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Protein

Zinc finger protein 436

Gene

ZNF436

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri138 – 16023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri166 – 18823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri194 – 21623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 24423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: GO_Central

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: GO_Central
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 436
Gene namesi
Name:ZNF436
Synonyms:KIAA1710
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20814. ZNF436.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134911283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Zinc finger protein 436PRO_0000047584Add
BLAST

Proteomic databases

PaxDbiQ9C0F3.
PRIDEiQ9C0F3.

PTM databases

PhosphoSiteiQ9C0F3.

Expressioni

Tissue specificityi

Expressed in fetal brain, heart, liver, spleen, bladder, lung, skin, skeletal muscle, stomach and pancreas.1 Publication

Gene expression databases

BgeeiQ9C0F3.
CleanExiHS_ZNF436.
ExpressionAtlasiQ9C0F3. baseline and differential.
GenevestigatoriQ9C0F3.

Organism-specific databases

HPAiHPA043817.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434632EBI-8489702,EBI-349968

Protein-protein interaction databases

BioGridi123316. 5 interactions.
IntActiQ9C0F3. 4 interactions.
MINTiMINT-8417741.
STRINGi9606.ENSP00000313582.

Structurei

3D structure databases

ProteinModelPortaliQ9C0F3.
SMRiQ9C0F3. Positions 140-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8673KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri138 – 16023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri166 – 18823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri194 – 21623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 24423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120459.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9C0F3.
KOiK09228.
OMAiHCNECGE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9C0F3.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C0F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATLLMAGS QAPVTFEDMA MYLTREEWRP LDAAQRDLYR DVMQENYGNV
60 70 80 90 100
VSLDFEIRSE NEVNPKQEIS EDVQFGTTSE RPAENAEENP ESEEGFESGD
110 120 130 140 150
RSERQWGDLT AEEWVSYPLQ PVTDLLVHKE VHTGIRYHIC SHCGKAFSQI
160 170 180 190 200
SDLNRHQKTH TGDRPYKCYE CGKGFSRSSH LIQHQRTHTG ERPYDCNECG
210 220 230 240 250
KSFGRSSHLI QHQTIHTGEK PHKCNECGKS FCRLSHLIQH QRTHSGEKPY
260 270 280 290 300
ECEECGKSFS RSSHLAQHQR THTGEKPYEC NECGRGFSER SDLIKHYRVH
310 320 330 340 350
TGERPYKCDE CGKNFSQNSD LVRHRRAHTG EKPYHCNECG ENFSRISHLV
360 370 380 390 400
QHQRTHTGEK PYECNACGKS FSRSSHLITH QKIHTGEKPY ECNECWRSFG
410 420 430 440 450
ERSDLIKHQR THTGEKPYEC VQCGKGFTQS SNLITHQRVH TGEKPYECTE
460 470
CEKSFSRSSA LIKHKRVHTD
Length:470
Mass (Da):54,277
Last modified:March 26, 2002 - v2
Checksum:iD14EA2026529FCC7
GO

Sequence cautioni

The sequence BAB21801.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti196 – 1961C → G in a breast cancer sample; somatic mutation. 1 Publication
VAR_035579

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051497 mRNA. Translation: BAB21801.1. Different initiation.
AL834485 mRNA. Translation: CAD39143.1.
AL109936 Genomic DNA. Translation: CAI19029.1.
BC056400 mRNA. Translation: AAH56400.1.
CCDSiCCDS233.1.
RefSeqiNP_001070663.1. NM_001077195.1.
NP_085137.1. NM_030634.2.
UniGeneiHs.293798.

Genome annotation databases

EnsembliENST00000314011; ENSP00000313582; ENSG00000125945.
ENST00000374608; ENSP00000363736; ENSG00000125945.
GeneIDi80818.
KEGGihsa:80818.
UCSCiuc001bgt.3. human.

Polymorphism databases

DMDMi20141030.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051497 mRNA. Translation: BAB21801.1. Different initiation.
AL834485 mRNA. Translation: CAD39143.1.
AL109936 Genomic DNA. Translation: CAI19029.1.
BC056400 mRNA. Translation: AAH56400.1.
CCDSiCCDS233.1.
RefSeqiNP_001070663.1. NM_001077195.1.
NP_085137.1. NM_030634.2.
UniGeneiHs.293798.

3D structure databases

ProteinModelPortaliQ9C0F3.
SMRiQ9C0F3. Positions 140-469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123316. 5 interactions.
IntActiQ9C0F3. 4 interactions.
MINTiMINT-8417741.
STRINGi9606.ENSP00000313582.

PTM databases

PhosphoSiteiQ9C0F3.

Polymorphism databases

DMDMi20141030.

Proteomic databases

PaxDbiQ9C0F3.
PRIDEiQ9C0F3.

Protocols and materials databases

DNASUi80818.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314011; ENSP00000313582; ENSG00000125945.
ENST00000374608; ENSP00000363736; ENSG00000125945.
GeneIDi80818.
KEGGihsa:80818.
UCSCiuc001bgt.3. human.

Organism-specific databases

CTDi80818.
GeneCardsiGC01M023685.
HGNCiHGNC:20814. ZNF436.
HPAiHPA043817.
MIMi611703. gene.
neXtProtiNX_Q9C0F3.
PharmGKBiPA134911283.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120459.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9C0F3.
KOiK09228.
OMAiHCNECGE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9C0F3.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF436. human.
GeneWikiiZNF436.
GenomeRNAii80818.
NextBioi71214.
PROiQ9C0F3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9C0F3.
CleanExiHS_ZNF436.
ExpressionAtlasiQ9C0F3. baseline and differential.
GenevestigatoriQ9C0F3.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel zinc-finger protein ZNF436 suppresses transcriptional activities of AP-1 and SRE."
    Li Y., Du X., Li F., Deng Y., Yang Z., Wang Y., Pen Z., Wang Z., Yuan W., Zhu C., Wu X.
    Mol. Biol. Rep. 33:287-294(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Fetal heart.
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-196.

Entry informationi

Entry nameiZN436_HUMAN
AccessioniPrimary (citable) accession number: Q9C0F3
Secondary accession number(s): Q658I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 26, 2002
Last sequence update: March 26, 2002
Last modified: February 3, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.