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Protein

CLOCK-interacting pacemaker

Gene

CIPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock.By similarity

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processBiological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CLOCK-interacting pacemaker
Alternative name(s):
CLOCK-interacting circadian protein
Gene namesi
Name:CIPC
Synonyms:KIAA1737
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20365. CIPC.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi186K → A: Loss of predominant localization in the nucleus; when associated with A-187. No effect on CAD- AND HSPA5-binding; when associated with A-187. 1 Publication1
Mutagenesisi187K → A: Loss of predominant localization in the nucleus; when associated with A-186. No effect on CAD- AND HSPA5-binding; when associated with A-186. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000198894.
PharmGKBiPA134877961.

Polymorphism and mutation databases

BioMutaiKIAA1737.
DMDMi117949601.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002561331 – 399CLOCK-interacting pacemakerAdd BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei213PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9C0C6.
MaxQBiQ9C0C6.
PaxDbiQ9C0C6.
PeptideAtlasiQ9C0C6.
PRIDEiQ9C0C6.

PTM databases

iPTMnetiQ9C0C6.
PhosphoSitePlusiQ9C0C6.

Expressioni

Gene expression databases

BgeeiENSG00000198894.
ExpressionAtlasiQ9C0C6. baseline and differential.
GenevisibleiQ9C0C6. HS.

Organism-specific databases

HPAiHPA000644.

Interactioni

Subunit structurei

Interacts with CLOCK. Forms a ternary complex with the CLOCK-ARNTL/BMAL1 heterodimer. Interacts with CAD AND HSPA5 (PubMed:26657846).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RABGEF1Q9UJ413EBI-5654244,EBI-913954

Protein-protein interaction databases

BioGridi124541. 12 interactors.
IntActiQ9C0C6. 2 interactors.
STRINGi9606.ENSP00000355319.

Structurei

3D structure databases

ProteinModelPortaliQ9C0C6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili333 – 359Sequence analysisAdd BLAST27

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi186 – 187Nuclear localization signal1 Publication2

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410ITM7. Eukaryota.
ENOG4111YPR. LUCA.
GeneTreeiENSGT00510000048522.
HOGENOMiHOG000054192.
HOVERGENiHBG081838.
InParanoidiQ9C0C6.
OMAiPVSPCHA.
OrthoDBiEOG091G0KQJ.
PhylomeDBiQ9C0C6.
TreeFamiTF332579.

Family and domain databases

InterProiView protein in InterPro
IPR031602. CIPC.
PfamiView protein in Pfam
PF15800. CiPC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9C0C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKNPSRES PRRLSAKVGK GTEMKKVARQ LGMAAAESDK DSGFSDGSSE
60 70 80 90 100
CLSSAEQMES EDMLSALGWS REDRPRQNSK TAKNAFPTLS PMVVMKNVLV
110 120 130 140 150
KQGSSSSQLQ SWTVQPSFEV ISAQPQLLFL HPPVPSPVSP CHTGEKKSDS
160 170 180 190 200
RNYLPILNSY TKIAPHPGKR GLSLGPEEKG TSGVQKKICT ERLGPSLSSS
210 220 230 240 250
EPTKAGAVPS SPSTPAPPSA KLAEDSALQG VPSLVAGGSP QTLQPVSSSH
260 270 280 290 300
VAKAPSLTFA SPASPVCASD STLHGLESNS PLSPLSANYS SPLWAAEHLC
310 320 330 340 350
RSPDIFSEQR QSKHRRFQNT LVVLHKSGLL EITLKTKELI RQNQATQVEL
360 370 380 390
DQLKEQTQLF IEATKSRAPQ AWAKLQASLT PGSSNTGSDL EAFSDHPAI
Length:399
Mass (Da):42,692
Last modified:October 31, 2006 - v2
Checksum:iA02AE8F6543781D9
GO

Sequence cautioni

The sequence BAB21828 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02888131L → F1 PublicationCorresponds to variant dbSNP:rs11552006Ensembl.1
Natural variantiVAR_049526203T → A. Corresponds to variant dbSNP:rs759593Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051524 mRNA. Translation: BAB21828.1. Different initiation.
AK315124 mRNA. Translation: BAG37578.1.
AL834514 mRNA. Translation: CAD39170.1.
AC007686 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81270.1.
BC037300 mRNA. Translation: AAH37300.1.
CCDSiCCDS9855.1.
RefSeqiNP_219494.2. NM_033426.2.
UniGeneiHs.709066.

Genome annotation databases

EnsembliENST00000361786; ENSP00000355319; ENSG00000198894.
GeneIDi85457.
KEGGihsa:85457.
UCSCiuc001xtd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCIPC_HUMAN
AccessioniPrimary (citable) accession number: Q9C0C6
Secondary accession number(s): B2RCI1, Q8N389, Q8NDZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: August 30, 2017
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot