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Protein

Activating molecule in BECN1-regulated autophagy protein 1

Gene

AMBRA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity).By similarity

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • activation of mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
  • autophagy Source: GO_Central
  • cell differentiation Source: UniProtKB-KW
  • negative regulation of cell proliferation Source: Ensembl
  • negative regulation of neuron apoptotic process Source: Ensembl
  • neural tube development Source: Ensembl
  • positive regulation of mitochondrion degradation Source: ParkinsonsUK-UCL
  • positive regulation of phosphatidylinositol 3-kinase activity Source: ParkinsonsUK-UCL
  • regulation of autophagosome assembly Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Autophagy, Differentiation, Neurogenesis

Enzyme and pathway databases

SignaLinkiQ9C0C7.

Names & Taxonomyi

Protein namesi
Recommended name:
Activating molecule in BECN1-regulated autophagy protein 1
Gene namesi
Name:AMBRA1
Synonyms:KIAA1736
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25990. AMBRA1.

Subcellular locationi

GO - Cellular componenti

  • autophagosome Source: UniProtKB-SubCell
  • axoneme Source: UniProtKB
  • cytoplasm Source: MGI
  • cytosol Source: ParkinsonsUK-UCL
  • mitochondrial outer membrane Source: ParkinsonsUK-UCL
  • mitochondrion Source: ParkinsonsUK-UCL
  • phagocytic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376307.

Polymorphism and mutation databases

BioMutaiAMBRA1.
DMDMi166215833.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12981298Activating molecule in BECN1-regulated autophagy protein 1PRO_0000315703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei639 – 6391Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9C0C7.
PaxDbiQ9C0C7.
PRIDEiQ9C0C7.

PTM databases

PhosphoSiteiQ9C0C7.

Expressioni

Gene expression databases

BgeeiQ9C0C7.
CleanExiHS_AMBRA1.
ExpressionAtlasiQ9C0C7. baseline and differential.
GenevisibleiQ9C0C7. HS.

Organism-specific databases

HPAiCAB017825.
HPA038535.

Interactioni

Subunit structurei

Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3 (By similarity). Interacts with BECN2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2P1041510EBI-2512975,EBI-77694
BECN1Q144578EBI-2512975,EBI-949378
vifP125045EBI-2512975,EBI-779991From a different organism.

Protein-protein interaction databases

BioGridi120765. 31 interactions.
DIPiDIP-53597N.
IntActiQ9C0C7. 19 interactions.
MINTiMINT-8177757.
STRINGi9606.ENSP00000318313.

Structurei

3D structure databases

ProteinModelPortaliQ9C0C7.
SMRiQ9C0C7. Positions 28-201, 1010-1037.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati51 – 9040WD 1Add
BLAST
Repeati93 – 13341WD 2Add
BLAST
Repeati135 – 17541WD 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi268 – 27710Poly-Pro
Compositional biasi592 – 63948Ser-richAdd
BLAST

Sequence similaritiesi

Contains 3 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG317724.
GeneTreeiENSGT00390000016223.
HOGENOMiHOG000033925.
HOVERGENiHBG103818.
InParanoidiQ9C0C7.
KOiK17985.
OMAiHPSTEHM.
OrthoDBiEOG7HB58G.
PhylomeDBiQ9C0C7.
TreeFamiTF328981.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0C7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVVPEKNAV RILWGRERGA RAMGAQRLLQ ELVEDKTRWM KWEGKRVELP
60 70 80 90 100
DSPRSTFLLA FSPDRTLLAS THVNHNIYIT EVKTGKCVHS LIGHRRTPWC
110 120 130 140 150
VTFHPTISGL IASGCLDGEV RIWDLHGGSE SWFTDSNNAI ASLAFHPTAQ
160 170 180 190 200
LLLIATANEI HFWDWSRREP FAVVKTASEM ERVRLVRFDP LGHYLLTAIV
210 220 230 240 250
NPSNQQGDDE PEIPIDGTEL SHYRQRALLQ SQPVRRTPLL HNFLHMLSSR
260 270 280 290 300
SSGIQVGEQS TVQDSATPSP PPPPPQPSTE RPRTSAYIRL RQRVSYPTAE
310 320 330 340 350
CCQHLGILCL CSRCSGTRVP SLLPHQDSVP PASARATTPS FSFVQTEPFH
360 370 380 390 400
PPEQASSTQQ DQGLLNRPSA FSTVQSSTAG NTLRNLSLGP TRRSLGGPLS
410 420 430 440 450
SHPSRYHREI APGLTGSEWT RTVLSLNSRS EAESMPPPRT SASSVSLLSV
460 470 480 490 500
LRQQEGGSQA SVYTSATEGR GFPASGLATE SDGGNGSSQN NSGSIRHELQ
510 520 530 540 550
CDLRRFFLEY DRLQELDQSL SGEAPQTQQA QEMLNNNIES ERPGPSHQPT
560 570 580 590 600
PHSSENNSNL SRGHLNRCRA CHNLLTFNND TLRWERTTPN YSSGEASSSW
610 620 630 640 650
QVPSSFESVP SSGSQLPPLE RTEGQTPSSS RLELSSSASP QEERTVGVAF
660 670 680 690 700
NQETGHWERI YTQSSRSGTV SQEALHQDMP EESSEEDSLR RRLLESSLIS
710 720 730 740 750
LSRYDGAGSR EHPIYPDPAR LSPAAYYAQR MIQYLSRRDS IRQRSMRYQQ
760 770 780 790 800
NRLRSSTSSS SSDNQGPSVE GTDLEFEDFE DNGDRSRHRA PRNARMSAPS
810 820 830 840 850
LGRFVPRRFL LPEYLPYAGI FHERGQPGLA THSSVNRVLA GAVIGDGQSA
860 870 880 890 900
VASNIANTTY RLQWWDFTKF DLPEISNASV NVLVQNCKIY NDASCDISAD
910 920 930 940 950
GQLLAAFIPS SQRGFPDEGI LAVYSLAPHN LGEMLYTKRF GPNAISVSLS
960 970 980 990 1000
PMGRYVMVGL ASRRILLHPS TEHMVAQVFR LQQAHGGETS MRRVFNVLYP
1010 1020 1030 1040 1050
MPADQRRHVS INSARWLPEP GLGLAYGTNK GDLVICRPEA LNSGVEYYWD
1060 1070 1080 1090 1100
QLNETVFTVH SNSRSSERPG TSRATWRTDR DMGLMNAIGL QPRNPATSVT
1110 1120 1130 1140 1150
SQGTQTLALQ LQNAETQTER EVPEPGTAAS GPGEGEGSEY GASGEDALSR
1160 1170 1180 1190 1200
IQRLMAEGGM TAVVQREQST TMASMGGFGN NIIVSHRIHR SSQTGTEPGA
1210 1220 1230 1240 1250
AHTSSPQPST SRGLLPEAGQ LAERGLSPRT ASWDQPGTPG REPTQPTLPS
1260 1270 1280 1290
SSPVPIPVSL PSAEGPTLHC ELTNNNHLLD GGSSRGDAAG PRGEPRNR
Length:1,298
Mass (Da):142,507
Last modified:January 15, 2008 - v2
Checksum:i44FE9CDFFFE6811E
GO
Isoform 2 (identifier: Q9C0C7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     721-780: Missing.

Show »
Length:1,238
Mass (Da):135,528
Checksum:iEE24A481D1388999
GO
Isoform 3 (identifier: Q9C0C7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     691-719: Missing.

Show »
Length:1,269
Mass (Da):139,269
Checksum:iC9902123C4EE6199
GO
Isoform 4 (identifier: Q9C0C7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-344: Missing.

Show »
Length:1,208
Mass (Da):132,837
Checksum:i3BA3D281C30318F1
GO
Isoform 5 (identifier: Q9C0C7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-344: Missing.
     691-691: R → RRSLALSPRL...ITGVSHRAWP

Show »
Length:1,301
Mass (Da):142,585
Checksum:i0EF81F37DFCA142D
GO
Isoform 6 (identifier: Q9C0C7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-344: Missing.
     691-719: Missing.
     864-880: WWDFTKFDLPEISNASV → GGGTSLSLTSLKSVMLP
     881-1298: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:761
Mass (Da):84,428
Checksum:i4512BD3DCDD64FE1
GO

Sequence cautioni

Isoform 6 : The sequence AL834190 differs from that shown. Reason: Frameshift at position 745. Curated
The sequence BAA91067.1 differs from that shown. Reason: Frameshift at position 682. Curated
The sequence BAB14457.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB21827.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti165 – 1651W → R in BAA91067 (PubMed:14702039).Curated
Sequence conflicti793 – 7931N → K in AL834190 (PubMed:17974005).Curated
Sequence conflicti869 – 8691K → E in BAB14457 (PubMed:14702039).Curated
Sequence conflicti983 – 9831Q → L in BAB14457 (PubMed:14702039).Curated
Sequence conflicti1105 – 11051Q → E in AAH45609 (PubMed:15489334).Curated
Sequence conflicti1268 – 12681L → V in AAH45609 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei255 – 34490Missing in isoform 4, isoform 5 and isoform 6. 3 PublicationsVSP_030654Add
BLAST
Alternative sequencei691 – 71929Missing in isoform 3 and isoform 6. 2 PublicationsVSP_030655Add
BLAST
Alternative sequencei691 – 6911R → RRSLALSPRLEYSGAILAHC KLRLPGSCHSPASASQVAGT TGAHHHARLIFAFLVEMEFH HVSQAGLELLTSGDLPTSAS QSAGITGVSHRAWP in isoform 5. 1 PublicationVSP_030656
Alternative sequencei721 – 78060Missing in isoform 2. 1 PublicationVSP_030657Add
BLAST
Alternative sequencei864 – 88017WWDFT…SNASV → GGGTSLSLTSLKSVMLP in isoform 6. 1 PublicationVSP_045989Add
BLAST
Alternative sequencei881 – 1298418Missing in isoform 6. 1 PublicationVSP_045990Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ870924 mRNA. Translation: ABI74670.1.
AB051523 mRNA. Translation: BAB21827.1. Different initiation.
AK000301 mRNA. Translation: BAA91067.1. Frameshift.
AK023197 mRNA. Translation: BAB14457.1. Different initiation.
AL834190 mRNA. No translation available.
AC024293 Genomic DNA. No translation available.
AC115097 Genomic DNA. No translation available.
AC116021 Genomic DNA. No translation available.
AC127035 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW67996.1.
CH471064 Genomic DNA. Translation: EAW67999.1.
CH471064 Genomic DNA. Translation: EAW68001.1.
BC045609 mRNA. Translation: AAH45609.1.
CCDSiCCDS31475.1. [Q9C0C7-4]
CCDS73281.1. [Q9C0C7-2]
RefSeqiNP_001254711.1. NM_001267782.1. [Q9C0C7-5]
NP_001254712.1. NM_001267783.1.
NP_001287660.1. NM_001300731.1. [Q9C0C7-2]
NP_060219.2. NM_017749.3. [Q9C0C7-4]
XP_005253066.1. XM_005253009.2. [Q9C0C7-1]
XP_005253068.1. XM_005253011.2. [Q9C0C7-3]
XP_005253071.1. XM_005253014.2. [Q9C0C7-4]
XP_006718322.1. XM_006718259.1. [Q9C0C7-1]
UniGeneiHs.654644.

Genome annotation databases

EnsembliENST00000314845; ENSP00000318313; ENSG00000110497. [Q9C0C7-4]
ENST00000458649; ENSP00000415327; ENSG00000110497.
ENST00000528950; ENSP00000433945; ENSG00000110497. [Q9C0C7-3]
ENST00000534300; ENSP00000431926; ENSG00000110497. [Q9C0C7-2]
GeneIDi55626.
KEGGihsa:55626.
UCSCiuc001ncu.2. human. [Q9C0C7-4]
uc001ncv.3. human. [Q9C0C7-5]
uc001ncw.3. human.
uc001ncx.3. human. [Q9C0C7-2]
uc009ylc.2. human. [Q9C0C7-3]
uc010rgu.2. human. [Q9C0C7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ870924 mRNA. Translation: ABI74670.1.
AB051523 mRNA. Translation: BAB21827.1. Different initiation.
AK000301 mRNA. Translation: BAA91067.1. Frameshift.
AK023197 mRNA. Translation: BAB14457.1. Different initiation.
AL834190 mRNA. No translation available.
AC024293 Genomic DNA. No translation available.
AC115097 Genomic DNA. No translation available.
AC116021 Genomic DNA. No translation available.
AC127035 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW67996.1.
CH471064 Genomic DNA. Translation: EAW67999.1.
CH471064 Genomic DNA. Translation: EAW68001.1.
BC045609 mRNA. Translation: AAH45609.1.
CCDSiCCDS31475.1. [Q9C0C7-4]
CCDS73281.1. [Q9C0C7-2]
RefSeqiNP_001254711.1. NM_001267782.1. [Q9C0C7-5]
NP_001254712.1. NM_001267783.1.
NP_001287660.1. NM_001300731.1. [Q9C0C7-2]
NP_060219.2. NM_017749.3. [Q9C0C7-4]
XP_005253066.1. XM_005253009.2. [Q9C0C7-1]
XP_005253068.1. XM_005253011.2. [Q9C0C7-3]
XP_005253071.1. XM_005253014.2. [Q9C0C7-4]
XP_006718322.1. XM_006718259.1. [Q9C0C7-1]
UniGeneiHs.654644.

3D structure databases

ProteinModelPortaliQ9C0C7.
SMRiQ9C0C7. Positions 28-201, 1010-1037.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120765. 31 interactions.
DIPiDIP-53597N.
IntActiQ9C0C7. 19 interactions.
MINTiMINT-8177757.
STRINGi9606.ENSP00000318313.

PTM databases

PhosphoSiteiQ9C0C7.

Polymorphism and mutation databases

BioMutaiAMBRA1.
DMDMi166215833.

Proteomic databases

MaxQBiQ9C0C7.
PaxDbiQ9C0C7.
PRIDEiQ9C0C7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314845; ENSP00000318313; ENSG00000110497. [Q9C0C7-4]
ENST00000458649; ENSP00000415327; ENSG00000110497.
ENST00000528950; ENSP00000433945; ENSG00000110497. [Q9C0C7-3]
ENST00000534300; ENSP00000431926; ENSG00000110497. [Q9C0C7-2]
GeneIDi55626.
KEGGihsa:55626.
UCSCiuc001ncu.2. human. [Q9C0C7-4]
uc001ncv.3. human. [Q9C0C7-5]
uc001ncw.3. human.
uc001ncx.3. human. [Q9C0C7-2]
uc009ylc.2. human. [Q9C0C7-3]
uc010rgu.2. human. [Q9C0C7-1]

Organism-specific databases

CTDi55626.
GeneCardsiGC11M046417.
H-InvDBHIX0009602.
HGNCiHGNC:25990. AMBRA1.
HPAiCAB017825.
HPA038535.
MIMi611359. gene.
neXtProtiNX_Q9C0C7.
PharmGKBiPA162376307.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG317724.
GeneTreeiENSGT00390000016223.
HOGENOMiHOG000033925.
HOVERGENiHBG103818.
InParanoidiQ9C0C7.
KOiK17985.
OMAiHPSTEHM.
OrthoDBiEOG7HB58G.
PhylomeDBiQ9C0C7.
TreeFamiTF328981.

Enzyme and pathway databases

SignaLinkiQ9C0C7.

Miscellaneous databases

ChiTaRSiAMBRA1. human.
GenomeRNAii55626.
NextBioi60248.
PROiQ9C0C7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9C0C7.
CleanExiHS_AMBRA1.
ExpressionAtlasiQ9C0C7. baseline and differential.
GenevisibleiQ9C0C7. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 464-1298.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    Tissue: Melanoma.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Testis.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism."
    He C., Wei Y., Sun K., Li B., Dong X., Zou Z., Liu Y., Kinch L.N., Khan S., Sinha S., Xavier R.J., Grishin N.V., Xiao G., Eskelinen E.L., Scherer P.E., Whistler J.L., Levine B.
    Cell 154:1085-1099(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BECN2.
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiAMRA1_HUMAN
AccessioniPrimary (citable) accession number: Q9C0C7
Secondary accession number(s): A6XN33
, D3DQP8, G3V193, Q86XD6, Q9H8Z0, Q9NXE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 22, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.