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Protein

Zinc finger protein 518B

Gene

ZNF518B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri162 – 184C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 213C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1036 – 1058C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 518B
Gene namesi
Name:ZNF518B
Synonyms:KIAA1729
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000178163.7
HGNCiHGNC:29365 ZNF518B
MIMi617734 gene
neXtProtiNX_Q9C0D4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178163
PharmGKBiPA162410199

Polymorphism and mutation databases

BioMutaiZNF518B
DMDMi166979949

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172551 – 1074Zinc finger protein 518BAdd BLAST1074

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki482Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki491Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki558Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki594Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki809Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki846Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki860Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9C0D4
MaxQBiQ9C0D4
PaxDbiQ9C0D4
PeptideAtlasiQ9C0D4
PRIDEiQ9C0D4
ProteomicsDBi80013

PTM databases

iPTMnetiQ9C0D4
PhosphoSitePlusiQ9C0D4

Expressioni

Gene expression databases

BgeeiENSG00000178163
CleanExiHS_ZNF518B
ExpressionAtlasiQ9C0D4 baseline and differential
GenevisibleiQ9C0D4 HS

Organism-specific databases

HPAiHPA031215
HPA031216

Interactioni

Protein-protein interaction databases

BioGridi124544, 2 interactors
IntActiQ9C0D4, 3 interactors
STRINGi9606.ENSP00000317614

Structurei

3D structure databases

ProteinModelPortaliQ9C0D4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri162 – 184C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 213C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1036 – 1058C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000064040
HOGENOMiHOG000155751
HOVERGENiHBG095602
InParanoidiQ9C0D4
OMAiHKNNYQV
OrthoDBiEOG091G00VJ
PhylomeDBiQ9C0D4
TreeFamiTF332842

Family and domain databases

InterProiView protein in InterPro
IPR027760 ZNF518
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR45151 PTHR45151, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C0D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDIGQQLYT THLNGGHNSL TMSPKQPDAN GAPRPNRQEA QTLLYQGSEA
60 70 80 90 100
EAAMMTIATC AKCKSVHKIS LQDLQKGTGK DGMYVCFQCS LGAAPPNFHF
110 120 130 140 150
VSNNSSATHV GNKTENFSSS VNSKFKVRNF KPGKYYCDKC RFSTKDPLQY
160 170 180 190 200
KKHTLQHEEI KFICSHCSYI SYTKGEFQRH LVKHTGIFPY QCEYCDYGAI
210 220 230 240 250
RNDYIVKHTK RVHERAGAKR PVKAVAKLEP KRTGTSKQNP ELLKASNPRT
260 270 280 290 300
TFQNKWSDQL SGFSLHANKD KMHNIMLLPE PKEYQKDVVC IPNKMTLSEP
310 320 330 340 350
NEVNLFENKN VEVEVLSPAK EPVQPGMPLT VVAPAELVVP ANCLAQLIDV
360 370 380 390 400
KVVNGTQQLV LKLFPLEENN CLEAGRDNGG NSERMVKEKG SNEQEKVLSA
410 420 430 440 450
EKTKSLTVDG NVGKLVGIDS FQPSVQKQLK NVKWVRSYDF IMPNSSVHNN
460 470 480 490 500
GKSFINSETI EDFQKKNNLY PHRTAFPSVA LKGHSLASVF KNSVLRSLGA
510 520 530 540 550
ASNPFPYKAA VCFAESGRNL HSSSQQLLPF AASPATCSFS GEKGLLPVSE
560 570 580 590 600
NDLESTSKVN IPVKVVSSNR KQEDNQTEEH KAVSTVGQIS SQHKSEYLHI
610 620 630 640 650
NITGEDRSQQ PGDKPLELKN SERTNNTNDG PVISSVFSLS SGSENVPEGI
660 670 680 690 700
KWNSSTSKIK SIELLRRKIA QLIESCGKPS SLASNSAHRR SVGQASKGTS
710 720 730 740 750
KATSEGIQEI NVSLTGLGHS TGTLQKPPND GGITGNRQLT HQQIYPHFAD
760 770 780 790 800
GSNRKTKSRV ARKAHVATPV LIPKGAVLRV LNSSENAHII EATCEAPVSI
810 820 830 840 850
PCSERQLIKP VPFCPVRQAD SDLQPLRSER GPIDMSPNIE TPLRPKLRKE
860 870 880 890 900
SAVCSTIHRK TGLLYGQQGS SELNKQGRLL SRSLSISRNK TKQVHLSRKK
910 920 930 940 950
NKIQAEPSRC LKDPSIFQVA RQLRLIAAKP DQLIKCPRRN QPVIVLNHPD
960 970 980 990 1000
VDSPEVTNVM KVINKYKGNV LKVVLSERTR CQLGIRRHHV RLTYQNAEEA
1010 1020 1030 1040 1050
SQIKRQMMLK MKLKKVHKNN YQVVDSLPDD SSQCVFKCWF CGRLYEDQEE
1060 1070
WMSHGQRHLI EATRDWDVLS SKGK
Length:1,074
Mass (Da):119,531
Last modified:February 5, 2008 - v2
Checksum:iC61B56FE1A3EB7CB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti452K → E in BAB71650 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06195592G → S. Corresponds to variant dbSNP:rs10007352Ensembl.1
Natural variantiVAR_038491105S → P1 PublicationCorresponds to variant dbSNP:rs10016702Ensembl.1
Natural variantiVAR_038492523S → N2 PublicationsCorresponds to variant dbSNP:rs9291410Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110768 Genomic DNA No translation available.
AB051516 mRNA Translation: BAB21820.1
AK058072 mRNA Translation: BAB71650.2
CCDSiCCDS33960.1
RefSeqiNP_444270.2, NM_053042.2
XP_005248250.1, XM_005248193.2
XP_016864273.1, XM_017008784.1
XP_016864274.1, XM_017008785.1
XP_016864275.1, XM_017008786.1
UniGeneiHs.455089

Genome annotation databases

EnsembliENST00000326756; ENSP00000317614; ENSG00000178163
GeneIDi85460
KEGGihsa:85460
UCSCiuc003gmn.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZ518B_HUMAN
AccessioniPrimary (citable) accession number: Q9C0D4
Secondary accession number(s): Q96LN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 20, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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