Q9C0D3 (ZY11B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein zyg-11 homolog B

Gene names

Name:	ZYG11B
Synonyms:	KIAA1730

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	744 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.
Subunit structure	Interacts with TCEB1/Elongin C. Part of an E3 ubiquitin ligase complex including ZYG11B, CUL2 and Elongin BC. Ref.4
Sequence similarities	Belongs to the zyg-11 family. Contains 2 ARM repeats. Contains 3 LRR (leucine-rich) repeats.
Sequence caution	The sequence BAB21821.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Alternative splicing
Domain	Leucine-rich repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9C0D3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9C0D3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-578: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 744	744	Protein zyg-11 homolog B		PRO_0000305087
Regions
	Repeat	185 – 208	24	LRR 1
	Repeat	216 – 236	21	LRR 2
	Repeat	237 – 261	25	LRR 3
Natural variations
	Alternative sequence	1 – 578	578	Missing in isoform 2.		VSP_028224
Experimental info
	Mutagenesis	18	1	L → S: Abolishes interaction with TCEB1. Ref.4
	Sequence conflict	672	1	W → C in BAB14596. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 2, 2007. Version 2. Checksum: 0D8C19251CA67573	FASTA	744	83,921
	10 20 30 40 50 60 MPEDQAGAAM EEASPYSLLD ICLNFLTTHL EKFCSARQDG TLCLQEPGVF PQEVADRLLR 70 80 90 100 110 120 TMAFHGLLND GTVGIFRGNQ MRLKRACIRK AKISAVAFRK AFCHHKLVEL DATGVNADIT 130 140 150 160 170 180 ITDIISGLGS NKWIQQNLQC LVLNSLTLSL EDPYERCFSR LSGLRALSIT NVLFYNEDLA 190 200 210 220 230 240 EVASLPRLES LDISNTSITD ITALLACKDR LKSLTMHHLK CLKMTTTQIL DVVRELKHLN 250 260 270 280 290 300 HLDISDDKQF TSDIALRLLE QKDILPNLVS LDVSGRKHVT DKAVEAFIQQ RPSMQFVGLL 310 320 330 340 350 360 ATDAGYSEFL TGEGHLKVSG EANETQIAEA LKRYSERAFF VREALFHLFS LTHVMEKTKP 370 380 390 400 410 420 EILKLVVTGM RNHPMNLPVQ LAASACVFNL TKQDLAAGMP VRLLADVTHL LLKAMEHFPN 430 440 450 460 470 480 HQQLQKNCLL SLCSDRILQD VPFNRFEAAK LVMQWLCNHE DQNMQRMAVA IISILAAKLS 490 500 510 520 530 540 TEQTAQLGTE LFIVRQLLQI VKQKTNQNSV DTTLKFTLSA LWNLTDESPT TCRHFIENQG 550 560 570 580 590 600 LELFMRVLES FPTESSIQQK VLGLLNNIAE VQELHSELMW KDFIDHISSL LHSVEVEVSY 610 620 630 640 650 660 FAAGIIAHLI SRGEQAWTLS RSQRNSLLDD LHSAILKWPT PECEMVAYRS FNPFFPLLGC 670 680 690 700 710 720 FTTPGVQLWA VWAMQHVCSK NPSRYCSMLI EEGGLQHLYN IKDHEHTDPH VQQIAVAILD 730 740 SLEKHIVRHG RPPPCKKQPQ ARLN
	Isoform 2 [UniParc]. Checksum: 0225A6D407596545	FASTA	166	19,006
	10 20 30 40 50 60 MWKDFIDHIS SLLHSVEVEV SYFAAGIIAH LISRGEQAWT LSRSQRNSLL DDLHSAILKW 70 80 90 100 110 120 PTPECEMVAY RSFNPFFPLL GCFTTPGVQL WAVWAMQHVC SKNPSRYCSM LIEEGGLQHL 130 140 150 160 YNIKDHEHTD PHVQQIAVAI LDSLEKHIVR HGRPPPCKKQ PQARLN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 265-744 (ISOFORM 1). Tissue: Brain.
[4]	"The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components." Vasudevan S., Starostina N.G., Kipreos E.T. EMBO Rep. 8:279-286(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TCEB1, IDENTIFICATION IN COMPLEX WITH TCEB1 AND CUL2, MUTAGENESIS OF LEU-18.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB051517 mRNA. Translation: BAB21821.1. Different initiation. AK023518 mRNA. Translation: BAB14596.1. BC029832 mRNA. Translation: AAH29832.2.
IPI	IPI00155199. IPI00867680.
RefSeq	NP_078922.1. NM_024646.2.
UniGene	Hs.476280.
3D structure databases
ProteinModelPortal	Q9C0D3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9C0D3. 3 interactions.
MINT	MINT-2816988.
STRING	9606.ENSP00000294353.
PTM databases
PhosphoSite	Q9C0D3.
Polymorphism databases
DMDM	158706479.
Proteomic databases
PaxDb	Q9C0D3.
PRIDE	Q9C0D3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000294353; ENSP00000294353; ENSG00000162378.
GeneID	79699.
KEGG	hsa:79699.
UCSC	uc001cuj.3. human. uc009vzh.3. human.
Organism-specific databases
CTD	79699.
GeneCards	GC01P053192.
HGNC	HGNC:25820. ZYG11B.
HPA	HPA028156.
neXtProt	NX_Q9C0D3.
PharmGKB	PA142670468.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG255988.
HOGENOM	HOG000004816.
HOVERGEN	HBG108780.
InParanoid	Q9C0D3.
KO	K10350.
OMA	ERCFSQL.
OrthoDB	EOG4W6NVB.
Gene expression databases
ArrayExpress	Q9C0D3.
Bgee	Q9C0D3.
CleanEx	HS_ZYG11B.
Genevestigator	Q9C0D3.
Family and domain databases
Gene3D	1.25.10.10. 2 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR001611. Leu-rich_rpt. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS51450. LRR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZYG11B. human.
GenomeRNAi	79699.
NextBio	69000.

Entry information

Entry name

ZY11B_HUMAN

Accession

Primary (citable) accession number: Q9C0D3
Secondary accession number(s): Q8N2X3, Q9H8L8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	May 1, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.