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Protein

Protein tweety homolog 3

Gene

TTYH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable large-conductance Ca2+-activated chloride channel. May play a role in Ca2+ signal transduction.1 Publication

GO - Molecular functioni

  • chloride channel activity Source: UniProtKB
  • intracellular calcium activated chloride channel activity Source: FlyBase

GO - Biological processi

  • chloride transmembrane transport Source: GOC
  • chloride transport Source: FlyBase
  • ion transmembrane transport Source: Reactome
  • transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Chloride

Enzyme and pathway databases

ReactomeiR-HSA-2672351. Stimuli-sensing channels.

Protein family/group databases

TCDBi1.A.48.1.4. the anion channel tweety (tweety) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tweety homolog 3
Short name:
hTTY3
Gene namesi
Name:TTYH3
Synonyms:KIAA1691
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22222. TTYH3.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242ExtracellularSequence analysisAdd
BLAST
Transmembranei43 – 6321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini64 – 8623CytoplasmicSequence analysisAdd
BLAST
Transmembranei87 – 10721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini108 – 211104ExtracellularSequence analysisAdd
BLAST
Transmembranei212 – 23221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini233 – 2364CytoplasmicSequence analysis
Transmembranei237 – 25721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini258 – 386129ExtracellularSequence analysisAdd
BLAST
Transmembranei387 – 40721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini408 – 523116CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • chloride channel complex Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi128 – 1281T → A: Does not affect N-glycosylation state. 1 Publication
Mutagenesisi146 – 1461T → A: Does not affect N-glycosylation state. 1 Publication
Mutagenesisi353 – 3531T → A: Abolishes N-glycosylation. 1 Publication
Mutagenesisi367 – 3671R → Q: Induces a stronger permeability to cations. 1 Publication
Mutagenesisi370 – 3701H → D: Shows a different ion selectivity. 1 Publication

Organism-specific databases

PharmGKBiPA134908427.

Polymorphism and mutation databases

BioMutaiTTYH3.
DMDMi162416242.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Protein tweety homolog 3PRO_0000312251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence analysis
Glycosylationi144 – 1441N-linked (GlcNAc...)1 Publication
Glycosylationi351 – 3511N-linked (GlcNAc...)1 Publication
Modified residuei496 – 4961PhosphoserineBy similarity
Modified residuei504 – 5041PhosphoserineBy similarity
Modified residuei522 – 5221PhosphoserineCombined sources

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9C0H2.
MaxQBiQ9C0H2.
PaxDbiQ9C0H2.
PRIDEiQ9C0H2.

PTM databases

iPTMnetiQ9C0H2.
PhosphoSiteiQ9C0H2.
SwissPalmiQ9C0H2.

Expressioni

Tissue specificityi

Expressed in excitable tissues. Expressed in the brain, heart, skeletal muscle, colon, spleen, kidney and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiQ9C0H2.
CleanExiHS_TTYH3.
ExpressionAtlasiQ9C0H2. baseline and differential.
GenevisibleiQ9C0H2. HS.

Organism-specific databases

HPAiHPA053520.

Interactioni

Protein-protein interaction databases

BioGridi123277. 25 interactions.
IntActiQ9C0H2. 3 interactions.
STRINGi9606.ENSP00000258796.

Structurei

3D structure databases

ProteinModelPortaliQ9C0H2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tweety family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4433. Eukaryota.
ENOG410ZNTN. LUCA.
GeneTreeiENSGT00390000010182.
HOGENOMiHOG000070449.
HOVERGENiHBG108621.
InParanoidiQ9C0H2.
OMAiLCYDGLE.
OrthoDBiEOG7DFXC1.
PhylomeDBiQ9C0H2.
TreeFamiTF319025.

Family and domain databases

InterProiIPR006990. Tweety.
[Graphical view]
PANTHERiPTHR12424. PTHR12424. 1 hit.
PfamiPF04906. Tweety. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0H2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGVSYAAPW WVSLLHRLPH FDLSWEATSS QFRPEDTDYQ QALLLLGAAA
60 70 80 90 100
LACLALDLLF LLFYSFWLCC RRRKSEEHLD ADCCCTAWCV IIATLVCSAG
110 120 130 140 150
IAVGFYGNGE TSDGIHRATY SLRHANRTVA GVQDRVWDTA VGLNHTAEPS
160 170 180 190 200
LQTLERQLAG RPEPLRAVQR LQGLLETLLG YTAAIPFWRN TAVSLEVLAE
210 220 230 240 250
QVDLYDWYRW LGYLGLLLLD VIICLLVLVG LIRSSKGILV GVCLLGVLAL
260 270 280 290 300
VISWGALGLE LAVSVGSSDF CVDPDAYVTK MVEEYSVLSG DILQYYLACS
310 320 330 340 350
PRAANPFQQK LSGSHKALVE MQDVVAELLR TVPWEQPATK DPLLRVQEVL
360 370 380 390 400
NGTEVNLQHL TALVDCRSLH LDYVQALTGF CYDGVEGLIY LALFSFVTAL
410 420 430 440 450
MFSSIVCSVP HTWQQKRGPD EDGEEEAAPG PRQAHDSLYR VHMPSLYSCG
460 470 480 490 500
SSYGSETSIP AAAHTVSNAP VTEYMSQNAN FQNPRCENTP LIGRESPPPS
510 520
YTSSMRAKYL ATSQPRPDSS GSH
Length:523
Mass (Da):57,545
Last modified:December 4, 2007 - v3
Checksum:iB398391787BA0301
GO
Isoform 2 (identifier: Q9C0H2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-241: Missing.

Note: No experimental confirmation available.
Show »
Length:491
Mass (Da):54,139
Checksum:i55B1B419CA483973
GO
Isoform 3 (identifier: Q9C0H2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: MAGVSYAAPW...AEQVDLYDWY → MPSGVPGCWP...VPWRTPRFAC

Note: No experimental confirmation available.
Show »
Length:352
Mass (Da):38,486
Checksum:i6424BEBAB65DE76D
GO
Isoform 4 (identifier: Q9C0H2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     501-523: YTSSMRAKYLATSQPRPDSSGSH → RYLAALDSGSHAGWQFKPMDSARTLW

Note: No experimental confirmation available.
Show »
Length:526
Mass (Da):57,982
Checksum:i37735FE203C594D9
GO

Sequence cautioni

The sequence BAB21782.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence EAL23958.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti169 – 1691Q → K in BAB84984 (PubMed:12693554).Curated
Sequence conflicti346 – 3461V → F in BE263005 (PubMed:15489334).Curated
Sequence conflicti520 – 5201S → R in BAB84984 (PubMed:12693554).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 208208MAGVS…LYDWY → MPSGVPGCWPQLPLKGPWRP TPRPRVPVPWRTPRFAC in isoform 3. 1 PublicationVSP_029769Add
BLAST
Alternative sequencei210 – 24132Missing in isoform 2. 1 PublicationVSP_029770Add
BLAST
Alternative sequencei501 – 52323YTSSM…SSGSH → RYLAALDSGSHAGWQFKPMD SARTLW in isoform 4. 1 PublicationVSP_042220Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB162931 mRNA. Translation: BAD20190.1.
AB051478 mRNA. Translation: BAB21782.2. Different initiation.
AK124608 mRNA. Translation: BAC85898.1.
AC006028 Genomic DNA. No translation available.
AC073462 Genomic DNA. No translation available.
CH236953 Genomic DNA. Translation: EAL23958.1. Sequence problems.
CH471144 Genomic DNA. Translation: EAW87266.1.
BC131824 mRNA. Translation: AAI31825.1.
BC152447 mRNA. Translation: AAI52448.1.
BE263005 mRNA. No translation available.
AK074158 mRNA. Translation: BAB84984.1.
CCDSiCCDS34588.1. [Q9C0H2-1]
RefSeqiNP_079526.1. NM_025250.2. [Q9C0H2-1]
XP_011513837.1. XM_011515535.1. [Q9C0H2-4]
UniGeneiHs.440899.

Genome annotation databases

EnsembliENST00000258796; ENSP00000258796; ENSG00000136295. [Q9C0H2-1]
ENST00000403167; ENSP00000385015; ENSG00000136295. [Q9C0H2-3]
ENST00000407643; ENSP00000385316; ENSG00000136295. [Q9C0H2-2]
GeneIDi80727.
KEGGihsa:80727.
UCSCiuc003smp.4. human. [Q9C0H2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB162931 mRNA. Translation: BAD20190.1.
AB051478 mRNA. Translation: BAB21782.2. Different initiation.
AK124608 mRNA. Translation: BAC85898.1.
AC006028 Genomic DNA. No translation available.
AC073462 Genomic DNA. No translation available.
CH236953 Genomic DNA. Translation: EAL23958.1. Sequence problems.
CH471144 Genomic DNA. Translation: EAW87266.1.
BC131824 mRNA. Translation: AAI31825.1.
BC152447 mRNA. Translation: AAI52448.1.
BE263005 mRNA. No translation available.
AK074158 mRNA. Translation: BAB84984.1.
CCDSiCCDS34588.1. [Q9C0H2-1]
RefSeqiNP_079526.1. NM_025250.2. [Q9C0H2-1]
XP_011513837.1. XM_011515535.1. [Q9C0H2-4]
UniGeneiHs.440899.

3D structure databases

ProteinModelPortaliQ9C0H2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123277. 25 interactions.
IntActiQ9C0H2. 3 interactions.
STRINGi9606.ENSP00000258796.

Protein family/group databases

TCDBi1.A.48.1.4. the anion channel tweety (tweety) family.

PTM databases

iPTMnetiQ9C0H2.
PhosphoSiteiQ9C0H2.
SwissPalmiQ9C0H2.

Polymorphism and mutation databases

BioMutaiTTYH3.
DMDMi162416242.

Proteomic databases

EPDiQ9C0H2.
MaxQBiQ9C0H2.
PaxDbiQ9C0H2.
PRIDEiQ9C0H2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258796; ENSP00000258796; ENSG00000136295. [Q9C0H2-1]
ENST00000403167; ENSP00000385015; ENSG00000136295. [Q9C0H2-3]
ENST00000407643; ENSP00000385316; ENSG00000136295. [Q9C0H2-2]
GeneIDi80727.
KEGGihsa:80727.
UCSCiuc003smp.4. human. [Q9C0H2-1]

Organism-specific databases

CTDi80727.
GeneCardsiTTYH3.
HGNCiHGNC:22222. TTYH3.
HPAiHPA053520.
MIMi608919. gene.
neXtProtiNX_Q9C0H2.
PharmGKBiPA134908427.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4433. Eukaryota.
ENOG410ZNTN. LUCA.
GeneTreeiENSGT00390000010182.
HOGENOMiHOG000070449.
HOVERGENiHBG108621.
InParanoidiQ9C0H2.
OMAiLCYDGLE.
OrthoDBiEOG7DFXC1.
PhylomeDBiQ9C0H2.
TreeFamiTF319025.

Enzyme and pathway databases

ReactomeiR-HSA-2672351. Stimuli-sensing channels.

Miscellaneous databases

ChiTaRSiTTYH3. human.
GenomeRNAii80727.
NextBioi71042.
PROiQ9C0H2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9C0H2.
CleanExiHS_TTYH3.
ExpressionAtlasiQ9C0H2. baseline and differential.
GenevisibleiQ9C0H2. HS.

Family and domain databases

InterProiIPR006990. Tweety.
[Graphical view]
PANTHERiPTHR12424. PTHR12424. 1 hit.
PfamiPF04906. Tweety. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human Cl(-) channel family related to Drosophila flightless locus."
    Suzuki M., Mizuno A.
    J. Biol. Chem. 279:22461-22468(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, GLYCOSYLATION AT ASN-351, TOPOLOGY, MUTAGENESIS OF THR-128; THR-146; THR-353; ARG-367 AND HIS-370.
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Cerebellum.
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 342-523 (ISOFORM 4).
  9. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 138-523 (ISOFORM 2).
    Tissue: Spleen.
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-144.
    Tissue: Liver.
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTTYH3_HUMAN
AccessioniPrimary (citable) accession number: Q9C0H2
Secondary accession number(s): A4D201
, B7WP98, Q6L749, Q6ZVG3, Q8TEG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: March 16, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The current is completely inhibited by the addition of an anion permeability inhibitor. Addition of a Ca2+ ionophore induces an outward-rectified current in mock-transfected cells, but it introduced an overt linear current in TTYH3-transfected cells.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.