL2150836.

Polymorphism and mutation databases

BioMutaiSRCIN1.
DMDMi296452948.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720111 – 1183SRC kinase signaling inhibitor 1Add BLAST1183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineCombined sources1
Modified residuei52PhosphothreonineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei64PhosphoserineCombined sources1
Modified residuei225PhosphoserineBy similarity1
Modified residuei241PhosphotyrosineBy similarity1
Modified residuei298PhosphoserineBy similarity1
Modified residuei307PhosphoserineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei329Omega-N-methylarginineBy similarity1
Modified residuei336Omega-N-methylarginineBy similarity1
Modified residuei343PhosphoserineBy similarity1
Modified residuei362PhosphoserineBy similarity1
Modified residuei364PhosphoserineCombined sources1
Modified residuei396PhosphotyrosineBy similarity1
Modified residuei493PhosphoserineBy similarity1
Modified residuei496PhosphoserineBy similarity1
Modified residuei500PhosphoserineBy similarity1
Modified residuei501Omega-N-methylarginineBy similarity1
Modified residuei503PhosphoserineBy similarity1
Modified residuei513PhosphoserineBy similarity1
Modified residuei515PhosphoserineBy similarity1
Modified residuei517PhosphoserineBy similarity1
Modified residuei522PhosphoserineBy similarity1
Modified residuei598PhosphoserineBy similarity1
Modified residuei621PhosphoserineBy similarity1
Modified residuei624PhosphothreonineBy similarity1
Modified residuei637PhosphothreonineBy similarity1
Modified residuei844PhosphoserineBy similarity1
Modified residuei857PhosphoserineCombined sources1
Modified residuei866PhosphoserineCombined sources1
Modified residuei884PhosphothreonineCombined sources1
Modified residuei987PhosphoserineBy similarity1
Modified residuei1043PhosphoserineBy similarity1
Modified residuei1060PhosphoserineBy similarity1

Post-translational modificationi

Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9C0H9.
MaxQBiQ9C0H9.
PaxDbiQ9C0H9.
PeptideAtlasiQ9C0H9.
PRIDEiQ9C0H9.

PTM databases

iPTMnetiQ9C0H9.
PhosphoSitePlusiQ9C0H9.

Expressioni

Tissue specificityi

Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.1 Publication

Gene expression databases

BgeeiENSG00000277363.
ExpressionAtlasiQ9C0H9. baseline and differential.

Organism-specific databases

HPAiHPA009701.
HPA063795.

Interactioni

Subunit structurei

Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas and SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3.By similarity4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein domain specific binding Source: Ensembl
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123275. 11 interactors.
ELMiQ9C0H9.
IntActiQ9C0H9. 4 interactors.
MINTiQ9C0H9.
STRINGi9606.ENSP00000264659.

Structurei

3D structure databases

ProteinModelPortaliQ9C0H9.
SMRiQ9C0H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni647 – 697Interaction with SNAP25By similarityAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili654 – 674Sequence analysisAdd BLAST21
Coiled coili726 – 746Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi471 – 504Pro-richAdd BLAST34
Compositional biasi956 – 1014Pro-richAdd BLAST59

Sequence similaritiesi

Belongs to the SRCIN1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHFG. Eukaryota.
ENOG410XTBA. LUCA.
GeneTreeiENSGT00390000012399.
HOGENOMiHOG000293351.
HOVERGENiHBG019587.
InParanoidiQ9C0H9.
KOiK19930.
OrthoDBiEOG091G00Q1.
PhylomeDBiQ9C0H9.
TreeFamiTF332255.

Family and domain databases

InterProiView protein in InterPro
IPR022782. AIP3_C.
IPR026727. Srcin1.
PANTHERiPTHR22741:SF5. PTHR22741:SF5. 1 hit.
PfamiView protein in Pfam
PF03915. AIP3. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0H9-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNAPSQDPE RSSPPMLSAD DAEYPREYRT LGGGGGGGSG GRRFSNVGLV
60 70 80 90 100
HTSERRHTVI AAQSLEALSG LQKADADRKR DAFMDHLKSK YPQHALALRG
110 120 130 140 150
QQDRMREQPN YWSFKTRSSR HTQGAQPGLA DQAAKLSYAS AESLETMSEA
160 170 180 190 200
ELPLGFSRMN RFRQSLPLSR SASQTKLRSP GVLFLQFGEE TRRVHITHEV
210 220 230 240 250
SSLDTLHALI AHMFPQKLTM GMLKSPNTAI LIKDEARNVF YELEDVRDIQ
260 270 280 290 300
DRSIIKIYRK EPLYAAFPGS HLTNGDLRRE MVYASRESSP TRRLNNLSPA
310 320 330 340 350
PHLASGSPPP GLPSGLPSGL QSGSPSRSRL SYAGGRPPSY AGSPVHHAAE
360 370 380 390 400
RLGGAPAAQG VSPSPSAILE RRDVKPDEDL ASKAGGMVLV KGEGLYADPY
410 420 430 440 450
GLLHEGRLSL AAAAGDPFAY PGAGGLYKRG SVRSLSTYSA AALQSDLEDS
460 470 480 490 500
LYKAAGGGGP LYGDGYGFRL PPSSPQKLAD VAAPPGGPPP PHSPYSGPPS
510 520 530 540 550
RGSPVRQSFR KDSGSSSVFA ESPGGKTRSA GSASTAGAPP SELFPGPGER
560 570 580 590 600
SLVGFGPPVP AKDTETRERM EAMEKQIASL TGLVQSALLR GSEPETPSEK
610 620 630 640 650
IEGSNGAATP SAPCGSGGRS SGATPVSGPP PPSASSTPAG QPTAVSRLQM
660 670 680 690 700
QLHLRGLQNS ASDLRGQLQQ LRKLQLQNQE SVRALLKRTE AELSMRVSEA
710 720 730 740 750
ARRQEDPLQR QRTLVEEERL RYLNDEELIT QQLNDLEKSV EKIQRDVSHN
760 770 780 790 800
HRLVPGPELE EKALVLKQLG ETLTELKAHF PGLQSKMRVV LRVEVEAVKF
810 820 830 840 850
LKEEPQRLDG LLKRCRGVTD TLAQIRRQVD EGVWPPPNNL LSQSPKKVTA
860 870 880 890 900
ETDFNKSVDF EMPPPSPPLN LHELSGPAEG ASLTPKGGNP TKGLDTPGKR
910 920 930 940 950
SVDKAVSVEA AERDWEEKRA ALTQYSAKDI NRLLEETQAE LLKAIPDLDC
960 970 980 990 1000
ASKAHPGPAP TPDHKPPKAP HGQKAAPRTE PSGRRGSDEL TVPRYRTEKP
1010 1020 1030 1040 1050
SKSPPPPPPR RSFPSSHGLT TTRTGEVVVT SKKDSAFIKK AESEELEVQK
1060 1070 1080 1090 1100
PQVKLRRAVS EVARPASTPP IMASAIKDED DEDRIIAELE SGGGSVPPMK
1110 1120 1130 1140 1150
VVTPGASRLK AAQGQAGSPD KSKHGKQRAE YMRIQAQQQA TKPSKEMSGS
1160 1170 1180
NETSSPVSEK PSASRTSIPV LTSFGARNSS ISF
Length:1,183
Mass (Da):127,105
Last modified:March 28, 2018 - v4
Checksum:i52BF566E715EF6FF
GO
Isoform 2Curated (identifier: Q9C0H9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-180: MGNAPSQDPE...SASQTKLRSP → MRGAWVHLHS...SDSEGGVSFA
     1141-1183: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,012
Mass (Da):107,997
Checksum:i0B1EEB2BFB499E47
GO
Isoform 3 (identifier: Q9C0H9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-694: Missing.
     910-951: AAERDWEEKR...LKAIPDLDCA → VLGPGIVGGA...FFLGGGGPVP
     952-1183: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:257
Mass (Da):28,590
Checksum:iFA12D8010D0C52D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177L → P in BAD03968 (Ref. 1) Curated1
Sequence conflicti442Missing AA sequence (PubMed:14657239).Curated1
Sequence conflicti609T → I in BAC86634 (PubMed:14702039).Curated1
Sequence conflicti720L → I AA sequence (PubMed:14657239).Curated1
Sequence conflicti833V → M AA sequence (PubMed:14657239).Curated1
Sequence conflicti841 – 842LS → IN AA sequence (PubMed:14657239).Curated2
Sequence conflicti971H → E AA sequence (PubMed:14657239).Curated1
Sequence conflicti978R → K AA sequence (PubMed:14657239).Curated1
Sequence conflicti995Y → R AA sequence (PubMed:14657239).Curated1
Sequence conflicti1086I → L AA sequence (PubMed:14657239).Curated1
Sequence conflicti1115Q → P AA sequence (PubMed:14657239).Curated1
Sequence conflicti1122S → G AA sequence (PubMed:14657239).Curated1
Sequence conflicti1140A → V in BAC86634 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0594501 – 694Missing in isoform 3. Add BLAST694
Alternative sequenceiVSP_0594511 – 180MGNAP…KLRSP → MRGAWVHLHSGAASSLRPCR CGAGAAPKSSPRSPGGRRGD GSSDSEGGVSFA in isoform 2. Add BLAST180
Alternative sequenceiVSP_059452910 – 951AAERD…DLDCA → VLGPGIVGGAMSQVHTFLRP SFLEWGVPILWVFFLGGGGP VP in isoform 3. Add BLAST42
Alternative sequenceiVSP_059453952 – 1183Missing in isoform 3. Add BLAST232
Alternative sequenceiVSP_0594541141 – 1183Missing in isoform 2. Add BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB127405 mRNA. Translation: BAD03968.1.
AK126665 mRNA. Translation: BAC86634.1.
AC006449 Genomic DNA. No translation available.
AC115090 Genomic DNA. No translation available.
AC129916 Genomic DNA. No translation available.
AC244153 Genomic DNA. No translation available.
KC877653 Genomic DNA. No translation available.
BC033233 mRNA. Translation: AAH33233.1.
AB051471 mRNA. Translation: BAB21775.1.
CCDSiCCDS45660.1. [Q9C0H9-5]
RefSeqiNP_079524.2. NM_025248.2. [Q9C0H9-5]
UniGeneiHs.448872.

Genome annotation databases

EnsembliENST00000615049; ENSP00000480869; ENSG00000273608. [Q9C0H9-5]
ENST00000617146; ENSP00000484715; ENSG00000277363. [Q9C0H9-5]
GeneIDi80725.
KEGGihsa:80725.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSRCN1_HUMAN
AccessioniPrimary (citable) accession number: Q9C0H9
Secondary accession number(s): Q75T46, Q8N4W8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 28, 2018
Last modified: March 28, 2018
This is version 142 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome