Q9C0C4 (SEM4C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Semaphorin-4C

Gene names

Name:	SEMA4C
Synonyms:	KIAA1739, SEMAI
ORF Names:	UNQ5855/PRO34487

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	833 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration By similarity. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. Ref.4
Subunit structure	Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) By similarity. Interacts with NCDN By similarity. Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 By similarity.
Subcellular location	Cell junction › synapse › postsynaptic cell membrane › postsynaptic density; Single-pass type I membrane protein By similarity. Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Belongs to the semaphorin family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 PSI domain. Contains 1 Sema domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Cell junction Cell membrane Cytoplasmic vesicle Membrane Postsynaptic cell membrane Synapse
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell migration in hindbrain Inferred from sequence or structural similarity. Source: UniProtKB cerebellum development Inferred from electronic annotation. Source: Compara muscle cell differentiation Inferred from direct assay Ref.4. Source: UniProtKB neural tube closure Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of stress-activated MAPK cascade Inferred from direct assay Ref.4. Source: UniProtKB semaphorin-plexin signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic density Inferred from sequence or structural similarity. Source: UniProtKB postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 833	813	Semaphorin-4C		PRO_0000032325
Regions
	Topological domain	21 – 663	643	Extracellular Potential
	Transmembrane	664 – 684	21	Helical; Potential
	Topological domain	685 – 833	149	Cytoplasmic Potential
	Domain	30 – 497	468	Sema
	Domain	499 – 551	53	PSI
	Domain	556 – 644	89	Ig-like C2-type
	Region	46 – 489	444	Dominant negative effect on myogenic differentiation By similarity
	Motif	830 – 833	4	PDZ-binding
	Compositional bias	708 – 773	66	Pro-rich
Amino acid modifications
	Glycosylation	106	1	N-linked (GlcNAc...) Potential
	Glycosylation	121	1	N-linked (GlcNAc...) Potential
	Glycosylation	310	1	N-linked (GlcNAc...) Potential
	Glycosylation	419	1	N-linked (GlcNAc...) Potential
	Glycosylation	522	1	N-linked (GlcNAc...) Potential
	Glycosylation	564	1	N-linked (GlcNAc...) Potential
	Disulfide bond	99 ↔ 110		By similarity
	Disulfide bond	128 ↔ 137		By similarity
	Disulfide bond	261 ↔ 370		By similarity
	Disulfide bond	285 ↔ 330		By similarity
	Disulfide bond	500 ↔ 517		By similarity
	Disulfide bond	509 ↔ 526		By similarity
Experimental info
	Sequence conflict	602	1	S → T in AAQ89201. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9C0C4 [UniParc]. Last modified May 24, 2004. Version 2. Checksum: 075FDC0A392F0CE3	FASTA	833	92,623
