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Protein

FH2 domain-containing protein 1

Gene

FHDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
FH2 domain-containing protein 1
Gene namesi
Name:FHDC1
Synonyms:KIAA1727
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:29363. FHDC1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388490.

Polymorphism and mutation databases

BioMutaiFHDC1.
DMDMi166977313.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11431143FH2 domain-containing protein 1PRO_0000317280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei500 – 5001PhosphoserineCombined sources
Modified residuei650 – 6501PhosphoserineBy similarity
Modified residuei660 – 6601PhosphoserineCombined sources
Modified residuei664 – 6641PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9C0D6.
PaxDbiQ9C0D6.
PeptideAtlasiQ9C0D6.
PRIDEiQ9C0D6.

PTM databases

iPTMnetiQ9C0D6.
PhosphoSiteiQ9C0D6.

Expressioni

Gene expression databases

BgeeiQ9C0D6.
CleanExiHS_FHDC1.
GenevisibleiQ9C0D6. HS.

Organism-specific databases

HPAiHPA008527.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000260008.

Structurei

3D structure databases

ProteinModelPortaliQ9C0D6.
SMRiQ9C0D6. Positions 106-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini87 – 482396FH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FH2 (formin homology 2) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1922. Eukaryota.
ENOG410XQR0. LUCA.
GeneTreeiENSGT00760000118986.
HOGENOMiHOG000090204.
HOVERGENiHBG107919.
InParanoidiQ9C0D6.
OMAiFLHPRPI.
OrthoDBiEOG725DGP.
PhylomeDBiQ9C0D6.
TreeFamiTF324020.

Family and domain databases

InterProiIPR015425. FH2_Formin.
[Graphical view]
PfamiPF02181. FH2. 1 hit.
[Graphical view]
SMARTiSM00498. FH2. 1 hit.
[Graphical view]
PROSITEiPS51444. FH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C0D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVMNCVSLV SDKENGNIAT APGFMIGQTP PPAPPPPPPP PPPSPPCSCS
60 70 80 90 100
REECPSSPPP PPPPPLPGEP PIPPPPPGLP PTTHMNGYSH LGKKKRMRSF
110 120 130 140 150
FWKTIPEEQV RGKTNIWTLA ARQEHHYQID TKTIEELFGQ QEDTTKSSLP
160 170 180 190 200
RRGRTLNSSF REAREEITIL DAKRSMNIGI FLKQFKKSPR SIVEDIHQGK
210 220 230 240 250
SEHYGSETLR EFLKFLPESE EVKKLKAFSG DVSKLSLADS FLYGLIQVPN
260 270 280 290 300
YSLRIEAMVL KKEFLPSCSS LYTDITVLRT AIKELMSCEE LHSILHLVLQ
310 320 330 340 350
AGNIMNAGGY AGNAVGFKLS SLLKLADTKA NKPGMNLLHF VAQEAQKKDT
360 370 380 390 400
ILLNFSEKLH HVQKTARLSL ENTEAELHLL FVRTKSLKEN IQRDGELCQQ
410 420 430 440 450
MEDFLQFAIE KLRELECWKQ ELQDEAYTLI DFFCEDKKTM KLDECFQIFR
460 470 480 490 500
DFCTKFNKAV KDNHDREAQE LRQLQRLKEQ EQKQRSWATG ELGAFGRSSS
510 520 530 540 550
ENDVELLTKK GAEGLLPFLH PRPISPSSPS YRPPNTRRSR LSLGPSADRE
560 570 580 590 600
LLTFLESSTG SPEEPNKFHS LPRSSPRQAR PTIACLEPAE VRHQDSSFAH
610 620 630 640 650
KPQASGGQEE APNPPSAQAH QLAAAQPENH ASAFPRARRQ GVSVLRKRYS
660 670 680 690 700
EPVSLGSAQS PPLSPLALGI KEHELVTGLA QFNLQGSQGM EETSQLTLSD
710 720 730 740 750
FSPMELESVG HRGPQSLSAS SSSLTPMGRD ALGSLSPALE DGKAAPDEPG
760 770 780 790 800
SAALGSVGSS DPENKDPRPL FCISDTTDCS LTLDCSEGTD SRPRGGDPEE
810 820 830 840 850
GGEGDGSMSS GVGEMGDSQV SSNPTSSPPG EAPAPVSVDS EPSCKGGLPR
860 870 880 890 900
DKPTKRKDVV APKRGSLKEA SPGASKPGSA RRSQGAVAKS VRTLTASENE
910 920 930 940 950
SMRKVMPITK SSRGAGWRRP ELSSRGPSQN PPSSTDTVWS RQNSVRRAST
960 970 980 990 1000
GAEEQRLPRG SSGSSSTRPG RDVPLQPRGS FKKPSAKPLR NLPRQKPEEN
1010 1020 1030 1040 1050
KTCRAHSEGP ESPKEEPKTP SVPSVPHELP RVPSFARNTV ASSSRSMRTD
1060 1070 1080 1090 1100
LPPVAKAPGI TRTVSQRQLR VKGDPEDAAP KDSSTLRRAS SARAPKKRPE
1110 1120 1130 1140
SAEGPSANTE APLKARGAGE RASLRRKDSS RTTLGRILNP LRK
Length:1,143
Mass (Da):124,762
Last modified:February 5, 2008 - v2
Checksum:iA656741E826F59CC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti297 – 2971L → F.1 Publication
VAR_069394
Natural varianti639 – 6391R → C.1 Publication
Corresponds to variant rs3811833 [ dbSNP | Ensembl ].
VAR_050990

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093599 Genomic DNA. No translation available.
AB051514 mRNA. Translation: BAB21818.1.
CCDSiCCDS34081.1.
RefSeqiNP_203751.2. NM_033393.2.
XP_005263376.1. XM_005263319.2.
XP_006714456.1. XM_006714393.2.
XP_011530690.1. XM_011532388.1.
XP_011530691.1. XM_011532389.1.
UniGeneiHs.132629.

Genome annotation databases

EnsembliENST00000260008; ENSP00000260008; ENSG00000137460.
ENST00000511601; ENSP00000427567; ENSG00000137460.
GeneIDi85462.
KEGGihsa:85462.
UCSCiuc003inf.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093599 Genomic DNA. No translation available.
AB051514 mRNA. Translation: BAB21818.1.
CCDSiCCDS34081.1.
RefSeqiNP_203751.2. NM_033393.2.
XP_005263376.1. XM_005263319.2.
XP_006714456.1. XM_006714393.2.
XP_011530690.1. XM_011532388.1.
XP_011530691.1. XM_011532389.1.
UniGeneiHs.132629.

3D structure databases

ProteinModelPortaliQ9C0D6.
SMRiQ9C0D6. Positions 106-485.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000260008.

PTM databases

iPTMnetiQ9C0D6.
PhosphoSiteiQ9C0D6.

Polymorphism and mutation databases

BioMutaiFHDC1.
DMDMi166977313.

Proteomic databases

EPDiQ9C0D6.
PaxDbiQ9C0D6.
PeptideAtlasiQ9C0D6.
PRIDEiQ9C0D6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260008; ENSP00000260008; ENSG00000137460.
ENST00000511601; ENSP00000427567; ENSG00000137460.
GeneIDi85462.
KEGGihsa:85462.
UCSCiuc003inf.2. human.

Organism-specific databases

CTDi85462.
GeneCardsiFHDC1.
H-InvDBHIX0004576.
HGNCiHGNC:29363. FHDC1.
HPAiHPA008527.
neXtProtiNX_Q9C0D6.
PharmGKBiPA162388490.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1922. Eukaryota.
ENOG410XQR0. LUCA.
GeneTreeiENSGT00760000118986.
HOGENOMiHOG000090204.
HOVERGENiHBG107919.
InParanoidiQ9C0D6.
OMAiFLHPRPI.
OrthoDBiEOG725DGP.
PhylomeDBiQ9C0D6.
TreeFamiTF324020.

Miscellaneous databases

GenomeRNAii85462.
PROiQ9C0D6.

Gene expression databases

BgeeiQ9C0D6.
CleanExiHS_FHDC1.
GenevisibleiQ9C0D6. HS.

Family and domain databases

InterProiIPR015425. FH2_Formin.
[Graphical view]
PfamiPF02181. FH2. 1 hit.
[Graphical view]
SMARTiSM00498. FH2. 1 hit.
[Graphical view]
PROSITEiPS51444. FH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-1143, VARIANT CYS-639.
    Tissue: Brain.
  3. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-500; SER-660 AND SER-664, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: VARIANT PHE-297.

Entry informationi

Entry nameiFHDC1_HUMAN
AccessioniPrimary (citable) accession number: Q9C0D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 6, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.