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Q9C0C7

- AMRA1_HUMAN

UniProt

Q9C0C7 - AMRA1_HUMAN

Protein

Activating molecule in BECN1-regulated autophagy protein 1

Gene

AMBRA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. negative regulation of cell proliferation Source: Ensembl
    4. negative regulation of neuron apoptotic process Source: Ensembl
    5. neural tube development Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Autophagy, Differentiation, Neurogenesis

    Enzyme and pathway databases

    SignaLinkiQ9C0C7.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activating molecule in BECN1-regulated autophagy protein 1
    Gene namesi
    Name:AMBRA1
    Synonyms:KIAA1736
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:25990. AMBRA1.

    Subcellular locationi

    Cytoplasmic vesicleautophagosome By similarity
    Note: Localizes also to discrete punctae along the ciliary axoneme.By similarity

    GO - Cellular componenti

    1. autophagic vacuole Source: UniProtKB-SubCell
    2. axoneme Source: UniProtKB
    3. cytoplasm Source: MGI
    4. cytoplasmic vesicle Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162376307.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12981298Activating molecule in BECN1-regulated autophagy protein 1PRO_0000315703Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei639 – 6391Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9C0C7.
    PaxDbiQ9C0C7.
    PRIDEiQ9C0C7.

    PTM databases

    PhosphoSiteiQ9C0C7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9C0C7.
    BgeeiQ9C0C7.
    CleanExiHS_AMBRA1.
    GenevestigatoriQ9C0C7.

    Organism-specific databases

    HPAiCAB017825.
    HPA038535.

    Interactioni

    Subunit structurei

    Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3 By similarity. Interacts with BECN1P1/BECN2.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BCL2P1041510EBI-2512975,EBI-77694
    BECN1Q144576EBI-2512975,EBI-949378
    vifP125045EBI-2512975,EBI-779991From a different organism.

    Protein-protein interaction databases

    BioGridi120765. 27 interactions.
    DIPiDIP-53597N.
    IntActiQ9C0C7. 19 interactions.
    MINTiMINT-8177757.
    STRINGi9606.ENSP00000318313.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C0C7.
    SMRiQ9C0C7. Positions 28-201.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati51 – 9040WD 1Add
    BLAST
    Repeati93 – 13341WD 2Add
    BLAST
    Repeati135 – 17541WD 3Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi268 – 27710Poly-Pro
    Compositional biasi592 – 63948Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 3 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG317724.
    HOGENOMiHOG000033925.
    HOVERGENiHBG103818.
    KOiK17985.
    OMAiHPSTEHM.
    OrthoDBiEOG7HB58G.
    PhylomeDBiQ9C0C7.
    TreeFamiTF328981.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 3 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9C0C7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKVVPEKNAV RILWGRERGA RAMGAQRLLQ ELVEDKTRWM KWEGKRVELP     50
    DSPRSTFLLA FSPDRTLLAS THVNHNIYIT EVKTGKCVHS LIGHRRTPWC 100
    VTFHPTISGL IASGCLDGEV RIWDLHGGSE SWFTDSNNAI ASLAFHPTAQ 150
    LLLIATANEI HFWDWSRREP FAVVKTASEM ERVRLVRFDP LGHYLLTAIV 200
    NPSNQQGDDE PEIPIDGTEL SHYRQRALLQ SQPVRRTPLL HNFLHMLSSR 250
    SSGIQVGEQS TVQDSATPSP PPPPPQPSTE RPRTSAYIRL RQRVSYPTAE 300
    CCQHLGILCL CSRCSGTRVP SLLPHQDSVP PASARATTPS FSFVQTEPFH 350
    PPEQASSTQQ DQGLLNRPSA FSTVQSSTAG NTLRNLSLGP TRRSLGGPLS 400
    SHPSRYHREI APGLTGSEWT RTVLSLNSRS EAESMPPPRT SASSVSLLSV 450
    LRQQEGGSQA SVYTSATEGR GFPASGLATE SDGGNGSSQN NSGSIRHELQ 500
    CDLRRFFLEY DRLQELDQSL SGEAPQTQQA QEMLNNNIES ERPGPSHQPT 550
    PHSSENNSNL SRGHLNRCRA CHNLLTFNND TLRWERTTPN YSSGEASSSW 600
    QVPSSFESVP SSGSQLPPLE RTEGQTPSSS RLELSSSASP QEERTVGVAF 650
    NQETGHWERI YTQSSRSGTV SQEALHQDMP EESSEEDSLR RRLLESSLIS 700
    LSRYDGAGSR EHPIYPDPAR LSPAAYYAQR MIQYLSRRDS IRQRSMRYQQ 750
    NRLRSSTSSS SSDNQGPSVE GTDLEFEDFE DNGDRSRHRA PRNARMSAPS 800
    LGRFVPRRFL LPEYLPYAGI FHERGQPGLA THSSVNRVLA GAVIGDGQSA 850
    VASNIANTTY RLQWWDFTKF DLPEISNASV NVLVQNCKIY NDASCDISAD 900
    GQLLAAFIPS SQRGFPDEGI LAVYSLAPHN LGEMLYTKRF GPNAISVSLS 950
    PMGRYVMVGL ASRRILLHPS TEHMVAQVFR LQQAHGGETS MRRVFNVLYP 1000
    MPADQRRHVS INSARWLPEP GLGLAYGTNK GDLVICRPEA LNSGVEYYWD 1050
    QLNETVFTVH SNSRSSERPG TSRATWRTDR DMGLMNAIGL QPRNPATSVT 1100
    SQGTQTLALQ LQNAETQTER EVPEPGTAAS GPGEGEGSEY GASGEDALSR 1150
    IQRLMAEGGM TAVVQREQST TMASMGGFGN NIIVSHRIHR SSQTGTEPGA 1200
    AHTSSPQPST SRGLLPEAGQ LAERGLSPRT ASWDQPGTPG REPTQPTLPS 1250
    SSPVPIPVSL PSAEGPTLHC ELTNNNHLLD GGSSRGDAAG PRGEPRNR 1298
    Length:1,298
    Mass (Da):142,507
    Last modified:January 15, 2008 - v2
    Checksum:i44FE9CDFFFE6811E
    GO
    Isoform 2 (identifier: Q9C0C7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         721-780: Missing.

    Show »
    Length:1,238
    Mass (Da):135,528
    Checksum:iEE24A481D1388999
    GO
    Isoform 3 (identifier: Q9C0C7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         691-719: Missing.

    Show »
    Length:1,269
    Mass (Da):139,269
    Checksum:iC9902123C4EE6199
    GO
    Isoform 4 (identifier: Q9C0C7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         255-344: Missing.

    Show »
    Length:1,208
    Mass (Da):132,837
    Checksum:i3BA3D281C30318F1
    GO
    Isoform 5 (identifier: Q9C0C7-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         255-344: Missing.
         691-691: R → RRSLALSPRL...ITGVSHRAWP

    Show »
    Length:1,301
    Mass (Da):142,585
    Checksum:i0EF81F37DFCA142D
    GO
    Isoform 6 (identifier: Q9C0C7-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         255-344: Missing.
         691-719: Missing.
         864-880: WWDFTKFDLPEISNASV → GGGTSLSLTSLKSVMLP
         881-1298: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:761
    Mass (Da):84,428
    Checksum:i4512BD3DCDD64FE1
    GO

