Q9C0D5 (TANC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein TANC1

Alternative name(s):
Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1

Gene names

Name:	TANC1
Synonyms:	KIAA1728

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1861 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a scaffold component in the postsynaptic density By similarity.
Subunit structure	Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1 By similarity. Interacts with TNIK. Interacts with MINK1 By similarity. Ref.4
Subcellular location	Cell junction › synapse › postsynaptic cell membrane › postsynaptic density By similarity.
Post-translational modification	Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A. Ref.4 Ref.5 Ref.6
Sequence similarities	Belongs to the TANC family. Contains 11 ANK repeats. Contains 3 TPR repeats.
Sequence caution	The sequence AAH37329.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH37329.1 differs from that shown. Reason: The cDNA sequence appears to be not correctly spliced at its 3'-end.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Repeat TPR repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic density Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9C0D5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9C0D5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     122-227: Missing.

Note: Incomplete sequence. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1861	1861	Protein TANC1		PRO_0000316959
Regions
	Repeat	896 – 928	33	ANK 1
	Repeat	934 – 963	30	ANK 2
	Repeat	967 – 996	30	ANK 3
	Repeat	1000 – 1029	30	ANK 4
	Repeat	1040 – 1069	30	ANK 5
	Repeat	1078 – 1107	30	ANK 6
	Repeat	1111 – 1140	30	ANK 7
	Repeat	1144 – 1173	30	ANK 8
	Repeat	1177 – 1206	30	ANK 9
	Repeat	1210 – 1239	30	ANK 10
	Repeat	1243 – 1272	30	ANK 11
	Repeat	1289 – 1322	34	TPR 1
	Repeat	1336 – 1369	34	TPR 2
	Repeat	1371 – 1403	33	TPR 3
	Compositional bias	170 – 243	74	Ser-rich
	Compositional bias	1659 – 1689	31	Ser-rich
Amino acid modifications
	Modified residue	63	1	Phosphoserine Ref.6
	Modified residue	66	1	Phosphoserine Ref.6
	Modified residue	207	1	Phosphoserine Ref.6
	Modified residue	214	1	Phosphoserine Ref.6
	Modified residue	1665	1	Phosphoserine Ref.5
	Modified residue	1668	1	Phosphoserine Ref.5
Natural variations
	Alternative sequence	122 – 227	106	Missing in isoform 2.		VSP_030828
	Natural variant	30	1	P → S. Corresponds to variant rs34588551 [ dbSNP | Ensembl ].		VAR_061022
	Natural variant	251	1	N → S. Ref.2 Ref.3 Corresponds to variant rs12466551 [ dbSNP | Ensembl ].		VAR_038435
	Natural variant	1511	1	G → S. Corresponds to variant rs13421084 [ dbSNP | Ensembl ].		VAR_038436
	Natural variant	1573	1	T → A. Ref.3 Corresponds to variant rs4664277 [ dbSNP | Ensembl ].		VAR_038437

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: E9BE1083E5FB9413	FASTA	1,861	202,219
	10 20 30 40 50 60 MLKAVLKKSR EGGKGGKKEA GSDFGPETSP VLHLDHSADS PVSSLPTAED TYRVSLAKGV 70 80 90 100 110 120 SMSLPSSPLL PRQSHLVQSR VNKKSPGPVR KPKYVESPRV PGDAVIMPFR EVAKPTEPDE 130 140 150 160 170 180 HEAKADNEPS CSPAAQELLT RLGFLLGEGI PSATHITIED KNETMCTALS QGISPCSTLT 190 200 210 220 230 240 SSTASPSTDS PCSTLNSCVS KTAANKSPCE TISSPSSTLE SKDSGIIATI TSSSENDDRS 250 260 270 280 290 300 GSSLEWNKDG NLRLGVQKGV LHDRRADNCS PVAEEETTGS AESTLPKAES SAGDGPVPYS 310 320 330 340 350 360 QGSSSLIMPR PNSVAATSST KLEDLSYLDG QRNAPLRTSI RLPWHNTAGG RAQEVKARFA 370 380 390 400 410 420 PYKPQDILLK PLLFEVPSIT TDSVFVGRDW LFHQIEENLR NTELAENRGA VVVGNVGFGK 430 440 450 460 470 480 TAIISKLVAL SCHGSRMRQI ASNSPGSSPK TSDPTQDLHF TPLLSPSSST SASSTAKTPL 490 500 510 520 530 540 GSISAENQRP REDAVKYLAS KVVAYHYCQA DNTYTCLVPE FVHSIAALLC RSHQLAAYRD 550 560 570 580 590 600 LLIKEPQLQS MLSLRSCVQD PVAAFKRGVL EPLTNLRNEQ KIPEEEYIIL IDGLNEAEFH 610 620 630 640 650 660 KPDYGDTLSS FITKIISKFP AWLKLIVTVR ANFQEIISAL PFVKLSLDDF PDNKDIHSDL 670 680 690 700 710 720 HAYVQHRVHS SQDILSNISL NGKADATLIG KVSSHLVLRS LGSYLYLKLT LDLFQRGHLV 730 740 750 760 770 780 IKSASYKVVP VSLSELYLLQ CNMKFMTQSA FERALPILNV ALASLHPMTD EQIFQAINAG 790 800 810 820 830 840 HIQGEQGWED FQQRMDALSC FLIKRRDKTR MFCHPSFREW LVWRADGENT AFLCEPRNGH 850 860 870 880 890 900 ALLAFMFSRQ EGKLNRQQTM ELGHHILKAH IFKGLSKKTG ISSSHLQALW IGYSTEGLSA 910 920 930 940 950 960 ALASLRNLYT PNVKVSRLLI LGGANVNYRT EVLNNAPILC VQSHLGHEEV VTLLLEFGAC 970 980 990 1000 1010 1020 LDGTSENGMT ALCYAAAAGH MKLVCLLTKK GVRVDHLDKK GQCALVHSAL RGHGDILQYL 1030 1040 1050 1060 1070 1080 LTCEWSPGPP QPGTLRKSHA LQQALTAAAS MGHSSVVQCL LGMEKEHEVE VNGTDTLWGE 1090 1100 1110 1120 1130 1140 TALTAAAGRG KLEVCELLLG HGAAVSRTNR RGVPPLFCAA RQGHWQIVRL LLERGCDVNL 1150 1160 1170 1180 1190 1200 SDKQGRTPLM VAACEGHLST VEFLLSKGAA LSSLDKEGLS ALSWACLKGH RAVVQYLVEE 1210 1220 1230 1240 1250 1260 GAAIDQTDKN GRTPLDLAAF YGDAETVLYL VEKGAVIEHV DHSGMRPLDR AIGCRNTSVV 1270 1280 1290 1300 1310 1320 VALLRKGAKL GNAAWAMATS KPDILIILLQ KLMEEGNVMY KKGKMKEAAQ RYQYALRKFP 1330 1340 1350 1360 1370 1380 REGFGEDMRP FNELRVSLYL NLSRCRRKTN DFGMAEEFAS KALELKPKSY EAFYARARAK 1390 1400 1410 1420 1430 1440 RNSRQFVAAL ADLQEAVKLC PTNQEVKRLL ARVEEECKQL QRSQQQKQQG PLPAPLNDSE 1450 1460 1470 1480 1490 1500 NEEDTPTPGL SDHFHSEETE EEETSPQEES VSPTPRSQPS SSVPSSYIRN LQEGLQSKGR 1510 1520 1530 1540 1550 1560 PVSPQSRAGI GKSLREPVAQ PGLLLQPSKQ AQIVKTSQHL GSGQSAVRNG SMKVQISSQN 1570 1580 1590 1600 1610 1620 PPPSPMPGRI AATPAGSRTQ HLEGTGTFTT RAGCGHFGDR LGPSQNVRLQ CGENGPAHPL 1630 1640 1650 1660 1670 1680 PSKTKTTERL LSHSSVAVDA APPNQGGLAT CSDVRHPASL TSSGSSGSPS SSIKMSSSTS 1690 1700 1710 1720 1730 1740 SLTSSSSFSD GFKVQGPDTR IKDKVVTHVQ SGTAEHRPRN TPFMGIMDKT ARFQQQSNPP 1750 1760 1770 1780 1790 1800 SRSWHCPAPE GLLTNTSSAA GLQSANTEKP SLMQVGGYNN QAKTCSVSTL SASVHNGAQV 1810 1820 1830 1840 1850 1860 KELEESKCQI PVHSQENRIT KTVSHLYQES ISKQQPHISN EAHRSHLTAA KPKRSFIESN V
