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Q9C0D7

- ZC12C_HUMAN

UniProt

Q9C0D7 - ZC12C_HUMAN

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Protein

Probable ribonuclease ZC3H12C

Gene
ZC3H12C, KIAA1726, MCPIP3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May function as RNase and regulate the levels of target RNA species Reviewed prediction.

Cofactori

Magnesium Reviewed prediction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri410 – 43526C3H1-typeAdd
BLAST

GO - Molecular functioni

  1. endonuclease activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribonuclease ZC3H12C (EC:3.1.-.-)
Alternative name(s):
MCP-induced protein 3
Zinc finger CCCH domain-containing protein 12C
Gene namesi
Name:ZC3H12C
Synonyms:KIAA1726, MCPIP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:29362. ZC3H12C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394739.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 883883Probable ribonuclease ZC3H12CPRO_0000337843Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei230 – 2301Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9C0D7.
PaxDbiQ9C0D7.
PRIDEiQ9C0D7.

PTM databases

PhosphoSiteiQ9C0D7.

Expressioni

Inductioni

By cytokines (TNF-alpha and interleukin-1) in acute monocytic leukemia cell line THP-1 cells.1 Publication

Gene expression databases

ArrayExpressiQ9C0D7.
BgeeiQ9C0D7.
CleanExiHS_ZC3H12C.
GenevestigatoriQ9C0D7.

Organism-specific databases

HPAiHPA038837.

Interactioni

Protein-protein interaction databases

BioGridi124547. 1 interaction.
IntActiQ9C0D7. 2 interactions.
STRINGi9606.ENSP00000278590.

Structurei

3D structure databases

ProteinModelPortaliQ9C0D7.
SMRiQ9C0D7. Positions 244-406.

Family & Domainsi

Sequence similaritiesi

Belongs to the ZC3H12 family.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri410 – 43526C3H1-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG259385.
HOGENOMiHOG000060218.
HOVERGENiHBG080308.
InParanoidiQ9C0D7.
OMAiPMMMATK.
OrthoDBiEOG7NSB2F.
PhylomeDBiQ9C0D7.
TreeFamiTF315783.

Family and domain databases

InterProiIPR021869. RNase_Zc3h12.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF11977. RNase_Zc3h12a. 1 hit.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9C0D7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPGGGSQEYG VLCIQEYRKN SKVESSTRNN FMGLKDHLGH DLGHLYVEST    50
DPQLSPAVPW STVENPSMDT VNVGKDEKEA SEENASSGDS EENTNSDHES 100
EQLGSISVEP GLITKTHRQL CRSPCLEPHI LKRNEILQDF KPEESQTTSK 150
EAKKPPDVVR EYQTKLEFAL KLGYSEEQVQ LVLNKLGTDA LINDILGELV 200
KLGNKSEADQ TVSTINTITR ETSSLESQRS ESPMQEIVTD DGENLRPIVI 250
DGSNVAMSHG NKEVFSCRGI KLAVDWFLER GHKDITVFVP AWRKEQSRPD 300
ALITDQEILR KLEKEKILVF TPSRRVQGRR VVCYDDRFIV KLAFESDGII 350
VSNDNYRDLA NEKPEWKKFI DERLLMYSFV NDKFMPPDDP LGRHGPSLDN 400
FLRKKPIVPE HKKQPCPYGK KCTYGHKCKY YHPERGSQPQ RSVADELRAM 450
SRNTAAKTAN EGGLVKSNSV PCSTKADSTS DVKRGAPKRQ SDPSIRTQVY 500
QDLEEKLPTK NKLETRSVPS LVSIPATSTA KPQSTTSLSN GLPSGVHFPP 550
QDQRPQGQYP SMMMATKNHG TPMPYEQYPK CDSPVDIGYY SMLNAYSNLS 600
LSGPRSPERR FSLDTDYRIS SVASDCSSEG SMSCGSSDSY VGYNDRSYVS 650
SPDPQLEENL KCQHMHPHSR LNPQPFLQNF HDPLTRGQSY SHEEPKFHHK 700
PPLPHLALHL PHSAVGARSS CPGDYPSPPS SAHSKAPHLG RSLVATRIDS 750
ISDSRLYDSS PSRQRKPYSR QEGLGSWERP GYGIDAYGYR QTYSLPDNST 800
QPCYEQFTFQ SLPEQQEPAW RIPYCGMPQD PPRYQDNREK IYINLCNIFP 850
PDLVRIVMKR NPHMTDAQQL AAAILVEKSQ LGY 883
Length:883
Mass (Da):99,340
Last modified:June 10, 2008 - v2
Checksum:iBF369391C5A36854
GO
Isoform 2 (identifier: Q9C0D7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MPGGGSQ → MSLYFPAN

Note: No experimental confirmation available.

Show »
Length:884
Mass (Da):99,650
Checksum:i74012D3E93A318B1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 77MPGGGSQ → MSLYFPAN in isoform 2. VSP_054127

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691D → G in BAG58377. 1 Publication
Sequence conflicti574 – 5741P → A in BAG58377. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK295437 mRNA. Translation: BAG58377.1.
AK299100 mRNA. Translation: BAG61159.1.
AP000901 Genomic DNA. No translation available.
AP001889 Genomic DNA. No translation available.
AB051513 mRNA. Translation: BAB21817.1.
CCDSiCCDS44727.1. [Q9C0D7-1]
RefSeqiNP_203748.1. NM_033390.1. [Q9C0D7-1]
UniGeneiHs.376289.

Genome annotation databases

EnsembliENST00000278590; ENSP00000278590; ENSG00000149289.
ENST00000528673; ENSP00000431821; ENSG00000149289.
GeneIDi85463.
KEGGihsa:85463.
UCSCiuc001pkr.4. human. [Q9C0D7-1]

Polymorphism databases

DMDMi190485746.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK295437 mRNA. Translation: BAG58377.1 .
AK299100 mRNA. Translation: BAG61159.1 .
AP000901 Genomic DNA. No translation available.
AP001889 Genomic DNA. No translation available.
AB051513 mRNA. Translation: BAB21817.1 .
CCDSi CCDS44727.1. [Q9C0D7-1 ]
RefSeqi NP_203748.1. NM_033390.1. [Q9C0D7-1 ]
UniGenei Hs.376289.

3D structure databases

ProteinModelPortali Q9C0D7.
SMRi Q9C0D7. Positions 244-406.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124547. 1 interaction.
IntActi Q9C0D7. 2 interactions.
STRINGi 9606.ENSP00000278590.

PTM databases

PhosphoSitei Q9C0D7.

Polymorphism databases

DMDMi 190485746.

Proteomic databases

MaxQBi Q9C0D7.
PaxDbi Q9C0D7.
PRIDEi Q9C0D7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278590 ; ENSP00000278590 ; ENSG00000149289 .
ENST00000528673 ; ENSP00000431821 ; ENSG00000149289 .
GeneIDi 85463.
KEGGi hsa:85463.
UCSCi uc001pkr.4. human. [Q9C0D7-1 ]

Organism-specific databases

CTDi 85463.
GeneCardsi GC11P109964.
HGNCi HGNC:29362. ZC3H12C.
HPAi HPA038837.
MIMi 615001. gene.
neXtProti NX_Q9C0D7.
PharmGKBi PA128394739.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259385.
HOGENOMi HOG000060218.
HOVERGENi HBG080308.
InParanoidi Q9C0D7.
OMAi PMMMATK.
OrthoDBi EOG7NSB2F.
PhylomeDBi Q9C0D7.
TreeFami TF315783.

Miscellaneous databases

GenomeRNAii 85463.
NextBioi 35472196.
PROi Q9C0D7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9C0D7.
Bgeei Q9C0D7.
CleanExi HS_ZC3H12C.
Genevestigatori Q9C0D7.

Family and domain databases

InterProi IPR021869. RNase_Zc3h12.
IPR000571. Znf_CCCH.
[Graphical view ]
Pfami PF11977. RNase_Zc3h12a. 1 hit.
[Graphical view ]
PROSITEi PS50103. ZF_C3H1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Corpus callosum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 260-883 (ISOFORM 1/2).
    Tissue: Brain.
  4. "A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages."
    Liang J., Wang J., Azfer A., Song W., Tromp G., Kolattukudy P.E., Fu M.
    J. Biol. Chem. 283:6337-6346(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, INDUCTION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiZC12C_HUMAN
AccessioniPrimary (citable) accession number: Q9C0D7
Secondary accession number(s): B4DI65, B4DR47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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