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Protein

Zinc finger protein 436

Gene

ZNF436

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri138 – 160C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri166 – 188C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125945-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 436
Gene namesi
Name:ZNF436
Synonyms:KIAA1710
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20814. ZNF436.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80818.
OpenTargetsiENSG00000125945.
ENSG00000283009.
PharmGKBiPA134911283.

Polymorphism and mutation databases

BioMutaiZNF436.
DMDMi20141030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475841 – 470Zinc finger protein 436Add BLAST470

Proteomic databases

EPDiQ9C0F3.
PaxDbiQ9C0F3.
PeptideAtlasiQ9C0F3.
PRIDEiQ9C0F3.

PTM databases

iPTMnetiQ9C0F3.
PhosphoSitePlusiQ9C0F3.

Expressioni

Tissue specificityi

Expressed in fetal brain, heart, liver, spleen, bladder, lung, skin, skeletal muscle, stomach and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000125945.
CleanExiHS_ZNF436.
ExpressionAtlasiQ9C0F3. baseline and differential.
GenevisibleiQ9C0F3. HS.

Organism-specific databases

HPAiHPA043817.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434632EBI-8489702,EBI-349968

Protein-protein interaction databases

BioGridi123316. 5 interactors.
IntActiQ9C0F3. 4 interactors.
MINTiMINT-8417741.
STRINGi9606.ENSP00000313582.

Structurei

3D structure databases

ProteinModelPortaliQ9C0F3.
SMRiQ9C0F3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 86KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri138 – 160C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri166 – 188C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133674.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9C0F3.
KOiK09228.
OMAiERPVGNT.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9C0F3.
TreeFamiTF337055.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C0F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATLLMAGS QAPVTFEDMA MYLTREEWRP LDAAQRDLYR DVMQENYGNV
60 70 80 90 100
VSLDFEIRSE NEVNPKQEIS EDVQFGTTSE RPAENAEENP ESEEGFESGD
110 120 130 140 150
RSERQWGDLT AEEWVSYPLQ PVTDLLVHKE VHTGIRYHIC SHCGKAFSQI
160 170 180 190 200
SDLNRHQKTH TGDRPYKCYE CGKGFSRSSH LIQHQRTHTG ERPYDCNECG
210 220 230 240 250
KSFGRSSHLI QHQTIHTGEK PHKCNECGKS FCRLSHLIQH QRTHSGEKPY
260 270 280 290 300
ECEECGKSFS RSSHLAQHQR THTGEKPYEC NECGRGFSER SDLIKHYRVH
310 320 330 340 350
TGERPYKCDE CGKNFSQNSD LVRHRRAHTG EKPYHCNECG ENFSRISHLV
360 370 380 390 400
QHQRTHTGEK PYECNACGKS FSRSSHLITH QKIHTGEKPY ECNECWRSFG
410 420 430 440 450
ERSDLIKHQR THTGEKPYEC VQCGKGFTQS SNLITHQRVH TGEKPYECTE
460 470
CEKSFSRSSA LIKHKRVHTD
Length:470
Mass (Da):54,277
Last modified:March 27, 2002 - v2
Checksum:iD14EA2026529FCC7
GO

Sequence cautioni

The sequence BAB21801 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035579196C → G in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051497 mRNA. Translation: BAB21801.1. Different initiation.
AL834485 mRNA. Translation: CAD39143.1.
AL109936 Genomic DNA. Translation: CAI19029.1.
BC056400 mRNA. Translation: AAH56400.1.
CCDSiCCDS233.1.
RefSeqiNP_001070663.1. NM_001077195.1.
NP_085137.1. NM_030634.2.
UniGeneiHs.293798.

Genome annotation databases

EnsembliENST00000314011; ENSP00000313582; ENSG00000125945.
ENST00000374608; ENSP00000363736; ENSG00000125945.
ENST00000635349; ENSP00000489127; ENSG00000283009.
ENST00000635400; ENSP00000489469; ENSG00000283009.
GeneIDi80818.
KEGGihsa:80818.
UCSCiuc001bgt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051497 mRNA. Translation: BAB21801.1. Different initiation.
AL834485 mRNA. Translation: CAD39143.1.
AL109936 Genomic DNA. Translation: CAI19029.1.
BC056400 mRNA. Translation: AAH56400.1.
CCDSiCCDS233.1.
RefSeqiNP_001070663.1. NM_001077195.1.
NP_085137.1. NM_030634.2.
UniGeneiHs.293798.

3D structure databases

ProteinModelPortaliQ9C0F3.
SMRiQ9C0F3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123316. 5 interactors.
IntActiQ9C0F3. 4 interactors.
MINTiMINT-8417741.
STRINGi9606.ENSP00000313582.

PTM databases

iPTMnetiQ9C0F3.
PhosphoSitePlusiQ9C0F3.

Polymorphism and mutation databases

BioMutaiZNF436.
DMDMi20141030.

Proteomic databases

EPDiQ9C0F3.
PaxDbiQ9C0F3.
PeptideAtlasiQ9C0F3.
PRIDEiQ9C0F3.

Protocols and materials databases

DNASUi80818.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314011; ENSP00000313582; ENSG00000125945.
ENST00000374608; ENSP00000363736; ENSG00000125945.
ENST00000635349; ENSP00000489127; ENSG00000283009.
ENST00000635400; ENSP00000489469; ENSG00000283009.
GeneIDi80818.
KEGGihsa:80818.
UCSCiuc001bgt.4. human.

Organism-specific databases

CTDi80818.
DisGeNETi80818.
GeneCardsiZNF436.
HGNCiHGNC:20814. ZNF436.
HPAiHPA043817.
MIMi611703. gene.
neXtProtiNX_Q9C0F3.
OpenTargetsiENSG00000125945.
ENSG00000283009.
PharmGKBiPA134911283.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133674.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9C0F3.
KOiK09228.
OMAiERPVGNT.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9C0F3.
TreeFamiTF337055.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125945-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF436. human.
GeneWikiiZNF436.
GenomeRNAii80818.
PROiQ9C0F3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125945.
CleanExiHS_ZNF436.
ExpressionAtlasiQ9C0F3. baseline and differential.
GenevisibleiQ9C0F3. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN436_HUMAN
AccessioniPrimary (citable) accession number: Q9C0F3
Secondary accession number(s): Q658I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.