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Protein

CLOCK-interacting pacemaker

Gene

CIPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor which acts as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. Stimulates ARNTL/BMAL1-dependent phosphorylation of CLOCK (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CLOCK-interacting pacemaker
Alternative name(s):
CLOCK-interacting circadian protein
Gene namesi
Name:CIPC
Synonyms:KIAA1737
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20365. CIPC.

Subcellular locationi

  • Nucleus By similarity

  • Note: Co-localizes with CLOCK in the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134877961.

Polymorphism and mutation databases

BioMutaiKIAA1737.
DMDMi117949601.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399CLOCK-interacting pacemakerPRO_0000256133Add
BLAST

Proteomic databases

MaxQBiQ9C0C6.
PaxDbiQ9C0C6.
PRIDEiQ9C0C6.

PTM databases

iPTMnetiQ9C0C6.
PhosphoSiteiQ9C0C6.

Expressioni

Gene expression databases

BgeeiQ9C0C6.
ExpressionAtlasiQ9C0C6. baseline and differential.
GenevisibleiQ9C0C6. HS.

Organism-specific databases

HPAiHPA000644.

Interactioni

Subunit structurei

Interacts with CLOCK. Forms a ternary complex with the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RABGEF1Q9UJ413EBI-5654244,EBI-913954

Protein-protein interaction databases

BioGridi124541. 11 interactions.
IntActiQ9C0C6. 2 interactions.
STRINGi9606.ENSP00000355319.

Structurei

3D structure databases

ProteinModelPortaliQ9C0C6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili333 – 35927Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi104 – 1074Poly-Ser

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410ITM7. Eukaryota.
ENOG4111YPR. LUCA.
GeneTreeiENSGT00510000048522.
HOGENOMiHOG000054192.
HOVERGENiHBG081838.
InParanoidiQ9C0C6.
OMAiPVSPCHA.
OrthoDBiEOG7R56SP.
PhylomeDBiQ9C0C6.
TreeFamiTF332579.

Family and domain databases

InterProiIPR031602. CIPC.
[Graphical view]
PfamiPF15800. CiPC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C0C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKNPSRES PRRLSAKVGK GTEMKKVARQ LGMAAAESDK DSGFSDGSSE
60 70 80 90 100
CLSSAEQMES EDMLSALGWS REDRPRQNSK TAKNAFPTLS PMVVMKNVLV
110 120 130 140 150
KQGSSSSQLQ SWTVQPSFEV ISAQPQLLFL HPPVPSPVSP CHTGEKKSDS
160 170 180 190 200
RNYLPILNSY TKIAPHPGKR GLSLGPEEKG TSGVQKKICT ERLGPSLSSS
210 220 230 240 250
EPTKAGAVPS SPSTPAPPSA KLAEDSALQG VPSLVAGGSP QTLQPVSSSH
260 270 280 290 300
VAKAPSLTFA SPASPVCASD STLHGLESNS PLSPLSANYS SPLWAAEHLC
310 320 330 340 350
RSPDIFSEQR QSKHRRFQNT LVVLHKSGLL EITLKTKELI RQNQATQVEL
360 370 380 390
DQLKEQTQLF IEATKSRAPQ AWAKLQASLT PGSSNTGSDL EAFSDHPAI
Length:399
Mass (Da):42,692
Last modified:October 31, 2006 - v2
Checksum:iA02AE8F6543781D9
GO

Sequence cautioni

The sequence BAB21828.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311L → F.1 Publication
Corresponds to variant rs11552006 [ dbSNP | Ensembl ].
VAR_028881
Natural varianti203 – 2031T → A.
Corresponds to variant rs759593 [ dbSNP | Ensembl ].
VAR_049526

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051524 mRNA. Translation: BAB21828.1. Different initiation.
AK315124 mRNA. Translation: BAG37578.1.
AL834514 mRNA. Translation: CAD39170.1.
AC007686 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81270.1.
BC037300 mRNA. Translation: AAH37300.1.
CCDSiCCDS9855.1.
RefSeqiNP_219494.2. NM_033426.2.
UniGeneiHs.709066.

Genome annotation databases

EnsembliENST00000361786; ENSP00000355319; ENSG00000198894.
GeneIDi85457.
KEGGihsa:85457.
UCSCiuc001xtd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051524 mRNA. Translation: BAB21828.1. Different initiation.
AK315124 mRNA. Translation: BAG37578.1.
AL834514 mRNA. Translation: CAD39170.1.
AC007686 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81270.1.
BC037300 mRNA. Translation: AAH37300.1.
CCDSiCCDS9855.1.
RefSeqiNP_219494.2. NM_033426.2.
UniGeneiHs.709066.

3D structure databases

ProteinModelPortaliQ9C0C6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124541. 11 interactions.
IntActiQ9C0C6. 2 interactions.
STRINGi9606.ENSP00000355319.

PTM databases

iPTMnetiQ9C0C6.
PhosphoSiteiQ9C0C6.

Polymorphism and mutation databases

BioMutaiKIAA1737.
DMDMi117949601.

Proteomic databases

MaxQBiQ9C0C6.
PaxDbiQ9C0C6.
PRIDEiQ9C0C6.

Protocols and materials databases

DNASUi85457.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361786; ENSP00000355319; ENSG00000198894.
GeneIDi85457.
KEGGihsa:85457.
UCSCiuc001xtd.4. human.

Organism-specific databases

CTDi85457.
GeneCardsiCIPC.
HGNCiHGNC:20365. CIPC.
HPAiHPA000644.
neXtProtiNX_Q9C0C6.
PharmGKBiPA134877961.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITM7. Eukaryota.
ENOG4111YPR. LUCA.
GeneTreeiENSGT00510000048522.
HOGENOMiHOG000054192.
HOVERGENiHBG081838.
InParanoidiQ9C0C6.
OMAiPVSPCHA.
OrthoDBiEOG7R56SP.
PhylomeDBiQ9C0C6.
TreeFamiTF332579.

Miscellaneous databases

GenomeRNAii85457.
PROiQ9C0C6.

Gene expression databases

BgeeiQ9C0C6.
ExpressionAtlasiQ9C0C6. baseline and differential.
GenevisibleiQ9C0C6. HS.

Family and domain databases

InterProiIPR031602. CIPC.
[Graphical view]
PfamiPF15800. CiPC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Melanoma.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-31.
    Tissue: Testis.

Entry informationi

Entry nameiCIPC_HUMAN
AccessioniPrimary (citable) accession number: Q9C0C6
Secondary accession number(s): B2RCI1, Q8N389, Q8NDZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 8, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.