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Q9C0D7

- ZC12C_HUMAN

UniProt

Q9C0D7 - ZC12C_HUMAN

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Protein
Probable ribonuclease ZC3H12C
Gene
ZC3H12C, KIAA1726, MCPIP3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May function as RNase and regulate the levels of target RNA species Reviewed prediction.

Cofactori

Magnesium Reviewed prediction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri410 – 43526C3H1-type
Add
BLAST

GO - Molecular functioni

  1. endonuclease activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Ligandi

    Magnesium, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ribonuclease ZC3H12C (EC:3.1.-.-)
    Alternative name(s):
    MCP-induced protein 3
    Zinc finger CCCH domain-containing protein 12C
    Gene namesi
    Name:ZC3H12C
    Synonyms:KIAA1726, MCPIP3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:29362. ZC3H12C.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394739.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 883883Probable ribonuclease ZC3H12C
    PRO_0000337843Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei230 – 2301Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9C0D7.
    PaxDbiQ9C0D7.
    PRIDEiQ9C0D7.

    PTM databases

    PhosphoSiteiQ9C0D7.

    Expressioni

    Inductioni

    By cytokines (TNF-alpha and interleukin-1) in acute monocytic leukemia cell line THP-1 cells.1 Publication

    Gene expression databases

    ArrayExpressiQ9C0D7.
    BgeeiQ9C0D7.
    CleanExiHS_ZC3H12C.
    GenevestigatoriQ9C0D7.

    Organism-specific databases

    HPAiHPA038837.

    Interactioni

    Protein-protein interaction databases

    BioGridi124547. 1 interaction.
    IntActiQ9C0D7. 2 interactions.
    STRINGi9606.ENSP00000278590.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C0D7.
    SMRiQ9C0D7. Positions 244-406.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ZC3H12 family.

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG259385.
    HOGENOMiHOG000060218.
    HOVERGENiHBG080308.
    InParanoidiQ9C0D7.
    OMAiPMMMATK.
    OrthoDBiEOG7NSB2F.
    PhylomeDBiQ9C0D7.
    TreeFamiTF315783.

    Family and domain databases

    InterProiIPR021869. RNase_Zc3h12.
    IPR000571. Znf_CCCH.
    [Graphical view]
    PfamiPF11977. RNase_Zc3h12a. 1 hit.
    [Graphical view]
    PROSITEiPS50103. ZF_C3H1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9C0D7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPGGGSQEYG VLCIQEYRKN SKVESSTRNN FMGLKDHLGH DLGHLYVEST    50
    DPQLSPAVPW STVENPSMDT VNVGKDEKEA SEENASSGDS EENTNSDHES 100
    EQLGSISVEP GLITKTHRQL CRSPCLEPHI LKRNEILQDF KPEESQTTSK 150
    EAKKPPDVVR EYQTKLEFAL KLGYSEEQVQ LVLNKLGTDA LINDILGELV 200
    KLGNKSEADQ TVSTINTITR ETSSLESQRS ESPMQEIVTD DGENLRPIVI 250
    DGSNVAMSHG NKEVFSCRGI KLAVDWFLER GHKDITVFVP AWRKEQSRPD 300
    ALITDQEILR KLEKEKILVF TPSRRVQGRR VVCYDDRFIV KLAFESDGII 350
    VSNDNYRDLA NEKPEWKKFI DERLLMYSFV NDKFMPPDDP LGRHGPSLDN 400
    FLRKKPIVPE HKKQPCPYGK KCTYGHKCKY YHPERGSQPQ RSVADELRAM 450
    SRNTAAKTAN EGGLVKSNSV PCSTKADSTS DVKRGAPKRQ SDPSIRTQVY 500
    QDLEEKLPTK NKLETRSVPS LVSIPATSTA KPQSTTSLSN GLPSGVHFPP 550
    QDQRPQGQYP SMMMATKNHG TPMPYEQYPK CDSPVDIGYY SMLNAYSNLS 600
    LSGPRSPERR FSLDTDYRIS SVASDCSSEG SMSCGSSDSY VGYNDRSYVS 650
    SPDPQLEENL KCQHMHPHSR LNPQPFLQNF HDPLTRGQSY SHEEPKFHHK 700
    PPLPHLALHL PHSAVGARSS CPGDYPSPPS SAHSKAPHLG RSLVATRIDS 750
    ISDSRLYDSS PSRQRKPYSR QEGLGSWERP GYGIDAYGYR QTYSLPDNST 800
    QPCYEQFTFQ SLPEQQEPAW RIPYCGMPQD PPRYQDNREK IYINLCNIFP 850
    PDLVRIVMKR NPHMTDAQQL AAAILVEKSQ LGY 883
    Length:883
    Mass (Da):99,340
    Last modified:June 10, 2008 - v2
    Checksum:iBF369391C5A36854
    GO
    Isoform 2 (identifier: Q9C0D7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-7: MPGGGSQ → MSLYFPAN

    Note: No experimental confirmation available.

    Show »
    Length:884
    Mass (Da):99,650
    Checksum:i74012D3E93A318B1
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 77MPGGGSQ → MSLYFPAN in isoform 2.
    VSP_054127

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti69 – 691D → G in BAG58377. 1 Publication
    Sequence conflicti574 – 5741P → A in BAG58377. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK295437 mRNA. Translation: BAG58377.1.
    AK299100 mRNA. Translation: BAG61159.1.
    AP000901 Genomic DNA. No translation available.
    AP001889 Genomic DNA. No translation available.
    AB051513 mRNA. Translation: BAB21817.1.
    CCDSiCCDS44727.1. [Q9C0D7-1]
    RefSeqiNP_203748.1. NM_033390.1. [Q9C0D7-1]
    UniGeneiHs.376289.

    Genome annotation databases

    EnsembliENST00000278590; ENSP00000278590; ENSG00000149289.
    ENST00000528673; ENSP00000431821; ENSG00000149289.
    GeneIDi85463.
    KEGGihsa:85463.
    UCSCiuc001pkr.4. human. [Q9C0D7-1]

    Polymorphism databases

    DMDMi190485746.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK295437 mRNA. Translation: BAG58377.1 .
    AK299100 mRNA. Translation: BAG61159.1 .
    AP000901 Genomic DNA. No translation available.
    AP001889 Genomic DNA. No translation available.
    AB051513 mRNA. Translation: BAB21817.1 .
    CCDSi CCDS44727.1. [Q9C0D7-1 ]
    RefSeqi NP_203748.1. NM_033390.1. [Q9C0D7-1 ]
    UniGenei Hs.376289.

    3D structure databases

    ProteinModelPortali Q9C0D7.
    SMRi Q9C0D7. Positions 244-406.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 124547. 1 interaction.
    IntActi Q9C0D7. 2 interactions.
    STRINGi 9606.ENSP00000278590.

    PTM databases

    PhosphoSitei Q9C0D7.

    Polymorphism databases

    DMDMi 190485746.

    Proteomic databases

    MaxQBi Q9C0D7.
    PaxDbi Q9C0D7.
    PRIDEi Q9C0D7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278590 ; ENSP00000278590 ; ENSG00000149289 .
    ENST00000528673 ; ENSP00000431821 ; ENSG00000149289 .
    GeneIDi 85463.
    KEGGi hsa:85463.
    UCSCi uc001pkr.4. human. [Q9C0D7-1 ]

    Organism-specific databases

    CTDi 85463.
    GeneCardsi GC11P109964.
    HGNCi HGNC:29362. ZC3H12C.
    HPAi HPA038837.
    MIMi 615001. gene.
    neXtProti NX_Q9C0D7.
    PharmGKBi PA128394739.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259385.
    HOGENOMi HOG000060218.
    HOVERGENi HBG080308.
    InParanoidi Q9C0D7.
    OMAi PMMMATK.
    OrthoDBi EOG7NSB2F.
    PhylomeDBi Q9C0D7.
    TreeFami TF315783.

    Miscellaneous databases

    GenomeRNAii 85463.
    NextBioi 35472196.
    PROi Q9C0D7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9C0D7.
    Bgeei Q9C0D7.
    CleanExi HS_ZC3H12C.
    Genevestigatori Q9C0D7.

    Family and domain databases

    InterProi IPR021869. RNase_Zc3h12.
    IPR000571. Znf_CCCH.
    [Graphical view ]
    Pfami PF11977. RNase_Zc3h12a. 1 hit.
    [Graphical view ]
    PROSITEi PS50103. ZF_C3H1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Corpus callosum.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 260-883 (ISOFORM 1/2).
      Tissue: Brain.
    4. "A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages."
      Liang J., Wang J., Azfer A., Song W., Tromp G., Kolattukudy P.E., Fu M.
      J. Biol. Chem. 283:6337-6346(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, INDUCTION.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiZC12C_HUMAN
    AccessioniPrimary (citable) accession number: Q9C0D7
    Secondary accession number(s): B4DI65, B4DR47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: September 3, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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