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Q9C0F3

- ZN436_HUMAN

UniProt

Q9C0F3 - ZN436_HUMAN

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Protein

Zinc finger protein 436

Gene

ZNF436

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri138 – 16023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri166 – 18823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri194 – 21623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 24423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 436
Gene namesi
Name:ZNF436
Synonyms:KIAA1710
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:20814. ZNF436.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134911283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Zinc finger protein 436PRO_0000047584Add
BLAST

Proteomic databases

PaxDbiQ9C0F3.
PRIDEiQ9C0F3.

PTM databases

PhosphoSiteiQ9C0F3.

Expressioni

Tissue specificityi

Expressed in fetal brain, heart, liver, spleen, bladder, lung, skin, skeletal muscle, stomach and pancreas.1 Publication

Gene expression databases

BgeeiQ9C0F3.
CleanExiHS_ZNF436.
ExpressionAtlasiQ9C0F3. baseline and differential.
GenevestigatoriQ9C0F3.

Organism-specific databases

HPAiHPA043817.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434632EBI-8489702,EBI-349968

Protein-protein interaction databases

BioGridi123316. 5 interactions.
IntActiQ9C0F3. 4 interactions.
MINTiMINT-8417741.
STRINGi9606.ENSP00000313582.

Structurei

3D structure databases

ProteinModelPortaliQ9C0F3.
SMRiQ9C0F3. Positions 140-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8673KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri138 – 16023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri166 – 18823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri194 – 21623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 24423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120459.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9C0F3.
KOiK09228.
OMAiHCNECGE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9C0F3.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C0F3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATLLMAGS QAPVTFEDMA MYLTREEWRP LDAAQRDLYR DVMQENYGNV
60 70 80 90 100
VSLDFEIRSE NEVNPKQEIS EDVQFGTTSE RPAENAEENP ESEEGFESGD
110 120 130 140 150
RSERQWGDLT AEEWVSYPLQ PVTDLLVHKE VHTGIRYHIC SHCGKAFSQI
160 170 180 190 200
SDLNRHQKTH TGDRPYKCYE CGKGFSRSSH LIQHQRTHTG ERPYDCNECG
210 220 230 240 250
KSFGRSSHLI QHQTIHTGEK PHKCNECGKS FCRLSHLIQH QRTHSGEKPY
260 270 280 290 300
ECEECGKSFS RSSHLAQHQR THTGEKPYEC NECGRGFSER SDLIKHYRVH
310 320 330 340 350
TGERPYKCDE CGKNFSQNSD LVRHRRAHTG EKPYHCNECG ENFSRISHLV
360 370 380 390 400
QHQRTHTGEK PYECNACGKS FSRSSHLITH QKIHTGEKPY ECNECWRSFG
410 420 430 440 450
ERSDLIKHQR THTGEKPYEC VQCGKGFTQS SNLITHQRVH TGEKPYECTE
460 470
CEKSFSRSSA LIKHKRVHTD
Length:470
Mass (Da):54,277
Last modified:March 27, 2002 - v2
Checksum:iD14EA2026529FCC7
GO

Sequence cautioni

The sequence BAB21801.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti196 – 1961C → G in a breast cancer sample; somatic mutation. 1 Publication
VAR_035579

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051497 mRNA. Translation: BAB21801.1. Different initiation.
AL834485 mRNA. Translation: CAD39143.1.
AL109936 Genomic DNA. Translation: CAI19029.1.
BC056400 mRNA. Translation: AAH56400.1.
CCDSiCCDS233.1.
RefSeqiNP_001070663.1. NM_001077195.1.
NP_085137.1. NM_030634.2.
UniGeneiHs.293798.

Genome annotation databases

EnsembliENST00000314011; ENSP00000313582; ENSG00000125945.
ENST00000374608; ENSP00000363736; ENSG00000125945.
GeneIDi80818.
KEGGihsa:80818.
UCSCiuc001bgt.3. human.

Polymorphism databases

DMDMi20141030.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051497 mRNA. Translation: BAB21801.1 . Different initiation.
AL834485 mRNA. Translation: CAD39143.1 .
AL109936 Genomic DNA. Translation: CAI19029.1 .
BC056400 mRNA. Translation: AAH56400.1 .
CCDSi CCDS233.1.
RefSeqi NP_001070663.1. NM_001077195.1.
NP_085137.1. NM_030634.2.
UniGenei Hs.293798.

3D structure databases

ProteinModelPortali Q9C0F3.
SMRi Q9C0F3. Positions 140-469.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123316. 5 interactions.
IntActi Q9C0F3. 4 interactions.
MINTi MINT-8417741.
STRINGi 9606.ENSP00000313582.

PTM databases

PhosphoSitei Q9C0F3.

Polymorphism databases

DMDMi 20141030.

Proteomic databases

PaxDbi Q9C0F3.
PRIDEi Q9C0F3.

Protocols and materials databases

DNASUi 80818.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314011 ; ENSP00000313582 ; ENSG00000125945 .
ENST00000374608 ; ENSP00000363736 ; ENSG00000125945 .
GeneIDi 80818.
KEGGi hsa:80818.
UCSCi uc001bgt.3. human.

Organism-specific databases

CTDi 80818.
GeneCardsi GC01M023685.
HGNCi HGNC:20814. ZNF436.
HPAi HPA043817.
MIMi 611703. gene.
neXtProti NX_Q9C0F3.
PharmGKBi PA134911283.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00770000120459.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q9C0F3.
KOi K09228.
OMAi HCNECGE.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q9C0F3.
TreeFami TF337055.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSi ZNF436. human.
GeneWikii ZNF436.
GenomeRNAii 80818.
NextBioi 71214.
PROi Q9C0F3.
SOURCEi Search...

Gene expression databases

Bgeei Q9C0F3.
CleanExi HS_ZNF436.
ExpressionAtlasi Q9C0F3. baseline and differential.
Genevestigatori Q9C0F3.

Family and domain databases

Gene3Di 3.30.160.60. 12 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel zinc-finger protein ZNF436 suppresses transcriptional activities of AP-1 and SRE."
    Li Y., Du X., Li F., Deng Y., Yang Z., Wang Y., Pen Z., Wang Z., Yuan W., Zhu C., Wu X.
    Mol. Biol. Rep. 33:287-294(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Fetal heart.
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-196.

Entry informationi

Entry nameiZN436_HUMAN
AccessioniPrimary (citable) accession number: Q9C0F3
Secondary accession number(s): Q658I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: November 26, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3