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Protein

Semaphorin-4C

Gene

SEMA4C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168758-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4C
Gene namesi
Name:SEMA4C
Synonyms:KIAA1739, SEMAI
ORF Names:UNQ5855/PRO34487
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:10731. SEMA4C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 663ExtracellularSequence analysisAdd BLAST643
Transmembranei664 – 684HelicalSequence analysisAdd BLAST21
Topological domaini685 – 833CytoplasmicSequence analysisAdd BLAST149

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi54910.
OpenTargetsiENSG00000168758.
PharmGKBiPA35653.

Polymorphism and mutation databases

BioMutaiSEMA4C.
DMDMi47606208.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003232521 – 833Semaphorin-4CAdd BLAST813

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi99 ↔ 110By similarity
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi128 ↔ 137By similarity
Disulfide bondi261 ↔ 370By similarity
Disulfide bondi285 ↔ 330By similarity
Glycosylationi310N-linked (GlcNAc...)Sequence analysis1
Glycosylationi419N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi500 ↔ 517By similarity
Disulfide bondi509 ↔ 526By similarity
Glycosylationi522N-linked (GlcNAc...)Sequence analysis1
Glycosylationi564N-linked (GlcNAc...)Sequence analysis1
Modified residuei742PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9C0C4.
MaxQBiQ9C0C4.
PaxDbiQ9C0C4.
PeptideAtlasiQ9C0C4.
PRIDEiQ9C0C4.

PTM databases

iPTMnetiQ9C0C4.
PhosphoSitePlusiQ9C0C4.

Expressioni

Gene expression databases

BgeeiENSG00000168758.
CleanExiHS_SEMA4C.
ExpressionAtlasiQ9C0C4. baseline and differential.
GenevisibleiQ9C0C4. HS.

Organism-specific databases

HPAiHPA011090.

Interactioni

Subunit structurei

Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) (By similarity). Interacts with NCDN (By similarity). Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT31Q153235EBI-10303490,EBI-948001
KRT40Q6A1623EBI-10303490,EBI-10171697
NOTCH2NLQ7Z3S95EBI-10303490,EBI-945833
PNMA1Q8ND905EBI-10303490,EBI-302345
RCHY1Q96PM53EBI-10303490,EBI-947779

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120254. 21 interactors.
IntActiQ9C0C4. 12 interactors.
STRINGi9606.ENSP00000306844.

Structurei

3D structure databases

ProteinModelPortaliQ9C0C4.
SMRiQ9C0C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 497SemaPROSITE-ProRule annotationAdd BLAST468
Domaini499 – 551PSIAdd BLAST53
Domaini556 – 644Ig-like C2-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 489Dominant negative effect on myogenic differentiationBy similarityAdd BLAST444

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi830 – 833PDZ-binding4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi708 – 773Pro-richAdd BLAST66

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000116087.
HOVERGENiHBG061165.
InParanoidiQ9C0C4.
KOiK06521.
OMAiQPYNASH.
OrthoDBiEOG091G01W0.
PhylomeDBiQ9C0C4.
TreeFamiTF316102.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR002165. Plexin_repeat.
IPR016201. PSI.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9C0C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPHWAVWLL AARLWGLGIG AEVWWNLVPR KTVSSGELAT VVRRFSQTGI
60 70 80 90 100
QDFLTLTLTE PTGLLYVGAR EALFAFSMEA LELQGAISWE APVEKKTECI
110 120 130 140 150
QKGKNNQTEC FNFIRFLQPY NASHLYVCGT YAFQPKCTYV NMLTFTLEHG
160 170 180 190 200
EFEDGKGKCP YDPAKGHAGL LVDGELYSAT LNNFLGTEPI ILRNMGPHHS
210 220 230 240 250
MKTEYLAFWL NEPHFVGSAY VPESVGSFTG DDDKVYFFFR ERAVESDCYA
260 270 280 290 300
EQVVARVARV CKGDMGGART LQRKWTTFLK ARLACSAPNW QLYFNQLQAM
310 320 330 340 350
HTLQDTSWHN TTFFGVFQAQ WGDMYLSAIC EYQLEEIQRV FEGPYKEYHE
360 370 380 390 400
EAQKWDRYTD PVPSPRPGSC INNWHRRHGY TSSLELPDNI LNFVKKHPLM
410 420 430 440 450
EEQVGPRWSR PLLVKKGTNF THLVADRVTG LDGATYTVLF IGTGDGWLLK
460 470 480 490 500
AVSLGPWVHL IEELQLFDQE PMRSLVLSQS KKLLFAGSRS QLVQLPVADC
510 520 530 540 550
MKYRSCADCV LARDPYCAWS VNTSRCVAVG GHSGSLLIQH VMTSDTSGIC
560 570 580 590 600
NLRGSKKVRP TPKNITVVAG TDLVLPCHLS SNLAHARWTF GGRDLPAEQP
610 620 630 640 650
GSFLYDARLQ ALVVMAAQPR HAGAYHCFSE EQGARLAAEG YLVAVVAGPS
660 670 680 690 700
VTLEARAPLE NLGLVWLAVV ALGAVCLVLL LLVLSLRRRL REELEKGAKA
710 720 730 740 750
TERTLVYPLE LPKEPTSPPF RPCPEPDEKL WDPVGYYYSD GSLKIVPGHA
760 770 780 790 800
RCQPGGGPPS PPPGIPGQPL PSPTRLHLGG GRNSNANGYV RLQLGGEDRG
810 820 830
GLGHPLPELA DELRRKLQQR QPLPDSNPEE SSV
Length:833
Mass (Da):92,623
Last modified:May 24, 2004 - v2
Checksum:i075FDC0A392F0CE3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti602S → T in AAQ89201 (PubMed:12975309).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358842 mRNA. Translation: AAQ89201.1.
BC017476 mRNA. Translation: AAH17476.2.
BC109103 mRNA. Translation: AAI09104.1.
BC109104 mRNA. Translation: AAI09105.1.
AB051526 mRNA. Translation: BAB21830.1.
CCDSiCCDS2029.1.
RefSeqiNP_060259.4. NM_017789.4.
XP_011509680.1. XM_011511378.2.
XP_011509681.1. XM_011511379.2.
XP_011509682.1. XM_011511380.1.
XP_011509683.1. XM_011511381.1.
XP_011509684.1. XM_011511382.2.
XP_011509685.1. XM_011511383.1.
UniGeneiHs.516220.

Genome annotation databases

EnsembliENST00000305476; ENSP00000306844; ENSG00000168758.
GeneIDi54910.
KEGGihsa:54910.
UCSCiuc002sxh.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358842 mRNA. Translation: AAQ89201.1.
BC017476 mRNA. Translation: AAH17476.2.
BC109103 mRNA. Translation: AAI09104.1.
BC109104 mRNA. Translation: AAI09105.1.
AB051526 mRNA. Translation: BAB21830.1.
CCDSiCCDS2029.1.
RefSeqiNP_060259.4. NM_017789.4.
XP_011509680.1. XM_011511378.2.
XP_011509681.1. XM_011511379.2.
XP_011509682.1. XM_011511380.1.
XP_011509683.1. XM_011511381.1.
XP_011509684.1. XM_011511382.2.
XP_011509685.1. XM_011511383.1.
UniGeneiHs.516220.

3D structure databases

ProteinModelPortaliQ9C0C4.
SMRiQ9C0C4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120254. 21 interactors.
IntActiQ9C0C4. 12 interactors.
STRINGi9606.ENSP00000306844.

PTM databases

iPTMnetiQ9C0C4.
PhosphoSitePlusiQ9C0C4.

Polymorphism and mutation databases

BioMutaiSEMA4C.
DMDMi47606208.

Proteomic databases

EPDiQ9C0C4.
MaxQBiQ9C0C4.
PaxDbiQ9C0C4.
PeptideAtlasiQ9C0C4.
PRIDEiQ9C0C4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305476; ENSP00000306844; ENSG00000168758.
GeneIDi54910.
KEGGihsa:54910.
UCSCiuc002sxh.5. human.

Organism-specific databases

CTDi54910.
DisGeNETi54910.
GeneCardsiSEMA4C.
HGNCiHGNC:10731. SEMA4C.
HPAiHPA011090.
MIMi604462. gene.
neXtProtiNX_Q9C0C4.
OpenTargetsiENSG00000168758.
PharmGKBiPA35653.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000116087.
HOVERGENiHBG061165.
InParanoidiQ9C0C4.
KOiK06521.
OMAiQPYNASH.
OrthoDBiEOG091G01W0.
PhylomeDBiQ9C0C4.
TreeFamiTF316102.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168758-MONOMER.

Miscellaneous databases

GeneWikiiSEMA4C.
GenomeRNAii54910.
PROiQ9C0C4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168758.
CleanExiHS_SEMA4C.
ExpressionAtlasiQ9C0C4. baseline and differential.
GenevisibleiQ9C0C4. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR002165. Plexin_repeat.
IPR016201. PSI.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEM4C_HUMAN
AccessioniPrimary (citable) accession number: Q9C0C4
Secondary accession number(s): Q32MJ3, Q7Z5X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.