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Q9C0F3

- ZN436_HUMAN

UniProt

Q9C0F3 - ZN436_HUMAN

Protein

Zinc finger protein 436

Gene

ZNF436

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    May be a transcriptional repressor.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri138 – 16023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri166 – 18823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri194 – 21623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri222 – 24423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri250 – 27223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri278 – 30023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri306 – 32823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri334 – 35623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri362 – 38423C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri390 – 41223C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri418 – 44023C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri446 – 46823C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 436
    Gene namesi
    Name:ZNF436
    Synonyms:KIAA1710
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:20814. ZNF436.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134911283.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 470470Zinc finger protein 436PRO_0000047584Add
    BLAST

    Proteomic databases

    PaxDbiQ9C0F3.
    PRIDEiQ9C0F3.

    PTM databases

    PhosphoSiteiQ9C0F3.

    Expressioni

    Tissue specificityi

    Expressed in fetal brain, heart, liver, spleen, bladder, lung, skin, skeletal muscle, stomach and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ9C0F3.
    BgeeiQ9C0F3.
    CleanExiHS_ZNF436.
    GenevestigatoriQ9C0F3.

    Organism-specific databases

    HPAiHPA043817.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SUV39H1O434632EBI-8489702,EBI-349968

    Protein-protein interaction databases

    BioGridi123316. 5 interactions.
    IntActiQ9C0F3. 4 interactions.
    MINTiMINT-8417741.
    STRINGi9606.ENSP00000313582.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C0F3.
    SMRiQ9C0F3. Positions 111-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 8673KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri138 – 16023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri166 – 18823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri194 – 21623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri222 – 24423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri250 – 27223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri278 – 30023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri306 – 32823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri334 – 35623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri362 – 38423C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri390 – 41223C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri418 – 44023C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri446 – 46823C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9C0F3.
    KOiK09228.
    OMAiHCNECGE.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9C0F3.
    TreeFamiTF337055.

    Family and domain databases

    Gene3Di3.30.160.60. 12 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9C0F3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATLLMAGS QAPVTFEDMA MYLTREEWRP LDAAQRDLYR DVMQENYGNV    50
    VSLDFEIRSE NEVNPKQEIS EDVQFGTTSE RPAENAEENP ESEEGFESGD 100
    RSERQWGDLT AEEWVSYPLQ PVTDLLVHKE VHTGIRYHIC SHCGKAFSQI 150
    SDLNRHQKTH TGDRPYKCYE CGKGFSRSSH LIQHQRTHTG ERPYDCNECG 200
    KSFGRSSHLI QHQTIHTGEK PHKCNECGKS FCRLSHLIQH QRTHSGEKPY 250
    ECEECGKSFS RSSHLAQHQR THTGEKPYEC NECGRGFSER SDLIKHYRVH 300
    TGERPYKCDE CGKNFSQNSD LVRHRRAHTG EKPYHCNECG ENFSRISHLV 350
    QHQRTHTGEK PYECNACGKS FSRSSHLITH QKIHTGEKPY ECNECWRSFG 400
    ERSDLIKHQR THTGEKPYEC VQCGKGFTQS SNLITHQRVH TGEKPYECTE 450
    CEKSFSRSSA LIKHKRVHTD 470
    Length:470
    Mass (Da):54,277
    Last modified:March 27, 2002 - v2
    Checksum:iD14EA2026529FCC7
    GO

    Sequence cautioni

    The sequence BAB21801.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti196 – 1961C → G in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035579

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051497 mRNA. Translation: BAB21801.1. Different initiation.
    AL834485 mRNA. Translation: CAD39143.1.
    AL109936 Genomic DNA. Translation: CAI19029.1.
    BC056400 mRNA. Translation: AAH56400.1.
    CCDSiCCDS233.1.
    RefSeqiNP_001070663.1. NM_001077195.1.
    NP_085137.1. NM_030634.2.
    UniGeneiHs.293798.

    Genome annotation databases

    EnsembliENST00000314011; ENSP00000313582; ENSG00000125945.
    ENST00000374608; ENSP00000363736; ENSG00000125945.
    GeneIDi80818.
    KEGGihsa:80818.
    UCSCiuc001bgt.3. human.

    Polymorphism databases

    DMDMi20141030.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051497 mRNA. Translation: BAB21801.1 . Different initiation.
    AL834485 mRNA. Translation: CAD39143.1 .
    AL109936 Genomic DNA. Translation: CAI19029.1 .
    BC056400 mRNA. Translation: AAH56400.1 .
    CCDSi CCDS233.1.
    RefSeqi NP_001070663.1. NM_001077195.1.
    NP_085137.1. NM_030634.2.
    UniGenei Hs.293798.

    3D structure databases

    ProteinModelPortali Q9C0F3.
    SMRi Q9C0F3. Positions 111-469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123316. 5 interactions.
    IntActi Q9C0F3. 4 interactions.
    MINTi MINT-8417741.
    STRINGi 9606.ENSP00000313582.

    PTM databases

    PhosphoSitei Q9C0F3.

    Polymorphism databases

    DMDMi 20141030.

    Proteomic databases

    PaxDbi Q9C0F3.
    PRIDEi Q9C0F3.

    Protocols and materials databases

    DNASUi 80818.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314011 ; ENSP00000313582 ; ENSG00000125945 .
    ENST00000374608 ; ENSP00000363736 ; ENSG00000125945 .
    GeneIDi 80818.
    KEGGi hsa:80818.
    UCSCi uc001bgt.3. human.

    Organism-specific databases

    CTDi 80818.
    GeneCardsi GC01M023685.
    HGNCi HGNC:20814. ZNF436.
    HPAi HPA043817.
    MIMi 611703. gene.
    neXtProti NX_Q9C0F3.
    PharmGKBi PA134911283.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9C0F3.
    KOi K09228.
    OMAi HCNECGE.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9C0F3.
    TreeFami TF337055.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    ChiTaRSi ZNF436. human.
    GeneWikii ZNF436.
    GenomeRNAii 80818.
    NextBioi 71214.
    PROi Q9C0F3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9C0F3.
    Bgeei Q9C0F3.
    CleanExi HS_ZNF436.
    Genevestigatori Q9C0F3.

    Family and domain databases

    Gene3Di 3.30.160.60. 12 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel zinc-finger protein ZNF436 suppresses transcriptional activities of AP-1 and SRE."
      Li Y., Du X., Li F., Deng Y., Yang Z., Wang Y., Pen Z., Wang Z., Yuan W., Zhu C., Wu X.
      Mol. Biol. Rep. 33:287-294(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Fetal heart.
    2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-196.

    Entry informationi

    Entry nameiZN436_HUMAN
    AccessioniPrimary (citable) accession number: Q9C0F3
    Secondary accession number(s): Q658I9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3