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Q9C0C4

- SEM4C_HUMAN

UniProt

Q9C0C4 - SEM4C_HUMAN

Protein

Semaphorin-4C

Gene

SEMA4C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (24 May 2004)
      Previous versions | rss
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    Functioni

    Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration By similarity. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.By similarity1 Publication

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    GO - Biological processi

    1. cell migration in hindbrain Source: UniProtKB
    2. cerebellum development Source: Ensembl
    3. muscle cell differentiation Source: UniProtKB
    4. neural tube closure Source: UniProtKB
    5. positive regulation of stress-activated MAPK cascade Source: UniProtKB
    6. semaphorin-plexin signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Semaphorin-4C
    Gene namesi
    Name:SEMA4C
    Synonyms:KIAA1739, SEMAI
    ORF Names:UNQ5855/PRO34487
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:10731. SEMA4C.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. extracellular space Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW
    4. postsynaptic density Source: UniProtKB
    5. postsynaptic membrane Source: UniProtKB-KW
    6. synaptic vesicle membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35653.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 833813Semaphorin-4CPRO_0000032325Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi99 ↔ 110By similarity
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi128 ↔ 137By similarity
    Disulfide bondi261 ↔ 370By similarity
    Disulfide bondi285 ↔ 330By similarity
    Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi500 ↔ 517By similarity
    Disulfide bondi509 ↔ 526By similarity
    Glycosylationi522 – 5221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi564 – 5641N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9C0C4.
    PaxDbiQ9C0C4.
    PRIDEiQ9C0C4.

    PTM databases

    PhosphoSiteiQ9C0C4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9C0C4.
    BgeeiQ9C0C4.
    CleanExiHS_SEMA4C.
    GenevestigatoriQ9C0C4.

    Organism-specific databases

    HPAiHPA011090.

    Interactioni

    Subunit structurei

    Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) By similarity. Interacts with NCDN By similarity. Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi120254. 5 interactions.
    STRINGi9606.ENSP00000306844.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C0C4.
    SMRiQ9C0C4. Positions 28-632.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 663643ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini685 – 833149CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei664 – 68421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 497468SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini499 – 55153PSIAdd
    BLAST
    Domaini556 – 64489Ig-like C2-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni46 – 489444Dominant negative effect on myogenic differentiationBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi830 – 8334PDZ-binding

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi708 – 77366Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the semaphorin family.Curated
    Contains 1 PSI domain.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293968.
    HOGENOMiHOG000116087.
    HOVERGENiHBG061165.
    InParanoidiQ9C0C4.
    KOiK06521.
    OMAiASHLYVC.
    OrthoDBiEOG712TVJ.
    PhylomeDBiQ9C0C4.
    TreeFamiTF316102.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PANTHERiPTHR11036. PTHR11036. 1 hit.
    PfamiPF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9C0C4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPHWAVWLL AARLWGLGIG AEVWWNLVPR KTVSSGELAT VVRRFSQTGI    50
    QDFLTLTLTE PTGLLYVGAR EALFAFSMEA LELQGAISWE APVEKKTECI 100
    QKGKNNQTEC FNFIRFLQPY NASHLYVCGT YAFQPKCTYV NMLTFTLEHG 150
    EFEDGKGKCP YDPAKGHAGL LVDGELYSAT LNNFLGTEPI ILRNMGPHHS 200
    MKTEYLAFWL NEPHFVGSAY VPESVGSFTG DDDKVYFFFR ERAVESDCYA 250
    EQVVARVARV CKGDMGGART LQRKWTTFLK ARLACSAPNW QLYFNQLQAM 300
    HTLQDTSWHN TTFFGVFQAQ WGDMYLSAIC EYQLEEIQRV FEGPYKEYHE 350
    EAQKWDRYTD PVPSPRPGSC INNWHRRHGY TSSLELPDNI LNFVKKHPLM 400
    EEQVGPRWSR PLLVKKGTNF THLVADRVTG LDGATYTVLF IGTGDGWLLK 450
    AVSLGPWVHL IEELQLFDQE PMRSLVLSQS KKLLFAGSRS QLVQLPVADC 500
    MKYRSCADCV LARDPYCAWS VNTSRCVAVG GHSGSLLIQH VMTSDTSGIC 550
    NLRGSKKVRP TPKNITVVAG TDLVLPCHLS SNLAHARWTF GGRDLPAEQP 600
    GSFLYDARLQ ALVVMAAQPR HAGAYHCFSE EQGARLAAEG YLVAVVAGPS 650
    VTLEARAPLE NLGLVWLAVV ALGAVCLVLL LLVLSLRRRL REELEKGAKA 700
    TERTLVYPLE LPKEPTSPPF RPCPEPDEKL WDPVGYYYSD GSLKIVPGHA 750
    RCQPGGGPPS PPPGIPGQPL PSPTRLHLGG GRNSNANGYV RLQLGGEDRG 800
    GLGHPLPELA DELRRKLQQR QPLPDSNPEE SSV 833
    Length:833
    Mass (Da):92,623
    Last modified:May 24, 2004 - v2
    Checksum:i075FDC0A392F0CE3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti602 – 6021S → T in AAQ89201. (PubMed:12975309)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358842 mRNA. Translation: AAQ89201.1.
    BC017476 mRNA. Translation: AAH17476.2.
    BC109103 mRNA. Translation: AAI09104.1.
    BC109104 mRNA. Translation: AAI09105.1.
    AB051526 mRNA. Translation: BAB21830.1.
    CCDSiCCDS2029.1.
    RefSeqiNP_060259.4. NM_017789.4.
    UniGeneiHs.516220.

    Genome annotation databases

    EnsembliENST00000305476; ENSP00000306844; ENSG00000168758.
    GeneIDi54910.
    KEGGihsa:54910.
    UCSCiuc002sxg.4. human.

    Polymorphism databases

    DMDMi47606208.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358842 mRNA. Translation: AAQ89201.1 .
    BC017476 mRNA. Translation: AAH17476.2 .
    BC109103 mRNA. Translation: AAI09104.1 .
    BC109104 mRNA. Translation: AAI09105.1 .
    AB051526 mRNA. Translation: BAB21830.1 .
    CCDSi CCDS2029.1.
    RefSeqi NP_060259.4. NM_017789.4.
    UniGenei Hs.516220.

    3D structure databases

    ProteinModelPortali Q9C0C4.
    SMRi Q9C0C4. Positions 28-632.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120254. 5 interactions.
    STRINGi 9606.ENSP00000306844.

    PTM databases

    PhosphoSitei Q9C0C4.

    Polymorphism databases

    DMDMi 47606208.

    Proteomic databases

    MaxQBi Q9C0C4.
    PaxDbi Q9C0C4.
    PRIDEi Q9C0C4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305476 ; ENSP00000306844 ; ENSG00000168758 .
    GeneIDi 54910.
    KEGGi hsa:54910.
    UCSCi uc002sxg.4. human.

    Organism-specific databases

    CTDi 54910.
    GeneCardsi GC02M097525.
    HGNCi HGNC:10731. SEMA4C.
    HPAi HPA011090.
    MIMi 604462. gene.
    neXtProti NX_Q9C0C4.
    PharmGKBi PA35653.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293968.
    HOGENOMi HOG000116087.
    HOVERGENi HBG061165.
    InParanoidi Q9C0C4.
    KOi K06521.
    OMAi ASHLYVC.
    OrthoDBi EOG712TVJ.
    PhylomeDBi Q9C0C4.
    TreeFami TF316102.

    Miscellaneous databases

    GeneWikii SEMA4C.
    GenomeRNAii 54910.
    NextBioi 57962.
    PROi Q9C0C4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9C0C4.
    Bgeei Q9C0C4.
    CleanExi HS_SEMA4C.
    Genevestigatori Q9C0C4.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    PANTHERi PTHR11036. PTHR11036. 1 hit.
    Pfami PF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    3. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-833.
      Tissue: Brain.
    4. "Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway."
      Wu H., Wang X., Liu S., Wu Y., Zhao T., Chen X., Zhu L., Wu Y., Ding X., Peng X., Yuan J., Wang X., Fan W., Fan M.
      Eur. J. Cell Biol. 86:331-344(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSEM4C_HUMAN
    AccessioniPrimary (citable) accession number: Q9C0C4
    Secondary accession number(s): Q32MJ3, Q7Z5X0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3