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Q9C0C4 (SEM4C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Semaphorin-4C
Gene names
Name:SEMA4C
Synonyms:KIAA1739, SEMAI
ORF Names:UNQ5855/PRO34487
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length833 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration By similarity. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. Ref.4

Subunit structure

Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) By similarity. Interacts with NCDN By similarity. Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 By similarity.

Subcellular location

Cell junctionsynapsepostsynaptic cell membranepostsynaptic density; Single-pass type I membrane protein By similarity. Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the semaphorin family.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 PSI domain.

Contains 1 Sema domain.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentCell junction
Cell membrane
Cytoplasmic vesicle
Membrane
Postsynaptic cell membrane
Synapse
   DomainImmunoglobulin domain
Signal
Transmembrane
Transmembrane helix
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell migration in hindbrain

Inferred from sequence or structural similarity. Source: UniProtKB

cerebellum development

Inferred from electronic annotation. Source: Ensembl

muscle cell differentiation

Inferred from direct assay Ref.4. Source: UniProtKB

neural tube closure

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of stress-activated MAPK cascade

Inferred from direct assay Ref.4. Source: UniProtKB

semaphorin-plexin signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

extracellular space

Inferred from direct assay PubMed 22664934. Source: UniProt

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

postsynaptic density

Inferred from sequence or structural similarity. Source: UniProtKB

postsynaptic membrane

Inferred from electronic annotation. Source: UniProtKB-KW

synaptic vesicle membrane

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionreceptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 833813Semaphorin-4C
PRO_0000032325

Regions

Topological domain21 – 663643Extracellular Potential
Transmembrane664 – 68421Helical; Potential
Topological domain685 – 833149Cytoplasmic Potential
Domain30 – 497468Sema
Domain499 – 55153PSI
Domain556 – 64489Ig-like C2-type
Region46 – 489444Dominant negative effect on myogenic differentiation By similarity
Motif830 – 8334PDZ-binding
Compositional bias708 – 77366Pro-rich

Amino acid modifications

Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation1211N-linked (GlcNAc...) Potential
Glycosylation3101N-linked (GlcNAc...) Potential
Glycosylation4191N-linked (GlcNAc...) Potential
Glycosylation5221N-linked (GlcNAc...) Potential
Glycosylation5641N-linked (GlcNAc...) Potential
Disulfide bond99 ↔ 110 By similarity
Disulfide bond128 ↔ 137 By similarity
Disulfide bond261 ↔ 370 By similarity
Disulfide bond285 ↔ 330 By similarity
Disulfide bond500 ↔ 517 By similarity
Disulfide bond509 ↔ 526 By similarity

Experimental info

Sequence conflict6021S → T in AAQ89201. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9C0C4 [UniParc].

Last modified May 24, 2004. Version 2.
Checksum: 075FDC0A392F0CE3

FASTA83392,623
        10         20         30         40         50         60 
MAPHWAVWLL AARLWGLGIG AEVWWNLVPR KTVSSGELAT VVRRFSQTGI QDFLTLTLTE 

        70         80         90        100        110        120 
PTGLLYVGAR EALFAFSMEA LELQGAISWE APVEKKTECI QKGKNNQTEC FNFIRFLQPY 

       130        140        150        160        170        180 
NASHLYVCGT YAFQPKCTYV NMLTFTLEHG EFEDGKGKCP YDPAKGHAGL LVDGELYSAT 

       190        200        210        220        230        240 
LNNFLGTEPI ILRNMGPHHS MKTEYLAFWL NEPHFVGSAY VPESVGSFTG DDDKVYFFFR 

       250        260        270        280        290        300 
ERAVESDCYA EQVVARVARV CKGDMGGART LQRKWTTFLK ARLACSAPNW QLYFNQLQAM 

       310        320        330        340        350        360 
HTLQDTSWHN TTFFGVFQAQ WGDMYLSAIC EYQLEEIQRV FEGPYKEYHE EAQKWDRYTD 

       370        380        390        400        410        420 
PVPSPRPGSC INNWHRRHGY TSSLELPDNI LNFVKKHPLM EEQVGPRWSR PLLVKKGTNF 

       430        440        450        460        470        480 
THLVADRVTG LDGATYTVLF IGTGDGWLLK AVSLGPWVHL IEELQLFDQE PMRSLVLSQS 

       490        500        510        520        530        540 
KKLLFAGSRS QLVQLPVADC MKYRSCADCV LARDPYCAWS VNTSRCVAVG GHSGSLLIQH 

       550        560        570        580        590        600 
VMTSDTSGIC NLRGSKKVRP TPKNITVVAG TDLVLPCHLS SNLAHARWTF GGRDLPAEQP 

       610        620        630        640        650        660 
GSFLYDARLQ ALVVMAAQPR HAGAYHCFSE EQGARLAAEG YLVAVVAGPS VTLEARAPLE 

       670        680        690        700        710        720 
NLGLVWLAVV ALGAVCLVLL LLVLSLRRRL REELEKGAKA TERTLVYPLE LPKEPTSPPF 

       730        740        750        760        770        780 
RPCPEPDEKL WDPVGYYYSD GSLKIVPGHA RCQPGGGPPS PPPGIPGQPL PSPTRLHLGG 

       790        800        810        820        830 
GRNSNANGYV RLQLGGEDRG GLGHPLPELA DELRRKLQQR QPLPDSNPEE SSV 

« Hide

References

« Hide 'large scale' references
[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[3]"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-833.
Tissue: Brain.
[4]"Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway."
Wu H., Wang X., Liu S., Wu Y., Zhao T., Chen X., Zhu L., Wu Y., Ding X., Peng X., Yuan J., Wang X., Fan W., Fan M.
Eur. J. Cell Biol. 86:331-344(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358842 mRNA. Translation: AAQ89201.1.
BC017476 mRNA. Translation: AAH17476.2.
BC109103 mRNA. Translation: AAI09104.1.
BC109104 mRNA. Translation: AAI09105.1.
AB051526 mRNA. Translation: BAB21830.1.
CCDSCCDS2029.1.
RefSeqNP_060259.4. NM_017789.4.
UniGeneHs.516220.

3D structure databases

ProteinModelPortalQ9C0C4.
SMRQ9C0C4. Positions 28-632.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120254. 5 interactions.
STRING9606.ENSP00000306844.

PTM databases

PhosphoSiteQ9C0C4.

Polymorphism databases

DMDM47606208.

Proteomic databases

MaxQBQ9C0C4.
PaxDbQ9C0C4.
PRIDEQ9C0C4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000305476; ENSP00000306844; ENSG00000168758.
GeneID54910.
KEGGhsa:54910.
UCSCuc002sxg.4. human.

Organism-specific databases

CTD54910.
GeneCardsGC02M097525.
HGNCHGNC:10731. SEMA4C.
HPAHPA011090.
MIM604462. gene.
neXtProtNX_Q9C0C4.
PharmGKBPA35653.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG293968.
HOGENOMHOG000116087.
HOVERGENHBG061165.
InParanoidQ9C0C4.
KOK06521.
OMAASHLYVC.
OrthoDBEOG712TVJ.
PhylomeDBQ9C0C4.
TreeFamTF316102.

Gene expression databases

ArrayExpressQ9C0C4.
BgeeQ9C0C4.
CleanExHS_SEMA4C.
GenevestigatorQ9C0C4.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERPTHR11036. PTHR11036. 1 hit.
PfamPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSEMA4C.
GenomeRNAi54910.
NextBio57962.
PROQ9C0C4.
SOURCESearch...

Entry information

Entry nameSEM4C_HUMAN
AccessionPrimary (citable) accession number: Q9C0C4
Secondary accession number(s): Q32MJ3, Q7Z5X0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM