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Protein

Protein TANC1

Gene

TANC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a scaffold component in the postsynaptic density.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115183-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TANC1
Alternative name(s):
Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1
Gene namesi
Name:TANC1
Synonyms:KIAA1728
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29364. TANC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi85461.
OpenTargetsiENSG00000115183.
PharmGKBiPA142670838.

Polymorphism and mutation databases

BioMutaiTANC1.
DMDMi296452941.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003169591 – 1861Protein TANC1Add BLAST1861

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei207PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei1439PhosphoserineBy similarity1
Modified residuei1668PhosphoserineCombined sources1
Modified residuei1676PhosphoserineBy similarity1
Modified residuei1677PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9C0D5.
MaxQBiQ9C0D5.
PaxDbiQ9C0D5.
PeptideAtlasiQ9C0D5.
PRIDEiQ9C0D5.

PTM databases

iPTMnetiQ9C0D5.
PhosphoSitePlusiQ9C0D5.

Expressioni

Gene expression databases

BgeeiENSG00000115183.
CleanExiHS_TANC1.
ExpressionAtlasiQ9C0D5. baseline and differential.
GenevisibleiQ9C0D5. HS.

Organism-specific databases

HPAiHPA036750.

Interactioni

Subunit structurei

Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1 (By similarity). Interacts with TNIK. Interacts with MINK1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi124545. 9 interactors.
IntActiQ9C0D5. 5 interactors.
STRINGi9606.ENSP00000263635.

Structurei

3D structure databases

ProteinModelPortaliQ9C0D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati896 – 928ANK 1Add BLAST33
Repeati934 – 963ANK 2Add BLAST30
Repeati967 – 996ANK 3Add BLAST30
Repeati1000 – 1029ANK 4Add BLAST30
Repeati1040 – 1069ANK 5Add BLAST30
Repeati1078 – 1107ANK 6Add BLAST30
Repeati1111 – 1140ANK 7Add BLAST30
Repeati1144 – 1173ANK 8Add BLAST30
Repeati1177 – 1206ANK 9Add BLAST30
Repeati1210 – 1239ANK 10Add BLAST30
Repeati1243 – 1272ANK 11Add BLAST30
Repeati1289 – 1322TPR 1Add BLAST34
Repeati1336 – 1369TPR 2Add BLAST34
Repeati1371 – 1403TPR 3Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi170 – 243Ser-richAdd BLAST74
Compositional biasi1659 – 1689Ser-richAdd BLAST31

Sequence similaritiesi

Belongs to the TANC family.Curated
Contains 11 ANK repeats.PROSITE-ProRule annotation
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000231045.
HOVERGENiHBG061464.
InParanoidiQ9C0D5.
OMAiEHRPRNT.
OrthoDBiEOG091G00QZ.
PhylomeDBiQ9C0D5.
TreeFamiTF323159.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 10 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF48452. SSF48452. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0D5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKAVLKKSR EGGKGGKKEA GSDFGPETSP VLHLDHSADS PVSSLPTAED
60 70 80 90 100
TYRVSLAKGV SMSLPSSPLL PRQSHLVQSR VNKKSPGPVR KPKYVESPRV
110 120 130 140 150
PGDAVIMPFR EVAKPTEPDE HEAKADNEPS CSPAAQELLT RLGFLLGEGI
160 170 180 190 200
PSATHITIED KNETMCTALS QGISPCSTLT SSTASPSTDS PCSTLNSCVS
210 220 230 240 250
KTAANKSPCE TISSPSSTLE SKDSGIIATI TSSSENDDRS GSSLEWNKDG
260 270 280 290 300
NLRLGVQKGV LHDRRADNCS PVAEEETTGS AESTLPKAES SAGDGPVPYS
310 320 330 340 350
QGSSSLIMPR PNSVAATSST KLEDLSYLDG QRNAPLRTSI RLPWHNTAGG
360 370 380 390 400
RAQEVKARFA PYKPQDILLK PLLFEVPSIT TDSVFVGRDW LFHQIEENLR
410 420 430 440 450
NTELAENRGA VVVGNVGFGK TAIISKLVAL SCHGSRMRQI ASNSPGSSPK
460 470 480 490 500
TSDPTQDLHF TPLLSPSSST SASSTAKTPL GSISAENQRP REDAVKYLAS
510 520 530 540 550
KVVAYHYCQA DNTYTCLVPE FVHSIAALLC RSHQLAAYRD LLIKEPQLQS
560 570 580 590 600
MLSLRSCVQD PVAAFKRGVL EPLTNLRNEQ KIPEEEYIIL IDGLNEAEFH
610 620 630 640 650
KPDYGDTLSS FITKIISKFP AWLKLIVTVR ANFQEIISAL PFVKLSLDDF
660 670 680 690 700
PDNKDIHSDL HAYVQHRVHS SQDILSNISL NGKADATLIG KVSSHLVLRS
710 720 730 740 750
LGSYLYLKLT LDLFQRGHLV IKSASYKVVP VSLSELYLLQ CNMKFMTQSA
760 770 780 790 800
FERALPILNV ALASLHPMTD EQIFQAINAG HIQGEQGWED FQQRMDALSC
810 820 830 840 850
FLIKRRDKTR MFCHPSFREW LVWRADGENT AFLCEPRNGH ALLAFMFSRQ
860 870 880 890 900
EGKLNRQQTM ELGHHILKAH IFKGLSKKTG ISSSHLQALW IGYSTEGLSA
910 920 930 940 950
ALASLRNLYT PNVKVSRLLI LGGANVNYRT EVLNNAPILC VQSHLGHEEV
960 970 980 990 1000
VTLLLEFGAC LDGTSENGMT ALCYAAAAGH MKLVCLLTKK GVRVDHLDKK
1010 1020 1030 1040 1050
GQCALVHSAL RGHGDILQYL LTCEWSPGPP QPGTLRKSHA LQQALTAAAS
1060 1070 1080 1090 1100
MGHSSVVQCL LGMEKEHEVE VNGTDTLWGE TALTAAAGRG KLEVCELLLG
1110 1120 1130 1140 1150
HGAAVSRTNR RGVPPLFCAA RQGHWQIVRL LLERGCDVNL SDKQGRTPLM
1160 1170 1180 1190 1200
VAACEGHLST VEFLLSKGAA LSSLDKEGLS ALSWACLKGH RAVVQYLVEE
1210 1220 1230 1240 1250
GAAIDQTDKN GRTPLDLAAF YGDAETVLYL VEKGAVIEHV DHSGMRPLDR
1260 1270 1280 1290 1300
AIGCRNTSVV VALLRKGAKL GNAAWAMATS KPDILIILLQ KLMEEGNVMY
1310 1320 1330 1340 1350
KKGKMKEAAQ RYQYALRKFP REGFGEDMRP FNELRVSLYL NLSRCRRKTN
1360 1370 1380 1390 1400
DFGMAEEFAS KALELKPKSY EAFYARARAK RNSRQFVAAL ADLQEAVKLC
1410 1420 1430 1440 1450
PTNQEVKRLL ARVEEECKQL QRSQQQKQQG PLPAPLNDSE NEEDTPTPGL
1460 1470 1480 1490 1500
SDHFHSEETE EEETSPQEES VSPTPRSQPS SSVPSSYIRN LQEGLQSKGR
1510 1520 1530 1540 1550
PVSPQSRAGI GKSLREPVAQ PGLLLQPSKQ AQIVKTSQHL GSGQSAVRNG
1560 1570 1580 1590 1600
SMKVQISSQN PPPSPMPGRI AATPAGSRTQ HLEGTGTFTT RAGCGHFGDR
1610 1620 1630 1640 1650
LGPSQNVRLQ CGENGPAHPL PSKTKTTERL LSHSSVAVDA APPNQGGLAT
1660 1670 1680 1690 1700
CSDVRHPASL TSSGSSGSPS SSIKMSSSTS SLTSSSSFSD GFKVQGPDTR
1710 1720 1730 1740 1750
IKDKVVTHVQ SGTAEHRPRN TPFMGIMDKT ARFQQQSNPP SRSWHCPAPE
1760 1770 1780 1790 1800
GLLTNTSSAA GLQSANTEKP SLMQVGGYNN QAKTCSVSTL SASVHNGAQV
1810 1820 1830 1840 1850
KELEESKCQI PVHSQENRIT KTVSHLYQES ISKQQPHISN EAHRSHLTAA
1860
KPKRSFIESN V
Length:1,861
Mass (Da):202,219
Last modified:May 18, 2010 - v3
Checksum:iE9BE1083E5FB9413
GO
Isoform 2 (identifier: Q9C0D5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-227: Missing.

Note: Incomplete sequence. No experimental confirmation available.
Show »
Length:1,755
Mass (Da):191,427
Checksum:iB00C28AF4CA6E30D
GO

Sequence cautioni

The sequence AAH37329 differs from that shown. The cDNA sequence appears to be not correctly spliced at its 3'-end.Curated
The sequence AAH37329 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06102230P → S.Corresponds to variant rs34588551dbSNPEnsembl.1
Natural variantiVAR_038435251N → S.2 PublicationsCorresponds to variant rs12466551dbSNPEnsembl.1
Natural variantiVAR_0384361511G → S.Corresponds to variant rs13421084dbSNPEnsembl.1
Natural variantiVAR_0384371573T → A.1 PublicationCorresponds to variant rs4664277dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030828122 – 227Missing in isoform 2. 1 PublicationAdd BLAST106

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009307 Genomic DNA. No translation available.
AC010093 Genomic DNA. No translation available.
BC037329 mRNA. Translation: AAH37329.1. Sequence problems.
AB051515 mRNA. Translation: BAB21819.1.
CCDSiCCDS42766.1. [Q9C0D5-1]
RefSeqiNP_001139381.1. NM_001145909.1.
NP_203752.2. NM_033394.2. [Q9C0D5-1]
XP_006712873.1. XM_006712810.3. [Q9C0D5-1]
XP_011510360.1. XM_011512058.2. [Q9C0D5-2]
UniGeneiHs.61590.

Genome annotation databases

EnsembliENST00000263635; ENSP00000263635; ENSG00000115183. [Q9C0D5-1]
GeneIDi85461.
KEGGihsa:85461.
UCSCiuc002uag.4. human. [Q9C0D5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009307 Genomic DNA. No translation available.
AC010093 Genomic DNA. No translation available.
BC037329 mRNA. Translation: AAH37329.1. Sequence problems.
AB051515 mRNA. Translation: BAB21819.1.
CCDSiCCDS42766.1. [Q9C0D5-1]
RefSeqiNP_001139381.1. NM_001145909.1.
NP_203752.2. NM_033394.2. [Q9C0D5-1]
XP_006712873.1. XM_006712810.3. [Q9C0D5-1]
XP_011510360.1. XM_011512058.2. [Q9C0D5-2]
UniGeneiHs.61590.

3D structure databases

ProteinModelPortaliQ9C0D5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124545. 9 interactors.
IntActiQ9C0D5. 5 interactors.
STRINGi9606.ENSP00000263635.

PTM databases

iPTMnetiQ9C0D5.
PhosphoSitePlusiQ9C0D5.

Polymorphism and mutation databases

BioMutaiTANC1.
DMDMi296452941.

Proteomic databases

EPDiQ9C0D5.
MaxQBiQ9C0D5.
PaxDbiQ9C0D5.
PeptideAtlasiQ9C0D5.
PRIDEiQ9C0D5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263635; ENSP00000263635; ENSG00000115183. [Q9C0D5-1]
GeneIDi85461.
KEGGihsa:85461.
UCSCiuc002uag.4. human. [Q9C0D5-1]

Organism-specific databases

CTDi85461.
DisGeNETi85461.
GeneCardsiTANC1.
H-InvDBHIX0022500.
HGNCiHGNC:29364. TANC1.
HPAiHPA036750.
MIMi611397. gene.
neXtProtiNX_Q9C0D5.
OpenTargetsiENSG00000115183.
PharmGKBiPA142670838.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000231045.
HOVERGENiHBG061464.
InParanoidiQ9C0D5.
OMAiEHRPRNT.
OrthoDBiEOG091G00QZ.
PhylomeDBiQ9C0D5.
TreeFamiTF323159.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115183-MONOMER.

Miscellaneous databases

ChiTaRSiTANC1. human.
GenomeRNAii85461.
PROiQ9C0D5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115183.
CleanExiHS_TANC1.
ExpressionAtlasiQ9C0D5. baseline and differential.
GenevisibleiQ9C0D5. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 10 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF48452. SSF48452. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTANC1_HUMAN
AccessioniPrimary (citable) accession number: Q9C0D5
Secondary accession number(s): C9JD88, Q49AI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.