Q9C0C7 (AMRA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Activating molecule in BECN1-regulated autophagy protein 1

Gene names

Name:	AMBRA1
Synonyms:	KIAA1736

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1298 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation By similarity.
Subunit structure	Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3 By similarity.
Subcellular location	Cytoplasmic vesicle › autophagosome By similarity.
Sequence similarities	Contains 3 WD repeats.
Sequence caution	The sequence BAA91067.1 differs from that shown. Reason: Frameshift at position 682. The sequence BAB14457.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB21827.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Autophagy Differentiation Neurogenesis
Cellular component	Cytoplasmic vesicle
Coding sequence diversity	Alternative splicing
Domain	Repeat WD repeat
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara neural tube development Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara
Cellular_component	autophagic vacuole Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from direct assay Ref.1. Source: MGI cytoplasmic vesicle Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
vif	P12504	5	EBI-2512975,EBI-779991	From a different organism.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9C0C7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9C0C7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     721-780: Missing.

Isoform 3 (identifier: Q9C0C7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     691-719: Missing.

Isoform 4 (identifier: Q9C0C7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     255-344: Missing.

Isoform 5 (identifier: Q9C0C7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     255-344: Missing.
     691-691: R → RRSLALSPRL...ITGVSHRAWP

Isoform 6 (identifier: Q9C0C7-6)

The sequence of this isoform differs from the canonical sequence as follows:
     255-344: Missing.
     691-719: Missing.
     864-868: WWDFT → VVGLH
     869-1298: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1298	1298	Activating molecule in BECN1-regulated autophagy protein 1		PRO_0000315703
Regions
	Repeat	51 – 90	40	WD 1
	Repeat	93 – 133	41	WD 2
	Repeat	135 – 175	41	WD 3
	Compositional bias	268 – 277	10	Poly-Pro
	Compositional bias	592 – 639	48	Ser-rich
Amino acid modifications
	Modified residue	639	1	Phosphoserine Ref.9 Ref.10 Ref.11
Natural variations
	Alternative sequence	255 – 344	90	Missing in isoform 4, isoform 5 and isoform 6.		VSP_030654
	Alternative sequence	691 – 719	29	Missing in isoform 3 and isoform 6.		VSP_030655
	Alternative sequence	691	1	R → RRSLALSPRLEYSGAILAHC KLRLPGSCHSPASASQVAGT TGAHHHARLIFAFLVEMEFH HVSQAGLELLTSGDLPTSAS QSAGITGVSHRAWP in isoform 5.		VSP_030656
	Alternative sequence	721 – 780	60	Missing in isoform 2.		VSP_030657
	Alternative sequence	864 – 868	5	WWDFT → VVGLH in isoform 6.		VSP_045989
	Alternative sequence	869 – 1298	430	Missing in isoform 6.		VSP_045990
Experimental info
	Sequence conflict	165	1	W → R in BAA91067. Ref.3
	Sequence conflict	793	1	N → K in AL834190. Ref.4
	Sequence conflict	869	1	K → E in BAB14457. Ref.3
	Sequence conflict	983	1	Q → L in BAB14457. Ref.3
	Sequence conflict	1105	1	Q → E in AAH45609. Ref.7
	Sequence conflict	1268	1	L → V in AAH45609. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 44FE9CDFFFE6811E	FASTA	1,298	142,507
	10 20 30 40 50 60 MKVVPEKNAV RILWGRERGA RAMGAQRLLQ ELVEDKTRWM KWEGKRVELP DSPRSTFLLA 70 80 90 100 110 120 FSPDRTLLAS THVNHNIYIT EVKTGKCVHS LIGHRRTPWC VTFHPTISGL IASGCLDGEV 130 140 150 160 170 180 RIWDLHGGSE SWFTDSNNAI ASLAFHPTAQ LLLIATANEI HFWDWSRREP FAVVKTASEM 190 200 210 220 230 240 ERVRLVRFDP LGHYLLTAIV NPSNQQGDDE PEIPIDGTEL SHYRQRALLQ SQPVRRTPLL 250 260 270 280 290 300 HNFLHMLSSR SSGIQVGEQS TVQDSATPSP PPPPPQPSTE RPRTSAYIRL RQRVSYPTAE 310 320 330 340 350 360 CCQHLGILCL CSRCSGTRVP SLLPHQDSVP PASARATTPS FSFVQTEPFH PPEQASSTQQ 370 380 390 400 410 420 DQGLLNRPSA FSTVQSSTAG NTLRNLSLGP TRRSLGGPLS SHPSRYHREI APGLTGSEWT 430 440 450 460 470 480 RTVLSLNSRS EAESMPPPRT SASSVSLLSV LRQQEGGSQA SVYTSATEGR GFPASGLATE 490 500 510 520 530 540 SDGGNGSSQN NSGSIRHELQ CDLRRFFLEY DRLQELDQSL SGEAPQTQQA QEMLNNNIES 550 560 570 580 590 600 ERPGPSHQPT PHSSENNSNL SRGHLNRCRA CHNLLTFNND TLRWERTTPN YSSGEASSSW 610 620 630 640 650 660 QVPSSFESVP SSGSQLPPLE RTEGQTPSSS RLELSSSASP QEERTVGVAF NQETGHWERI 670 680 690 700 710 720 YTQSSRSGTV SQEALHQDMP EESSEEDSLR RRLLESSLIS LSRYDGAGSR EHPIYPDPAR 730 740 750 760 770 780 LSPAAYYAQR MIQYLSRRDS IRQRSMRYQQ NRLRSSTSSS SSDNQGPSVE GTDLEFEDFE 790 800 810 820 830 840 DNGDRSRHRA PRNARMSAPS LGRFVPRRFL LPEYLPYAGI FHERGQPGLA THSSVNRVLA 850 860 870 880 890 900 GAVIGDGQSA VASNIANTTY RLQWWDFTKF DLPEISNASV NVLVQNCKIY NDASCDISAD 910 920 930 940 950 960 GQLLAAFIPS SQRGFPDEGI LAVYSLAPHN LGEMLYTKRF GPNAISVSLS PMGRYVMVGL 970 980 990 1000 1010 1020 ASRRILLHPS TEHMVAQVFR LQQAHGGETS MRRVFNVLYP MPADQRRHVS INSARWLPEP 1030 1040 1050 1060 1070 1080 GLGLAYGTNK GDLVICRPEA LNSGVEYYWD QLNETVFTVH SNSRSSERPG TSRATWRTDR 1090 1100 1110 1120 1130 1140 DMGLMNAIGL QPRNPATSVT SQGTQTLALQ LQNAETQTER EVPEPGTAAS GPGEGEGSEY 1150 1160 1170 1180 1190 1200 GASGEDALSR IQRLMAEGGM TAVVQREQST TMASMGGFGN NIIVSHRIHR SSQTGTEPGA 1210 1220 1230 1240 1250 1260 AHTSSPQPST SRGLLPEAGQ LAERGLSPRT ASWDQPGTPG REPTQPTLPS SSPVPIPVSL 1270 1280 1290 PSAEGPTLHC ELTNNNHLLD GGSSRGDAAG PRGEPRNR
	Isoform 2 [UniParc]. Checksum: EE24A481D1388999	FASTA	1,238	135,528
	10 20 30 40 50 60 MKVVPEKNAV RILWGRERGA RAMGAQRLLQ ELVEDKTRWM KWEGKRVELP DSPRSTFLLA 70 80 90 100 110 120 FSPDRTLLAS THVNHNIYIT EVKTGKCVHS LIGHRRTPWC VTFHPTISGL IASGCLDGEV 130 140 150 160 170 180 RIWDLHGGSE SWFTDSNNAI ASLAFHPTAQ LLLIATANEI HFWDWSRREP FAVVKTASEM 190 200 210 220 230 240 ERVRLVRFDP LGHYLLTAIV NPSNQQGDDE PEIPIDGTEL SHYRQRALLQ SQPVRRTPLL 250 260 270 280 290 300 HNFLHMLSSR SSGIQVGEQS TVQDSATPSP PPPPPQPSTE RPRTSAYIRL RQRVSYPTAE 310 320 330 340 350 360 CCQHLGILCL CSRCSGTRVP SLLPHQDSVP PASARATTPS FSFVQTEPFH PPEQASSTQQ 370 380 390 400 410 420 DQGLLNRPSA FSTVQSSTAG NTLRNLSLGP TRRSLGGPLS SHPSRYHREI APGLTGSEWT 430 440 450 460 470 480 RTVLSLNSRS EAESMPPPRT SASSVSLLSV LRQQEGGSQA SVYTSATEGR GFPASGLATE 490 500 510 520 530 540 SDGGNGSSQN NSGSIRHELQ CDLRRFFLEY DRLQELDQSL SGEAPQTQQA QEMLNNNIES 550 560 570 580 590 600 ERPGPSHQPT PHSSENNSNL SRGHLNRCRA CHNLLTFNND TLRWERTTPN YSSGEASSSW 610 620 630 640 650 660 QVPSSFESVP SSGSQLPPLE RTEGQTPSSS RLELSSSASP QEERTVGVAF NQETGHWERI 670 680 690 700 710 720 YTQSSRSGTV SQEALHQDMP EESSEEDSLR RRLLESSLIS LSRYDGAGSR EHPIYPDPAR 730 740 750 760 770 780 DNGDRSRHRA PRNARMSAPS LGRFVPRRFL LPEYLPYAGI FHERGQPGLA THSSVNRVLA 790 800 810 820 830 840 GAVIGDGQSA VASNIANTTY RLQWWDFTKF DLPEISNASV NVLVQNCKIY NDASCDISAD 850 860 870 880 890 900 GQLLAAFIPS SQRGFPDEGI LAVYSLAPHN LGEMLYTKRF GPNAISVSLS PMGRYVMVGL 910 920 930 940 950 960 ASRRILLHPS TEHMVAQVFR LQQAHGGETS MRRVFNVLYP MPADQRRHVS INSARWLPEP 970 980 990 1000 1010 1020 GLGLAYGTNK GDLVICRPEA LNSGVEYYWD QLNETVFTVH SNSRSSERPG TSRATWRTDR 1030 1040 1050 1060 1070 1080 DMGLMNAIGL QPRNPATSVT SQGTQTLALQ LQNAETQTER EVPEPGTAAS GPGEGEGSEY 1090 1100 1110 1120 1130 1140 GASGEDALSR IQRLMAEGGM TAVVQREQST TMASMGGFGN NIIVSHRIHR SSQTGTEPGA 1150 1160 1170 1180 1190 1200 AHTSSPQPST SRGLLPEAGQ LAERGLSPRT ASWDQPGTPG REPTQPTLPS SSPVPIPVSL 1210 1220 1230 PSAEGPTLHC ELTNNNHLLD GGSSRGDAAG PRGEPRNR
	Isoform 3 [UniParc]. Checksum: C9902123C4EE6199	FASTA	1,269	139,269
	10 20 30 40 50 60 MKVVPEKNAV RILWGRERGA RAMGAQRLLQ ELVEDKTRWM KWEGKRVELP DSPRSTFLLA 70 80 90 100 110 120 FSPDRTLLAS THVNHNIYIT EVKTGKCVHS LIGHRRTPWC VTFHPTISGL IASGCLDGEV 130 140 150 160 170 180 RIWDLHGGSE SWFTDSNNAI ASLAFHPTAQ LLLIATANEI HFWDWSRREP FAVVKTASEM 190 200 210 220 230 240 ERVRLVRFDP LGHYLLTAIV NPSNQQGDDE PEIPIDGTEL SHYRQRALLQ SQPVRRTPLL 250 260 270 280 290 300 HNFLHMLSSR SSGIQVGEQS TVQDSATPSP PPPPPQPSTE RPRTSAYIRL RQRVSYPTAE 310 320 330 340 350 360 CCQHLGILCL CSRCSGTRVP SLLPHQDSVP PASARATTPS FSFVQTEPFH PPEQASSTQQ 370 380 390 400 410 420 DQGLLNRPSA FSTVQSSTAG NTLRNLSLGP TRRSLGGPLS SHPSRYHREI APGLTGSEWT 430 440 450 460 470 480 RTVLSLNSRS EAESMPPPRT SASSVSLLSV LRQQEGGSQA SVYTSATEGR GFPASGLATE 490 500 510 520 530 540 SDGGNGSSQN NSGSIRHELQ CDLRRFFLEY DRLQELDQSL SGEAPQTQQA QEMLNNNIES 550 560 570 580 590 600 ERPGPSHQPT PHSSENNSNL SRGHLNRCRA CHNLLTFNND TLRWERTTPN YSSGEASSSW 610 620 630 640 650 660 QVPSSFESVP SSGSQLPPLE RTEGQTPSSS RLELSSSASP QEERTVGVAF NQETGHWERI 670 680 690 700 710 720 YTQSSRSGTV SQEALHQDMP EESSEEDSLR RLSPAAYYAQ RMIQYLSRRD SIRQRSMRYQ 730 740 750 760 770 780 QNRLRSSTSS SSSDNQGPSV EGTDLEFEDF EDNGDRSRHR APRNARMSAP SLGRFVPRRF 790 800 810 820 830 840 LLPEYLPYAG IFHERGQPGL ATHSSVNRVL AGAVIGDGQS AVASNIANTT YRLQWWDFTK 850 860 870 880 890 900 FDLPEISNAS VNVLVQNCKI YNDASCDISA DGQLLAAFIP SSQRGFPDEG ILAVYSLAPH 910 920 930 940 950 960 NLGEMLYTKR FGPNAISVSL SPMGRYVMVG LASRRILLHP STEHMVAQVF RLQQAHGGET 970 980 990 1000 1010 1020 SMRRVFNVLY PMPADQRRHV SINSARWLPE PGLGLAYGTN KGDLVICRPE ALNSGVEYYW 1030 1040 1050 1060 1070 1080 DQLNETVFTV HSNSRSSERP GTSRATWRTD RDMGLMNAIG LQPRNPATSV TSQGTQTLAL 1090 1100 1110 1120 1130 1140 QLQNAETQTE REVPEPGTAA SGPGEGEGSE YGASGEDALS RIQRLMAEGG MTAVVQREQS 1150 1160 1170 1180 1190 1200 TTMASMGGFG NNIIVSHRIH RSSQTGTEPG AAHTSSPQPS TSRGLLPEAG QLAERGLSPR 1210 1220 1230 1240 1250 1260 TASWDQPGTP GREPTQPTLP SSSPVPIPVS LPSAEGPTLH CELTNNNHLL DGGSSRGDAA GPRGEPRNR
	Isoform 4 [UniParc]. Checksum: 3BA3D281C30318F1	FASTA	1,208	132,837
	10 20 30 40 50 60 MKVVPEKNAV RILWGRERGA RAMGAQRLLQ ELVEDKTRWM KWEGKRVELP DSPRSTFLLA 70 80 90 100 110 120 FSPDRTLLAS THVNHNIYIT EVKTGKCVHS LIGHRRTPWC VTFHPTISGL IASGCLDGEV 130 140 150 160 170 180 RIWDLHGGSE SWFTDSNNAI ASLAFHPTAQ LLLIATANEI HFWDWSRREP FAVVKTASEM 190 200 210 220 230 240 ERVRLVRFDP LGHYLLTAIV NPSNQQGDDE PEIPIDGTEL SHYRQRALLQ SQPVRRTPLL 250 260 270 280 290 300 HNFLHMLSSR SSGIQTEPFH PPEQASSTQQ DQGLLNRPSA FSTVQSSTAG NTLRNLSLGP 310 320 330 340 350 360 TRRSLGGPLS SHPSRYHREI APGLTGSEWT RTVLSLNSRS EAESMPPPRT SASSVSLLSV 370 380 390 400 410 420 LRQQEGGSQA SVYTSATEGR GFPASGLATE SDGGNGSSQN NSGSIRHELQ CDLRRFFLEY 430 440 450 460 470 480 DRLQELDQSL SGEAPQTQQA QEMLNNNIES ERPGPSHQPT PHSSENNSNL SRGHLNRCRA 490 500 510 520 530 540 CHNLLTFNND TLRWERTTPN YSSGEASSSW QVPSSFESVP SSGSQLPPLE RTEGQTPSSS 550 560 570 580 590 600 RLELSSSASP QEERTVGVAF NQETGHWERI YTQSSRSGTV SQEALHQDMP EESSEEDSLR 610 620 630 640 650 660 RRLLESSLIS LSRYDGAGSR EHPIYPDPAR LSPAAYYAQR MIQYLSRRDS IRQRSMRYQQ 670 680 690 700 710 720 NRLRSSTSSS SSDNQGPSVE GTDLEFEDFE DNGDRSRHRA PRNARMSAPS LGRFVPRRFL 730 740 750 760 770 780 LPEYLPYAGI FHERGQPGLA THSSVNRVLA GAVIGDGQSA VASNIANTTY RLQWWDFTKF 790 800 810 820 830 840 DLPEISNASV NVLVQNCKIY NDASCDISAD GQLLAAFIPS SQRGFPDEGI LAVYSLAPHN 850 860 870 880 890 900 LGEMLYTKRF GPNAISVSLS PMGRYVMVGL ASRRILLHPS TEHMVAQVFR LQQAHGGETS 910 920 930 940 950 960 MRRVFNVLYP MPADQRRHVS INSARWLPEP GLGLAYGTNK GDLVICRPEA LNSGVEYYWD 970 980 990 1000 1010 1020 QLNETVFTVH SNSRSSERPG TSRATWRTDR DMGLMNAIGL QPRNPATSVT SQGTQTLALQ 1030 1040 1050 1060 1070 1080 LQNAETQTER EVPEPGTAAS GPGEGEGSEY GASGEDALSR IQRLMAEGGM TAVVQREQST 1090 1100 1110 1120 1130 1140 TMASMGGFGN NIIVSHRIHR SSQTGTEPGA AHTSSPQPST SRGLLPEAGQ LAERGLSPRT 1150 1160 1170 1180 1190 1200 ASWDQPGTPG REPTQPTLPS SSPVPIPVSL PSAEGPTLHC ELTNNNHLLD GGSSRGDAAG PRGEPRNR
	Isoform 5 [UniParc]. Checksum: 0EF81F37DFCA142D	FASTA	1,301	142,585
	10 20 30 40 50 60 MKVVPEKNAV RILWGRERGA RAMGAQRLLQ ELVEDKTRWM KWEGKRVELP DSPRSTFLLA 70 80 90 100 110 120 FSPDRTLLAS THVNHNIYIT EVKTGKCVHS LIGHRRTPWC VTFHPTISGL IASGCLDGEV 130 140 150 160 170 180 RIWDLHGGSE SWFTDSNNAI ASLAFHPTAQ LLLIATANEI HFWDWSRREP FAVVKTASEM 190 200 210 220 230 240 ERVRLVRFDP LGHYLLTAIV NPSNQQGDDE PEIPIDGTEL SHYRQRALLQ SQPVRRTPLL 250 260 270 280 290 300 HNFLHMLSSR SSGIQTEPFH PPEQASSTQQ DQGLLNRPSA FSTVQSSTAG NTLRNLSLGP 310 320 330 340 350 360 TRRSLGGPLS SHPSRYHREI APGLTGSEWT RTVLSLNSRS EAESMPPPRT SASSVSLLSV 370 380 390 400 410 420 LRQQEGGSQA SVYTSATEGR GFPASGLATE SDGGNGSSQN NSGSIRHELQ CDLRRFFLEY 430 440 450 460 470 480 DRLQELDQSL SGEAPQTQQA QEMLNNNIES ERPGPSHQPT PHSSENNSNL SRGHLNRCRA 490 500 510 520 530 540 CHNLLTFNND TLRWERTTPN YSSGEASSSW QVPSSFESVP SSGSQLPPLE RTEGQTPSSS 550 560 570 580 590 600 RLELSSSASP QEERTVGVAF NQETGHWERI YTQSSRSGTV SQEALHQDMP EESSEEDSLR 610 620 630 640 650 660 RRSLALSPRL EYSGAILAHC KLRLPGSCHS PASASQVAGT TGAHHHARLI FAFLVEMEFH 670 680 690 700 710 720 HVSQAGLELL TSGDLPTSAS QSAGITGVSH RAWPRLLESS LISLSRYDGA GSREHPIYPD 730 740 750 760 770 780 PARLSPAAYY AQRMIQYLSR RDSIRQRSMR YQQNRLRSST SSSSSDNQGP SVEGTDLEFE 790 800 810 820 830 840 DFEDNGDRSR HRAPRNARMS APSLGRFVPR RFLLPEYLPY AGIFHERGQP GLATHSSVNR 850 860 870 880 890 900 VLAGAVIGDG QSAVASNIAN TTYRLQWWDF TKFDLPEISN ASVNVLVQNC KIYNDASCDI 910 920 930 940 950 960 SADGQLLAAF IPSSQRGFPD EGILAVYSLA PHNLGEMLYT KRFGPNAISV SLSPMGRYVM 970 980 990 1000 1010 1020 VGLASRRILL HPSTEHMVAQ VFRLQQAHGG ETSMRRVFNV LYPMPADQRR HVSINSARWL 1030 1040 1050 1060 1070 1080 PEPGLGLAYG TNKGDLVICR PEALNSGVEY YWDQLNETVF TVHSNSRSSE RPGTSRATWR 1090 1100 1110 1120 1130 1140 TDRDMGLMNA IGLQPRNPAT SVTSQGTQTL ALQLQNAETQ TEREVPEPGT AASGPGEGEG 1150 1160 1170 1180 1190 1200 SEYGASGEDA LSRIQRLMAE GGMTAVVQRE QSTTMASMGG FGNNIIVSHR IHRSSQTGTE 1210 1220 1230 1240 1250 1260 PGAAHTSSPQ PSTSRGLLPE AGQLAERGLS PRTASWDQPG TPGREPTQPT LPSSSPVPIP 1270 1280 1290 1300 VSLPSAEGPT LHCELTNNNH LLDGGSSRGD AAGPRGEPRN R
	Isoform 6 [UniParc]. Checksum: 409B6D25B2F73711	FASTA	749	83,304
	10 20 30 40 50 60 MKVVPEKNAV RILWGRERGA RAMGAQRLLQ ELVEDKTRWM KWEGKRVELP DSPRSTFLLA 70 80 90 100 110 120 FSPDRTLLAS THVNHNIYIT EVKTGKCVHS LIGHRRTPWC VTFHPTISGL IASGCLDGEV 130 140 150 160 170 180 RIWDLHGGSE SWFTDSNNAI ASLAFHPTAQ LLLIATANEI HFWDWSRREP FAVVKTASEM 190 200 210 220 230 240 ERVRLVRFDP LGHYLLTAIV NPSNQQGDDE PEIPIDGTEL SHYRQRALLQ SQPVRRTPLL 250 260 270 280 290 300 HNFLHMLSSR SSGIQTEPFH PPEQASSTQQ DQGLLNRPSA FSTVQSSTAG NTLRNLSLGP 310 320 330 340 350 360 TRRSLGGPLS SHPSRYHREI APGLTGSEWT RTVLSLNSRS EAESMPPPRT SASSVSLLSV 370 380 390 400 410 420 LRQQEGGSQA SVYTSATEGR GFPASGLATE SDGGNGSSQN NSGSIRHELQ CDLRRFFLEY 430 440 450 460 470 480 DRLQELDQSL SGEAPQTQQA QEMLNNNIES ERPGPSHQPT PHSSENNSNL SRGHLNRCRA 490 500 510 520 530 540 CHNLLTFNND TLRWERTTPN YSSGEASSSW QVPSSFESVP SSGSQLPPLE RTEGQTPSSS 550 560 570 580 590 600 RLELSSSASP QEERTVGVAF NQETGHWERI YTQSSRSGTV SQEALHQDMP EESSEEDSLR 610 620 630 640 650 660 RLSPAAYYAQ RMIQYLSRRD SIRQRSMRYQ QNRLRSSTSS SSSDNQGPSV EGTDLEFEDF 670 680 690 700 710 720 EDNGDRSRHR APRNARMSAP SLGRFVPRRF LLPEYLPYAG IFHERGQPGL ATHSSVNRVL 730 740 AGAVIGDGQS AVASNIANTT YRLQVVGLH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ambra1 regulates autophagy and development of the nervous system." Maria Fimia G., Stoykova A., Romagnoli A., Giunta L., Di Bartolomeo S., Nardacci R., Corazzari M., Fuoco C., Ucar A., Schwartz P., Gruss P., Piacentini M., Chowdhury K., Cecconi F. Nature 447:1121-1125(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Brain.
[2]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 464-1298.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Melanoma.
[5]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Testis.
[8]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ870924 mRNA. Translation: ABI74670.1. AB051523 mRNA. Translation: BAB21827.1. Different initiation. AK000301 mRNA. Translation: BAA91067.1. Frameshift. AK023197 mRNA. Translation: BAB14457.1. Different initiation. AL834190 mRNA. No translation available. AC024293 Genomic DNA. No translation available. AC115097 Genomic DNA. No translation available. AC116021 Genomic DNA. No translation available. AC127035 Genomic DNA. No translation available. CH471064 Genomic DNA. Translation: EAW67996.1. CH471064 Genomic DNA. Translation: EAW67999.1. CH471064 Genomic DNA. Translation: EAW68001.1. BC045609 mRNA. Translation: AAH45609.1.
IPI	IPI00106552. IPI00177605. IPI00398257. IPI00855865. IPI00877906.
RefSeq	NP_001254711.1. NM_001267782.1. NP_001254712.1. NM_001267783.1. NP_060219.2. NM_017749.3.
UniGene	Hs.654644.
3D structure databases
ProteinModelPortal	Q9C0C7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9C0C7. 15 interactions.
MINT	MINT-8177757.
STRING	9606.ENSP00000318313.
PTM databases
PhosphoSite	Q9C0C7.
Polymorphism databases
DMDM	166215833.
Proteomic databases
PaxDb	Q9C0C7.
PRIDE	Q9C0C7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298834; ENSP00000298834; ENSG00000110497. ENST00000314845; ENSP00000318313; ENSG00000110497. ENST00000426438; ENSP00000410899; ENSG00000110497. ENST00000458649; ENSP00000415327; ENSG00000110497. ENST00000528950; ENSP00000433945; ENSG00000110497. ENST00000533727; ENSP00000433372; ENSG00000110497. ENST00000534300; ENSP00000431926; ENSG00000110497.
GeneID	55626.
KEGG	hsa:55626.
UCSC	uc001ncu.1. human. uc001ncv.2. human. uc001ncx.2. human. uc009ylc.1. human. uc010rgu.1. human.
Organism-specific databases
CTD	55626.
GeneCards	GC11M046417.
H-InvDB	HIX0009602.
HGNC	HGNC:25990. AMBRA1.
HPA	CAB017825.
MIM	611359. gene.
neXtProt	NX_Q9C0C7.
PharmGKB	PA162376307.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG317724.
HOGENOM	HOG000033925.
HOVERGEN	HBG103818.
OMA	YPDPARD.
Enzyme and pathway databases
SignaLink	Q9C0C7.
Gene expression databases
ArrayExpress	Q9C0C7.
Bgee	Q9C0C7.
CleanEx	HS_AMBRA1.
Genevestigator	Q9C0C7.
Family and domain databases
Gene3D	2.130.10.10. 2 hits.
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 1 hit. [Graphical view]
SMART	SM00320. WD40. 3 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	AMBRA1. human.
GenomeRNAi	55626.
NextBio	60248.
SOURCE	Search...

Entry information

Entry name

AMRA1_HUMAN

Accession

Primary (citable) accession number: Q9C0C7
Secondary accession number(s): A6XN33 , D3DQP8, G3V193, Q86XD6, Q9H8Z0, Q9NXE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	May 29, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.