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Protein

Kelch-like protein 4

Gene

KLHL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102271-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 4
Gene namesi
Name:KLHL4
Synonyms:KIAA1687
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6355. KLHL4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi56062.
OpenTargetsiENSG00000102271.
PharmGKBiPA30145.

Polymorphism and mutation databases

BioMutaiKLHL4.
DMDMi17378645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191041 – 718Kelch-like protein 4Add BLAST718

Proteomic databases

EPDiQ9C0H6.
MaxQBiQ9C0H6.
PaxDbiQ9C0H6.
PeptideAtlasiQ9C0H6.
PRIDEiQ9C0H6.

PTM databases

iPTMnetiQ9C0H6.
PhosphoSitePlusiQ9C0H6.

Expressioni

Tissue specificityi

Expressed in adult fibroblasts and in a range of fetal tissues including tongue, palate, and mandible.

Gene expression databases

BgeeiENSG00000102271.
CleanExiHS_KLHL4.
ExpressionAtlasiQ9C0H6. baseline and differential.
GenevisibleiQ9C0H6. HS.

Organism-specific databases

HPAiHPA029192.

Interactioni

Protein-protein interaction databases

BioGridi121035. 1 interactor.
IntActiQ9C0H6. 2 interactors.
STRINGi9606.ENSP00000362206.

Structurei

3D structure databases

ProteinModelPortaliQ9C0H6.
SMRiQ9C0H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 249BTBPROSITE-ProRule annotationAdd BLAST68
Repeati430 – 476Kelch 1Add BLAST47
Repeati477 – 523Kelch 2Add BLAST47
Repeati525 – 570Kelch 3Add BLAST46
Repeati571 – 617Kelch 4Add BLAST47
Repeati619 – 670Kelch 5Add BLAST52
Repeati671 – 717Kelch 6Add BLAST47

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118931.
HOGENOMiHOG000230814.
HOVERGENiHBG014286.
InParanoidiQ9C0H6.
KOiK10442.
OMAiHIGTMNG.
OrthoDBiEOG091G04QJ.
PhylomeDBiQ9C0H6.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0H6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVSGKKEFD VKQILRLRWR WFSHPFQGST NTGSCLQQEG YEHRGTPVQG
60 70 80 90 100
RLKSHSRDRN GLKKSNSPVH HNILAPVPGP APAHQRAVQN LQQHNLIVHF
110 120 130 140 150
QANEDTPKSV PEKNLFKEAC EKRAQDLEMM ADDNIEDSTA RLDTQHSEDM
160 170 180 190 200
NATRSEEQFH VINHAEQTLR KMENYLKEKQ LCDVLLIAGH LRIPAHRLVL
210 220 230 240 250
SAVSDYFAAM FTNDVLEAKQ EEVRMEGVDP NALNSLVQYA YTGVLQLKED
260 270 280 290 300
TIESLLAAAC LLQLTQVIDV CSNFLIKQLH PSNCLGIRSF GDAQGCTELL
310 320 330 340 350
NVAHKYTMEH FIEVIKNQEF LLLPANEISK LLCSDDINVP DEETIFHALM
360 370 380 390 400
QWVGHDVQNR QGELGMLLSY IRLPLLPPQL LADLETSSMF TGDLECQKLL
410 420 430 440 450
MEAMKYHLLP ERRSMMQSPR TKPRKSTVGA LYAVGGMDAM KGTTTIEKYD
460 470 480 490 500
LRTNSWLHIG TMNGRRLQFG VAVIDNKLYV VGGRDGLKTL NTVECFNPVG
510 520 530 540 550
KIWTVMPPMS THRHGLGVAT LEGPMYAVGG HDGWSYLNTV ERWDPEGRQW
560 570 580 590 600
NYVASMSTPR STVGVVALNN KLYAIGGRDG SSCLKSMEYF DPHTNKWSLC
610 620 630 640 650
APMSKRRGGV GVATYNGFLY VVGGHDAPAS NHCSRLSDCV ERYDPKGDSW
660 670 680 690 700
STVAPLSVPR DAVAVCPLGD KLYVVGGYDG HTYLNTVESY DAQRNEWKEE
710
VPVNIGRAGA CVVVVKLP
Length:718
Mass (Da):80,245
Last modified:September 26, 2001 - v2
Checksum:iD7385BAAD63B150A
GO
Isoform 2 (identifier: Q9C0H6-2) [UniParc]FASTAAdd to basket
Also known as: KLHL4c

The sequence of this isoform differs from the canonical sequence as follows:
     700-718: EVPVNIGRAGACVVVVKLP → SMQELLQNFYTTQKLKETLGH

Show »
Length:720
Mass (Da):80,835
Checksum:i9746972C5B276C00
GO

Sequence cautioni

The sequence BAB14199 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB21778 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002818700 – 718EVPVN…VVKLP → SMQELLQNFYTTQKLKETLG H in isoform 2. 2 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284765 mRNA. Translation: AAK49441.1.
AF284766 mRNA. Translation: AAK49442.1.
AB051474 mRNA. Translation: BAB21778.1. Different initiation.
AL832514 mRNA. Translation: CAI46201.1.
AL035424, Z95400 Genomic DNA. Translation: CAI42085.1.
Z95400, AL035424 Genomic DNA. Translation: CAI42741.1.
CH471104 Genomic DNA. Translation: EAW98553.1.
BC140839 mRNA. Translation: AAI40840.1.
BC140840 mRNA. Translation: AAI40841.1.
AK022715 mRNA. Translation: BAB14199.1. Different initiation.
CCDSiCCDS14456.1. [Q9C0H6-2]
CCDS14457.1. [Q9C0H6-1]
RefSeqiNP_061990.2. NM_019117.4. [Q9C0H6-1]
NP_476503.1. NM_057162.2. [Q9C0H6-2]
UniGeneiHs.49075.

Genome annotation databases

EnsembliENST00000373114; ENSP00000362206; ENSG00000102271. [Q9C0H6-2]
ENST00000373119; ENSP00000362211; ENSG00000102271. [Q9C0H6-1]
GeneIDi56062.
KEGGihsa:56062.
UCSCiuc004efa.3. human. [Q9C0H6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284765 mRNA. Translation: AAK49441.1.
AF284766 mRNA. Translation: AAK49442.1.
AB051474 mRNA. Translation: BAB21778.1. Different initiation.
AL832514 mRNA. Translation: CAI46201.1.
AL035424, Z95400 Genomic DNA. Translation: CAI42085.1.
Z95400, AL035424 Genomic DNA. Translation: CAI42741.1.
CH471104 Genomic DNA. Translation: EAW98553.1.
BC140839 mRNA. Translation: AAI40840.1.
BC140840 mRNA. Translation: AAI40841.1.
AK022715 mRNA. Translation: BAB14199.1. Different initiation.
CCDSiCCDS14456.1. [Q9C0H6-2]
CCDS14457.1. [Q9C0H6-1]
RefSeqiNP_061990.2. NM_019117.4. [Q9C0H6-1]
NP_476503.1. NM_057162.2. [Q9C0H6-2]
UniGeneiHs.49075.

3D structure databases

ProteinModelPortaliQ9C0H6.
SMRiQ9C0H6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121035. 1 interactor.
IntActiQ9C0H6. 2 interactors.
STRINGi9606.ENSP00000362206.

PTM databases

iPTMnetiQ9C0H6.
PhosphoSitePlusiQ9C0H6.

Polymorphism and mutation databases

BioMutaiKLHL4.
DMDMi17378645.

Proteomic databases

EPDiQ9C0H6.
MaxQBiQ9C0H6.
PaxDbiQ9C0H6.
PeptideAtlasiQ9C0H6.
PRIDEiQ9C0H6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373114; ENSP00000362206; ENSG00000102271. [Q9C0H6-2]
ENST00000373119; ENSP00000362211; ENSG00000102271. [Q9C0H6-1]
GeneIDi56062.
KEGGihsa:56062.
UCSCiuc004efa.3. human. [Q9C0H6-1]

Organism-specific databases

CTDi56062.
DisGeNETi56062.
GeneCardsiKLHL4.
HGNCiHGNC:6355. KLHL4.
HPAiHPA029192.
MIMi300348. gene.
neXtProtiNX_Q9C0H6.
OpenTargetsiENSG00000102271.
PharmGKBiPA30145.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118931.
HOGENOMiHOG000230814.
HOVERGENiHBG014286.
InParanoidiQ9C0H6.
KOiK10442.
OMAiHIGTMNG.
OrthoDBiEOG091G04QJ.
PhylomeDBiQ9C0H6.
TreeFamiTF329218.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102271-MONOMER.

Miscellaneous databases

GenomeRNAii56062.
PROiQ9C0H6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102271.
CleanExiHS_KLHL4.
ExpressionAtlasiQ9C0H6. baseline and differential.
GenevisibleiQ9C0H6. HS.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLHL4_HUMAN
AccessioniPrimary (citable) accession number: Q9C0H6
Secondary accession number(s): B2RTW2, Q9Y3J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: November 2, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.