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Protein

Protein lunapark

Gene

LNP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in tubular endoplasmic reticulum network formation and maintenance. May be involved in limb and central nervous system development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri276 – 301C4-type; plays a role in ER morphologyBy similarityAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144320-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lunapark
Gene namesi
Name:LNP
Synonyms:KIAA1715
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:21610. KIAA1715.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 45CytoplasmicBy similarityAdd BLAST44
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Topological domaini67 – 77LumenalBy similarityAdd BLAST11
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 428CytoplasmicBy similarityAdd BLAST330

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: MGI
  • endoplasmic reticulum tubular network Source: GO_Central
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi80856.
OpenTargetsiENSG00000144320.
PharmGKBiPA134938939.

Polymorphism and mutation databases

BioMutaiLNP.
DMDMi114149979.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002483102 – 428Protein lunaparkAdd BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei177PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei213PhosphothreonineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei414PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9C0E8.
MaxQBiQ9C0E8.
PaxDbiQ9C0E8.
PeptideAtlasiQ9C0E8.
PRIDEiQ9C0E8.

PTM databases

iPTMnetiQ9C0E8.
PhosphoSitePlusiQ9C0E8.

Miscellaneous databases

PMAP-CutDBQ9C0E8.

Expressioni

Gene expression databases

BgeeiENSG00000144320.
CleanExiHS_KIAA1715.
ExpressionAtlasiQ9C0E8. baseline and differential.
GenevisibleiQ9C0E8. HS.

Organism-specific databases

HPAiHPA014205.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KLHL12Q53G594EBI-11024283,EBI-740929

Protein-protein interaction databases

BioGridi123333. 33 interactors.
IntActiQ9C0E8. 16 interactors.
STRINGi9606.ENSP00000272748.

Structurei

3D structure databases

ProteinModelPortaliQ9C0E8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili16 – 41Sequence analysisAdd BLAST26
Coiled coili102 – 128Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi178 – 250Pro-richAdd BLAST73

Sequence similaritiesi

Belongs to the lunapark family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri276 – 301C4-type; plays a role in ER morphologyBy similarityAdd BLAST26

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG2846. Eukaryota.
ENOG4111I2R. LUCA.
GeneTreeiENSGT00390000001859.
HOGENOMiHOG000231891.
HOVERGENiHBG079498.
InParanoidiQ9C0E8.
OMAiWSIRTVI.
OrthoDBiEOG091G0IRW.
PhylomeDBiQ9C0E8.
TreeFamiTF315086.

Family and domain databases

InterProiIPR019273. Lunapark_dom.
[Graphical view]
PfamiPF10058. zinc_ribbon_10. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0E8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGLFSRWRT KPSTVEVLES IDKEIQALEE FREKNQRLQK LWVGRLILYS
60 70 80 90 100
SVLYLFTCLI VYLWYLPDEF TARLAMTLPF FAFPLIIWSI RTVIIFFFSK
110 120 130 140 150
RTERNNEALD DLKSQRKKIL EEVMEKETYK TAKLILERFD PDSKKAKECE
160 170 180 190 200
PPSAGAAVTA RPGQEIRQRT AAQRNLSPTP ASPNQGPPPQ VPVSPGPPKD
210 220 230 240 250
SSAPGGPPER TVTPALSSNV LPRHLGSPAT SVPGMGLHPP GPPLARPILP
260 270 280 290 300
RERGALDRIV EYLVGDGPQN RYALICQQCF SHNGMALKEE FEYIAFRCAY
310 320 330 340 350
CFFLNPARKT RPQAPRLPEF SFEKRQVVEG SSSVGPLPSG SVLSSDNQFN
360 370 380 390 400
EESLEHDVLD DNTEQTDDKI PATEQTNQVI EKASDSEEPE EKQETENEEA
410 420
SVIETNSTVP GADSIPDPEL SGESLTAE
Length:428
Mass (Da):47,740
Last modified:September 5, 2006 - v2
Checksum:iF5BBA4186C2691BF
GO
Isoform 2 (identifier: Q9C0E8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MGGLFSRWR → MEGK

Note: No experimental confirmation available.
Show »
Length:423
Mass (Da):47,094
Checksum:iCAF46E3EB956B8BC
GO
Isoform 3 (identifier: Q9C0E8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.
Show »
Length:305
Mass (Da):33,001
Checksum:i2FDFED2CFE7C83EC
GO
Isoform 4 (identifier: Q9C0E8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     235-235: M → MEMGLPHIAQAGLEHLSSSDLSTSTSQSAGIT

Note: No experimental confirmation available.
Show »
Length:459
Mass (Da):50,848
Checksum:i367198608E69DDF1
GO

Sequence cautioni

The sequence BAB21806 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti262Y → H in BAB71207 (PubMed:14702039).Curated1
Sequence conflicti374E → G in AAH31530 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0202381 – 123Missing in isoform 3. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_0202391 – 9MGGLFSRWR → MEGK in isoform 2. 1 Publication9
Alternative sequenceiVSP_054427235M → MEMGLPHIAQAGLEHLSSSD LSTSTSQSAGIT in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051502 mRNA. Translation: BAB21806.1. Different initiation.
AK056532 mRNA. Translation: BAB71207.1.
AC016751 Genomic DNA. No translation available.
AC016915 Genomic DNA. No translation available.
BC031530 mRNA. Translation: AAH31530.1.
BC105132 mRNA. Translation: AAI05133.1.
BC105134 mRNA. Translation: AAI05135.1.
BC110329 mRNA. Translation: AAI10330.1.
BC143681 mRNA. Translation: AAI43682.1.
AL832947 mRNA. Translation: CAH56306.1.
CCDSiCCDS33332.1. [Q9C0E8-1]
CCDS77488.1. [Q9C0E8-3]
CCDS77489.1. [Q9C0E8-4]
RefSeqiNP_001291937.1. NM_001305008.1.
NP_001291938.1. NM_001305009.1. [Q9C0E8-4]
NP_001291940.1. NM_001305011.1. [Q9C0E8-3]
NP_085153.1. NM_030650.2. [Q9C0E8-1]
XP_006712846.1. XM_006712783.2. [Q9C0E8-1]
XP_016860544.1. XM_017005055.1. [Q9C0E8-3]
UniGeneiHs.209561.

Genome annotation databases

EnsembliENST00000272748; ENSP00000272748; ENSG00000144320. [Q9C0E8-1]
ENST00000409660; ENSP00000386237; ENSG00000144320. [Q9C0E8-3]
ENST00000544803; ENSP00000440905; ENSG00000144320. [Q9C0E8-4]
GeneIDi80856.
KEGGihsa:80856.
UCSCiuc002ukc.2. human. [Q9C0E8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051502 mRNA. Translation: BAB21806.1. Different initiation.
AK056532 mRNA. Translation: BAB71207.1.
AC016751 Genomic DNA. No translation available.
AC016915 Genomic DNA. No translation available.
BC031530 mRNA. Translation: AAH31530.1.
BC105132 mRNA. Translation: AAI05133.1.
BC105134 mRNA. Translation: AAI05135.1.
BC110329 mRNA. Translation: AAI10330.1.
BC143681 mRNA. Translation: AAI43682.1.
AL832947 mRNA. Translation: CAH56306.1.
CCDSiCCDS33332.1. [Q9C0E8-1]
CCDS77488.1. [Q9C0E8-3]
CCDS77489.1. [Q9C0E8-4]
RefSeqiNP_001291937.1. NM_001305008.1.
NP_001291938.1. NM_001305009.1. [Q9C0E8-4]
NP_001291940.1. NM_001305011.1. [Q9C0E8-3]
NP_085153.1. NM_030650.2. [Q9C0E8-1]
XP_006712846.1. XM_006712783.2. [Q9C0E8-1]
XP_016860544.1. XM_017005055.1. [Q9C0E8-3]
UniGeneiHs.209561.

3D structure databases

ProteinModelPortaliQ9C0E8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123333. 33 interactors.
IntActiQ9C0E8. 16 interactors.
STRINGi9606.ENSP00000272748.

PTM databases

iPTMnetiQ9C0E8.
PhosphoSitePlusiQ9C0E8.

Polymorphism and mutation databases

BioMutaiLNP.
DMDMi114149979.

Proteomic databases

EPDiQ9C0E8.
MaxQBiQ9C0E8.
PaxDbiQ9C0E8.
PeptideAtlasiQ9C0E8.
PRIDEiQ9C0E8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272748; ENSP00000272748; ENSG00000144320. [Q9C0E8-1]
ENST00000409660; ENSP00000386237; ENSG00000144320. [Q9C0E8-3]
ENST00000544803; ENSP00000440905; ENSG00000144320. [Q9C0E8-4]
GeneIDi80856.
KEGGihsa:80856.
UCSCiuc002ukc.2. human. [Q9C0E8-1]

Organism-specific databases

CTDi80856.
DisGeNETi80856.
GeneCardsiKIAA1715.
HGNCiHGNC:21610. KIAA1715.
HPAiHPA014205.
MIMi610236. gene.
neXtProtiNX_Q9C0E8.
OpenTargetsiENSG00000144320.
PharmGKBiPA134938939.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2846. Eukaryota.
ENOG4111I2R. LUCA.
GeneTreeiENSGT00390000001859.
HOGENOMiHOG000231891.
HOVERGENiHBG079498.
InParanoidiQ9C0E8.
OMAiWSIRTVI.
OrthoDBiEOG091G0IRW.
PhylomeDBiQ9C0E8.
TreeFamiTF315086.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144320-MONOMER.

Miscellaneous databases

ChiTaRSiKIAA1715. human.
GenomeRNAii80856.
PMAP-CutDBQ9C0E8.
PROiQ9C0E8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144320.
CleanExiHS_KIAA1715.
ExpressionAtlasiQ9C0E8. baseline and differential.
GenevisibleiQ9C0E8. HS.

Family and domain databases

InterProiIPR019273. Lunapark_dom.
[Graphical view]
PfamiPF10058. zinc_ribbon_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLNP_HUMAN
AccessioniPrimary (citable) accession number: Q9C0E8
Secondary accession number(s): B7ZLA8
, Q2M2V8, Q2YD99, Q658W8, Q8N5V9, Q96MS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: November 30, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.