Q9C0E8 (LNP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein lunapark

Gene names

Name:	LNP
Synonyms:	KIAA1715

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in limb and central nervous system development By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the lunapark family.
Sequence caution	The sequence BAB21806.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Transmembrane Transmembrane helix
Molecular function	Developmental protein
PTM	Lipoprotein Myristate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Inferred from electronic annotation. Source: Compara embryonic digit morphogenesis Inferred from electronic annotation. Source: Compara embryonic forelimb morphogenesis Inferred from electronic annotation. Source: Compara limb development Non-traceable author statement PubMed 12732147. Source: UniProtKB
Cellular_component	integral to membrane Non-traceable author statement PubMed 12732147. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CHMP1A	Q9HD42	1	EBI-1047206,EBI-1057156

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9C0E8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9C0E8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MGGLFSRWR → MEGK

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9C0E8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	Protein lunapark		PRO_0000248310
Regions
	Topological domain	1 – 45	45	Cytoplasmic Potential
	Transmembrane	46 – 66	21	Helical; Potential
	Topological domain	67 – 77	11	Extracellular Potential
	Transmembrane	78 – 98	21	Helical; Potential
	Topological domain	99 – 428	330	Cytoplasmic Potential
	Coiled coil	16 – 41	26	Potential
	Coiled coil	102 – 128	27	Potential
	Compositional bias	178 – 250	73	Pro-rich
Amino acid modifications
	Modified residue	177	1	Phosphoserine Ref.8
	Modified residue	182	1	Phosphoserine Ref.5 Ref.8
	Modified residue	194	1	Phosphoserine Ref.5 Ref.8
	Modified residue	321	1	Phosphoserine Ref.5
	Modified residue	414	1	Phosphoserine By similarity
	Lipidation	2	1	N-myristoyl glycine Ref.7
Natural variations
	Alternative sequence	1 – 123	123	Missing in isoform 3.		VSP_020238
	Alternative sequence	1 – 9	9	MGGLFSRWR → MEGK in isoform 2.		VSP_020239
Experimental info
	Sequence conflict	262	1	Y → H in BAB71207. Ref.2
	Sequence conflict	374	1	E → G in AAH31530. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: F5BBA4186C2691BF	FASTA	428	47,740
	10 20 30 40 50 60 MGGLFSRWRT KPSTVEVLES IDKEIQALEE FREKNQRLQK LWVGRLILYS SVLYLFTCLI 70 80 90 100 110 120 VYLWYLPDEF TARLAMTLPF FAFPLIIWSI RTVIIFFFSK RTERNNEALD DLKSQRKKIL 130 140 150 160 170 180 EEVMEKETYK TAKLILERFD PDSKKAKECE PPSAGAAVTA RPGQEIRQRT AAQRNLSPTP 190 200 210 220 230 240 ASPNQGPPPQ VPVSPGPPKD SSAPGGPPER TVTPALSSNV LPRHLGSPAT SVPGMGLHPP 250 260 270 280 290 300 GPPLARPILP RERGALDRIV EYLVGDGPQN RYALICQQCF SHNGMALKEE FEYIAFRCAY 310 320 330 340 350 360 CFFLNPARKT RPQAPRLPEF SFEKRQVVEG SSSVGPLPSG SVLSSDNQFN EESLEHDVLD 370 380 390 400 410 420 DNTEQTDDKI PATEQTNQVI EKASDSEEPE EKQETENEEA SVIETNSTVP GADSIPDPEL SGESLTAE
	Isoform 2 [UniParc]. Checksum: CAF46E3EB956B8BC	FASTA	423	47,094
	10 20 30 40 50 60 MEGKTKPSTV EVLESIDKEI QALEEFREKN QRLQKLWVGR LILYSSVLYL FTCLIVYLWY 70 80 90 100 110 120 LPDEFTARLA MTLPFFAFPL IIWSIRTVII FFFSKRTERN NEALDDLKSQ RKKILEEVME 130 140 150 160 170 180 KETYKTAKLI LERFDPDSKK AKECEPPSAG AAVTARPGQE IRQRTAAQRN LSPTPASPNQ 190 200 210 220 230 240 GPPPQVPVSP GPPKDSSAPG GPPERTVTPA LSSNVLPRHL GSPATSVPGM GLHPPGPPLA 250 260 270 280 290 300 RPILPRERGA LDRIVEYLVG DGPQNRYALI CQQCFSHNGM ALKEEFEYIA FRCAYCFFLN 310 320 330 340 350 360 PARKTRPQAP RLPEFSFEKR QVVEGSSSVG PLPSGSVLSS DNQFNEESLE HDVLDDNTEQ 370 380 390 400 410 420 TDDKIPATEQ TNQVIEKASD SEEPEEKQET ENEEASVIET NSTVPGADSI PDPELSGESL TAE
	Isoform 3 [UniParc]. Checksum: 2FDFED2CFE7C83EC	FASTA	305	33,001
	10 20 30 40 50 60 MEKETYKTAK LILERFDPDS KKAKECEPPS AGAAVTARPG QEIRQRTAAQ RNLSPTPASP 70 80 90 100 110 120 NQGPPPQVPV SPGPPKDSSA PGGPPERTVT PALSSNVLPR HLGSPATSVP GMGLHPPGPP 130 140 150 160 170 180 LARPILPRER GALDRIVEYL VGDGPQNRYA LICQQCFSHN GMALKEEFEY IAFRCAYCFF 190 200 210 220 230 240 LNPARKTRPQ APRLPEFSFE KRQVVEGSSS VGPLPSGSVL SSDNQFNEES LEHDVLDDNT 250 260 270 280 290 300 EQTDDKIPAT EQTNQVIEKA SDSEEPEEKQ ETENEEASVI ETNSTVPGAD SIPDPELSGE SLTAE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Adrenal cortex and Brain.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-428. Tissue: Stomach.
[5]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182; SER-194 AND SER-321, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[7]	"Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system." Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E., Tsunasawa S., Utsumi T. Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract] Cited for: MYRISTOYLATION AT GLY-2.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177; SER-182 AND SER-194, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB051502 mRNA. Translation: BAB21806.1. Different initiation. AK056532 mRNA. Translation: BAB71207.1. BC031530 mRNA. Translation: AAH31530.1. BC105132 mRNA. Translation: AAI05133.1. BC105134 mRNA. Translation: AAI05135.1. BC110329 mRNA. Translation: AAI10330.1. AL832947 mRNA. Translation: CAH56306.1.
IPI	IPI00028369. IPI00784901. IPI00785171.
RefSeq	NP_085153.1. NM_030650.1.
UniGene	Hs.209561.
3D structure databases
ProteinModelPortal	Q9C0E8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000272748.
PTM databases
PhosphoSite	Q9C0E8.
Polymorphism databases
DMDM	114149979.
Proteomic databases
PaxDb	Q9C0E8.
PRIDE	Q9C0E8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000272748; ENSP00000272748; ENSG00000144320. ENST00000409660; ENSP00000386237; ENSG00000144320.
GeneID	80856.
KEGG	hsa:80856.
UCSC	uc002ukc.1. human. uc010fqw.1. human.
Organism-specific databases
CTD	80856.
GeneCards	GC02M176788.
HGNC	HGNC:21610. KIAA1715.
HPA	HPA014205.
MIM	610236. gene.
neXtProt	NX_Q9C0E8.
PharmGKB	PA134938939.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG115207.
HOGENOM	HOG000231891.
HOVERGEN	HBG079498.
InParanoid	Q9C0E8.
OrthoDB	EOG4ZS943.
Gene expression databases
ArrayExpress	Q9C0E8.
Bgee	Q9C0E8.
CleanEx	HS_KIAA1715.
Genevestigator	Q9C0E8.
GermOnline	ENSG00000144320. Homo sapiens.
Family and domain databases
InterPro	IPR019273. DUF2296. [Graphical view]
Pfam	PF10058. DUF2296. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	80856.
NextBio	71304.
PMAP-CutDB	Q9C0E8.
SOURCE	Search...

Entry information

Entry name

LNP_HUMAN

Accession

Primary (citable) accession number: Q9C0E8
Secondary accession number(s): Q2M2V8 , Q2YD99, Q658W8, Q8N5V9, Q96MS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	April 3, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.