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Protein

Zinc finger protein 436

Gene

ZNF436

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri138 – 160C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri166 – 188C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 436
Gene namesi
Name:ZNF436
Synonyms:KIAA1710
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000125945.14
HGNCiHGNC:20814 ZNF436
MIMi611703 gene
neXtProtiNX_Q9C0F3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80818
OpenTargetsiENSG00000125945
PharmGKBiPA134911283

Polymorphism and mutation databases

BioMutaiZNF436
DMDMi20141030

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475841 – 470Zinc finger protein 436Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki66Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9C0F3
PaxDbiQ9C0F3
PeptideAtlasiQ9C0F3
PRIDEiQ9C0F3

PTM databases

iPTMnetiQ9C0F3
PhosphoSitePlusiQ9C0F3

Expressioni

Tissue specificityi

Expressed in fetal brain, heart, liver, spleen, bladder, lung, skin, skeletal muscle, stomach and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000125945
CleanExiHS_ZNF436
ExpressionAtlasiQ9C0F3 baseline and differential
GenevisibleiQ9C0F3 HS

Organism-specific databases

HPAiHPA043817

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434632EBI-8489702,EBI-349968

Protein-protein interaction databases

BioGridi123316, 7 interactors
IntActiQ9C0F3, 5 interactors
MINTiQ9C0F3
STRINGi9606.ENSP00000313582

Structurei

3D structure databases

ProteinModelPortaliQ9C0F3
SMRiQ9C0F3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 86KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri138 – 160C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri166 – 188C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144036
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9C0F3
KOiK09228
OMAiERPVGNT
OrthoDBiEOG091G02KC
PhylomeDBiQ9C0F3
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequencei

Sequence statusi: Complete.

Q9C0F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATLLMAGS QAPVTFEDMA MYLTREEWRP LDAAQRDLYR DVMQENYGNV
60 70 80 90 100
VSLDFEIRSE NEVNPKQEIS EDVQFGTTSE RPAENAEENP ESEEGFESGD
110 120 130 140 150
RSERQWGDLT AEEWVSYPLQ PVTDLLVHKE VHTGIRYHIC SHCGKAFSQI
160 170 180 190 200
SDLNRHQKTH TGDRPYKCYE CGKGFSRSSH LIQHQRTHTG ERPYDCNECG
210 220 230 240 250
KSFGRSSHLI QHQTIHTGEK PHKCNECGKS FCRLSHLIQH QRTHSGEKPY
260 270 280 290 300
ECEECGKSFS RSSHLAQHQR THTGEKPYEC NECGRGFSER SDLIKHYRVH
310 320 330 340 350
TGERPYKCDE CGKNFSQNSD LVRHRRAHTG EKPYHCNECG ENFSRISHLV
360 370 380 390 400
QHQRTHTGEK PYECNACGKS FSRSSHLITH QKIHTGEKPY ECNECWRSFG
410 420 430 440 450
ERSDLIKHQR THTGEKPYEC VQCGKGFTQS SNLITHQRVH TGEKPYECTE
460 470
CEKSFSRSSA LIKHKRVHTD
Length:470
Mass (Da):54,277
Last modified:March 27, 2002 - v2
Checksum:iD14EA2026529FCC7
GO

Sequence cautioni

The sequence BAB21801 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035579196C → G in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051497 mRNA Translation: BAB21801.1 Different initiation.
AL834485 mRNA Translation: CAD39143.1
AL109936 Genomic DNA No translation available.
BC056400 mRNA Translation: AAH56400.1
CCDSiCCDS233.1
RefSeqiNP_001070663.1, NM_001077195.1
NP_085137.1, NM_030634.2
UniGeneiHs.293798

Genome annotation databases

EnsembliENST00000314011; ENSP00000313582; ENSG00000125945
ENST00000374608; ENSP00000363736; ENSG00000125945
ENST00000635349; ENSP00000489127; ENSG00000283009
ENST00000635400; ENSP00000489469; ENSG00000283009
GeneIDi80818
KEGGihsa:80818
UCSCiuc001bgt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN436_HUMAN
AccessioniPrimary (citable) accession number: Q9C0F3
Secondary accession number(s): Q658I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: May 23, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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