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Q9C0D3

- ZY11B_HUMAN

UniProt

Q9C0D3 - ZY11B_HUMAN

Protein

Protein zyg-11 homolog B

Gene

ZYG11B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein zyg-11 homolog B
    Gene namesi
    Name:ZYG11B
    Synonyms:KIAA1730
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25820. ZYG11B.

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi18 – 181L → S: Abolishes interaction with TCEB1. 1 Publication

    Organism-specific databases

    PharmGKBiPA142670468.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 744744Protein zyg-11 homolog BPRO_0000305087Add
    BLAST

    Proteomic databases

    MaxQBiQ9C0D3.
    PaxDbiQ9C0D3.
    PRIDEiQ9C0D3.

    PTM databases

    PhosphoSiteiQ9C0D3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9C0D3.
    BgeeiQ9C0D3.
    CleanExiHS_ZYG11B.
    GenevestigatoriQ9C0D3.

    Organism-specific databases

    HPAiHPA028156.

    Interactioni

    Subunit structurei

    Interacts with TCEB1/Elongin C. Part of an E3 ubiquitin ligase complex including ZYG11B, CUL2 and Elongin BC.1 Publication

    Protein-protein interaction databases

    BioGridi122820. 10 interactions.
    IntActiQ9C0D3. 3 interactions.
    MINTiMINT-2816988.
    STRINGi9606.ENSP00000294353.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C0D3.
    SMRiQ9C0D3. Positions 80-202, 250-301.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati185 – 20824LRR 1Add
    BLAST
    Repeati216 – 23621LRR 2Add
    BLAST
    Repeati237 – 26125LRR 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the zyg-11 family.Curated
    Contains 2 ARM repeats.Curated
    Contains 3 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG255988.
    HOGENOMiHOG000004816.
    HOVERGENiHBG108780.
    InParanoidiQ9C0D3.
    KOiK10350.
    OMAiERCFSQL.
    OrthoDBiEOG72ZCD9.
    PhylomeDBiQ9C0D3.
    TreeFamiTF313007.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR001611. Leu-rich_rpt.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    PROSITEiPS51450. LRR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9C0D3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPEDQAGAAM EEASPYSLLD ICLNFLTTHL EKFCSARQDG TLCLQEPGVF    50
    PQEVADRLLR TMAFHGLLND GTVGIFRGNQ MRLKRACIRK AKISAVAFRK 100
    AFCHHKLVEL DATGVNADIT ITDIISGLGS NKWIQQNLQC LVLNSLTLSL 150
    EDPYERCFSR LSGLRALSIT NVLFYNEDLA EVASLPRLES LDISNTSITD 200
    ITALLACKDR LKSLTMHHLK CLKMTTTQIL DVVRELKHLN HLDISDDKQF 250
    TSDIALRLLE QKDILPNLVS LDVSGRKHVT DKAVEAFIQQ RPSMQFVGLL 300
    ATDAGYSEFL TGEGHLKVSG EANETQIAEA LKRYSERAFF VREALFHLFS 350
    LTHVMEKTKP EILKLVVTGM RNHPMNLPVQ LAASACVFNL TKQDLAAGMP 400
    VRLLADVTHL LLKAMEHFPN HQQLQKNCLL SLCSDRILQD VPFNRFEAAK 450
    LVMQWLCNHE DQNMQRMAVA IISILAAKLS TEQTAQLGTE LFIVRQLLQI 500
    VKQKTNQNSV DTTLKFTLSA LWNLTDESPT TCRHFIENQG LELFMRVLES 550
    FPTESSIQQK VLGLLNNIAE VQELHSELMW KDFIDHISSL LHSVEVEVSY 600
    FAAGIIAHLI SRGEQAWTLS RSQRNSLLDD LHSAILKWPT PECEMVAYRS 650
    FNPFFPLLGC FTTPGVQLWA VWAMQHVCSK NPSRYCSMLI EEGGLQHLYN 700
    IKDHEHTDPH VQQIAVAILD SLEKHIVRHG RPPPCKKQPQ ARLN 744
    Length:744
    Mass (Da):83,921
    Last modified:October 2, 2007 - v2
    Checksum:i0D8C19251CA67573
    GO
    Isoform 2 (identifier: Q9C0D3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-578: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:166
    Mass (Da):19,006
    Checksum:i0225A6D407596545
    GO

    Sequence cautioni

    The sequence BAB21821.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti672 – 6721W → C in BAB14596. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 578578Missing in isoform 2. 1 PublicationVSP_028224Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051517 mRNA. Translation: BAB21821.1. Different initiation.
    AK023518 mRNA. Translation: BAB14596.1.
    BC029832 mRNA. Translation: AAH29832.2.
    CCDSiCCDS30717.1. [Q9C0D3-1]
    RefSeqiNP_078922.1. NM_024646.2. [Q9C0D3-1]
    UniGeneiHs.476280.

    Genome annotation databases

    EnsembliENST00000294353; ENSP00000294353; ENSG00000162378. [Q9C0D3-1]
    GeneIDi79699.
    KEGGihsa:79699.
    UCSCiuc001cuj.3. human. [Q9C0D3-1]
    uc009vzh.3. human. [Q9C0D3-2]

    Polymorphism databases

    DMDMi158706479.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051517 mRNA. Translation: BAB21821.1 . Different initiation.
    AK023518 mRNA. Translation: BAB14596.1 .
    BC029832 mRNA. Translation: AAH29832.2 .
    CCDSi CCDS30717.1. [Q9C0D3-1 ]
    RefSeqi NP_078922.1. NM_024646.2. [Q9C0D3-1 ]
    UniGenei Hs.476280.

    3D structure databases

    ProteinModelPortali Q9C0D3.
    SMRi Q9C0D3. Positions 80-202, 250-301.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122820. 10 interactions.
    IntActi Q9C0D3. 3 interactions.
    MINTi MINT-2816988.
    STRINGi 9606.ENSP00000294353.

    PTM databases

    PhosphoSitei Q9C0D3.

    Polymorphism databases

    DMDMi 158706479.

    Proteomic databases

    MaxQBi Q9C0D3.
    PaxDbi Q9C0D3.
    PRIDEi Q9C0D3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294353 ; ENSP00000294353 ; ENSG00000162378 . [Q9C0D3-1 ]
    GeneIDi 79699.
    KEGGi hsa:79699.
    UCSCi uc001cuj.3. human. [Q9C0D3-1 ]
    uc009vzh.3. human. [Q9C0D3-2 ]

    Organism-specific databases

    CTDi 79699.
    GeneCardsi GC01P053192.
    HGNCi HGNC:25820. ZYG11B.
    HPAi HPA028156.
    neXtProti NX_Q9C0D3.
    PharmGKBi PA142670468.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG255988.
    HOGENOMi HOG000004816.
    HOVERGENi HBG108780.
    InParanoidi Q9C0D3.
    KOi K10350.
    OMAi ERCFSQL.
    OrthoDBi EOG72ZCD9.
    PhylomeDBi Q9C0D3.
    TreeFami TF313007.

    Miscellaneous databases

    ChiTaRSi ZYG11B. human.
    GenomeRNAii 79699.
    NextBioi 69000.
    PROi Q9C0D3.

    Gene expression databases

    ArrayExpressi Q9C0D3.
    Bgeei Q9C0D3.
    CleanExi HS_ZYG11B.
    Genevestigatori Q9C0D3.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR001611. Leu-rich_rpt.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    PROSITEi PS51450. LRR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 265-744 (ISOFORM 1).
      Tissue: Brain.
    4. "The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components."
      Vasudevan S., Starostina N.G., Kipreos E.T.
      EMBO Rep. 8:279-286(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TCEB1, IDENTIFICATION IN COMPLEX WITH TCEB1 AND CUL2, MUTAGENESIS OF LEU-18.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZY11B_HUMAN
    AccessioniPrimary (citable) accession number: Q9C0D3
    Secondary accession number(s): Q8N2X3, Q9H8L8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3