Q9C0D7 (ZC12C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable ribonuclease ZC3H12C
EC=3.1.-.-

Alternative name(s):
MCP-induced protein 3
Zinc finger CCCH domain-containing protein 12C

Gene names

Name:	ZC3H12C
Synonyms:	KIAA1726, MCPIP3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	883 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as RNase and regulate the levels of target RNA species Potential.
Cofactor	Magnesium Potential.
Induction	By cytokines (TNF-alpha and interleukin-1) in acute monocytic leukemia cell line THP-1 cells. Ref.3
Sequence similarities	Belongs to the ZC3H12 family. Contains 1 C3H1-type zinc finger.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	Magnesium Metal-binding Zinc
Molecular function	Endonuclease Hydrolase Nuclease
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Molecular_function	endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 883	883	Probable ribonuclease ZC3H12C		PRO_0000337843
Regions
	Zinc finger	410 – 435	26	C3H1-type
Amino acid modifications
	Modified residue	230	1	Phosphoserine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9C0D7 [UniParc]. Last modified June 10, 2008. Version 2. Checksum: BF369391C5A36854	FASTA	883	99,340
	10 20 30 40 50 60 MPGGGSQEYG VLCIQEYRKN SKVESSTRNN FMGLKDHLGH DLGHLYVEST DPQLSPAVPW 70 80 90 100 110 120 STVENPSMDT VNVGKDEKEA SEENASSGDS EENTNSDHES EQLGSISVEP GLITKTHRQL 130 140 150 160 170 180 CRSPCLEPHI LKRNEILQDF KPEESQTTSK EAKKPPDVVR EYQTKLEFAL KLGYSEEQVQ 190 200 210 220 230 240 LVLNKLGTDA LINDILGELV KLGNKSEADQ TVSTINTITR ETSSLESQRS ESPMQEIVTD 250 260 270 280 290 300 DGENLRPIVI DGSNVAMSHG NKEVFSCRGI KLAVDWFLER GHKDITVFVP AWRKEQSRPD 310 320 330 340 350 360 ALITDQEILR KLEKEKILVF TPSRRVQGRR VVCYDDRFIV KLAFESDGII VSNDNYRDLA 370 380 390 400 410 420 NEKPEWKKFI DERLLMYSFV NDKFMPPDDP LGRHGPSLDN FLRKKPIVPE HKKQPCPYGK 430 440 450 460 470 480 KCTYGHKCKY YHPERGSQPQ RSVADELRAM SRNTAAKTAN EGGLVKSNSV PCSTKADSTS 490 500 510 520 530 540 DVKRGAPKRQ SDPSIRTQVY QDLEEKLPTK NKLETRSVPS LVSIPATSTA KPQSTTSLSN 550 560 570 580 590 600 GLPSGVHFPP QDQRPQGQYP SMMMATKNHG TPMPYEQYPK CDSPVDIGYY SMLNAYSNLS 610 620 630 640 650 660 LSGPRSPERR FSLDTDYRIS SVASDCSSEG SMSCGSSDSY VGYNDRSYVS SPDPQLEENL 670 680 690 700 710 720 KCQHMHPHSR LNPQPFLQNF HDPLTRGQSY SHEEPKFHHK PPLPHLALHL PHSAVGARSS 730 740 750 760 770 780 CPGDYPSPPS SAHSKAPHLG RSLVATRIDS ISDSRLYDSS PSRQRKPYSR QEGLGSWERP 790 800 810 820 830 840 GYGIDAYGYR QTYSLPDNST QPCYEQFTFQ SLPEQQEPAW RIPYCGMPQD PPRYQDNREK 850 860 870 880 IYINLCNIFP PDLVRIVMKR NPHMTDAQQL AAAILVEKSQ LGY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 260-883. Tissue: Brain.
[3]	"A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages." Liang J., Wang J., Azfer A., Song W., Tromp G., Kolattukudy P.E., Fu M. J. Biol. Chem. 283:6337-6346(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, INDUCTION.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP000901 Genomic DNA. No translation available. AB051513 mRNA. Translation: BAB21817.1.
IPI	IPI00981939.
RefSeq	NP_203748.1. NM_033390.1.
UniGene	Hs.376289.
3D structure databases
ProteinModelPortal	Q9C0D7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9C0D7. 2 interactions.
STRING	9606.ENSP00000278590.
PTM databases
PhosphoSite	Q9C0D7.
Polymorphism databases
DMDM	190485746.
Proteomic databases
PaxDb	Q9C0D7.
PRIDE	Q9C0D7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000278590; ENSP00000278590; ENSG00000149289.
GeneID	85463.
KEGG	hsa:85463.
UCSC	uc001pkr.4. human.
Organism-specific databases
CTD	85463.
GeneCards	GC11P109964.
HGNC	HGNC:29362. ZC3H12C.
HPA	HPA038837.
MIM	615001. gene.
neXtProt	NX_Q9C0D7.
PharmGKB	PA128394739.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG259385.
HOGENOM	HOG000060218.
HOVERGEN	HBG080308.
InParanoid	Q9C0D7.
OrthoDB	EOG4640B7.
Gene expression databases
ArrayExpress	Q9C0D7.
Bgee	Q9C0D7.
CleanEx	HS_ZC3H12C.
Genevestigator	Q9C0D7.
Family and domain databases
InterPro	IPR021869. RNase_Zc3h12. IPR000571. Znf_CCCH. [Graphical view]
Pfam	PF11977. RNase_Zc3h12a. 1 hit. [Graphical view]
PROSITE	PS50103. ZF_C3H1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	85463.
NextBio	76111.
SOURCE	Search...

Entry information

Entry name

ZC12C_HUMAN

Accession

Primary (citable) accession number: Q9C0D7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	May 1, 2013
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.