	10 20 30 40 50 60 MAPHWAVWLL AARLWGLGIG AEVWWNLVPR KTVSSGELAT VVRRFSQTGI QDFLTLTLTE 70 80 90 100 110 120 PTGLLYVGAR EALFAFSMEA LELQGAISWE APVEKKTECI QKGKNNQTEC FNFIRFLQPY 130 140 150 160 170 180 NASHLYVCGT YAFQPKCTYV NMLTFTLEHG EFEDGKGKCP YDPAKGHAGL LVDGELYSAT 190 200 210 220 230 240 LNNFLGTEPI ILRNMGPHHS MKTEYLAFWL NEPHFVGSAY VPESVGSFTG DDDKVYFFFR 250 260 270 280 290 300 ERAVESDCYA EQVVARVARV CKGDMGGART LQRKWTTFLK ARLACSAPNW QLYFNQLQAM 310 320 330 340 350 360 HTLQDTSWHN TTFFGVFQAQ WGDMYLSAIC EYQLEEIQRV FEGPYKEYHE EAQKWDRYTD 370 380 390 400 410 420 PVPSPRPGSC INNWHRRHGY TSSLELPDNI LNFVKKHPLM EEQVGPRWSR PLLVKKGTNF 430 440 450 460 470 480 THLVADRVTG LDGATYTVLF IGTGDGWLLK AVSLGPWVHL IEELQLFDQE PMRSLVLSQS 490 500 510 520 530 540 KKLLFAGSRS QLVQLPVADC MKYRSCADCV LARDPYCAWS VNTSRCVAVG GHSGSLLIQH 550 560 570 580 590 600 VMTSDTSGIC NLRGSKKVRP TPKNITVVAG TDLVLPCHLS SNLAHARWTF GGRDLPAEQP 610 620 630 640 650 660 GSFLYDARLQ ALVVMAAQPR HAGAYHCFSE EQGARLAAEG YLVAVVAGPS VTLEARAPLE 670 680 690 700 710 720 NLGLVWLAVV ALGAVCLVLL LLVLSLRRRL REELEKGAKA TERTLVYPLE LPKEPTSPPF 730 740 750 760 770 780 RPCPEPDEKL WDPVGYYYSD GSLKIVPGHA RCQPGGGPPS PPPGIPGQPL PSPTRLHLGG 790 800 810 820 830 GRNSNANGYV RLQLGGEDRG GLGHPLPELA DELRRKLQQR QPLPDSNPEE SSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[3]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-833. Tissue: Brain.
[4]	"Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway." Wu H., Wang X., Liu S., Wu Y., Zhao T., Chen X., Zhu L., Wu Y., Ding X., Peng X., Yuan J., Wang X., Fan W., Fan M. Eur. J. Cell Biol. 86:331-344(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358842 mRNA. Translation: AAQ89201.1. BC017476 mRNA. Translation: AAH17476.2. BC109103 mRNA. Translation: AAI09104.1. BC109104 mRNA. Translation: AAI09105.1. AB051526 mRNA. Translation: BAB21830.1.
IPI	IPI00073763.
RefSeq	NP_060259.4. NM_017789.4.
UniGene	Hs.516220.
3D structure databases
ProteinModelPortal	Q9C0C4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000306844.
PTM databases
PhosphoSite	Q9C0C4.
Polymorphism databases
DMDM	47606208.
Proteomic databases
PaxDb	Q9C0C4.
PRIDE	Q9C0C4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000305476; ENSP00000306844; ENSG00000168758.
GeneID	54910.
KEGG	hsa:54910.
UCSC	uc002sxg.4. human.
Organism-specific databases
CTD	54910.
GeneCards	GC02M097525.
HGNC	HGNC:10731. SEMA4C.
HPA	HPA011090.
MIM	604462. gene.
neXtProt	NX_Q9C0C4.
PharmGKB	PA35653.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG293968.
HOGENOM	HOG000116087.
HOVERGEN	HBG061165.
InParanoid	Q9C0C4.
KO	K06521.
OMA	YNASHLY.
OrthoDB	EOG4WH8K5.
PhylomeDB	Q9C0C4.
Gene expression databases
ArrayExpress	Q9C0C4.
Bgee	Q9C0C4.
CleanEx	HS_SEMA4C.
Genevestigator	Q9C0C4.
GermOnline	ENSG00000168758. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 1 hit. 2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003659. Plexin-like. IPR016201. Plexin-like_fold. IPR002165. Plexin_repeat. IPR027231. Semaphorin. IPR001627. Semaphorin/CD100_Ag. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
PANTHER	PTHR11036. PTHR11036. 1 hit.
Pfam	PF01437. PSI. 1 hit. PF01403. Sema. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. SM00423. PSI. 1 hit. SM00630. Sema. 1 hit. [Graphical view]
SUPFAM	SSF103575. Plexin-like_fold. 1 hit. SSF101912. Sema. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS51004. SEMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	54910.
NextBio	57962.
SOURCE	Search...

Entry information

Entry name

SEM4C_HUMAN

Accession

Primary (citable) accession number: Q9C0C4
Secondary accession number(s): Q32MJ3, Q7Z5X0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	May 24, 2004
Last modified:	May 1, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.