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Protein

Centrosomal protein of 295 kDa

Gene

CEP295

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Centriole-enriched protein that mediates centriole-to-centrosome conversion at late mitosis, but is dispensable for cartwheel removal or centriole disengagement.2 Publications

GO - Biological processi

  • positive regulation of organelle assembly Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 295 kDaImported
Gene namesi
Name:CEP295Imported
Synonyms:KIAA1731Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29366. CEP295.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671597.

Polymorphism and mutation databases

BioMutaiKIAA1731.
DMDMi296439480.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 26012601Centrosomal protein of 295 kDaPRO_0000324595Add
BLAST

Proteomic databases

EPDiQ9C0D2.
MaxQBiQ9C0D2.
PaxDbiQ9C0D2.
PRIDEiQ9C0D2.

PTM databases

iPTMnetiQ9C0D2.
PhosphoSiteiQ9C0D2.

Expressioni

Gene expression databases

BgeeiQ9C0D2.
CleanExiHS_KIAA1731.
ExpressionAtlasiQ9C0D2. baseline and differential.
GenevisibleiQ9C0D2. HS.

Organism-specific databases

HPAiHPA038595.
HPA038596.
HPA038597.

Interactioni

Protein-protein interaction databases

BioGridi124543. 24 interactions.
IntActiQ9C0D2. 20 interactions.
STRINGi9606.ENSP00000316681.

Structurei

3D structure databases

ProteinModelPortaliQ9C0D2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2478 – 2601124ALMS motifAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili207 – 27367Sequence analysisAdd
BLAST
Coiled coili500 – 55253Sequence analysisAdd
BLAST
Coiled coili1053 – 108230Sequence analysisAdd
BLAST
Coiled coili1498 – 154447Sequence analysisAdd
BLAST
Coiled coili1728 – 175831Sequence analysisAdd
BLAST
Coiled coili2556 – 258126Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IK6S. Eukaryota.
ENOG41124ZG. LUCA.
GeneTreeiENSGT00540000072076.
HOVERGENiHBG108044.
InParanoidiQ9C0D2.
OMAiQKSLWTI.
OrthoDBiEOG7SFHVS.
PhylomeDBiQ9C0D2.
TreeFamiTF331536.

Family and domain databases

InterProiIPR029299. ALMS_motif.
IPR029560. KIAA1731.
[Graphical view]
PANTHERiPTHR21553:SF25. PTHR21553:SF25. 3 hits.
PfamiPF15309. ALMS_motif. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0D2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRKVVNTHK LRLSPNEEAF ILKEDYERRR KLRLLQVREQ ERDIALQIRE
60 70 80 90 100
DIKQRRNQQF TRLAEELRAE WEESQTQKIQ NLEKLYLASL RSMGEGHRQA
110 120 130 140 150
KENEPDLDAL AQRAAERKRK ADLRHKEALK VQKNQKEILL KQKTWHIKAR
160 170 180 190 200
KEALLVEKER SAKITSLPPP PPTLFENIEV KRISAVKTNS STYHHLHTFV
210 220 230 240 250
NRETDTKRPD ARLAAEEEAK RLEELQKQAA QERMERFEKA HVRGFQAMKK
260 270 280 290 300
IHLAQNQEKL MKELKQLQQE DLARRRQTVA QMPPQLVELP YKRSEMKEDW
310 320 330 340 350
QRELEFAFED MYNADRKVKG NLILHLEPEP LPTVTNQIQD EELDLSMEQE
360 370 380 390 400
NLGAAEDLPV TEAEICSSET DVPLVMKTQQ IPSKVLFKKL LNKIRSQKSL
410 420 430 440 450
WTIKSMSEDE SEMITTVSEI ESKAPTVESG TIASKERTLS SGQEQVVESD
460 470 480 490 500
TLTIESGPLA SEDKPLSCGT NSGKEQEINE TLPITTVAQS SVLLHPQEAA
510 520 530 540 550
ARIRMSARQK QIMEIEEQKQ KQLELLEQIE QQKLRLETDC FRAQLEEEKR
560 570 580 590 600
KKTQPTGVGI APASCPVISD EDSHRQMIRN YQHQLLQQNR LHRQSVETAR
610 620 630 640 650
KQLLEYQTML KGRCPSVSAP SLITDSVISV PSWKSERPTA ISEHWDQGQR
660 670 680 690 700
LKLSPNKYQP IQPIQTSKLE QDHFQVARQN HFPQRQVETT ETLRASDILT
710 720 730 740 750
NQALESQEHL RQFSQTETQQ RDYKLVPKDS ETLSRALSHD RQLISQDARK
760 770 780 790 800
ISETFGATTF QSLESQQLFS ENSENISYHL TEPSSFVPLV PQHSFSSLPV
810 820 830 840 850
KVESGKIQEP FSAMSKSTVS TSHSIISQMH DRPLLPSENI TAQQGNMKAL
860 870 880 890 900
QEQLDLQKKV LQATQEAQEQ LLLCKQKEVE QQTGLSVFLP LVTPDSSALL
910 920 930 940 950
PSAKADLGRI QESSPTKNNI AVSSDHHVIS QLQDKRLSLS QPILSQQNNF
960 970 980 990 1000
KFLQEQLNIQ KDSLQARREA QEVLYVHKQS ELDRRVCSEQ AEPSFPFQVA
1010 1020 1030 1040 1050
QHTFTSLPSA DTKSGKIQEQ HSSKSEKGLV SCQSDIPISQ DGSLSFLQQF
1060 1070 1080 1090 1100
LPLHDSLKLL QEQLTKQRDT LQARHEAQVE LLLHRQRDLG DSKSGLVSSS
1110 1120 1130 1140 1150
SSPVVVQHSV ASQASAKAEP RRIQELYLSE KENVGPSCHL IIPTFQDKSL
1160 1170 1180 1190 1200
SFPQHSLAQQ ENLTILQEQS QIQRVILGAK EGTQEFVHTE SELEKRISSE
1210 1220 1230 1240 1250
QTGTSSSLSQ VDESERFQEC ISIKSDSTIP LSHPKIPRCQ ERLLRVSQHM
1260 1270 1280 1290 1300
LPLQDNLEEH QAWLDTEKEA FHFSQKTQEN TSSEQTGSSS FIPQLVQLSF
1310 1320 1330 1340 1350
TSLASAESGT ILEPLFTESE SKIFSSHLQI PQLQDRLLRI SQLIQPQQDN
1360 1370 1380 1390 1400
LKALQEQLAT QREAIILARQ EAREELLLHQ SEWEGRISPE QVDTSSLPLV
1410 1420 1430 1440 1450
PQHSFASLPL NESERNQEPC SINSDNIVSS GHSEIPTLPD GLLGLSHLVL
1460 1470 1480 1490 1500
PQQDNLIALE EHLHAQTDFL PSIEKTQKEL VLSKPCKFEE KVSSEHFIQS
1510 1520 1530 1540 1550
HHGDLQALQQ QLDTQKKAIR SIQEVQEELL LQRLSELEKR VSSEQVCSSS
1560 1570 1580 1590 1600
FVSQVPVADS ERTQKSFPTK SNDTLPSSHR EIPRLQDRLL SLSKPILPQQ
1610 1620 1630 1640 1650
DNMTAQLDAQ REVMYSYEKP QEELSLNKQR KLNKSESAEH TIPSLFLPKE
1660 1670 1680 1690 1700
TEHSFIPLPF AEAKPKSTCE LYSSQNEHAA PPSNPVIPGF QDRLLSFSQS
1710 1720 1730 1740 1750
VLTQQDNLGL QKQLDLQREV LHYSQKAQEK LLVQRQTALQ QQIQKHEETL
1760 1770 1780 1790 1800
KDFFKDSQIS KPTVENDLKT QKMGQLRDWF PNTQDLAGND QENIRHADRN
1810 1820 1830 1840 1850
NSDDNHLASE DTSAKQSGEH LEKDLGRRSS KPPVAKVKCG LDLNQHELSA
1860 1870 1880 1890 1900
IQEVESPAIG RTSILGKPGI YEDRDPLRVS ISREQSFFGS PLAHDPFSCL
1910 1920 1930 1940 1950
QLVGQENVCG DDYDEAVKLK ESVVENHAVL SYAVEEEHAY LGPTVKPDDK
1960 1970 1980 1990 2000
AKTLSYEPLS SATVSTGSLL SYENTDLSLT DPESFSEHMD DSKQESTTSK
2010 2020 2030 2040 2050
EEETNIISSI VPSTQDIYQR QNSSDVHKSL LPAVDETTCG HTHFQQMIDK
2060 2070 2080 2090 2100
YINEANLIPE KTDLQELEHI FPNLHHQLFK PLEPHPDFDL SSSSSGISPD
2110 2120 2130 2140 2150
NRDFYQRSDS SSESHCATGL SKSTVYFTAL RRTSMHSSLN TSPNQQPDTN
2160 2170 2180 2190 2200
LAHVGAHSFA TENIIGGSEQ CFEQLQPEYS SQEESQHADL PSIFSIEARD
2210 2220 2230 2240 2250
SSQGMKNQNY PSEEHTEILQ NKKKIVHFQL SIGNLSSVYS SSDEANVFDQ
2260 2270 2280 2290 2300
LNVQHSTPCG SNSSECSTKH QLESRKESMG FEELSKRGVV TMLQSQGLIE
2310 2320 2330 2340 2350
DNKNETCRVL DINPQVEETD SRLCVRTVEM GTSIQAPYSL TTQNEKYFEN
2360 2370 2380 2390 2400
SAETDIPKIT KKLSQLGESE LFASSGSFSL QSSIPVWETE TGHGIMEEPE
2410 2420 2430 2440 2450
LTLISTTDTS IAEMDFANLT LEEKSENEAK CFFQVSEFLP LVSATEASDY
2460 2470 2480 2490 2500
PAVSELSIEK PRTASTETPR RLTPVPGSLQ EAFIKRKKSF MERSHQRQKE
2510 2520 2530 2540 2550
IRNKIHVSEN SQIKTVKEKP SISSSVSRLK GVNKVRASFP EDRKTTQALR
2560 2570 2580 2590 2600
HQRGLRLYNQ LAEVKQQKEE KTKQEAYAQN RARAKEFHKK TLEKLRAKNT

C
Length:2,601
Mass (Da):295,176
Last modified:May 18, 2010 - v4
Checksum:iF18F9B2EE1DAADC7
GO
Isoform 2 (identifier: Q9C0D2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1772: Missing.
     1818-1865: Missing.

Note: No experimental confirmation available.
Show »
Length:781
Mass (Da):87,680
Checksum:i5B4B98F9A7DD805F
GO
Isoform 3 (identifier: Q9C0D2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2466-2466: T → TA

Note: No experimental confirmation available.
Show »
Length:2,602
Mass (Da):295,247
Checksum:i98BF6EE7B108180A
GO
Isoform 4 (identifier: Q9C0D2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1988: Missing.
     2466-2466: T → TA

Note: No experimental confirmation available.
Show »
Length:614
Mass (Da):69,177
Checksum:i47392AF4788E13FD
GO

Sequence cautioni

The sequence BAB21822.2 differs from that shown. Reason: Frameshift at position 2016. Curated
The sequence BAB21822.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB71582.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC04638.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti511 – 5111Q → H in BAB21822 (PubMed:11214970).Curated
Sequence conflicti1888 – 18881F → L in BAC04502 (PubMed:14702039).Curated
Sequence conflicti2026 – 20261V → L in BAC05264 (PubMed:14702039).Curated
Sequence conflicti2081 – 20811P → S in BAC05264 (PubMed:14702039).Curated
Sequence conflicti2278 – 22781S → G in BAC05264 (PubMed:14702039).Curated
Sequence conflicti2294 – 22941Q → R in BAC05264 (PubMed:14702039).Curated
Sequence conflicti2437 – 24371E → V in BAB71582 (PubMed:14702039).Curated
Sequence conflicti2437 – 24371E → V in BAC04502 (PubMed:14702039).Curated
Sequence conflicti2437 – 24371E → V in BAC04638 (PubMed:14702039).Curated
Sequence conflicti2437 – 24371E → V in BAC05264 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801Q → K.
Corresponds to variant rs7128850 [ dbSNP | Ensembl ].
VAR_059337
Natural varianti208 – 2081R → Q.1 Publication
Corresponds to variant rs10831088 [ dbSNP | Ensembl ].
VAR_059338
Natural varianti499 – 4991A → E.1 Publication
Corresponds to variant rs4753495 [ dbSNP | Ensembl ].
VAR_059339
Natural varianti1026 – 10261E → K.
Corresponds to variant rs3802771 [ dbSNP | Ensembl ].
VAR_059340
Natural varianti1270 – 12701A → G.
Corresponds to variant rs2298707 [ dbSNP | Ensembl ].
VAR_059341
Natural varianti1441 – 14411G → E.
Corresponds to variant rs3802773 [ dbSNP | Ensembl ].
VAR_059342
Natural varianti1459 – 14591L → R.
Corresponds to variant rs3802774 [ dbSNP | Ensembl ].
VAR_059343

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 19881988Missing in isoform 4. 1 PublicationVSP_032288Add
BLAST
Alternative sequencei1 – 17721772Missing in isoform 2. 1 PublicationVSP_032289Add
BLAST
Alternative sequencei1818 – 186548Missing in isoform 2. 1 PublicationVSP_032290Add
BLAST
Alternative sequencei2466 – 24661T → TA in isoform 3 and isoform 4. 1 PublicationVSP_032291

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051518 mRNA. Translation: BAB21822.2. Sequence problems.
AK057804 mRNA. Translation: BAB71582.1. Different initiation.
AK095218 mRNA. Translation: BAC04502.1.
AK095859 mRNA. Translation: BAC04638.1. Different initiation.
AK098232 mRNA. Translation: BAC05264.1.
AP001273 Genomic DNA. No translation available.
AP003499 Genomic DNA. No translation available.
CCDSiCCDS44708.1. [Q9C0D2-1]
RefSeqiNP_203753.1. NM_033395.1. [Q9C0D2-1]
UniGeneiHs.458418.

Genome annotation databases

EnsembliENST00000325212; ENSP00000316681; ENSG00000166004. [Q9C0D2-1]
ENST00000531700; ENSP00000437323; ENSG00000166004. [Q9C0D2-2]
GeneIDi85459.
KEGGihsa:85459.
UCSCiuc001pdu.1. human. [Q9C0D2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051518 mRNA. Translation: BAB21822.2. Sequence problems.
AK057804 mRNA. Translation: BAB71582.1. Different initiation.
AK095218 mRNA. Translation: BAC04502.1.
AK095859 mRNA. Translation: BAC04638.1. Different initiation.
AK098232 mRNA. Translation: BAC05264.1.
AP001273 Genomic DNA. No translation available.
AP003499 Genomic DNA. No translation available.
CCDSiCCDS44708.1. [Q9C0D2-1]
RefSeqiNP_203753.1. NM_033395.1. [Q9C0D2-1]
UniGeneiHs.458418.

3D structure databases

ProteinModelPortaliQ9C0D2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124543. 24 interactions.
IntActiQ9C0D2. 20 interactions.
STRINGi9606.ENSP00000316681.

PTM databases

iPTMnetiQ9C0D2.
PhosphoSiteiQ9C0D2.

Polymorphism and mutation databases

BioMutaiKIAA1731.
DMDMi296439480.

Proteomic databases

EPDiQ9C0D2.
MaxQBiQ9C0D2.
PaxDbiQ9C0D2.
PRIDEiQ9C0D2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325212; ENSP00000316681; ENSG00000166004. [Q9C0D2-1]
ENST00000531700; ENSP00000437323; ENSG00000166004. [Q9C0D2-2]
GeneIDi85459.
KEGGihsa:85459.
UCSCiuc001pdu.1. human. [Q9C0D2-1]

Organism-specific databases

CTDi85459.
GeneCardsiCEP295.
HGNCiHGNC:29366. CEP295.
HPAiHPA038595.
HPA038596.
HPA038597.
neXtProtiNX_Q9C0D2.
PharmGKBiPA142671597.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK6S. Eukaryota.
ENOG41124ZG. LUCA.
GeneTreeiENSGT00540000072076.
HOVERGENiHBG108044.
InParanoidiQ9C0D2.
OMAiQKSLWTI.
OrthoDBiEOG7SFHVS.
PhylomeDBiQ9C0D2.
TreeFamiTF331536.

Miscellaneous databases

ChiTaRSiKIAA1731. human.
GenomeRNAii85459.
NextBioi76099.
PROiQ9C0D2.

Gene expression databases

BgeeiQ9C0D2.
CleanExiHS_KIAA1731.
ExpressionAtlasiQ9C0D2. baseline and differential.
GenevisibleiQ9C0D2. HS.

Family and domain databases

InterProiIPR029299. ALMS_motif.
IPR029560. KIAA1731.
[Graphical view]
PANTHERiPTHR21553:SF25. PTHR21553:SF25. 3 hits.
PfamiPF15309. ALMS_motif. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-208 AND GLU-499.
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-2566 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2152-2601 (ISOFORM 3).
    Tissue: Cerebellum, Chondrocyte and Uterus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731."
    Knorz V.J., Spalluto C., Lessard M., Purvis T.L., Adigun F.F., Collin G.B., Hanley N.A., Wilson D.I., Hearn T.
    Mol. Biol. Cell 21:3617-3629(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, POSSIBLE FUNCTION.
  6. "Stabilization of cartwheel-less centrioles for duplication requires CEP295-mediated centriole-to-centrosome conversion."
    Izquierdo D., Wang W.J., Uryu K., Tsou M.F.
    Cell Rep. 8:957-965(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCE295_HUMAN
AccessioniPrimary (citable) accession number: Q9C0D2
Secondary accession number(s): C9J5H9
, C9JQY8, Q8N7L4, Q8N919, Q8N9B0, Q96LT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: April 13, 2016
This is version 90 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.