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Protein

Rho GTPase-activating protein 39

Gene

ARHGAP39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.
R-HSA-428543. Inactivation of Cdc42 and Rac.
SignaLinkiQ9C0H5.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 39
Gene namesi
Name:ARHGAP39
Synonyms:KIAA1688
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:29351. ARHGAP39.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165585391.

Polymorphism and mutation databases

BioMutaiARHGAP39.
DMDMi28380079.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 10831082Rho GTPase-activating protein 39PRO_0000076092Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei384 – 3841PhosphoserineBy similarity
Modified residuei388 – 3881PhosphoserineCombined sources
Modified residuei406 – 4061PhosphoserineCombined sources
Modified residuei407 – 4071PhosphoserineCombined sources
Modified residuei604 – 6041PhosphoserineCombined sources
Modified residuei715 – 7151PhosphoserineBy similarity
Modified residuei726 – 7261PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9C0H5.
PaxDbiQ9C0H5.
PRIDEiQ9C0H5.

PTM databases

iPTMnetiQ9C0H5.
PhosphoSiteiQ9C0H5.

Expressioni

Gene expression databases

BgeeiQ9C0H5.
GenevisibleiQ9C0H5. HS.

Organism-specific databases

HPAiHPA044491.

Interactioni

Protein-protein interaction databases

BioGridi123278. 14 interactions.
IntActiQ9C0H5. 12 interactions.
STRINGi9606.ENSP00000366522.

Structurei

3D structure databases

ProteinModelPortaliQ9C0H5.
SMRiQ9C0H5. Positions 69-96, 779-880, 887-1063.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 5834WW 1PROSITE-ProRule annotationAdd
BLAST
Domaini63 – 9735WW 2PROSITE-ProRule annotationAdd
BLAST
Domaini722 – 879158MyTH4PROSITE-ProRule annotationAdd
BLAST
Domaini890 – 1078189Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi234 – 367134Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 MyTH4 domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IG4K. Eukaryota.
ENOG410XQ23. LUCA.
GeneTreeiENSGT00390000003161.
HOGENOMiHOG000290162.
HOVERGENiHBG104061.
InParanoidiQ9C0H5.
OMAiRTSSLRW.
OrthoDBiEOG7BP81R.
PhylomeDBiQ9C0H5.
TreeFamiTF323577.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR000857. MyTH4_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00784. MyTH4. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00139. MyTH4. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51016. MYTH4. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0H5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQTQDYECR SHNVDLPESR IPGSNTRLEW VEIIEPRTRE RMYANLVTGE
60 70 80 90 100
CVWDPPAGVR IKRTSENQWW ELFDPNTSRF YYYNASTQRT VWHRPQGCDI
110 120 130 140 150
IPLAKLQTLK QNTESPRASA ESSPGRGSSV SREGSTSSSL EPEPDTEKAQ
160 170 180 190 200
ELPARAGRPA AFGTVKEDSG SSSPPGVFLE KDYEIYRDYS ADGQLLHYRT
210 220 230 240 250
SSLRWNSGAK ERMLIKVADR EPSFLAAQGN GYAPDGPPGV RSRRPSGSQH
260 270 280 290 300
SPSLQTFAPE ADGTIFFPER RPSPFLKRAE LPGSSSPLLA QPRKPSGDSQ
310 320 330 340 350
PSSPRYGYEP PLYEEPPVEY QAPIYDEPPM DVQFEAGGGY QAGSPQRSPG
360 370 380 390 400
RKPRPFLQPN KQGPPSPCQQ LVLTKQKCPE RFLSLEYSPA GKEYVRQLVY
410 420 430 440 450
VEQAGSSPKL RAGPRHKYAP NPGGGSYSLQ PSPCLLRDQR LGVKSGDYST
460 470 480 490 500
MEGPELRHSQ PPTPLPQAQE DAMSWSSQQD TLSSTGYSPG TRKRKSRKPS
510 520 530 540 550
LCQATSATPT EGPGDLLVEQ PLAEEQPPCG TSLAPVKRAE GEAEGARGAA
560 570 580 590 600
EPFLAQARLA WEAQQAHFHM KQRSSWDSQQ DGSGYESDGA LPLPMPGPVV
610 620 630 640 650
RAFSEDEALA QQENRHWRRG TFEKLGFPQI LLEKSVSVQT NLASPEPYLH
660 670 680 690 700
PSQSEDLAAC AQFESSRQSR SGVPSSSCVF PTFTLRKPSS ETDIENWASK
710 720 730 740 750
HFNKHTQGLF RRKVSIANML AWSSESIKKP MIVTSDRHVK KEACELFKLI
760 770 780 790 800
QMYMGDRRAK ADPLHVALEV ATKGWSVQGL RDELYIQLCR QTTENFRLES
810 820 830 840 850
LARGWELMAI CLAFFPPTPK FHSYLEGYIY RHMDPVNDTK GVAISTYAKY
860 870 880 890 900
CYHKLQKAAL TGAKKGLKKP NVEEIRHAKN AVFSPSMFGS ALQEVMGMQR
910 920 930 940 950
ERYPERQLPW VQTRLSEEVL ALNGDQTEGI FRVPGDIDEV NALKLQVDQW
960 970 980 990 1000
KVPTGLEDPH VPASLLKLWY RELEEPLIPH EFYEQCIAHY DSPEAAVAVV
1010 1020 1030 1040 1050
HALPRINRMV LCYLIRFLQV FVQPANVAVT KMDVSNLAMV MAPNCLRCQS
1060 1070 1080
DDPRVIFENT RKEMSFLRVL IQHLDTSFME GVL
Length:1,083
Mass (Da):121,286
Last modified:February 12, 2003 - v2
Checksum:i782B213B1DCB4072
GO
Isoform 2 (identifier: Q9C0H5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     840-840: K → KVTQHIKELLERNTKKKSKLRKKPKPYVEEPD

Show »
Length:1,114
Mass (Da):125,029
Checksum:iA232D306723FEAB6
GO

Sequence cautioni

The sequence BAB21779.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG64793.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei840 – 8401K → KVTQHIKELLERNTKKKSKL RKKPKPYVEEPD in isoform 2. 1 PublicationVSP_040749

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051475 mRNA. Translation: BAB21779.1. Different initiation.
AC084125 Genomic DNA. No translation available.
AK303851 mRNA. Translation: BAG64793.1. Different initiation.
CCDSiCCDS34971.1. [Q9C0H5-2]
CCDS78374.1. [Q9C0H5-1]
PIRiC59434.
RefSeqiNP_001295136.1. NM_001308207.1. [Q9C0H5-1]
NP_001295137.1. NM_001308208.1. [Q9C0H5-1]
NP_079527.1. NM_025251.2. [Q9C0H5-2]
XP_011515610.1. XM_011517308.1. [Q9C0H5-2]
XP_011515611.1. XM_011517309.1. [Q9C0H5-2]
UniGeneiHs.148988.

Genome annotation databases

EnsembliENST00000276826; ENSP00000276826; ENSG00000147799. [Q9C0H5-1]
ENST00000377307; ENSP00000366522; ENSG00000147799. [Q9C0H5-2]
GeneIDi80728.
KEGGihsa:80728.
UCSCiuc064rpe.1. human. [Q9C0H5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051475 mRNA. Translation: BAB21779.1. Different initiation.
AC084125 Genomic DNA. No translation available.
AK303851 mRNA. Translation: BAG64793.1. Different initiation.
CCDSiCCDS34971.1. [Q9C0H5-2]
CCDS78374.1. [Q9C0H5-1]
PIRiC59434.
RefSeqiNP_001295136.1. NM_001308207.1. [Q9C0H5-1]
NP_001295137.1. NM_001308208.1. [Q9C0H5-1]
NP_079527.1. NM_025251.2. [Q9C0H5-2]
XP_011515610.1. XM_011517308.1. [Q9C0H5-2]
XP_011515611.1. XM_011517309.1. [Q9C0H5-2]
UniGeneiHs.148988.

3D structure databases

ProteinModelPortaliQ9C0H5.
SMRiQ9C0H5. Positions 69-96, 779-880, 887-1063.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123278. 14 interactions.
IntActiQ9C0H5. 12 interactions.
STRINGi9606.ENSP00000366522.

PTM databases

iPTMnetiQ9C0H5.
PhosphoSiteiQ9C0H5.

Polymorphism and mutation databases

BioMutaiARHGAP39.
DMDMi28380079.

Proteomic databases

MaxQBiQ9C0H5.
PaxDbiQ9C0H5.
PRIDEiQ9C0H5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276826; ENSP00000276826; ENSG00000147799. [Q9C0H5-1]
ENST00000377307; ENSP00000366522; ENSG00000147799. [Q9C0H5-2]
GeneIDi80728.
KEGGihsa:80728.
UCSCiuc064rpe.1. human. [Q9C0H5-1]

Organism-specific databases

CTDi80728.
GeneCardsiARHGAP39.
H-InvDBHIX0007862.
HGNCiHGNC:29351. ARHGAP39.
HPAiHPA044491.
MIMi615880. gene.
neXtProtiNX_Q9C0H5.
PharmGKBiPA165585391.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG4K. Eukaryota.
ENOG410XQ23. LUCA.
GeneTreeiENSGT00390000003161.
HOGENOMiHOG000290162.
HOVERGENiHBG104061.
InParanoidiQ9C0H5.
OMAiRTSSLRW.
OrthoDBiEOG7BP81R.
PhylomeDBiQ9C0H5.
TreeFamiTF323577.

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.
R-HSA-428543. Inactivation of Cdc42 and Rac.
SignaLinkiQ9C0H5.

Miscellaneous databases

GenomeRNAii80728.
PROiQ9C0H5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9C0H5.
GenevisibleiQ9C0H5. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR000857. MyTH4_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00784. MyTH4. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00139. MyTH4. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51016. MYTH4. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 407-1083 (ISOFORM 2).
    Tissue: Trachea.
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406 AND SER-407, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-388 AND SER-604, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRHG39_HUMAN
AccessioniPrimary (citable) accession number: Q9C0H5
Secondary accession number(s): B4E1I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: February 12, 2003
Last modified: June 8, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.