SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9C0C4

- SEM4C_HUMAN

UniProt

Q9C0C4 - SEM4C_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Semaphorin-4C
Gene
SEMA4C, KIAA1739, SEMAI, UNQ5855/PRO34487
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration By similarity. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.1 Publication

GO - Molecular functioni

  1. receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cell migration in hindbrain Source: UniProtKB
  2. cerebellum development Source: Ensembl
  3. muscle cell differentiation Source: UniProtKB
  4. neural tube closure Source: UniProtKB
  5. positive regulation of stress-activated MAPK cascade Source: UniProtKB
  6. semaphorin-plexin signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4C
Gene namesi
Name:SEMA4C
Synonyms:KIAA1739, SEMAI
ORF Names:UNQ5855/PRO34487
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:10731. SEMA4C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 663643Extracellular Reviewed prediction
Add
BLAST
Transmembranei664 – 68421Helical; Reviewed prediction
Add
BLAST
Topological domaini685 – 833149Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. extracellular space Source: UniProt
  3. integral component of membrane Source: UniProtKB-KW
  4. postsynaptic density Source: UniProtKB
  5. postsynaptic membrane Source: UniProtKB-KW
  6. synaptic vesicle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35653.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 833813Semaphorin-4C
PRO_0000032325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi99 ↔ 110 By similarity
Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi121 – 1211N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi128 ↔ 137 By similarity
Disulfide bondi261 ↔ 370 By similarity
Disulfide bondi285 ↔ 330 By similarity
Glycosylationi310 – 3101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi419 – 4191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi500 ↔ 517 By similarity
Disulfide bondi509 ↔ 526 By similarity
Glycosylationi522 – 5221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi564 – 5641N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9C0C4.
PaxDbiQ9C0C4.
PRIDEiQ9C0C4.

PTM databases

PhosphoSiteiQ9C0C4.

Expressioni

Gene expression databases

ArrayExpressiQ9C0C4.
BgeeiQ9C0C4.
CleanExiHS_SEMA4C.
GenevestigatoriQ9C0C4.

Organism-specific databases

HPAiHPA011090.

Interactioni

Subunit structurei

Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) By similarity. Interacts with NCDN By similarity. Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 By similarity.

Protein-protein interaction databases

BioGridi120254. 5 interactions.
STRINGi9606.ENSP00000306844.

Structurei

3D structure databases

ProteinModelPortaliQ9C0C4.
SMRiQ9C0C4. Positions 28-632.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 497468Sema
Add
BLAST
Domaini499 – 55153PSI
Add
BLAST
Domaini556 – 64489Ig-like C2-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 489444Dominant negative effect on myogenic differentiation By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi830 – 8334PDZ-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi708 – 77366Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293968.
HOGENOMiHOG000116087.
HOVERGENiHBG061165.
InParanoidiQ9C0C4.
KOiK06521.
OMAiASHLYVC.
OrthoDBiEOG712TVJ.
PhylomeDBiQ9C0C4.
TreeFamiTF316102.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9C0C4-1 [UniParc]FASTAAdd to Basket

« Hide

MAPHWAVWLL AARLWGLGIG AEVWWNLVPR KTVSSGELAT VVRRFSQTGI    50
QDFLTLTLTE PTGLLYVGAR EALFAFSMEA LELQGAISWE APVEKKTECI 100
QKGKNNQTEC FNFIRFLQPY NASHLYVCGT YAFQPKCTYV NMLTFTLEHG 150
EFEDGKGKCP YDPAKGHAGL LVDGELYSAT LNNFLGTEPI ILRNMGPHHS 200
MKTEYLAFWL NEPHFVGSAY VPESVGSFTG DDDKVYFFFR ERAVESDCYA 250
EQVVARVARV CKGDMGGART LQRKWTTFLK ARLACSAPNW QLYFNQLQAM 300
HTLQDTSWHN TTFFGVFQAQ WGDMYLSAIC EYQLEEIQRV FEGPYKEYHE 350
EAQKWDRYTD PVPSPRPGSC INNWHRRHGY TSSLELPDNI LNFVKKHPLM 400
EEQVGPRWSR PLLVKKGTNF THLVADRVTG LDGATYTVLF IGTGDGWLLK 450
AVSLGPWVHL IEELQLFDQE PMRSLVLSQS KKLLFAGSRS QLVQLPVADC 500
MKYRSCADCV LARDPYCAWS VNTSRCVAVG GHSGSLLIQH VMTSDTSGIC 550
NLRGSKKVRP TPKNITVVAG TDLVLPCHLS SNLAHARWTF GGRDLPAEQP 600
GSFLYDARLQ ALVVMAAQPR HAGAYHCFSE EQGARLAAEG YLVAVVAGPS 650
VTLEARAPLE NLGLVWLAVV ALGAVCLVLL LLVLSLRRRL REELEKGAKA 700
TERTLVYPLE LPKEPTSPPF RPCPEPDEKL WDPVGYYYSD GSLKIVPGHA 750
RCQPGGGPPS PPPGIPGQPL PSPTRLHLGG GRNSNANGYV RLQLGGEDRG 800
GLGHPLPELA DELRRKLQQR QPLPDSNPEE SSV 833
Length:833
Mass (Da):92,623
Last modified:May 24, 2004 - v2
Checksum:i075FDC0A392F0CE3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti602 – 6021S → T in AAQ89201. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358842 mRNA. Translation: AAQ89201.1.
BC017476 mRNA. Translation: AAH17476.2.
BC109103 mRNA. Translation: AAI09104.1.
BC109104 mRNA. Translation: AAI09105.1.
AB051526 mRNA. Translation: BAB21830.1.
CCDSiCCDS2029.1.
RefSeqiNP_060259.4. NM_017789.4.
UniGeneiHs.516220.

Genome annotation databases

EnsembliENST00000305476; ENSP00000306844; ENSG00000168758.
GeneIDi54910.
KEGGihsa:54910.
UCSCiuc002sxg.4. human.

Polymorphism databases

DMDMi47606208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358842 mRNA. Translation: AAQ89201.1 .
BC017476 mRNA. Translation: AAH17476.2 .
BC109103 mRNA. Translation: AAI09104.1 .
BC109104 mRNA. Translation: AAI09105.1 .
AB051526 mRNA. Translation: BAB21830.1 .
CCDSi CCDS2029.1.
RefSeqi NP_060259.4. NM_017789.4.
UniGenei Hs.516220.

3D structure databases

ProteinModelPortali Q9C0C4.
SMRi Q9C0C4. Positions 28-632.
ModBasei Search...

Protein-protein interaction databases

BioGridi 120254. 5 interactions.
STRINGi 9606.ENSP00000306844.

PTM databases

PhosphoSitei Q9C0C4.

Polymorphism databases

DMDMi 47606208.

Proteomic databases

MaxQBi Q9C0C4.
PaxDbi Q9C0C4.
PRIDEi Q9C0C4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305476 ; ENSP00000306844 ; ENSG00000168758 .
GeneIDi 54910.
KEGGi hsa:54910.
UCSCi uc002sxg.4. human.

Organism-specific databases

CTDi 54910.
GeneCardsi GC02M097525.
HGNCi HGNC:10731. SEMA4C.
HPAi HPA011090.
MIMi 604462. gene.
neXtProti NX_Q9C0C4.
PharmGKBi PA35653.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293968.
HOGENOMi HOG000116087.
HOVERGENi HBG061165.
InParanoidi Q9C0C4.
KOi K06521.
OMAi ASHLYVC.
OrthoDBi EOG712TVJ.
PhylomeDBi Q9C0C4.
TreeFami TF316102.

Miscellaneous databases

GeneWikii SEMA4C.
GenomeRNAii 54910.
NextBioi 57962.
PROi Q9C0C4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9C0C4.
Bgeei Q9C0C4.
CleanExi HS_SEMA4C.
Genevestigatori Q9C0C4.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
Pfami PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  3. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-833.
    Tissue: Brain.
  4. "Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway."
    Wu H., Wang X., Liu S., Wu Y., Zhao T., Chen X., Zhu L., Wu Y., Ding X., Peng X., Yuan J., Wang X., Fan W., Fan M.
    Eur. J. Cell Biol. 86:331-344(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSEM4C_HUMAN
AccessioniPrimary (citable) accession number: Q9C0C4
Secondary accession number(s): Q32MJ3, Q7Z5X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi