Q9C0H9 (SRCN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SRC kinase signaling inhibitor 1

Alternative name(s):
SNAP-25-interacting protein
Short name=SNIP
p130Cas-associated protein
p140Cap

Gene names

Name:	SRCIN1
Synonyms:	KIAA1684, P140

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1055 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. Ref.6 Ref.7 Ref.10
Subunit structure	Interacts with the N-terminal coiled-coil region of SNAP25 By similarity. Interacts with BCAR1/p130Cas and SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3. Ref.6 Ref.7 Ref.9 Ref.10
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton. Cell projection › axon By similarity. Cell projection › dendrite By similarity. Cell junction › synapse By similarity. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density By similarity. Note: Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and in postsynaptic density fractions. Ref.6 Ref.10
Tissue specificity	Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue. Ref.8
Post-translational modification	Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands. Ref.6
Sequence similarities	Belongs to the SRCIN1 family.

Ontologies

Keywords
Biological process	Exocytosis
Cellular component	Cell junction Cell membrane Cell projection Cytoplasm Cytoskeleton Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	exocytosis Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of cell adhesion Inferred from electronic annotation. Source: Compara negative regulation of protein secretion Inferred from electronic annotation. Source: Compara negative regulation of protein tyrosine kinase activity Inferred from direct assay Ref.7. Source: UniProtKB positive regulation of protein tyrosine kinase activity Inferred from direct assay Ref.7. Source: UniProtKB regulation of cell migration Inferred from mutant phenotype Ref.7. Source: UniProtKB regulation of dendritic spine morphogenesis Inferred from mutant phenotype Ref.10. Source: UniProtKB substrate adhesion-dependent cell spreading Inferred from mutant phenotype Ref.7. Source: UniProtKB
Cellular_component	actin cytoskeleton Inferred from direct assay Ref.6. Source: MGI axon Inferred from sequence or structural similarity. Source: UniProtKB cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasm Inferred from direct assay Ref.10. Source: UniProtKB filopodium Inferred from electronic annotation. Source: Compara lamellipodium Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic density Inferred from sequence or structural similarity. Source: UniProtKB postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	protein kinase binding Inferred from direct assay Ref.7. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BCAR1	P56945	3	EBI-1393949,EBI-702093
SRC	P12931	3	EBI-1393949,EBI-621482

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9C0H9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9C0H9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1012-1055: ATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNSSISF → V

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9C0H9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-566: Missing.
     782-823: AAERDWEEKR...LKAIPDLDCA → VLGPGIVGGA...FFLGGGGPVP
     824-1055: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9C0H9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MRGAWVHLHS...SDSEGGVSFA → MGNAPSQDPE...SASQTKLRSP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1055	1055	SRC kinase signaling inhibitor 1		PRO_0000072011
Regions
	Region	519 – 569	51	Interaction with SNAP25 By similarity
	Coiled coil	433 – 460	28	Potential
	Coiled coil	521 – 546	26	Potential
	Coiled coil	588 – 650	63	Potential
	Compositional bias	343 – 376	34	Pro-rich
	Compositional bias	828 – 886	59	Pro-rich
Amino acid modifications
	Modified residue	97	1	Phosphoserine By similarity
	Modified residue	113	1	Phosphotyrosine By similarity
	Modified residue	179	1	Phosphoserine By similarity
	Modified residue	215	1	Phosphoserine By similarity
	Modified residue	234	1	Phosphoserine By similarity
	Modified residue	268	1	Phosphotyrosine By similarity
	Modified residue	385	1	Phosphoserine By similarity
	Modified residue	394	1	Phosphoserine By similarity
	Modified residue	476	1	Phosphoserine By similarity
	Modified residue	509	1	Phosphothreonine By similarity
	Modified residue	738	1	Phosphoserine By similarity
	Modified residue	779	1	Phosphoserine By similarity
	Modified residue	859	1	Phosphoserine By similarity
	Modified residue	915	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 566	566	Missing in isoform 3.		VSP_009366
	Alternative sequence	1 – 52	52	MRGAW…GVSFA → MGNAPSQDPERSSPPMLSAD DAEYPREYRTLGGGGGGGSG GRRFSNVGLVHTSERRHTVI AAQSLEALSGLQKADADRKR DAFMDHLKSKYPQHALALRG QQDRMREQPNYWSFKTRSSR HTQGAQPGLADQAAKLSYAS AESLETMSEAELPLGFSRMN RFRQSLPLSRSASQTKLRSP in isoform 4.		VSP_039240
	Alternative sequence	782 – 823	42	AAERD…DLDCA → VLGPGIVGGAMSQVHTFLRP SFLEWGVPILWVFFLGGGGP VP in isoform 3.		VSP_009367
	Alternative sequence	824 – 1055	232	Missing in isoform 3.		VSP_009368
	Alternative sequence	1012 – 1055	44	ATKPS…SSISF → V in isoform 2.		VSP_050630
Experimental info
	Sequence conflict	314	1	Missing AA sequence Ref.6
	Sequence conflict	481	1	T → I in BAC86634. Ref.2
	Sequence conflict	592	1	L → I AA sequence Ref.6
	Sequence conflict	705	1	V → M AA sequence Ref.6
	Sequence conflict	713 – 714	2	LS → IN AA sequence Ref.6
	Sequence conflict	843	1	H → E AA sequence Ref.6
	Sequence conflict	850	1	R → K AA sequence Ref.6
	Sequence conflict	867	1	Y → R AA sequence Ref.6
	Sequence conflict	958	1	I → L AA sequence Ref.6
	Sequence conflict	987	1	Q → P AA sequence Ref.6
	Sequence conflict	994	1	S → G AA sequence Ref.6
Isoform 4:
	Sequence conflict	177	1	L → P in BAD03968. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: CAB346DA20883EBD	FASTA	1,055	112,453
	10 20 30 40 50 60 MRGAWVHLHS GAASSLRPCR CGAGAAPKSS PRSPGGRRGD GSSDSEGGVS FAGVLFLQFG 70 80 90 100 110 120 EETRRVHITH EVSSLDTLHA LIAHMFPQKL TMGMLKSPNT AILIKDEARN VFYELEDVRD 130 140 150 160 170 180 IQDRSIIKIY RKEPLYAAFP GSHLTNGDLR REMVYASRES SPTRRLNNLS PAPHLASGSP 190 200 210 220 230 240 PPGLPSGLPS GLQSGSPSRS RLSYAGGRPP SYAGSPVHHA AERLGGAPAA QGVSPSPSAI 250 260 270 280 290 300 LERRDVKPDE DLASKAGGMV LVKGEGLYAD PYGLLHEGRL SLAAAAGDPF AYPGAGGLYK 310 320 330 340 350 360 RGSVRSLSTY SAAALQSDLE DSLYKAAGGG GPLYGDGYGF RLPPSSPQKL ADVAAPPGGP 370 380 390 400 410 420 PPPHSPYSGP PSRGSPVRQS FRKDSGSSSV FAESPGGKTR SAGSASTAGA PPSELFPGPG 430 440 450 460 470 480 ERSLVGFGPP VPAKDTETRE RMEAMEKQIA SLTGLVQSAL LRGSEPETPS EKIEGSNGAA 490 500 510 520 530 540 TPSAPCGSGG RSSGATPVSG PPPPSASSTP AGQPTAVSRL QMQLHLRGLQ NSASDLRGQL 550 560 570 580 590 600 QQLRKLQLQN QESVRALLKR TEAELSMRVS EAARRQEDPL QRQRTLVEEE RLRYLNDEEL 610 620 630 640 650 660 ITQQLNDLEK SVEKIQRDVS HNHRLVPGPE LEEKALVLKQ LGETLTELKA HFPGLQSKMR 670 680 690 700 710 720 VVLRVEVEAV KFLKEEPQRL DGLLKRCRGV TDTLAQIRRQ VDEGVWPPPN NLLSQSPKKV 730 740 750 760 770 780 TAETDFNKSV DFEMPPPSPP LNLHELSGPA EGASLTPKGG NPTKGLDTPG KRSVDKAVSV 790 800 810 820 830 840 EAAERDWEEK RAALTQYSAK DINRLLEETQ AELLKAIPDL DCASKAHPGP APTPDHKPPK 850 860 870 880 890 900 APHGQKAAPR TEPSGRRGSD ELTVPRYRTE KPSKSPPPPP PRRSFPSSHG LTTTRTGEVV 910 920 930 940 950 960 VTSKKDSAFI KKAESEELEV QKPQVKLRRA VSEVARPAST PPIMASAIKD EDDEDRIIAE 970 980 990 1000 1010 1020 LESGGGSVPP MKVVTPGASR LKAAQGQAGS PDKSKHGKQR AEYMRIQAQQ QATKPSKEMS 1030 1040 1050 GSNETSSPVS EKPSASRTSI PVLTSFGARN SSISF
	Isoform 2 [UniParc]. Checksum: 140EEB2BFB499E47	FASTA	1,012	108,025
	10 20 30 40 50 60 MRGAWVHLHS GAASSLRPCR CGAGAAPKSS PRSPGGRRGD GSSDSEGGVS FAGVLFLQFG 70 80 90 100 110 120 EETRRVHITH EVSSLDTLHA LIAHMFPQKL TMGMLKSPNT AILIKDEARN VFYELEDVRD 130 140 150 160 170 180 IQDRSIIKIY RKEPLYAAFP GSHLTNGDLR REMVYASRES SPTRRLNNLS PAPHLASGSP 190 200 210 220 230 240 PPGLPSGLPS GLQSGSPSRS RLSYAGGRPP SYAGSPVHHA AERLGGAPAA QGVSPSPSAI 250 260 270 280 290 300 LERRDVKPDE DLASKAGGMV LVKGEGLYAD PYGLLHEGRL SLAAAAGDPF AYPGAGGLYK 310 320 330 340 350 360 RGSVRSLSTY SAAALQSDLE DSLYKAAGGG GPLYGDGYGF RLPPSSPQKL ADVAAPPGGP 370 380 390 400 410 420 PPPHSPYSGP PSRGSPVRQS FRKDSGSSSV FAESPGGKTR SAGSASTAGA PPSELFPGPG 430 440 450 460 470 480 ERSLVGFGPP VPAKDTETRE RMEAMEKQIA SLTGLVQSAL LRGSEPETPS EKIEGSNGAA 490 500 510 520 530 540 TPSAPCGSGG RSSGATPVSG PPPPSASSTP AGQPTAVSRL QMQLHLRGLQ NSASDLRGQL 550 560 570 580 590 600 QQLRKLQLQN QESVRALLKR TEAELSMRVS EAARRQEDPL QRQRTLVEEE RLRYLNDEEL 610 620 630 640 650 660 ITQQLNDLEK SVEKIQRDVS HNHRLVPGPE LEEKALVLKQ LGETLTELKA HFPGLQSKMR 670 680 690 700 710 720 VVLRVEVEAV KFLKEEPQRL DGLLKRCRGV TDTLAQIRRQ VDEGVWPPPN NLLSQSPKKV 730 740 750 760 770 780 TAETDFNKSV DFEMPPPSPP LNLHELSGPA EGASLTPKGG NPTKGLDTPG KRSVDKAVSV 790 800 810 820 830 840 EAAERDWEEK RAALTQYSAK DINRLLEETQ AELLKAIPDL DCASKAHPGP APTPDHKPPK 850 860 870 880 890 900 APHGQKAAPR TEPSGRRGSD ELTVPRYRTE KPSKSPPPPP PRRSFPSSHG LTTTRTGEVV 910 920 930 940 950 960 VTSKKDSAFI KKAESEELEV QKPQVKLRRA VSEVARPAST PPIMASAIKD EDDEDRIIAE 970 980 990 1000 1010 LESGGGSVPP MKVVTPGASR LKAAQGQAGS PDKSKHGKQR AEYMRIQAQQ QV
	Isoform 3 [UniParc]. Checksum: FA12D8010D0C52D4	FASTA	257	28,590
	10 20 30 40 50 60 MRVSEAARRQ EDPLQRQRTL VEEERLRYLN DEELITQQLN DLEKSVEKIQ RDVSHNHRLV 70 80 90 100 110 120 PGPELEEKAL VLKQLGETLT ELKAHFPGLQ SKMRVVLRVE VEAVKFLKEE PQRLDGLLKR 130 140 150 160 170 180 CRGVTDTLAQ IRRQVDEGVW PPPNNLLSQS PKKVTAETDF NKSVDFEMPP PSPPLNLHEL 190 200 210 220 230 240 SGPAEGASLT PKGGNPTKGL DTPGKRSVDK AVSVEVLGPG IVGGAMSQVH TFLRPSFLEW 250 GVPILWVFFL GGGGPVP
	Isoform 4 [UniParc]. Checksum: 52BF566E715EF6FF	FASTA	1,183	127,105
	10 20 30 40 50 60 MGNAPSQDPE RSSPPMLSAD DAEYPREYRT LGGGGGGGSG GRRFSNVGLV HTSERRHTVI 70 80 90 100 110 120 AAQSLEALSG LQKADADRKR DAFMDHLKSK YPQHALALRG QQDRMREQPN YWSFKTRSSR 130 140 150 160 170 180 HTQGAQPGLA DQAAKLSYAS AESLETMSEA ELPLGFSRMN RFRQSLPLSR SASQTKLRSP 190 200 210 220 230 240 GVLFLQFGEE TRRVHITHEV SSLDTLHALI AHMFPQKLTM GMLKSPNTAI LIKDEARNVF 250 260 270 280 290 300 YELEDVRDIQ DRSIIKIYRK EPLYAAFPGS HLTNGDLRRE MVYASRESSP TRRLNNLSPA 310 320 330 340 350 360 PHLASGSPPP GLPSGLPSGL QSGSPSRSRL SYAGGRPPSY AGSPVHHAAE RLGGAPAAQG 370 380 390 400 410 420 VSPSPSAILE RRDVKPDEDL ASKAGGMVLV KGEGLYADPY GLLHEGRLSL AAAAGDPFAY 430 440 450 460 470 480 PGAGGLYKRG SVRSLSTYSA AALQSDLEDS LYKAAGGGGP LYGDGYGFRL PPSSPQKLAD 490 500 510 520 530 540 VAAPPGGPPP PHSPYSGPPS RGSPVRQSFR KDSGSSSVFA ESPGGKTRSA GSASTAGAPP 550 560 570 580 590 600 SELFPGPGER SLVGFGPPVP AKDTETRERM EAMEKQIASL TGLVQSALLR GSEPETPSEK 610 620 630 640 650 660 IEGSNGAATP SAPCGSGGRS SGATPVSGPP PPSASSTPAG QPTAVSRLQM QLHLRGLQNS 670 680 690 700 710 720 ASDLRGQLQQ LRKLQLQNQE SVRALLKRTE AELSMRVSEA ARRQEDPLQR QRTLVEEERL 730 740 750 760 770 780 RYLNDEELIT QQLNDLEKSV EKIQRDVSHN HRLVPGPELE EKALVLKQLG ETLTELKAHF 790 800 810 820 830 840 PGLQSKMRVV LRVEVEAVKF LKEEPQRLDG LLKRCRGVTD TLAQIRRQVD EGVWPPPNNL 850 860 870 880 890 900 LSQSPKKVTA ETDFNKSVDF EMPPPSPPLN LHELSGPAEG ASLTPKGGNP TKGLDTPGKR 910 920 930 940 950 960 SVDKAVSVEA AERDWEEKRA ALTQYSAKDI NRLLEETQAE LLKAIPDLDC ASKAHPGPAP 970 980 990 1000 1010 1020 TPDHKPPKAP HGQKAAPRTE PSGRRGSDEL TVPRYRTEKP SKSPPPPPPR RSFPSSHGLT 1030 1040 1050 1060 1070 1080 TTRTGEVVVT SKKDSAFIKK AESEELEVQK PQVKLRRAVS EVARPASTPP IMASAIKDED 1090 1100 1110 1120 1130 1140 DEDRIIAELE SGGGSVPPMK VVTPGASRLK AAQGQAGSPD KSKHGKQRAE YMRIQAQQQA 1150 1160 1170 1180 TKPSKEMSGS NETSSPVSEK PSASRTSIPV LTSFGARNSS ISF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens cDNA, SNIP homolog." Sugiyama A., Inoue H., Oka M. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Cerebellum.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Eye.
[5]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 294-1055 (ISOFORM 1). Tissue: Brain.
[6]	"p130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading." Di Stefano P., Cabodi S., Erba E.B., Margaria V., Bergatto E., Giuffrida M.G., Silengo L., Tarone G., Turco E., Defilippi P. Mol. Biol. Cell 15:787-800(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 306-325; 492-519; 583-593; 611-617; 700-719; 841-867; 884-895; 957-972; 983-1000 AND 1006-1017 (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BCAR1, PHOSPHORYLATION.
[7]	"p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity." Di Stefano P., Damiano L., Cabodi S., Aramu S., Tordella L., Praduroux A., Piva R., Cavallo F., Forni G., Silengo L., Tarone G., Turco E., Defilippi P. EMBO J. 26:2843-2855(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CSK AND SRC.
[8]	"SNIP/p140Cap mRNA expression is an unfavourable prognostic factor in breast cancer and is not expressed in normal breast tissue." Kennedy S., Clynes M., Doolan P., Mehta J.P., Rani S., Crown J., O'Driscoll L. Br. J. Cancer 98:1641-1645(2008) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[9]	"Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex." Ito H., Atsuzawa K., Sudo K., Di Stefano P., Iwamoto I., Morishita R., Takei S., Semba R., Defilippi P., Asano T., Usuda N., Nagata K. J. Neurochem. 107:61-72(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SORBS3 AND SYP.
[10]	"Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity." Jaworski J., Kapitein L.C., Gouveia S.M., Dortland B.R., Wulf P.S., Grigoriev I., Camera P., Spangler S.A., Di Stefano P., Demmers J., Krugers H., Defilippi P., Akhmanova A., Hoogenraad C.C. Neuron 61:85-100(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CTTN AND MAPRE3, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB127405 mRNA. Translation: BAD03968.1. AK126665 mRNA. Translation: BAC86634.1. AC115090 Genomic DNA. No translation available. AC129916 Genomic DNA. No translation available. BC033233 mRNA. Translation: AAH33233.1. AB051471 mRNA. Translation: BAB21775.1.
IPI	IPI00384305. IPI00396130. IPI00479643. IPI00964306.
RefSeq	NP_079524.2. NM_025248.2.
UniGene	Hs.448872.
3D structure databases
ProteinModelPortal	Q9C0H9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9C0H9. 4 interactions.
MINT	MINT-4777404.
STRING	9606.ENSP00000264659.
PTM databases
PhosphoSite	Q9C0H9.
Polymorphism databases
DMDM	296452948.
Proteomic databases
PaxDb	Q9C0H9.
PRIDE	Q9C0H9.
Protocols and materials databases
DNASU	80725.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264659; ENSP00000264659; ENSG00000017373. ENST00000570888; ENSP00000461232; ENSG00000262199.
GeneID	80725.
KEGG	hsa:80725.
UCSC	uc002hqd.3. human. uc002hqf.1. human. uc002hqg.3. human.
Organism-specific databases
CTD	80725.
GeneCards	GC17M036686.
H-InvDB	HIX0021064.
HGNC	HGNC:29506. SRCIN1.
HPA	HPA009701.
MIM	610786. gene.
neXtProt	NX_Q9C0H9.
PharmGKB	PA165432823.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG69680.
HOGENOM	HOG000293351.
HOVERGEN	HBG019587.
InParanoid	Q9C0H9.
OMA	AELSMRV.
OrthoDB	EOG418BMM.
Gene expression databases
ArrayExpress	Q9C0H9.
Bgee	Q9C0H9.
Genevestigator	Q9C0H9.
GermOnline	ENSG00000017373. Homo sapiens.
Family and domain databases
InterPro	IPR026727. Srcin1. [Graphical view]
PANTHER	PTHR22741:SF5. PTHR22741:SF5. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	SRCIN1. human.
GenomeRNAi	80725.
NextBio	71035.
SOURCE	Search...

Entry information

Entry name

SRCN1_HUMAN

Accession

Primary (citable) accession number: Q9C0H9
Secondary accession number(s): Q75T46, Q8N4W8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 102 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.