Q9C0F0 (ASXL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative Polycomb group protein ASXL3

Alternative name(s):
Additional sex combs-like protein 3

Gene names

Name:	ASXL3
Synonyms:	KIAA1713

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2248 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility By similarity.
Subcellular location	Nucleus Probable.
Tissue specificity	Expressed in pancreatic islet, testis, neuroblastoma, head and neck tumor. Ref.6
Sequence similarities	Belongs to the Asx family. Contains 1 PHD-type zinc finger.
Sequence caution	The sequence BAB71186.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9C0F0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9C0F0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-293: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9C0F0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1239-1254: SVCSTAISGAIKEHPF → KKKKKKKRAAALVLSL
     1255-2248: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2248	2248	Putative Polycomb group protein ASXL3		PRO_0000320670
Regions
	Zinc finger	2210 – 2247	38	PHD-type; atypical
	Compositional bias	609 – 787	179	Ser-rich
	Compositional bias	1051 – 1080	30	Ala-rich
	Compositional bias	1199 – 1357	159	Ser-rich
	Compositional bias	2017 – 2058	42	Pro-rich
Natural variations
	Alternative sequence	1 – 293	293	Missing in isoform 2.		VSP_031717
	Alternative sequence	1239 – 1254	16	SVCST…KEHPF → KKKKKKKRAAALVLSL in isoform 3.		VSP_031718
	Alternative sequence	1255 – 2248	994	Missing in isoform 3.		VSP_031719
	Natural variant	954	1	N → S. Ref.3 Ref.5 Corresponds to variant rs2282632 [ dbSNP | Ensembl ].		VAR_039267
	Natural variant	1415	1	M → R. Corresponds to variant rs16964887 [ dbSNP | Ensembl ].		VAR_039268
	Natural variant	1652	1	V → M. Corresponds to variant rs17746949 [ dbSNP | Ensembl ].		VAR_039269
	Natural variant	1708	1	M → V. Ref.2 Ref.3 Corresponds to variant rs7232237 [ dbSNP | Ensembl ].		VAR_039270
Experimental info
	Sequence conflict	727	1	E → K in BAD18599. Ref.2
	Sequence conflict	1079	1	A → V in CAB61377. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 26, 2008. Version 3. Checksum: E8BAC62B817F904D	FASTA	2,248	241,919
	10 20 30 40 50 60 MKDKRKKKDR TWAEAARLAL EKHPNSPMTA KQILEVIQKE GLKETSGTSP LACLNAMLHT 70 80 90 100 110 120 NTRIGDGTFF KIPGKSGLYA LKKEESSCPA DGTLDLVCES ELDGTDMAEA NAHGEENGVC 130 140 150 160 170 180 SKQVTDEASS TRDSSLTNTA VQSKLVSSFQ QHTKKALKQA LRQQQKRRNG VSMMVNKTVP 190 200 210 220 230 240 RVVLTPLKVS DEQSDSPSGS ESKNGEADSS DKEMKHGQKS PTGKQTSQHL KRLKKSGLGH 250 260 270 280 290 300 LKWTKAEDID IETPGSILVN TNLRALINKH TFASLPQHFQ QYLLLLLPEV DRQMGSDGIL 310 320 330 340 350 360 RLSTSALNNE FFAYAAQGWK QRLAEGEFTP EMQLRIRQEI EKEKKTEPWK EKFFERFYGE 370 380 390 400 410 420 KLGMSREESV KLTTGPNNAG AQSSSSCGTS GLPVSAQTAL AEQQPKSMKS PASPEPGFCA 430 440 450 460 470 480 TLCPMVEIPP KDIMAELESE DILIPEESVI QEEIAEEVET SICECQDENH KTIPEFSEEA 490 500 510 520 530 540 ESLTNSHEEP QIAPPEDNLE SCVMMNDVLE TLPHIEVKIE GKSESPQEEM TVVIDQLEVC 550 560 570 580 590 600 DSLIPSTSSM THVSDTEHKE SETAVETSTP KIKTGSSSLE GQFPNEGIAI DMELQSDPEE 610 620 630 640 650 660 QLSENACISE TSFSSESPEG ACTSLPSPGG ETQSTSEESC TPASLETTFC SEVSSTENTD 670 680 690 700 710 720 KYNQRNSTDE NFHASLMSEI SPISTSPEIS EASLMSNLPL TSEASPVSNL PLTSETSPMS 730 740 750 760 770 780 DLPLTSETSS VSSMLLTSET TFVSSLPLPS ETSPISNSSI NERMAHQQRK SPSVSEEPLS 790 800 810 820 830 840 PQKDESSATA KPLGENLTSQ QKNLSNTPEP IIMSSSSIAP EAFPSEDLHN KTLSQQTCKS 850 860 870 880 890 900 HVDTEKPYPA SIPELASTEM IKVKNHSVLQ RTEKKVLPSP LELSVFSEGT DNKGNELPSA 910 920 930 940 950 960 KLQDKQYISS VDKAPFSEGS RNKTHKQGST QSRLETSHTS KSSEPSKSPD GIRNESRDSE 970 980 990 1000 1010 1020 ISKRKTAEQH SFGICKEKRA RIEDDQSTRN ISSSSPPEKE QPPREEPRVP PLKIQLSKIG 1030 1040 1050 1060 1070 1080 PPFIIKSQPV SKPESRASTS TSVSGGRNTG ARTLADIKAR AQQARAQREA AAAAAVAAAA 1090 1100 1110 1120 1130 1140 SIVSGAMGSP GEGGKTRTLA HIKEQTKAKL FAKHQARAHL FQTSKETRLP PPLSSKEGPP 1150 1160 1170 1180 1190 1200 NLEVSSTPET KMEGSTGVII VNPNCRSPSN KSAHLRETTT VLQQSLNPSK LPETATDLSV 1210 1220 1230 1240 1250 1260 HSSDENIPVS HLSEKIVSST SSENSSVPML FNKNSVPVSV CSTAISGAIK EHPFVSSVDK 1270 1280 1290 1300 1310 1320 SSVLMSVDSA NTTISACNIS MLKTIQGTDT PCIAIIPKCI ESTPISATTE GSSISSSMDD 1330 1340 1350 1360 1370 1380 KQLLISSSSA SNLVSTQYTS VPTPSIGNNL PNLSTSSVLI PPMGINNRFP SEKIAIPGSE 1390 1400 1410 1420 1430 1440 EQATVSMGTT VRAALSCSDS VAVTDSLVAH PTVAMFTGNM LTINSYDSPP KLSAESLDKN 1450 1460 1470 1480 1490 1500 SGPRNRADNS GKPQQPPGGF APAAINRSIP CKVIVDHSTT LTSSLSLTVS VESSEASLDL 1510 1520 1530 1540 1550 1560 QGRPVRTEAS VQPVACPQVS VISRPEPVAN EGIDHSSTFI AASAAKQDSK TLPATCTSLR 1570 1580 1590 1600 1610 1620 ELPLVPDKLN EPTAPSHNFA EQARGPAPFK SEADTTCSNQ YNPSNRICWN DDGMRSTGQP 1630 1640 1650 1660 1670 1680 LVTHSGSSKQ KEYLEQSCPK AIKTEHANYL NVSELHPRNL VTNVALPVKS ELHEADKGFR 1690 1700 1710 1720 1730 1740 MDTEDFPGPE LPPPAAEGAS SVQQTQNMKA STSSPMEEAI SLATDALKRV PGAGSSGCRL 1750 1760 1770 1780 1790 1800 SSVEANNPLV TQLLQGNLPL EKVLPQPRLG AKLEINRLPL PLQTTSVGKT APERNVEIPP 1810 1820 1830 1840 1850 1860 SSPNPDGKGY LAGTLAPLQM RKRENHPKKR VARTVGEHTQ VKCEPGKLLV EPDVKGVPCV 1870 1880 1890 1900 1910 1920 ISSGISQLGH SQPFKQEWLN KHSMQNRIVH SPEVKQQKRL LPSCSFQQNL FHVDKNGGFH 1930 1940 1950 1960 1970 1980 TDAGTSHRQQ FYQMPVAARG PIPTAALLQA SSKTPVGCNA FAFNRHLEQK GLGEVSLSSA 1990 2000 2010 2020 2030 2040 PHQLRLANML SPNMPMKEGD EVGGTAHTMP NKALVHPPPP PPPPPPPPLA LPPPPPPPPP 2050 2060 2070 2080 2090 2100 LPPPLPNAEV PSDQKQPPVT METTKRLSWP QSTGICSNIK SEPLSFEEGL SSSCELGMKQ 2110 2120 2130 2140 2150 2160 VSYDQNEMKE QLKAFALKSA DFSSYLLSEP QKPFTQLAAQ KMQVQQQQQL CGNYPTIHFG 2170 2180 2190 2200 2210 2220 STSFKRAASA IEKSIGILGS GSNPATGLSG QNAQMPVQNF ADSSNADELE LKCSCRLKAM 2230 2240 IVCKGCGAFC HDDCIGPSKL CVACLVVR
	Isoform 2 [UniParc]. Checksum: BFD23FA2D4E83C5E	FASTA	1,955	209,679
	10 20 30 40 50 60 MGSDGILRLS TSALNNEFFA YAAQGWKQRL AEGEFTPEMQ LRIRQEIEKE KKTEPWKEKF 70 80 90 100 110 120 FERFYGEKLG MSREESVKLT TGPNNAGAQS SSSCGTSGLP VSAQTALAEQ QPKSMKSPAS 130 140 150 160 170 180 PEPGFCATLC PMVEIPPKDI MAELESEDIL IPEESVIQEE IAEEVETSIC ECQDENHKTI 190 200 210 220 230 240 PEFSEEAESL TNSHEEPQIA PPEDNLESCV MMNDVLETLP HIEVKIEGKS ESPQEEMTVV 250 260 270 280 290 300 IDQLEVCDSL IPSTSSMTHV SDTEHKESET AVETSTPKIK TGSSSLEGQF PNEGIAIDME 310 320 330 340 350 360 LQSDPEEQLS ENACISETSF SSESPEGACT SLPSPGGETQ STSEESCTPA SLETTFCSEV 370 380 390 400 410 420 SSTENTDKYN QRNSTDENFH ASLMSEISPI STSPEISEAS LMSNLPLTSE ASPVSNLPLT 430 440 450 460 470 480 SETSPMSDLP LTSETSSVSS MLLTSETTFV SSLPLPSETS PISNSSINER MAHQQRKSPS 490 500 510 520 530 540 VSEEPLSPQK DESSATAKPL GENLTSQQKN LSNTPEPIIM SSSSIAPEAF PSEDLHNKTL 550 560 570 580 590 600 SQQTCKSHVD TEKPYPASIP ELASTEMIKV KNHSVLQRTE KKVLPSPLEL SVFSEGTDNK 610 620 630 640 650 660 GNELPSAKLQ DKQYISSVDK APFSEGSRNK THKQGSTQSR LETSHTSKSS EPSKSPDGIR 670 680 690 700 710 720 NESRDSEISK RKTAEQHSFG ICKEKRARIE DDQSTRNISS SSPPEKEQPP REEPRVPPLK 730 740 750 760 770 780 IQLSKIGPPF IIKSQPVSKP ESRASTSTSV SGGRNTGART LADIKARAQQ ARAQREAAAA 790 800 810 820 830 840 AAVAAAASIV SGAMGSPGEG GKTRTLAHIK EQTKAKLFAK HQARAHLFQT SKETRLPPPL 850 860 870 880 890 900 SSKEGPPNLE VSSTPETKME GSTGVIIVNP NCRSPSNKSA HLRETTTVLQ QSLNPSKLPE 910 920 930 940 950 960 TATDLSVHSS DENIPVSHLS EKIVSSTSSE NSSVPMLFNK NSVPVSVCST AISGAIKEHP 970 980 990 1000 1010 1020 FVSSVDKSSV LMSVDSANTT ISACNISMLK TIQGTDTPCI AIIPKCIEST PISATTEGSS 1030 1040 1050 1060 1070 1080 ISSSMDDKQL LISSSSASNL VSTQYTSVPT PSIGNNLPNL STSSVLIPPM GINNRFPSEK 1090 1100 1110 1120 1130 1140 IAIPGSEEQA TVSMGTTVRA ALSCSDSVAV TDSLVAHPTV AMFTGNMLTI NSYDSPPKLS 1150 1160 1170 1180 1190 1200 AESLDKNSGP RNRADNSGKP QQPPGGFAPA AINRSIPCKV IVDHSTTLTS SLSLTVSVES 1210 1220 1230 1240 1250 1260 SEASLDLQGR PVRTEASVQP VACPQVSVIS RPEPVANEGI DHSSTFIAAS AAKQDSKTLP 1270 1280 1290 1300 1310 1320 ATCTSLRELP LVPDKLNEPT APSHNFAEQA RGPAPFKSEA DTTCSNQYNP SNRICWNDDG 1330 1340 1350 1360 1370 1380 MRSTGQPLVT HSGSSKQKEY LEQSCPKAIK TEHANYLNVS ELHPRNLVTN VALPVKSELH 1390 1400 1410 1420 1430 1440 EADKGFRMDT EDFPGPELPP PAAEGASSVQ QTQNMKASTS SPMEEAISLA TDALKRVPGA 1450 1460 1470 1480 1490 1500 GSSGCRLSSV EANNPLVTQL LQGNLPLEKV LPQPRLGAKL EINRLPLPLQ TTSVGKTAPE 1510 1520 1530 1540 1550 1560 RNVEIPPSSP NPDGKGYLAG TLAPLQMRKR ENHPKKRVAR TVGEHTQVKC EPGKLLVEPD 1570 1580 1590 1600 1610 1620 VKGVPCVISS GISQLGHSQP FKQEWLNKHS MQNRIVHSPE VKQQKRLLPS CSFQQNLFHV 1630 1640 1650 1660 1670 1680 DKNGGFHTDA GTSHRQQFYQ MPVAARGPIP TAALLQASSK TPVGCNAFAF NRHLEQKGLG 1690 1700 1710 1720 1730 1740 EVSLSSAPHQ LRLANMLSPN MPMKEGDEVG GTAHTMPNKA LVHPPPPPPP PPPPPLALPP 1750 1760 1770 1780 1790 1800 PPPPPPPLPP PLPNAEVPSD QKQPPVTMET TKRLSWPQST GICSNIKSEP LSFEEGLSSS 1810 1820 1830 1840 1850 1860 CELGMKQVSY DQNEMKEQLK AFALKSADFS SYLLSEPQKP FTQLAAQKMQ VQQQQQLCGN 1870 1880 1890 1900 1910 1920 YPTIHFGSTS FKRAASAIEK SIGILGSGSN PATGLSGQNA QMPVQNFADS SNADELELKC 1930 1940 1950 SCRLKAMIVC KGCGAFCHDD CIGPSKLCVA CLVVR
	Isoform 3 [UniParc]. Checksum: 9B69C5516D50595D	FASTA	1,254	136,233
	10 20 30 40 50 60 MKDKRKKKDR TWAEAARLAL EKHPNSPMTA KQILEVIQKE GLKETSGTSP LACLNAMLHT 70 80 90 100 110 120 NTRIGDGTFF KIPGKSGLYA LKKEESSCPA DGTLDLVCES ELDGTDMAEA NAHGEENGVC 130 140 150 160 170 180 SKQVTDEASS TRDSSLTNTA VQSKLVSSFQ QHTKKALKQA LRQQQKRRNG VSMMVNKTVP 190 200 210 220 230 240 RVVLTPLKVS DEQSDSPSGS ESKNGEADSS DKEMKHGQKS PTGKQTSQHL KRLKKSGLGH 250 260 270 280 290 300 LKWTKAEDID IETPGSILVN TNLRALINKH TFASLPQHFQ QYLLLLLPEV DRQMGSDGIL 310 320 330 340 350 360 RLSTSALNNE FFAYAAQGWK QRLAEGEFTP EMQLRIRQEI EKEKKTEPWK EKFFERFYGE 370 380 390 400 410 420 KLGMSREESV KLTTGPNNAG AQSSSSCGTS GLPVSAQTAL AEQQPKSMKS PASPEPGFCA 430 440 450 460 470 480 TLCPMVEIPP KDIMAELESE DILIPEESVI QEEIAEEVET SICECQDENH KTIPEFSEEA 490 500 510 520 530 540 ESLTNSHEEP QIAPPEDNLE SCVMMNDVLE TLPHIEVKIE GKSESPQEEM TVVIDQLEVC 550 560 570 580 590 600 DSLIPSTSSM THVSDTEHKE SETAVETSTP KIKTGSSSLE GQFPNEGIAI DMELQSDPEE 610 620 630 640 650 660 QLSENACISE TSFSSESPEG ACTSLPSPGG ETQSTSEESC TPASLETTFC SEVSSTENTD 670 680 690 700 710 720 KYNQRNSTDE NFHASLMSEI SPISTSPEIS EASLMSNLPL TSEASPVSNL PLTSETSPMS 730 740 750 760 770 780 DLPLTSETSS VSSMLLTSET TFVSSLPLPS ETSPISNSSI NERMAHQQRK SPSVSEEPLS 790 800 810 820 830 840 PQKDESSATA KPLGENLTSQ QKNLSNTPEP IIMSSSSIAP EAFPSEDLHN KTLSQQTCKS 850 860 870 880 890 900 HVDTEKPYPA SIPELASTEM IKVKNHSVLQ RTEKKVLPSP LELSVFSEGT DNKGNELPSA 910 920 930 940 950 960 KLQDKQYISS VDKAPFSEGS RNKTHKQGST QSRLETSHTS KSSEPSKSPD GIRNESRDSE 970 980 990 1000 1010 1020 ISKRKTAEQH SFGICKEKRA RIEDDQSTRN ISSSSPPEKE QPPREEPRVP PLKIQLSKIG 1030 1040 1050 1060 1070 1080 PPFIIKSQPV SKPESRASTS TSVSGGRNTG ARTLADIKAR AQQARAQREA AAAAAVAAAA 1090 1100 