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Protein

Zinc finger protein 518B

Gene

ZNF518B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri162 – 18423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri190 – 21324C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1036 – 105823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 518B
Gene namesi
Name:ZNF518B
Synonyms:KIAA1729
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:29365. ZNF518B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410199.

Polymorphism and mutation databases

BioMutaiZNF518B.
DMDMi166979949.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10741074Zinc finger protein 518BPRO_0000317255Add
BLAST

Proteomic databases

EPDiQ9C0D4.
MaxQBiQ9C0D4.
PaxDbiQ9C0D4.
PeptideAtlasiQ9C0D4.
PRIDEiQ9C0D4.

PTM databases

iPTMnetiQ9C0D4.
PhosphoSiteiQ9C0D4.

Expressioni

Gene expression databases

BgeeiQ9C0D4.
CleanExiHS_ZNF518B.
ExpressionAtlasiQ9C0D4. baseline and differential.
GenevisibleiQ9C0D4. HS.

Organism-specific databases

HPAiHPA031215.
HPA031216.

Interactioni

Protein-protein interaction databases

BioGridi124544. 2 interactions.
STRINGi9606.ENSP00000317614.

Structurei

3D structure databases

ProteinModelPortaliQ9C0D4.
SMRiQ9C0D4. Positions 133-166, 179-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri162 – 18423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri190 – 21324C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1036 – 105823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000064040.
HOGENOMiHOG000155751.
HOVERGENiHBG095602.
InParanoidiQ9C0D4.
OMAiHKNNYQV.
OrthoDBiEOG718KBB.
PhylomeDBiQ9C0D4.
TreeFamiTF332842.

Family and domain databases

InterProiIPR027775. C2H2_Znf_fam.
IPR028379. Znf_518B.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 3 hits.
PTHR10032:SF188. PTHR10032:SF188. 3 hits.
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C0D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDIGQQLYT THLNGGHNSL TMSPKQPDAN GAPRPNRQEA QTLLYQGSEA
60 70 80 90 100
EAAMMTIATC AKCKSVHKIS LQDLQKGTGK DGMYVCFQCS LGAAPPNFHF
110 120 130 140 150
VSNNSSATHV GNKTENFSSS VNSKFKVRNF KPGKYYCDKC RFSTKDPLQY
160 170 180 190 200
KKHTLQHEEI KFICSHCSYI SYTKGEFQRH LVKHTGIFPY QCEYCDYGAI
210 220 230 240 250
RNDYIVKHTK RVHERAGAKR PVKAVAKLEP KRTGTSKQNP ELLKASNPRT
260 270 280 290 300
TFQNKWSDQL SGFSLHANKD KMHNIMLLPE PKEYQKDVVC IPNKMTLSEP
310 320 330 340 350
NEVNLFENKN VEVEVLSPAK EPVQPGMPLT VVAPAELVVP ANCLAQLIDV
360 370 380 390 400
KVVNGTQQLV LKLFPLEENN CLEAGRDNGG NSERMVKEKG SNEQEKVLSA
410 420 430 440 450
EKTKSLTVDG NVGKLVGIDS FQPSVQKQLK NVKWVRSYDF IMPNSSVHNN
460 470 480 490 500
GKSFINSETI EDFQKKNNLY PHRTAFPSVA LKGHSLASVF KNSVLRSLGA
510 520 530 540 550
ASNPFPYKAA VCFAESGRNL HSSSQQLLPF AASPATCSFS GEKGLLPVSE
560 570 580 590 600
NDLESTSKVN IPVKVVSSNR KQEDNQTEEH KAVSTVGQIS SQHKSEYLHI
610 620 630 640 650
NITGEDRSQQ PGDKPLELKN SERTNNTNDG PVISSVFSLS SGSENVPEGI
660 670 680 690 700
KWNSSTSKIK SIELLRRKIA QLIESCGKPS SLASNSAHRR SVGQASKGTS
710 720 730 740 750
KATSEGIQEI NVSLTGLGHS TGTLQKPPND GGITGNRQLT HQQIYPHFAD
760 770 780 790 800
GSNRKTKSRV ARKAHVATPV LIPKGAVLRV LNSSENAHII EATCEAPVSI
810 820 830 840 850
PCSERQLIKP VPFCPVRQAD SDLQPLRSER GPIDMSPNIE TPLRPKLRKE
860 870 880 890 900
SAVCSTIHRK TGLLYGQQGS SELNKQGRLL SRSLSISRNK TKQVHLSRKK
910 920 930 940 950
NKIQAEPSRC LKDPSIFQVA RQLRLIAAKP DQLIKCPRRN QPVIVLNHPD
960 970 980 990 1000
VDSPEVTNVM KVINKYKGNV LKVVLSERTR CQLGIRRHHV RLTYQNAEEA
1010 1020 1030 1040 1050
SQIKRQMMLK MKLKKVHKNN YQVVDSLPDD SSQCVFKCWF CGRLYEDQEE
1060 1070
WMSHGQRHLI EATRDWDVLS SKGK
Length:1,074
Mass (Da):119,531
Last modified:February 5, 2008 - v2
Checksum:iC61B56FE1A3EB7CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti452 – 4521K → E in BAB71650 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921G → S.
Corresponds to variant rs10007352 [ dbSNP | Ensembl ].
VAR_061955
Natural varianti105 – 1051S → P.1 Publication
Corresponds to variant rs10016702 [ dbSNP | Ensembl ].
VAR_038491
Natural varianti523 – 5231S → N.2 Publications
Corresponds to variant rs9291410 [ dbSNP | Ensembl ].
VAR_038492

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110768 Genomic DNA. No translation available.
AB051516 mRNA. Translation: BAB21820.1.
AK058072 mRNA. Translation: BAB71650.2.
CCDSiCCDS33960.1.
RefSeqiNP_444270.2. NM_053042.2.
XP_005248250.1. XM_005248193.1.
UniGeneiHs.455089.

Genome annotation databases

EnsembliENST00000326756; ENSP00000317614; ENSG00000178163.
GeneIDi85460.
KEGGihsa:85460.
UCSCiuc003gmn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110768 Genomic DNA. No translation available.
AB051516 mRNA. Translation: BAB21820.1.
AK058072 mRNA. Translation: BAB71650.2.
CCDSiCCDS33960.1.
RefSeqiNP_444270.2. NM_053042.2.
XP_005248250.1. XM_005248193.1.
UniGeneiHs.455089.

3D structure databases

ProteinModelPortaliQ9C0D4.
SMRiQ9C0D4. Positions 133-166, 179-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124544. 2 interactions.
STRINGi9606.ENSP00000317614.

PTM databases

iPTMnetiQ9C0D4.
PhosphoSiteiQ9C0D4.

Polymorphism and mutation databases

BioMutaiZNF518B.
DMDMi166979949.

Proteomic databases

EPDiQ9C0D4.
MaxQBiQ9C0D4.
PaxDbiQ9C0D4.
PeptideAtlasiQ9C0D4.
PRIDEiQ9C0D4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326756; ENSP00000317614; ENSG00000178163.
GeneIDi85460.
KEGGihsa:85460.
UCSCiuc003gmn.4. human.

Organism-specific databases

CTDi85460.
GeneCardsiZNF518B.
HGNCiHGNC:29365. ZNF518B.
HPAiHPA031215.
HPA031216.
neXtProtiNX_Q9C0D4.
PharmGKBiPA162410199.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000064040.
HOGENOMiHOG000155751.
HOVERGENiHBG095602.
InParanoidiQ9C0D4.
OMAiHKNNYQV.
OrthoDBiEOG718KBB.
PhylomeDBiQ9C0D4.
TreeFamiTF332842.

Miscellaneous databases

ChiTaRSiZNF518B. human.
GenomeRNAii85460.
PROiQ9C0D4.

Gene expression databases

BgeeiQ9C0D4.
CleanExiHS_ZNF518B.
ExpressionAtlasiQ9C0D4. baseline and differential.
GenevisibleiQ9C0D4. HS.

Family and domain databases

InterProiIPR027775. C2H2_Znf_fam.
IPR028379. Znf_518B.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 3 hits.
PTHR10032:SF188. PTHR10032:SF188. 3 hits.
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-1074, VARIANTS PRO-105 AND ASN-523.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 442-1074, VARIANT ASN-523.
    Tissue: Testis.

Entry informationi

Entry nameiZ518B_HUMAN
AccessioniPrimary (citable) accession number: Q9C0D4
Secondary accession number(s): Q96LN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 6, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.