	Isoform 2 [UniParc]. Checksum: B00C28AF4CA6E30D	FASTA	1,755	191,427
	10 20 30 40 50 60 MLKAVLKKSR EGGKGGKKEA GSDFGPETSP VLHLDHSADS PVSSLPTAED TYRVSLAKGV 70 80 90 100 110 120 SMSLPSSPLL PRQSHLVQSR VNKKSPGPVR KPKYVESPRV PGDAVIMPFR EVAKPTEPDE 130 140 150 160 170 180 HATITSSSEN DDRSGSSLEW NKDGNLRLGV QKGVLHDRRA DNCSPVAEEE TTGSAESTLP 190 200 210 220 230 240 KAESSAGDGP VPYSQGSSSL IMPRPNSVAA TSSTKLEDLS YLDGQRNAPL RTSIRLPWHN 250 260 270 280 290 300 TAGGRAQEVK ARFAPYKPQD ILLKPLLFEV PSITTDSVFV GRDWLFHQIE ENLRNTELAE 310 320 330 340 350 360 NRGAVVVGNV GFGKTAIISK LVALSCHGSR MRQIASNSPG SSPKTSDPTQ DLHFTPLLSP 370 380 390 400 410 420 SSSTSASSTA KTPLGSISAE NQRPREDAVK YLASKVVAYH YCQADNTYTC LVPEFVHSIA 430 440 450 460 470 480 ALLCRSHQLA AYRDLLIKEP QLQSMLSLRS CVQDPVAAFK RGVLEPLTNL RNEQKIPEEE 490 500 510 520 530 540 YIILIDGLNE AEFHKPDYGD TLSSFITKII SKFPAWLKLI VTVRANFQEI ISALPFVKLS 550 560 570 580 590 600 LDDFPDNKDI HSDLHAYVQH RVHSSQDILS NISLNGKADA TLIGKVSSHL VLRSLGSYLY 610 620 630 640 650 660 LKLTLDLFQR GHLVIKSASY KVVPVSLSEL YLLQCNMKFM TQSAFERALP ILNVALASLH 670 680 690 700 710 720 PMTDEQIFQA INAGHIQGEQ GWEDFQQRMD ALSCFLIKRR DKTRMFCHPS FREWLVWRAD 730 740 750 760 770 780 GENTAFLCEP RNGHALLAFM FSRQEGKLNR QQTMELGHHI LKAHIFKGLS KKTGISSSHL 790 800 810 820 830 840 QALWIGYSTE GLSAALASLR NLYTPNVKVS RLLILGGANV NYRTEVLNNA PILCVQSHLG 850 860 870 880 890 900 HEEVVTLLLE FGACLDGTSE NGMTALCYAA AAGHMKLVCL LTKKGVRVDH LDKKGQCALV 910 920 930 940 950 960 HSALRGHGDI LQYLLTCEWS PGPPQPGTLR KSHALQQALT AAASMGHSSV VQCLLGMEKE 970 980 990 1000 1010 1020 HEVEVNGTDT LWGETALTAA AGRGKLEVCE LLLGHGAAVS RTNRRGVPPL FCAARQGHWQ 1030 1040 1050 1060 1070 1080 IVRLLLERGC DVNLSDKQGR TPLMVAACEG HLSTVEFLLS KGAALSSLDK EGLSALSWAC 1090 1100 1110 1120 1130 1140 LKGHRAVVQY LVEEGAAIDQ TDKNGRTPLD LAAFYGDAET VLYLVEKGAV IEHVDHSGMR 1150 1160 1170 1180 1190 1200 PLDRAIGCRN TSVVVALLRK GAKLGNAAWA MATSKPDILI ILLQKLMEEG NVMYKKGKMK 1210 1220 1230 1240 1250 1260 EAAQRYQYAL RKFPREGFGE DMRPFNELRV SLYLNLSRCR RKTNDFGMAE EFASKALELK 1270 1280 1290 1300 1310 1320 PKSYEAFYAR ARAKRNSRQF VAALADLQEA VKLCPTNQEV KRLLARVEEE CKQLQRSQQQ 1330 1340 1350 1360 1370 1380 KQQGPLPAPL NDSENEEDTP TPGLSDHFHS EETEEEETSP QEESVSPTPR SQPSSSVPSS 1390 1400 1410 1420 1430 1440 YIRNLQEGLQ SKGRPVSPQS RAGIGKSLRE PVAQPGLLLQ PSKQAQIVKT SQHLGSGQSA 1450 1460 1470 1480 1490 1500 VRNGSMKVQI SSQNPPPSPM PGRIAATPAG SRTQHLEGTG TFTTRAGCGH FGDRLGPSQN 1510 1520 1530 1540 1550 1560 VRLQCGENGP AHPLPSKTKT TERLLSHSSV AVDAAPPNQG GLATCSDVRH PASLTSSGSS 1570 1580 1590 1600 1610 1620 GSPSSSIKMS SSTSSLTSSS SFSDGFKVQG PDTRIKDKVV THVQSGTAEH RPRNTPFMGI 1630 1640 1650 1660 1670 1680 MDKTARFQQQ SNPPSRSWHC PAPEGLLTNT SSAAGLQSAN TEKPSLMQVG GYNNQAKTCS 1690 1700 1710 1720 1730 1740 VSTLSASVHN GAQVKELEES KCQIPVHSQE NRITKTVSHL YQESISKQQP HISNEAHRSH 1750 LTAAKPKRSF IESNV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-662 (ISOFORM 2), VARIANT SER-251. Tissue: Brain.
[3]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed: 11214970] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-1861 (ISOFORM 1), VARIANTS SER-251 AND ALA-1573. Tissue: Brain.
[4]	"MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1." Nonaka H., Takei K., Umikawa M., Oshiro M., Kuninaka K., Bayarjargal M., Asato T., Yamashiro Y., Uechi Y., Endo S., Suzuki T., Kariya K. Biochem. Biophys. Res. Commun. 377:573-578(2008) [PubMed: 18930710] [Abstract] Cited for: INTERACTION WITH TNIK, PHOSPHORYLATION.
[5]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1665 AND SER-1668, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63; SER-66; SER-207 AND SER-214, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC009307 Genomic DNA. No translation available. AC010093 Genomic DNA. No translation available. BC037329 mRNA. Translation: AAH37329.1. Sequence problems. AB051515 mRNA. Translation: BAB21819.1.
IPI	IPI00173946. IPI00885010.
RefSeq	NP_001139381.1. NM_001145909.1. NP_203752.2. NM_033394.2.
UniGene	Hs.61590.
3D structure databases
HSSP	HSSP built from PDB template 1IHB based on UniProtKB P42773.
ProteinModelPortal	Q9C0D5.
SMR	Q9C0D5. Positions 378-429, 909-1415.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9C0D5.
PTM databases
PhosphoSite	Q9C0D5.
Polymorphism databases
DMDM	296452941.
Proteomic databases
PeptideAtlas	Q9C0D5.
PRIDE	Q9C0D5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263635; ENSP00000263635; ENSG00000115183.
GeneID	85461.
KEGG	hsa:85461.
UCSC	uc002uag.1. human.
Organism-specific databases
CTD	85461.
GeneCards	GC02P159739.
H-InvDB	HIX0022500.
HGNC	HGNC:29364. TANC1.
HPA	HPA036750.
MIM	611397. gene.
neXtProt	NX_Q9C0D5.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11967.
GeneTree	ENSGT00600000084024.
HOGENOM	HBG443929.
HOVERGEN	HBG061464.
InParanoid	Q9C0D5.
OMA	IMDKTAR.
OrthoDB	EOG4TB49F.
PhylomeDB	Q9C0D5.
Gene expression databases
ArrayExpress	Q9C0D5.
Bgee	Q9C0D5.
CleanEx	HS_TANC1.
Genevestigator	Q9C0D5.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR013026. TPR-contain. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 2 hits. G3DSA:1.25.40.10. TPR-like_helical. 1 hit.
Pfam	PF00023. Ank. 1 hit. PF12796. Ank_2. 3 hits. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 10 hits. SM00028. TPR. 3 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 6 hits. PS50005. TPR. 3 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	76104.
SOURCE	Search...

Entry information

Entry name

TANC1_HUMAN

Accession

Primary (citable) accession number: Q9C0D5
Secondary accession number(s): C9JD88, Q49AI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.