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Q9C0D7 (ZC12C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ribonuclease ZC3H12C

EC=3.1.-.-
Alternative name(s):
MCP-induced protein 3
Zinc finger CCCH domain-containing protein 12C
Gene names
Name:ZC3H12C
Synonyms:KIAA1726, MCPIP3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length883 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as RNase and regulate the levels of target RNA species Potential.

Cofactor

Magnesium Potential.

Induction

By cytokines (TNF-alpha and interleukin-1) in acute monocytic leukemia cell line THP-1 cells. Ref.4

Sequence similarities

Belongs to the ZC3H12 family.

Contains 1 C3H1-type zinc finger.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainZinc-finger
   LigandMagnesium
Metal-binding
Zinc
   Molecular functionEndonuclease
Hydrolase
Nuclease
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionendonuclease activity

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9C0D7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9C0D7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MPGGGSQ → MSLYFPAN
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 883883Probable ribonuclease ZC3H12C
PRO_0000337843

Regions

Zinc finger410 – 43526C3H1-type

Amino acid modifications

Modified residue2301Phosphoserine Ref.5

Natural variations

Alternative sequence1 – 77MPGGGSQ → MSLYFPAN in isoform 2.
VSP_054127

Experimental info

Sequence conflict691D → G in BAG58377. Ref.1
Sequence conflict5741P → A in BAG58377. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 10, 2008. Version 2.
Checksum: BF369391C5A36854

FASTA88399,340
        10         20         30         40         50         60 
MPGGGSQEYG VLCIQEYRKN SKVESSTRNN FMGLKDHLGH DLGHLYVEST DPQLSPAVPW 

        70         80         90        100        110        120 
STVENPSMDT VNVGKDEKEA SEENASSGDS EENTNSDHES EQLGSISVEP GLITKTHRQL 

       130        140        150        160        170        180 
CRSPCLEPHI LKRNEILQDF KPEESQTTSK EAKKPPDVVR EYQTKLEFAL KLGYSEEQVQ 

       190        200        210        220        230        240 
LVLNKLGTDA LINDILGELV KLGNKSEADQ TVSTINTITR ETSSLESQRS ESPMQEIVTD 

       250        260        270        280        290        300 
DGENLRPIVI DGSNVAMSHG NKEVFSCRGI KLAVDWFLER GHKDITVFVP AWRKEQSRPD 

       310        320        330        340        350        360 
ALITDQEILR KLEKEKILVF TPSRRVQGRR VVCYDDRFIV KLAFESDGII VSNDNYRDLA 

       370        380        390        400        410        420 
NEKPEWKKFI DERLLMYSFV NDKFMPPDDP LGRHGPSLDN FLRKKPIVPE HKKQPCPYGK 

       430        440        450        460        470        480 
KCTYGHKCKY YHPERGSQPQ RSVADELRAM SRNTAAKTAN EGGLVKSNSV PCSTKADSTS 

       490        500        510        520        530        540 
DVKRGAPKRQ SDPSIRTQVY QDLEEKLPTK NKLETRSVPS LVSIPATSTA KPQSTTSLSN 

       550        560        570        580        590        600 
GLPSGVHFPP QDQRPQGQYP SMMMATKNHG TPMPYEQYPK CDSPVDIGYY SMLNAYSNLS 

       610        620        630        640        650        660 
LSGPRSPERR FSLDTDYRIS SVASDCSSEG SMSCGSSDSY VGYNDRSYVS SPDPQLEENL 

       670        680        690        700        710        720 
KCQHMHPHSR LNPQPFLQNF HDPLTRGQSY SHEEPKFHHK PPLPHLALHL PHSAVGARSS 

       730        740        750        760        770        780 
CPGDYPSPPS SAHSKAPHLG RSLVATRIDS ISDSRLYDSS PSRQRKPYSR QEGLGSWERP 

       790        800        810        820        830        840 
GYGIDAYGYR QTYSLPDNST QPCYEQFTFQ SLPEQQEPAW RIPYCGMPQD PPRYQDNREK 

       850        860        870        880 
IYINLCNIFP PDLVRIVMKR NPHMTDAQQL AAAILVEKSQ LGY 

« Hide

Isoform 2 [UniParc].

Checksum: 74012D3E93A318B1
Show »

FASTA88499,650

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Corpus callosum.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 260-883 (ISOFORM 1/2).
Tissue: Brain.
[4]"A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages."
Liang J., Wang J., Azfer A., Song W., Tromp G., Kolattukudy P.E., Fu M.
J. Biol. Chem. 283:6337-6346(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, INDUCTION.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK295437 mRNA. Translation: BAG58377.1.
AK299100 mRNA. Translation: BAG61159.1.
AP000901 Genomic DNA. No translation available.
AP001889 Genomic DNA. No translation available.
AB051513 mRNA. Translation: BAB21817.1.
RefSeqNP_203748.1. NM_033390.1.
UniGeneHs.376289.

3D structure databases

ProteinModelPortalQ9C0D7.
SMRQ9C0D7. Positions 244-406.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124547. 1 interaction.
IntActQ9C0D7. 2 interactions.
STRING9606.ENSP00000278590.

PTM databases

PhosphoSiteQ9C0D7.

Polymorphism databases

DMDM190485746.

Proteomic databases

PaxDbQ9C0D7.
PRIDEQ9C0D7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000278590; ENSP00000278590; ENSG00000149289.
ENST00000528673; ENSP00000431821; ENSG00000149289.
GeneID85463.
KEGGhsa:85463.
UCSCuc001pkr.4. human.

Organism-specific databases

CTD85463.
GeneCardsGC11P109964.
HGNCHGNC:29362. ZC3H12C.
HPAHPA038837.
MIM615001. gene.
neXtProtNX_Q9C0D7.
PharmGKBPA128394739.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG259385.
HOGENOMHOG000060218.
HOVERGENHBG080308.
InParanoidQ9C0D7.
OrthoDBEOG7NSB2F.
PhylomeDBQ9C0D7.
TreeFamTF315783.

Gene expression databases

ArrayExpressQ9C0D7.
BgeeQ9C0D7.
CleanExHS_ZC3H12C.
GenevestigatorQ9C0D7.

Family and domain databases

InterProIPR021869. RNase_Zc3h12.
IPR000571. Znf_CCCH.
[Graphical view]
PfamPF11977. RNase_Zc3h12a. 1 hit.
[Graphical view]
PROSITEPS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi85463.
NextBio76111.
PROQ9C0D7.
SOURCESearch...

Entry information

Entry nameZC12C_HUMAN
AccessionPrimary (citable) accession number: Q9C0D7
Secondary accession number(s): B4DI65, B4DR47
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: April 16, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM