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Q9C0C4

- SEM4C_HUMAN

UniProt

Q9C0C4 - SEM4C_HUMAN

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Protein

Semaphorin-4C

Gene

SEMA4C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.By similarity1 Publication

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. cell migration in hindbrain Source: UniProtKB
  2. cerebellum development Source: Ensembl
  3. muscle cell differentiation Source: UniProtKB
  4. neural tube closure Source: UniProtKB
  5. positive regulation of stress-activated MAPK cascade Source: UniProtKB
  6. semaphorin-plexin signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4C
Gene namesi
Name:SEMA4C
Synonyms:KIAA1739, SEMAI
ORF Names:UNQ5855/PRO34487
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:10731. SEMA4C.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. extracellular space Source: UniProt
  3. integral component of membrane Source: UniProtKB-KW
  4. postsynaptic density Source: UniProtKB
  5. postsynaptic membrane Source: UniProtKB-KW
  6. synaptic vesicle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35653.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 833813Semaphorin-4CPRO_0000032325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi99 ↔ 110By similarity
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi128 ↔ 137By similarity
Disulfide bondi261 ↔ 370By similarity
Disulfide bondi285 ↔ 330By similarity
Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi500 ↔ 517By similarity
Disulfide bondi509 ↔ 526By similarity
Glycosylationi522 – 5221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi564 – 5641N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9C0C4.
PaxDbiQ9C0C4.
PRIDEiQ9C0C4.

PTM databases

PhosphoSiteiQ9C0C4.

Expressioni

Gene expression databases

BgeeiQ9C0C4.
CleanExiHS_SEMA4C.
ExpressionAtlasiQ9C0C4. baseline and differential.
GenevestigatoriQ9C0C4.

Organism-specific databases

HPAiHPA011090.

Interactioni

Subunit structurei

Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) (By similarity). Interacts with NCDN (By similarity). Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi120254. 13 interactions.
STRINGi9606.ENSP00000306844.

Structurei

3D structure databases

ProteinModelPortaliQ9C0C4.
SMRiQ9C0C4. Positions 28-632.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 663643ExtracellularSequence AnalysisAdd
BLAST
Topological domaini685 – 833149CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei664 – 68421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 497468SemaPROSITE-ProRule annotationAdd
BLAST
Domaini499 – 55153PSIAdd
BLAST
Domaini556 – 64489Ig-like C2-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 489444Dominant negative effect on myogenic differentiationBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi830 – 8334PDZ-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi708 – 77366Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293968.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000116087.
HOVERGENiHBG061165.
InParanoidiQ9C0C4.
KOiK06521.
OMAiASHLYVC.
OrthoDBiEOG712TVJ.
PhylomeDBiQ9C0C4.
TreeFamiTF316102.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9C0C4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPHWAVWLL AARLWGLGIG AEVWWNLVPR KTVSSGELAT VVRRFSQTGI
60 70 80 90 100
QDFLTLTLTE PTGLLYVGAR EALFAFSMEA LELQGAISWE APVEKKTECI
110 120 130 140 150
QKGKNNQTEC FNFIRFLQPY NASHLYVCGT YAFQPKCTYV NMLTFTLEHG
160 170 180 190 200
EFEDGKGKCP YDPAKGHAGL LVDGELYSAT LNNFLGTEPI ILRNMGPHHS
210 220 230 240 250
MKTEYLAFWL NEPHFVGSAY VPESVGSFTG DDDKVYFFFR ERAVESDCYA
260 270 280 290 300
EQVVARVARV CKGDMGGART LQRKWTTFLK ARLACSAPNW QLYFNQLQAM
310 320 330 340 350
HTLQDTSWHN TTFFGVFQAQ WGDMYLSAIC EYQLEEIQRV FEGPYKEYHE
360 370 380 390 400
EAQKWDRYTD PVPSPRPGSC INNWHRRHGY TSSLELPDNI LNFVKKHPLM
410 420 430 440 450
EEQVGPRWSR PLLVKKGTNF THLVADRVTG LDGATYTVLF IGTGDGWLLK
460 470 480 490 500
AVSLGPWVHL IEELQLFDQE PMRSLVLSQS KKLLFAGSRS QLVQLPVADC
510 520 530 540 550
MKYRSCADCV LARDPYCAWS VNTSRCVAVG GHSGSLLIQH VMTSDTSGIC
560 570 580 590 600
NLRGSKKVRP TPKNITVVAG TDLVLPCHLS SNLAHARWTF GGRDLPAEQP
610 620 630 640 650
GSFLYDARLQ ALVVMAAQPR HAGAYHCFSE EQGARLAAEG YLVAVVAGPS
660 670 680 690 700
VTLEARAPLE NLGLVWLAVV ALGAVCLVLL LLVLSLRRRL REELEKGAKA
710 720 730 740 750
TERTLVYPLE LPKEPTSPPF RPCPEPDEKL WDPVGYYYSD GSLKIVPGHA
760 770 780 790 800
RCQPGGGPPS PPPGIPGQPL PSPTRLHLGG GRNSNANGYV RLQLGGEDRG
810 820 830
GLGHPLPELA DELRRKLQQR QPLPDSNPEE SSV
Length:833
Mass (Da):92,623
Last modified:May 24, 2004 - v2
Checksum:i075FDC0A392F0CE3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti602 – 6021S → T in AAQ89201. (PubMed:12975309)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358842 mRNA. Translation: AAQ89201.1.
BC017476 mRNA. Translation: AAH17476.2.
BC109103 mRNA. Translation: AAI09104.1.
BC109104 mRNA. Translation: AAI09105.1.
AB051526 mRNA. Translation: BAB21830.1.
CCDSiCCDS2029.1.
RefSeqiNP_060259.4. NM_017789.4.
UniGeneiHs.516220.

Genome annotation databases

EnsembliENST00000305476; ENSP00000306844; ENSG00000168758.
GeneIDi54910.
KEGGihsa:54910.
UCSCiuc002sxg.4. human.

Polymorphism databases

DMDMi47606208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358842 mRNA. Translation: AAQ89201.1 .
BC017476 mRNA. Translation: AAH17476.2 .
BC109103 mRNA. Translation: AAI09104.1 .
BC109104 mRNA. Translation: AAI09105.1 .
AB051526 mRNA. Translation: BAB21830.1 .
CCDSi CCDS2029.1.
RefSeqi NP_060259.4. NM_017789.4.
UniGenei Hs.516220.

3D structure databases

ProteinModelPortali Q9C0C4.
SMRi Q9C0C4. Positions 28-632.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120254. 13 interactions.
STRINGi 9606.ENSP00000306844.

PTM databases

PhosphoSitei Q9C0C4.

Polymorphism databases

DMDMi 47606208.

Proteomic databases

MaxQBi Q9C0C4.
PaxDbi Q9C0C4.
PRIDEi Q9C0C4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305476 ; ENSP00000306844 ; ENSG00000168758 .
GeneIDi 54910.
KEGGi hsa:54910.
UCSCi uc002sxg.4. human.

Organism-specific databases

CTDi 54910.
GeneCardsi GC02M097525.
HGNCi HGNC:10731. SEMA4C.
HPAi HPA011090.
MIMi 604462. gene.
neXtProti NX_Q9C0C4.
PharmGKBi PA35653.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293968.
GeneTreei ENSGT00760000118854.
HOGENOMi HOG000116087.
HOVERGENi HBG061165.
InParanoidi Q9C0C4.
KOi K06521.
OMAi ASHLYVC.
OrthoDBi EOG712TVJ.
PhylomeDBi Q9C0C4.
TreeFami TF316102.

Miscellaneous databases

GeneWikii SEMA4C.
GenomeRNAii 54910.
NextBioi 57962.
PROi Q9C0C4.
SOURCEi Search...

Gene expression databases

Bgeei Q9C0C4.
CleanExi HS_SEMA4C.
ExpressionAtlasi Q9C0C4. baseline and differential.
Genevestigatori Q9C0C4.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
Pfami PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  3. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-833.
    Tissue: Brain.
  4. "Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway."
    Wu H., Wang X., Liu S., Wu Y., Zhao T., Chen X., Zhu L., Wu Y., Ding X., Peng X., Yuan J., Wang X., Fan W., Fan M.
    Eur. J. Cell Biol. 86:331-344(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSEM4C_HUMAN
AccessioniPrimary (citable) accession number: Q9C0C4
Secondary accession number(s): Q32MJ3, Q7Z5X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3