    Sequence cautioni

    The sequence BAA91067.1 differs from that shown. Reason: Frameshift at position 682.
    Isoform 6 : The sequence AL834190 differs from that shown. Reason: Frameshift at position 745.
    The sequence BAB14457.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB21827.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti165 – 1651W → R in BAA91067. (PubMed:14702039)Curated
    Sequence conflicti793 – 7931N → K in AL834190. (PubMed:17974005)Curated
    Sequence conflicti869 – 8691K → E in BAB14457. (PubMed:14702039)Curated
    Sequence conflicti983 – 9831Q → L in BAB14457. (PubMed:14702039)Curated
    Sequence conflicti1105 – 11051Q → E in AAH45609. (PubMed:15489334)Curated
    Sequence conflicti1268 – 12681L → V in AAH45609. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei255 – 34490Missing in isoform 4, isoform 5 and isoform 6. 3 PublicationsVSP_030654Add
    BLAST
    Alternative sequencei691 – 71929Missing in isoform 3 and isoform 6. 2 PublicationsVSP_030655Add
    BLAST
    Alternative sequencei691 – 6911R → RRSLALSPRLEYSGAILAHC KLRLPGSCHSPASASQVAGT TGAHHHARLIFAFLVEMEFH HVSQAGLELLTSGDLPTSAS QSAGITGVSHRAWP in isoform 5. 1 PublicationVSP_030656
    Alternative sequencei721 – 78060Missing in isoform 2. 1 PublicationVSP_030657Add
    BLAST
    Alternative sequencei864 – 88017WWDFT…SNASV → GGGTSLSLTSLKSVMLP in isoform 6. 1 PublicationVSP_045989Add
    BLAST
    Alternative sequencei881 – 1298418Missing in isoform 6. 1 PublicationVSP_045990Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ870924 mRNA. Translation: ABI74670.1.
    AB051523 mRNA. Translation: BAB21827.1. Different initiation.
    AK000301 mRNA. Translation: BAA91067.1. Frameshift.
    AK023197 mRNA. Translation: BAB14457.1. Different initiation.
    AL834190 mRNA. No translation available.
    AC024293 Genomic DNA. No translation available.
    AC115097 Genomic DNA. No translation available.
    AC116021 Genomic DNA. No translation available.
    AC127035 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW67996.1.
    CH471064 Genomic DNA. Translation: EAW67999.1.
    CH471064 Genomic DNA. Translation: EAW68001.1.
    BC045609 mRNA. Translation: AAH45609.1.
    CCDSiCCDS31475.1. [Q9C0C7-4]
    RefSeqiNP_001254711.1. NM_001267782.1. [Q9C0C7-5]
    NP_001254712.1. NM_001267783.1.
    NP_060219.2. NM_017749.3. [Q9C0C7-4]
    XP_005253066.1. XM_005253009.2. [Q9C0C7-1]
    XP_005253068.1. XM_005253011.2. [Q9C0C7-3]
    XP_005253069.1. XM_005253012.2. [Q9C0C7-2]
    XP_005253071.1. XM_005253014.2. [Q9C0C7-4]
    XP_006718322.1. XM_006718259.1. [Q9C0C7-1]
    UniGeneiHs.654644.

    Genome annotation databases

    EnsembliENST00000314845; ENSP00000318313; ENSG00000110497. [Q9C0C7-4]
    ENST00000458649; ENSP00000415327; ENSG00000110497. [Q9C0C7-1]
    ENST00000528950; ENSP00000433945; ENSG00000110497. [Q9C0C7-3]
    ENST00000534300; ENSP00000431926; ENSG00000110497. [Q9C0C7-2]
    GeneIDi55626.
    KEGGihsa:55626.
    UCSCiuc001ncu.2. human. [Q9C0C7-4]
    uc001ncv.3. human. [Q9C0C7-5]
    uc001ncw.3. human.
    uc001ncx.3. human. [Q9C0C7-2]
    uc009ylc.2. human. [Q9C0C7-3]
    uc010rgu.2. human. [Q9C0C7-1]

    Polymorphism databases

    DMDMi166215833.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ870924 mRNA. Translation: ABI74670.1 .
    AB051523 mRNA. Translation: BAB21827.1 . Different initiation.
    AK000301 mRNA. Translation: BAA91067.1 . Frameshift.
    AK023197 mRNA. Translation: BAB14457.1 . Different initiation.
    AL834190 mRNA. No translation available.
    AC024293 Genomic DNA. No translation available.
    AC115097 Genomic DNA. No translation available.
    AC116021 Genomic DNA. No translation available.
    AC127035 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW67996.1 .
    CH471064 Genomic DNA. Translation: EAW67999.1 .
    CH471064 Genomic DNA. Translation: EAW68001.1 .
    BC045609 mRNA. Translation: AAH45609.1 .
    CCDSi CCDS31475.1. [Q9C0C7-4 ]
    RefSeqi NP_001254711.1. NM_001267782.1. [Q9C0C7-5 ]
    NP_001254712.1. NM_001267783.1.
    NP_060219.2. NM_017749.3. [Q9C0C7-4 ]
    XP_005253066.1. XM_005253009.2. [Q9C0C7-1 ]
    XP_005253068.1. XM_005253011.2. [Q9C0C7-3 ]
    XP_005253069.1. XM_005253012.2. [Q9C0C7-2 ]
    XP_005253071.1. XM_005253014.2. [Q9C0C7-4 ]
    XP_006718322.1. XM_006718259.1. [Q9C0C7-1 ]
    UniGenei Hs.654644.

    3D structure databases

    ProteinModelPortali Q9C0C7.
    SMRi Q9C0C7. Positions 28-201.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120765. 27 interactions.
    DIPi DIP-53597N.
    IntActi Q9C0C7. 19 interactions.
    MINTi MINT-8177757.
    STRINGi 9606.ENSP00000318313.

    PTM databases

    PhosphoSitei Q9C0C7.

    Polymorphism databases

    DMDMi 166215833.

    Proteomic databases

    MaxQBi Q9C0C7.
    PaxDbi Q9C0C7.
    PRIDEi Q9C0C7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314845 ; ENSP00000318313 ; ENSG00000110497 . [Q9C0C7-4 ]
    ENST00000458649 ; ENSP00000415327 ; ENSG00000110497 . [Q9C0C7-1 ]
    ENST00000528950 ; ENSP00000433945 ; ENSG00000110497 . [Q9C0C7-3 ]
    ENST00000534300 ; ENSP00000431926 ; ENSG00000110497 . [Q9C0C7-2 ]
    GeneIDi 55626.
    KEGGi hsa:55626.
    UCSCi uc001ncu.2. human. [Q9C0C7-4 ]
    uc001ncv.3. human. [Q9C0C7-5 ]
    uc001ncw.3. human.
    uc001ncx.3. human. [Q9C0C7-2 ]
    uc009ylc.2. human. [Q9C0C7-3 ]
    uc010rgu.2. human. [Q9C0C7-1 ]

    Organism-specific databases

    CTDi 55626.
    GeneCardsi GC11M046417.
    H-InvDB HIX0009602.
    HGNCi HGNC:25990. AMBRA1.
    HPAi CAB017825.
    HPA038535.
    MIMi 611359. gene.
    neXtProti NX_Q9C0C7.
    PharmGKBi PA162376307.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG317724.
    HOGENOMi HOG000033925.
    HOVERGENi HBG103818.
    KOi K17985.
    OMAi HPSTEHM.
    OrthoDBi EOG7HB58G.
    PhylomeDBi Q9C0C7.
    TreeFami TF328981.

    Enzyme and pathway databases

    SignaLinki Q9C0C7.

    Miscellaneous databases

    ChiTaRSi AMBRA1. human.
    GenomeRNAii 55626.
    NextBioi 60248.
    PROi Q9C0C7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9C0C7.
    Bgeei Q9C0C7.
    CleanExi HS_AMBRA1.
    Genevestigatori Q9C0C7.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 3 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Brain.
    2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 464-1298.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
      Tissue: Melanoma.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Testis.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism."
      He C., Wei Y., Sun K., Li B., Dong X., Zou Z., Liu Y., Kinch L.N., Khan S., Sinha S., Xavier R.J., Grishin N.V., Xiao G., Eskelinen E.L., Scherer P.E., Whistler J.L., Levine B.
      Cell 154:1085-1099(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BECN1P1/BECN2.

    Entry informationi

    Entry nameiAMRA1_HUMAN
    AccessioniPrimary (citable) accession number: Q9C0C7
    Secondary accession number(s): A6XN33
    , D3DQP8, G3V193, Q86XD6, Q9H8Z0, Q9NXE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3