1110 1120 1130 1140 SIVSGAMGSP GEGGKTRTLA HIKEQTKAKL FAKHQARAHL FQTSKETRLP PPLSSKEGPP 1150 1160 1170 1180 1190 1200 NLEVSSTPET KMEGSTGVII VNPNCRSPSN KSAHLRETTT VLQQSLNPSK LPETATDLSV 1210 1220 1230 1240 1250 HSSDENIPVS HLSEKIVSST SSENSSVPML FNKNSVPVKK KKKKKRAAAL VLSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed: 16177791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1238 (ISOFORM 2), VARIANT VAL-1708. Tissue: Testis.
[3]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed: 11214970] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 597-2248, VARIANTS SER-954 AND VAL-1708. Tissue: Brain.
[4]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 818-2248 (ISOFORM 3), VARIANT SER-954. Tissue: Testis.
[6]	"Identification and characterization of ASXL3 gene in silico." Katoh M., Katoh M. Int. J. Oncol. 24:1617-1622(2004) [PubMed: 15138607] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC023192 Genomic DNA. No translation available. AC090989 Genomic DNA. No translation available. AC010798 Genomic DNA. No translation available. AK056450 mRNA. Translation: BAB71186.1. Different initiation. AK131454 mRNA. Translation: BAD18599.1. AB051500 mRNA. Translation: BAB21804.2. AL133050 mRNA. Translation: CAB61377.1.
IPI	IPI00853376. IPI00885069. IPI00885096.
PIR	T42653.
RefSeq	NP_085135.1. NM_030632.1.
UniGene	Hs.464876.
3D structure databases
ProteinModelPortal	Q9C0F0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9C0F0.
Polymorphism databases
DMDM	172046234.
Proteomic databases
PRIDE	Q9C0F0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000269197; ENSP00000269197; ENSG00000141431.
GeneID	80816.
KEGG	hsa:80816.
UCSC	uc002kxq.2. human. uc010dmg.1. human.
Organism-specific databases
CTD	80816.
GeneCards	GC18P031158.
HGNC	HGNC:29357. ASXL3.
neXtProt	NX_Q9C0F0.
PharmGKB	PA162377010.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17418.
GeneTree	ENSGT00520000055578.
HOGENOM	HBG505917.
HOVERGEN	HBG100451.
InParanoid	Q9C0F0.
OMA	SSVLMSV.
OrthoDB	EOG4GQQ43.
Gene expression databases
ArrayExpress	Q9C0F0.
Bgee	Q9C0F0.
CleanEx	HS_ASXL3.
Genevestigator	Q9C0F0.
Family and domain databases
InterPro	IPR024811. ASX/ASX-like. [Graphical view]
KO	K11471.
PANTHER	PTHR13578. PTHR13578. 1 hit.
PROSITE	PS01359. ZF_PHD_1. False negative. PS50016. ZF_PHD_2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	71202.

Entry information

Entry name

ASXL3_HUMAN

Accession

Primary (citable) accession number: Q9C0F0
Secondary accession number(s): Q6ZMX6, Q96MU3, Q9UFC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 57 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.