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Protein

Protein zyg-11 homolog B

Gene

ZYG11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein zyg-11 homolog B
Gene namesi
Name:ZYG11B
Synonyms:KIAA1730
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25820. ZYG11B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi18 – 181L → S: Abolishes interaction with TCEB1. 1 Publication

Organism-specific databases

PharmGKBiPA142670468.

Polymorphism and mutation databases

BioMutaiZYG11B.
DMDMi158706479.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744Protein zyg-11 homolog BPRO_0000305087Add
BLAST

Proteomic databases

MaxQBiQ9C0D3.
PaxDbiQ9C0D3.
PRIDEiQ9C0D3.

PTM databases

PhosphoSiteiQ9C0D3.

Expressioni

Gene expression databases

BgeeiQ9C0D3.
CleanExiHS_ZYG11B.
ExpressionAtlasiQ9C0D3. baseline and differential.
GenevisibleiQ9C0D3. HS.

Organism-specific databases

HPAiHPA028156.

Interactioni

Subunit structurei

Interacts with TCEB1/Elongin C. Part of an E3 ubiquitin ligase complex including ZYG11B, CUL2 and Elongin BC.1 Publication

Protein-protein interaction databases

BioGridi122820. 26 interactions.
IntActiQ9C0D3. 3 interactions.
MINTiMINT-2816988.
STRINGi9606.ENSP00000294353.

Structurei

3D structure databases

ProteinModelPortaliQ9C0D3.
SMRiQ9C0D3. Positions 135-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati185 – 20824LRR 1Add
BLAST
Repeati216 – 23621LRR 2Add
BLAST
Repeati237 – 26125LRR 3Add
BLAST

Sequence similaritiesi

Belongs to the zyg-11 family.Curated
Contains 2 ARM repeats.Curated
Contains 3 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG255988.
GeneTreeiENSGT00530000063187.
HOGENOMiHOG000004816.
HOVERGENiHBG108780.
InParanoidiQ9C0D3.
KOiK10350.
OMAiHVCSKNA.
OrthoDBiEOG72ZCD9.
PhylomeDBiQ9C0D3.
TreeFamiTF313007.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS51450. LRR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0D3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEDQAGAAM EEASPYSLLD ICLNFLTTHL EKFCSARQDG TLCLQEPGVF
60 70 80 90 100
PQEVADRLLR TMAFHGLLND GTVGIFRGNQ MRLKRACIRK AKISAVAFRK
110 120 130 140 150
AFCHHKLVEL DATGVNADIT ITDIISGLGS NKWIQQNLQC LVLNSLTLSL
160 170 180 190 200
EDPYERCFSR LSGLRALSIT NVLFYNEDLA EVASLPRLES LDISNTSITD
210 220 230 240 250
ITALLACKDR LKSLTMHHLK CLKMTTTQIL DVVRELKHLN HLDISDDKQF
260 270 280 290 300
TSDIALRLLE QKDILPNLVS LDVSGRKHVT DKAVEAFIQQ RPSMQFVGLL
310 320 330 340 350
ATDAGYSEFL TGEGHLKVSG EANETQIAEA LKRYSERAFF VREALFHLFS
360 370 380 390 400
LTHVMEKTKP EILKLVVTGM RNHPMNLPVQ LAASACVFNL TKQDLAAGMP
410 420 430 440 450
VRLLADVTHL LLKAMEHFPN HQQLQKNCLL SLCSDRILQD VPFNRFEAAK
460 470 480 490 500
LVMQWLCNHE DQNMQRMAVA IISILAAKLS TEQTAQLGTE LFIVRQLLQI
510 520 530 540 550
VKQKTNQNSV DTTLKFTLSA LWNLTDESPT TCRHFIENQG LELFMRVLES
560 570 580 590 600
FPTESSIQQK VLGLLNNIAE VQELHSELMW KDFIDHISSL LHSVEVEVSY
610 620 630 640 650
FAAGIIAHLI SRGEQAWTLS RSQRNSLLDD LHSAILKWPT PECEMVAYRS
660 670 680 690 700
FNPFFPLLGC FTTPGVQLWA VWAMQHVCSK NPSRYCSMLI EEGGLQHLYN
710 720 730 740
IKDHEHTDPH VQQIAVAILD SLEKHIVRHG RPPPCKKQPQ ARLN
Length:744
Mass (Da):83,921
Last modified:October 2, 2007 - v2
Checksum:i0D8C19251CA67573
GO
Isoform 2 (identifier: Q9C0D3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-578: Missing.

Note: No experimental confirmation available.
Show »
Length:166
Mass (Da):19,006
Checksum:i0225A6D407596545
GO

Sequence cautioni

The sequence BAB21821.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti672 – 6721W → C in BAB14596 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 578578Missing in isoform 2. 1 PublicationVSP_028224Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051517 mRNA. Translation: BAB21821.1. Different initiation.
AK023518 mRNA. Translation: BAB14596.1.
BC029832 mRNA. Translation: AAH29832.2.
CCDSiCCDS30717.1. [Q9C0D3-1]
RefSeqiNP_078922.1. NM_024646.2. [Q9C0D3-1]
UniGeneiHs.476280.

Genome annotation databases

EnsembliENST00000294353; ENSP00000294353; ENSG00000162378.
GeneIDi79699.
KEGGihsa:79699.
UCSCiuc001cuj.3. human. [Q9C0D3-1]
uc009vzh.3. human. [Q9C0D3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051517 mRNA. Translation: BAB21821.1. Different initiation.
AK023518 mRNA. Translation: BAB14596.1.
BC029832 mRNA. Translation: AAH29832.2.
CCDSiCCDS30717.1. [Q9C0D3-1]
RefSeqiNP_078922.1. NM_024646.2. [Q9C0D3-1]
UniGeneiHs.476280.

3D structure databases

ProteinModelPortaliQ9C0D3.
SMRiQ9C0D3. Positions 135-277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122820. 26 interactions.
IntActiQ9C0D3. 3 interactions.
MINTiMINT-2816988.
STRINGi9606.ENSP00000294353.

PTM databases

PhosphoSiteiQ9C0D3.

Polymorphism and mutation databases

BioMutaiZYG11B.
DMDMi158706479.

Proteomic databases

MaxQBiQ9C0D3.
PaxDbiQ9C0D3.
PRIDEiQ9C0D3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294353; ENSP00000294353; ENSG00000162378.
GeneIDi79699.
KEGGihsa:79699.
UCSCiuc001cuj.3. human. [Q9C0D3-1]
uc009vzh.3. human. [Q9C0D3-2]

Organism-specific databases

CTDi79699.
GeneCardsiGC01P053192.
HGNCiHGNC:25820. ZYG11B.
HPAiHPA028156.
neXtProtiNX_Q9C0D3.
PharmGKBiPA142670468.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG255988.
GeneTreeiENSGT00530000063187.
HOGENOMiHOG000004816.
HOVERGENiHBG108780.
InParanoidiQ9C0D3.
KOiK10350.
OMAiHVCSKNA.
OrthoDBiEOG72ZCD9.
PhylomeDBiQ9C0D3.
TreeFamiTF313007.

Miscellaneous databases

ChiTaRSiZYG11B. human.
GenomeRNAii79699.
NextBioi69000.
PROiQ9C0D3.

Gene expression databases

BgeeiQ9C0D3.
CleanExiHS_ZYG11B.
ExpressionAtlasiQ9C0D3. baseline and differential.
GenevisibleiQ9C0D3. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS51450. LRR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 265-744 (ISOFORM 1).
    Tissue: Brain.
  4. "The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components."
    Vasudevan S., Starostina N.G., Kipreos E.T.
    EMBO Rep. 8:279-286(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TCEB1, IDENTIFICATION IN COMPLEX WITH TCEB1 AND CUL2, MUTAGENESIS OF LEU-18.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZY11B_HUMAN
AccessioniPrimary (citable) accession number: Q9C0D3
Secondary accession number(s): Q8N2X3, Q9H8L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 22, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.