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Q9C0D3 (ZY11B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein zyg-11 homolog B
Gene names
Name:ZYG11B
Synonyms:KIAA1730
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length744 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.

Subunit structure

Interacts with TCEB1/Elongin C. Part of an E3 ubiquitin ligase complex including ZYG11B, CUL2 and Elongin BC. Ref.4

Sequence similarities

Belongs to the zyg-11 family.

Contains 2 ARM repeats.

Contains 3 LRR (leucine-rich) repeats.

Sequence caution

The sequence BAB21821.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Coding sequence diversityAlternative splicing
   DomainLeucine-rich repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9C0D3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9C0D3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-578: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 744744Protein zyg-11 homolog B
PRO_0000305087

Regions

Repeat185 – 20824LRR 1
Repeat216 – 23621LRR 2
Repeat237 – 26125LRR 3

Natural variations

Alternative sequence1 – 578578Missing in isoform 2.
VSP_028224

Experimental info

Mutagenesis181L → S: Abolishes interaction with TCEB1. Ref.4
Sequence conflict6721W → C in BAB14596. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 2, 2007. Version 2.
Checksum: 0D8C19251CA67573

FASTA74483,921
        10         20         30         40         50         60 
MPEDQAGAAM EEASPYSLLD ICLNFLTTHL EKFCSARQDG TLCLQEPGVF PQEVADRLLR 

        70         80         90        100        110        120 
TMAFHGLLND GTVGIFRGNQ MRLKRACIRK AKISAVAFRK AFCHHKLVEL DATGVNADIT 

       130        140        150        160        170        180 
ITDIISGLGS NKWIQQNLQC LVLNSLTLSL EDPYERCFSR LSGLRALSIT NVLFYNEDLA 

       190        200        210        220        230        240 
EVASLPRLES LDISNTSITD ITALLACKDR LKSLTMHHLK CLKMTTTQIL DVVRELKHLN 

       250        260        270        280        290        300 
HLDISDDKQF TSDIALRLLE QKDILPNLVS LDVSGRKHVT DKAVEAFIQQ RPSMQFVGLL 

       310        320        330        340        350        360 
ATDAGYSEFL TGEGHLKVSG EANETQIAEA LKRYSERAFF VREALFHLFS LTHVMEKTKP 

       370        380        390        400        410        420 
EILKLVVTGM RNHPMNLPVQ LAASACVFNL TKQDLAAGMP VRLLADVTHL LLKAMEHFPN 

       430        440        450        460        470        480 
HQQLQKNCLL SLCSDRILQD VPFNRFEAAK LVMQWLCNHE DQNMQRMAVA IISILAAKLS 

       490        500        510        520        530        540 
TEQTAQLGTE LFIVRQLLQI VKQKTNQNSV DTTLKFTLSA LWNLTDESPT TCRHFIENQG 

       550        560        570        580        590        600 
LELFMRVLES FPTESSIQQK VLGLLNNIAE VQELHSELMW KDFIDHISSL LHSVEVEVSY 

       610        620        630        640        650        660 
FAAGIIAHLI SRGEQAWTLS RSQRNSLLDD LHSAILKWPT PECEMVAYRS FNPFFPLLGC 

       670        680        690        700        710        720 
FTTPGVQLWA VWAMQHVCSK NPSRYCSMLI EEGGLQHLYN IKDHEHTDPH VQQIAVAILD 

       730        740 
SLEKHIVRHG RPPPCKKQPQ ARLN 

« Hide

Isoform 2 [UniParc].

Checksum: 0225A6D407596545
Show »

FASTA16619,006

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 265-744 (ISOFORM 1).
Tissue: Brain.
[4]"The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components."
Vasudevan S., Starostina N.G., Kipreos E.T.
EMBO Rep. 8:279-286(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TCEB1, IDENTIFICATION IN COMPLEX WITH TCEB1 AND CUL2, MUTAGENESIS OF LEU-18.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB051517 mRNA. Translation: BAB21821.1. Different initiation.
AK023518 mRNA. Translation: BAB14596.1.
BC029832 mRNA. Translation: AAH29832.2.
CCDSCCDS30717.1. [Q9C0D3-1]
RefSeqNP_078922.1. NM_024646.2. [Q9C0D3-1]
UniGeneHs.476280.

3D structure databases

ProteinModelPortalQ9C0D3.
SMRQ9C0D3. Positions 80-202, 250-301.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122820. 10 interactions.
IntActQ9C0D3. 3 interactions.
MINTMINT-2816988.
STRING9606.ENSP00000294353.

PTM databases

PhosphoSiteQ9C0D3.

Polymorphism databases

DMDM158706479.

Proteomic databases

MaxQBQ9C0D3.
PaxDbQ9C0D3.
PRIDEQ9C0D3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000294353; ENSP00000294353; ENSG00000162378. [Q9C0D3-1]
GeneID79699.
KEGGhsa:79699.
UCSCuc001cuj.3. human. [Q9C0D3-1]
uc009vzh.3. human. [Q9C0D3-2]

Organism-specific databases

CTD79699.
GeneCardsGC01P053192.
HGNCHGNC:25820. ZYG11B.
HPAHPA028156.
neXtProtNX_Q9C0D3.
PharmGKBPA142670468.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG255988.
HOGENOMHOG000004816.
HOVERGENHBG108780.
InParanoidQ9C0D3.
KOK10350.
OMAERCFSQL.
OrthoDBEOG72ZCD9.
PhylomeDBQ9C0D3.
TreeFamTF313007.

Gene expression databases

ArrayExpressQ9C0D3.
BgeeQ9C0D3.
CleanExHS_ZYG11B.
GenevestigatorQ9C0D3.

Family and domain databases

Gene3D1.25.10.10. 2 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMSSF48371. SSF48371. 2 hits.
PROSITEPS51450. LRR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZYG11B. human.
GenomeRNAi79699.
NextBio69000.
PROQ9C0D3.

Entry information

Entry nameZY11B_HUMAN
AccessionPrimary (citable) accession number: Q9C0D3
Secondary accession number(s): Q8N2X3, Q9H8L8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 9, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM