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Q9C0C7

- AMRA1_HUMAN

UniProt

Q9C0C7 - AMRA1_HUMAN

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Protein

Activating molecule in BECN1-regulated autophagy protein 1

Gene

AMBRA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity).By similarity

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. negative regulation of cell proliferation Source: Ensembl
  4. negative regulation of neuron apoptotic process Source: Ensembl
  5. neural tube development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Autophagy, Differentiation, Neurogenesis

Enzyme and pathway databases

SignaLinkiQ9C0C7.

Names & Taxonomyi

Protein namesi
Recommended name:
Activating molecule in BECN1-regulated autophagy protein 1
Gene namesi
Name:AMBRA1
Synonyms:KIAA1736
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:25990. AMBRA1.

Subcellular locationi

Cytoplasmic vesicleautophagosome By similarity
Note: Localizes also to discrete punctae along the ciliary axoneme.By similarity

GO - Cellular componenti

  1. axoneme Source: UniProtKB
  2. cytoplasm Source: MGI
  3. phagocytic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12981298Activating molecule in BECN1-regulated autophagy protein 1PRO_0000315703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei639 – 6391Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9C0C7.
PaxDbiQ9C0C7.
PRIDEiQ9C0C7.

PTM databases

PhosphoSiteiQ9C0C7.

Expressioni

Gene expression databases

BgeeiQ9C0C7.
CleanExiHS_AMBRA1.
ExpressionAtlasiQ9C0C7. baseline and differential.
GenevestigatoriQ9C0C7.

Organism-specific databases

HPAiCAB017825.
HPA038535.

Interactioni

Subunit structurei

Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3 (By similarity). Interacts with BECN1P1/BECN2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2P1041510EBI-2512975,EBI-77694
BECN1Q144578EBI-2512975,EBI-949378
vifP125045EBI-2512975,EBI-779991From a different organism.

Protein-protein interaction databases

BioGridi120765. 39 interactions.
DIPiDIP-53597N.
IntActiQ9C0C7. 19 interactions.
MINTiMINT-8177757.
STRINGi9606.ENSP00000318313.

Structurei

3D structure databases

ProteinModelPortaliQ9C0C7.
SMRiQ9C0C7. Positions 28-201, 1010-1037.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati51 – 9040WD 1Add
BLAST
Repeati93 – 13341WD 2Add
BLAST
Repeati135 – 17541WD 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi268 – 27710Poly-Pro
Compositional biasi592 – 63948Ser-richAdd
BLAST

Sequence similaritiesi

Contains 3 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG317724.
GeneTreeiENSGT00390000016223.
HOGENOMiHOG000033925.
HOVERGENiHBG103818.
InParanoidiQ9C0C7.
KOiK17985.
OMAiHPSTEHM.
OrthoDBiEOG7HB58G.
PhylomeDBiQ9C0C7.
TreeFamiTF328981.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9C0C7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVVPEKNAV RILWGRERGA RAMGAQRLLQ ELVEDKTRWM KWEGKRVELP
60 70 80 90 100
DSPRSTFLLA FSPDRTLLAS THVNHNIYIT EVKTGKCVHS LIGHRRTPWC
110 120 130 140 150
VTFHPTISGL IASGCLDGEV RIWDLHGGSE SWFTDSNNAI ASLAFHPTAQ
160 170 180 190 200
LLLIATANEI HFWDWSRREP FAVVKTASEM ERVRLVRFDP LGHYLLTAIV
210 220 230 240 250
NPSNQQGDDE PEIPIDGTEL SHYRQRALLQ SQPVRRTPLL HNFLHMLSSR
260 270 280 290 300
SSGIQVGEQS TVQDSATPSP PPPPPQPSTE RPRTSAYIRL RQRVSYPTAE
310 320 330 340 350
CCQHLGILCL CSRCSGTRVP SLLPHQDSVP PASARATTPS FSFVQTEPFH
360 370 380 390 400
PPEQASSTQQ DQGLLNRPSA FSTVQSSTAG NTLRNLSLGP TRRSLGGPLS
410 420 430 440 450
SHPSRYHREI APGLTGSEWT RTVLSLNSRS EAESMPPPRT SASSVSLLSV
460 470 480 490 500
LRQQEGGSQA SVYTSATEGR GFPASGLATE SDGGNGSSQN NSGSIRHELQ
510 520 530 540 550
CDLRRFFLEY DRLQELDQSL SGEAPQTQQA QEMLNNNIES ERPGPSHQPT
560 570 580 590 600
PHSSENNSNL SRGHLNRCRA CHNLLTFNND TLRWERTTPN YSSGEASSSW
610 620 630 640 650
QVPSSFESVP SSGSQLPPLE RTEGQTPSSS RLELSSSASP QEERTVGVAF
660 670 680 690 700
NQETGHWERI YTQSSRSGTV SQEALHQDMP EESSEEDSLR RRLLESSLIS
710 720 730 740 750
LSRYDGAGSR EHPIYPDPAR LSPAAYYAQR MIQYLSRRDS IRQRSMRYQQ
760 770 780 790 800
NRLRSSTSSS SSDNQGPSVE GTDLEFEDFE DNGDRSRHRA PRNARMSAPS
810 820 830 840 850
LGRFVPRRFL LPEYLPYAGI FHERGQPGLA THSSVNRVLA GAVIGDGQSA
860 870 880 890 900
VASNIANTTY RLQWWDFTKF DLPEISNASV NVLVQNCKIY NDASCDISAD
910 920 930 940 950
GQLLAAFIPS SQRGFPDEGI LAVYSLAPHN LGEMLYTKRF GPNAISVSLS
960 970 980 990 1000
PMGRYVMVGL ASRRILLHPS TEHMVAQVFR LQQAHGGETS MRRVFNVLYP
1010 1020 1030 1040 1050
MPADQRRHVS INSARWLPEP GLGLAYGTNK GDLVICRPEA LNSGVEYYWD
1060 1070 1080 1090 1100
QLNETVFTVH SNSRSSERPG TSRATWRTDR DMGLMNAIGL QPRNPATSVT
1110 1120 1130 1140 1150
SQGTQTLALQ LQNAETQTER EVPEPGTAAS GPGEGEGSEY GASGEDALSR
1160 1170 1180 1190 1200
IQRLMAEGGM TAVVQREQST TMASMGGFGN NIIVSHRIHR SSQTGTEPGA
1210 1220 1230 1240 1250
AHTSSPQPST SRGLLPEAGQ LAERGLSPRT ASWDQPGTPG REPTQPTLPS
1260 1270 1280 1290
SSPVPIPVSL PSAEGPTLHC ELTNNNHLLD GGSSRGDAAG PRGEPRNR
Length:1,298
Mass (Da):142,507
Last modified:January 15, 2008 - v2
Checksum:i44FE9CDFFFE6811E
GO
Isoform 2 (identifier: Q9C0C7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     721-780: Missing.

Show »
Length:1,238
Mass (Da):135,528
Checksum:iEE24A481D1388999
GO
Isoform 3 (identifier: Q9C0C7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     691-719: Missing.

Show »
Length:1,269
Mass (Da):139,269
Checksum:iC9902123C4EE6199
GO
Isoform 4 (identifier: Q9C0C7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-344: Missing.

Show »
Length:1,208
Mass (Da):132,837
Checksum:i3BA3D281C30318F1
GO
Isoform 5 (identifier: Q9C0C7-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-344: Missing.
     691-691: R → RRSLALSPRL...ITGVSHRAWP

Show »
Length:1,301
Mass (Da):142,585
Checksum:i0EF81F37DFCA142D
GO
Isoform 6 (identifier: Q9C0C7-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-344: Missing.
     691-719: Missing.
     864-880: WWDFTKFDLPEISNASV → GGGTSLSLTSLKSVMLP
     881-1298: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:761
Mass (Da):84,428
Checksum:i4512BD3DCDD64FE1
GO

Sequence cautioni

Isoform 6 : The sequence AL834190 differs from that shown. Reason: Frameshift at position 745. Curated
The sequence BAA91067.1 differs from that shown. Reason: Frameshift at position 682. Curated
The sequence BAB14457.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB21827.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti165 – 1651W → R in BAA91067. (PubMed:14702039)Curated
Sequence conflicti793 – 7931N → K in AL834190. (PubMed:17974005)Curated
Sequence conflicti869 – 8691K → E in BAB14457. (PubMed:14702039)Curated
Sequence conflicti983 – 9831Q → L in BAB14457. (PubMed:14702039)Curated
Sequence conflicti1105 – 11051Q → E in AAH45609. (PubMed:15489334)Curated
Sequence conflicti1268 – 12681L → V in AAH45609. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei255 – 34490Missing in isoform 4, isoform 5 and isoform 6. 3 PublicationsVSP_030654Add
BLAST
Alternative sequencei691 – 71929Missing in isoform 3 and isoform 6. 2 PublicationsVSP_030655Add
BLAST
Alternative sequencei691 – 6911R → RRSLALSPRLEYSGAILAHC KLRLPGSCHSPASASQVAGT TGAHHHARLIFAFLVEMEFH HVSQAGLELLTSGDLPTSAS QSAGITGVSHRAWP in isoform 5. 1 PublicationVSP_030656
Alternative sequencei721 – 78060Missing in isoform 2. 1 PublicationVSP_030657Add
BLAST
Alternative sequencei864 – 88017WWDFT…SNASV → GGGTSLSLTSLKSVMLP in isoform 6. 1 PublicationVSP_045989Add
BLAST
Alternative sequencei881 – 1298418Missing in isoform 6. 1 PublicationVSP_045990Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ870924 mRNA. Translation: ABI74670.1.
AB051523 mRNA. Translation: BAB21827.1. Different initiation.
AK000301 mRNA. Translation: BAA91067.1. Frameshift.
AK023197 mRNA. Translation: BAB14457.1. Different initiation.
AL834190 mRNA. No translation available.
AC024293 Genomic DNA. No translation available.
AC115097 Genomic DNA. No translation available.
AC116021 Genomic DNA. No translation available.
AC127035 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW67996.1.
CH471064 Genomic DNA. Translation: EAW67999.1.
CH471064 Genomic DNA. Translation: EAW68001.1.
BC045609 mRNA. Translation: AAH45609.1.
CCDSiCCDS31475.1. [Q9C0C7-4]
CCDS73281.1. [Q9C0C7-2]
RefSeqiNP_001254711.1. NM_001267782.1. [Q9C0C7-5]
NP_001254712.1. NM_001267783.1.
NP_001287660.1. NM_001300731.1. [Q9C0C7-2]
NP_060219.2. NM_017749.3. [Q9C0C7-4]
XP_005253066.1. XM_005253009.2. [Q9C0C7-1]
XP_005253068.1. XM_005253011.2. [Q9C0C7-3]
XP_005253071.1. XM_005253014.2. [Q9C0C7-4]
XP_006718322.1. XM_006718259.1. [Q9C0C7-1]
UniGeneiHs.654644.

Genome annotation databases

EnsembliENST00000314845; ENSP00000318313; ENSG00000110497. [Q9C0C7-4]
ENST00000458649; ENSP00000415327; ENSG00000110497. [Q9C0C7-1]
ENST00000528950; ENSP00000433945; ENSG00000110497. [Q9C0C7-3]
ENST00000534300; ENSP00000431926; ENSG00000110497. [Q9C0C7-2]
GeneIDi55626.
KEGGihsa:55626.
UCSCiuc001ncu.2. human. [Q9C0C7-4]
uc001ncv.3. human. [Q9C0C7-5]
uc001ncw.3. human.
uc001ncx.3. human. [Q9C0C7-2]
uc009ylc.2. human. [Q9C0C7-3]
uc010rgu.2. human. [Q9C0C7-1]

Polymorphism databases

DMDMi166215833.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ870924 mRNA. Translation: ABI74670.1 .
AB051523 mRNA. Translation: BAB21827.1 . Different initiation.
AK000301 mRNA. Translation: BAA91067.1 . Frameshift.
AK023197 mRNA. Translation: BAB14457.1 . Different initiation.
AL834190 mRNA. No translation available.
AC024293 Genomic DNA. No translation available.
AC115097 Genomic DNA. No translation available.
AC116021 Genomic DNA. No translation available.
AC127035 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW67996.1 .
CH471064 Genomic DNA. Translation: EAW67999.1 .
CH471064 Genomic DNA. Translation: EAW68001.1 .
BC045609 mRNA. Translation: AAH45609.1 .
CCDSi CCDS31475.1. [Q9C0C7-4 ]
CCDS73281.1. [Q9C0C7-2 ]
RefSeqi NP_001254711.1. NM_001267782.1. [Q9C0C7-5 ]
NP_001254712.1. NM_001267783.1.
NP_001287660.1. NM_001300731.1. [Q9C0C7-2 ]
NP_060219.2. NM_017749.3. [Q9C0C7-4 ]
XP_005253066.1. XM_005253009.2. [Q9C0C7-1 ]
XP_005253068.1. XM_005253011.2. [Q9C0C7-3 ]
XP_005253071.1. XM_005253014.2. [Q9C0C7-4 ]
XP_006718322.1. XM_006718259.1. [Q9C0C7-1 ]
UniGenei Hs.654644.

3D structure databases

ProteinModelPortali Q9C0C7.
SMRi Q9C0C7. Positions 28-201, 1010-1037.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120765. 39 interactions.
DIPi DIP-53597N.
IntActi Q9C0C7. 19 interactions.
MINTi MINT-8177757.
STRINGi 9606.ENSP00000318313.

PTM databases

PhosphoSitei Q9C0C7.

Polymorphism databases

DMDMi 166215833.

Proteomic databases

MaxQBi Q9C0C7.
PaxDbi Q9C0C7.
PRIDEi Q9C0C7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314845 ; ENSP00000318313 ; ENSG00000110497 . [Q9C0C7-4 ]
ENST00000458649 ; ENSP00000415327 ; ENSG00000110497 . [Q9C0C7-1 ]
ENST00000528950 ; ENSP00000433945 ; ENSG00000110497 . [Q9C0C7-3 ]
ENST00000534300 ; ENSP00000431926 ; ENSG00000110497 . [Q9C0C7-2 ]
GeneIDi 55626.
KEGGi hsa:55626.
UCSCi uc001ncu.2. human. [Q9C0C7-4 ]
uc001ncv.3. human. [Q9C0C7-5 ]
uc001ncw.3. human.
uc001ncx.3. human. [Q9C0C7-2 ]
uc009ylc.2. human. [Q9C0C7-3 ]
uc010rgu.2. human. [Q9C0C7-1 ]

Organism-specific databases

CTDi 55626.
GeneCardsi GC11M046417.
H-InvDB HIX0009602.
HGNCi HGNC:25990. AMBRA1.
HPAi CAB017825.
HPA038535.
MIMi 611359. gene.
neXtProti NX_Q9C0C7.
PharmGKBi PA162376307.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG317724.
GeneTreei ENSGT00390000016223.
HOGENOMi HOG000033925.
HOVERGENi HBG103818.
InParanoidi Q9C0C7.
KOi K17985.
OMAi HPSTEHM.
OrthoDBi EOG7HB58G.
PhylomeDBi Q9C0C7.
TreeFami TF328981.

Enzyme and pathway databases

SignaLinki Q9C0C7.

Miscellaneous databases

ChiTaRSi AMBRA1. human.
GenomeRNAii 55626.
NextBioi 60248.
PROi Q9C0C7.
SOURCEi Search...

Gene expression databases

Bgeei Q9C0C7.
CleanExi HS_AMBRA1.
ExpressionAtlasi Q9C0C7. baseline and differential.
Genevestigatori Q9C0C7.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 3 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 464-1298.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    Tissue: Melanoma.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Testis.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism."
    He C., Wei Y., Sun K., Li B., Dong X., Zou Z., Liu Y., Kinch L.N., Khan S., Sinha S., Xavier R.J., Grishin N.V., Xiao G., Eskelinen E.L., Scherer P.E., Whistler J.L., Levine B.
    Cell 154:1085-1099(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BECN1P1/BECN2.

Entry informationi

Entry nameiAMRA1_HUMAN
AccessioniPrimary (citable) accession number: Q9C0C7
Secondary accession number(s): A6XN33
, D3DQP8, G3V193, Q86XD6, Q9H8Z0, Q9NXE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 26, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3