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Protein

182 kDa tankyrase-1-binding protein

Gene

TNKS1BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ankyrin binding Source: UniProtKB
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • enzyme binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149115-MONOMER.
ReactomeiR-HSA-429947. Deadenylation of mRNA.
R-HSA-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Names & Taxonomyi

Protein namesi
Recommended name:
182 kDa tankyrase-1-binding protein
Gene namesi
Name:TNKS1BP1
Synonyms:KIAA1741, TAB182
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19081. TNKS1BP1.

Subcellular locationi

GO - Cellular componenti

  • CCR4-NOT complex Source: UniProtKB
  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB-SubCell
  • cytosol Source: Reactome
  • nuclear telomeric heterochromatin Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149115.
PharmGKBiPA38789.

Polymorphism and mutation databases

BioMutaiTNKS1BP1.
DMDMi317373547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724371 – 1729182 kDa tankyrase-1-binding proteinAdd BLAST1729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei131PhosphothreonineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei221PhosphoserineCombined sources1
Modified residuei228PhosphoserineCombined sources1
Modified residuei239PhosphothreonineCombined sources1
Modified residuei287PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei429PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei494PhosphoserineCombined sources1
Modified residuei498PhosphoserineCombined sources1
Modified residuei501PhosphothreonineBy similarity1
Modified residuei601PhosphoserineCombined sources1
Modified residuei672PhosphoserineCombined sources1
Modified residuei691PhosphoserineCombined sources1
Modified residuei695PhosphoserineCombined sources1
Modified residuei712PhosphoserineCombined sources1
Modified residuei724PhosphoserineCombined sources1
Modified residuei744PhosphoserineCombined sources1
Modified residuei762PhosphoserineCombined sources1
Modified residuei806PhosphoserineCombined sources1
Modified residuei833PhosphothreonineCombined sources1
Modified residuei836PhosphoserineCombined sources1
Modified residuei851PhosphoserineCombined sources1
Modified residuei872PhosphoserineCombined sources1
Modified residuei877PhosphoserineCombined sources1
Modified residuei882PhosphoserineCombined sources1
Modified residuei893PhosphoserineCombined sources1
Modified residuei897PhosphotyrosineCombined sources1
Modified residuei899PhosphoserineCombined sources1
Modified residuei920PhosphoserineCombined sources1
Modified residuei936PhosphoserineCombined sources1
Modified residuei976PhosphoserineCombined sources1
Modified residuei979PhosphothreonineCombined sources1
Modified residuei983PhosphoserineCombined sources1
Modified residuei987PhosphoserineCombined sources1
Modified residuei1004PhosphoserineCombined sources1
Modified residuei1008PhosphoserineCombined sources1
Modified residuei1013PhosphoserineCombined sources1
Modified residuei1024PhosphoserineCombined sources1
Modified residuei1029PhosphoserineCombined sources1
Modified residuei1054PhosphoserineCombined sources1
Modified residuei1073PhosphoserineCombined sources1
Modified residuei1091PhosphoserineCombined sources1
Modified residuei1103PhosphoserineCombined sources1
Modified residuei1133PhosphoserineCombined sources1
Modified residuei1138PhosphoserineCombined sources1
Modified residuei1158PhosphoserineCombined sources1
Modified residuei1178PhosphoserineCombined sources1
Modified residuei1248PhosphoserineCombined sources1
Modified residuei1253PhosphoserineCombined sources1
Modified residuei1282PhosphothreonineCombined sources1
Modified residuei1297PhosphoserineCombined sources1
Modified residuei1328PhosphoserineCombined sources1
Modified residuei1331PhosphoserineCombined sources1
Modified residuei1383PhosphoserineCombined sources1
Modified residuei1385PhosphoserineCombined sources1
Modified residuei1435PhosphoserineCombined sources1
Modified residuei1439PhosphoserineCombined sources1
Modified residuei1450PhosphoserineCombined sources1
Modified residuei1452PhosphoserineCombined sources1
Modified residuei1473PhosphoserineCombined sources1
Modified residuei1476PhosphoserineCombined sources1
Modified residuei1503PhosphoserineCombined sources1
Modified residuei1506PhosphoserineCombined sources1
Modified residuei1518PhosphothreonineCombined sources1
Modified residuei1533PhosphoserineCombined sources1
Modified residuei1545PhosphoserineCombined sources1
Modified residuei1558PhosphoserineCombined sources1
Modified residuei1563PhosphothreonineCombined sources1
Modified residuei1620PhosphoserineCombined sources1
Modified residuei1621PhosphoserineCombined sources1
Modified residuei1631PhosphoserineCombined sources1
Modified residuei1644N6-methyllysineCombined sources1
Modified residuei1652PhosphoserineCombined sources1
Modified residuei1666PhosphoserineCombined sources1
Modified residuei1715PhosphoserineCombined sources1

Post-translational modificationi

ADP-ribosylated by TNKS1 (in vitro).

Keywords - PTMi

ADP-ribosylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9C0C2.
MaxQBiQ9C0C2.
PaxDbiQ9C0C2.
PeptideAtlasiQ9C0C2.
PRIDEiQ9C0C2.

PTM databases

iPTMnetiQ9C0C2.
PhosphoSitePlusiQ9C0C2.

Expressioni

Tissue specificityi

Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very low levels in brain and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000149115.
CleanExiHS_TNKS1BP1.
ExpressionAtlasiQ9C0C2. baseline and differential.
GenevisibleiQ9C0C2. HS.

Organism-specific databases

HPAiHPA037929.
HPA037930.

Interactioni

Subunit structurei

Binds to the ANK repeat domain of TNKS1 and TNKS2.

GO - Molecular functioni

  • ankyrin binding Source: UniProtKB
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124540. 43 interactors.
IntActiQ9C0C2. 22 interactors.
MINTiMINT-4538987.
STRINGi9606.ENSP00000350990.

Structurei

3D structure databases

ProteinModelPortaliQ9C0C2.
SMRiQ9C0C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni210 – 1572AcidicAdd BLAST1363
Regioni1450 – 1542Tankyrase-bindingAdd BLAST93

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1629 – 1635Nuclear localization signalSequence analysis7
Motifi1723 – 1729Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 103Arg/Glu/Lys/Pro-rich (charged)Add BLAST102
Compositional biasi127 – 767Pro-richAdd BLAST641
Compositional biasi1010 – 1340Gly-richAdd BLAST331
Compositional biasi1572 – 1729Arg/Glu/Lys-rich (charged)Add BLAST158

Phylogenomic databases

eggNOGiENOG410IK8U. Eukaryota.
ENOG410ZTHW. LUCA.
GeneTreeiENSGT00730000111391.
HOGENOMiHOG000001569.
HOVERGENiHBG080593.
InParanoidiQ9C0C2.
OMAiPDQPCVL.
OrthoDBiEOG091G01HQ.
PhylomeDBiQ9C0C2.
TreeFamiTF336029.

Family and domain databases

InterProiIPR032764. Tankyrase-bd_C.
[Graphical view]
PfamiPF15327. Tankyrase_bdg_C. 1 hit.
[Graphical view]
SMARTiSM01319. Tankyrase_bdg_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0C2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVSTLRESS AMASPLPREM EEELVPTGSE PGDTRAKPPV KPKPRALPAK
60 70 80 90 100
PALPAKPSLL VPVGPRPPRG PLAELPSARK MNMLAGPQPY GGSKRPLPFA
110 120 130 140 150
PRPAVEASTG GEATQETGKE EAGKEEPPPL TPPARCAAPG GVRKAPAPFR
160 170 180 190 200
PASERFAATT VEEILAKMEQ PRKEVLASPD RLWGSRLTFN HDGSSRYGPR
210 220 230 240 250
TYGTTTAPRD EDGSTLFRGW SQEGPVKSPA ECREEHSKTP EERSLPSDLA
260 270 280 290 300
FNGDLAKAAS SELPADISKP WIPSSPAPSS ENGGPASPGL PAEASGSGPG
310 320 330 340 350
SPHLHPPDKS SPCHSQLLEA QTPEASQASP CPAVTPSAPS AALPDEGSRH
360 370 380 390 400
TPSPGLPAEG APEAPRPSSP PPEVLEPHSL DQPPATSPRP LIEVGELLDL
410 420 430 440 450
TRTFPSGGEE EAKGDAHLRP TSLVQRRFSE GVLQSPSQDQ EKLGGSLAAL
460 470 480 490 500
PQGQGSQLAL DRPFGAESNW SLSQSFEWTF PTRPSGLGVW RLDSPPPSPI
510 520 530 540 550
TEASEAAEAA EAGNLAVSSR EEGVSQQGQG AGSAPSGSGS SWVQGDDPSM
560 570 580 590 600
SLTQKGDGES QPQFPAVPLE PLPTTEGTPG LPLQQAEERY ESQEPLAGQE
610 620 630 640 650
SPLPLATREA ALPILEPVLG QEQPAAPDQP CVLFADAPEP GQALPVEEEA
660 670 680 690 700
VTLARAETTQ ARTEAQDLCR ASPEPPGPES SSRWLDDLLA SPPPSGGGAR
710 720 730 740 750
RGAGAELKDT QSPSTCSEGL LGWSQKDLQS EFGITGDPQP SSFSPSSWCQ
760 770 780 790 800
GASQDYGLGG ASPRGDPGLG ERDWTSKYGQ GAGEGSTREW ASRCGIGQEE
810 820 830 840 850
MEASSSQDQS KVSAPGVLTA QDRVVGKPAQ LGTQRSQEAD VQDWEFRKRD
860 870 880 890 900
SQGTYSSRDA ELQDQEFGKR DSLGTYSSRD VSLGDWEFGK RDSLGAYASQ
910 920 930 940 950
DANEQGQDLG KRDHHGRYSS QDADEQDWEF QKRDVSLGTY GSRAAEPQEQ
960 970 980 990 1000
EFGKSAWIRD YSSGGSSRTL DAQDRSFGTR PLSSGFSPEE AQQQDEEFEK
1010 1020 1030 1040 1050
KIPSVEDSLG EGSRDAGRPG ERGSGGLFSP STAHVPDGAL GQRDQSSWQN
1060 1070 1080 1090 1100
SDASQEVGGH QERQQAGAQG PGSADLEDGE MGKRGWVGEF SLSVGPQREA
1110 1120 1130 1140 1150
AFSPGQQDWS RDFCIEASER SYQFGIIGND RVSGAGFSPS SKMEGGHFVP
1160 1170 1180 1190 1200
PGKTTAGSVD WTDQLGLRNL EVSSCVGSGG SSEARESAVG QMGWSGGLSL
1210 1220 1230 1240 1250
RDMNLTGCLE SGGSEEPGGI GVGEKDWTSD VNVKSKDLAE VGEGGGHSQA
1260 1270 1280 1290 1300
RESGVGQTDW SGVEAGEFLK SRERGVGQAD WTPDLGLRNM APGAVCSPGE
1310 1320 1330 1340 1350
SKELGVGQMD WGNNLGLRDL EVTCDPDSGG SQGLRGCGVG QMDWTQDLAP
1360 1370 1380 1390 1400
QNVELFGAPS EAREHGVGGV SQCPEPGLRH NGSLSPGLEA RDPLEARELG
1410 1420 1430 1440 1450
VGETSGPETQ GEDYSSSSLE PHPADPGMET GEALSFGASP GRCPARPPPS
1460 1470 1480 1490 1500
GSQGLLEEML AASSSKAVAR RESAASGLGG LLEEEGAGAG AAQEEVLEPG
1510 1520 1530 1540 1550
RDSPPSWRPQ PDGEASQTED VDGTWGSSAA RWSDQGPAQT SRRPSQGPPA
1560 1570 1580 1590 1600
RSPSQDFSFI EDTEILDSAM YRSRANLGRK RGHRAPVIRP GGTLGLSEAA
1610 1620 1630 1640 1650
DSDAHLFQDS TEPRASRVPS SDEEVVEEPQ SRRTRMSLGT KGLKVNLFPG
1660 1670 1680 1690 1700
LSPSALKAKL RPRNRSAEEG ELAESKSSQK ESAVQRSKSC KVPGLGKPLT
1710 1720
LPPKPEKSSG SEGSSPNWLQ ALKLKKKKV
Length:1,729
Mass (Da):181,796
Last modified:January 11, 2011 - v4
Checksum:i561FA5C27C923036
GO
Isoform 2 (identifier: Q9C0C2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.
     1275-1327: GVGQADWTPD...RDLEVTCDPD → LGRHIYALCI...SSSSLPWVFF
     1328-1729: Missing.

Note: No experimental confirmation available.
Show »
Length:778
Mass (Da):82,677
Checksum:iA08CC80D7372B25D
GO

Sequence cautioni

The sequence BAB21832 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB84939 differs from that shown. Reason: Frameshift at positions 1070, 1098 and 1466.Curated
The sequence BAB84939 differs from that shown. Reason: Frameshift at positions 1071, 1097 and 1467.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84L → P in AAM15531 (PubMed:11854288).Curated1
Sequence conflicti388P → S in AAM15531 (PubMed:11854288).Curated1
Sequence conflicti554Q → H in BAB84939 (PubMed:15489334).Curated1
Sequence conflicti604P → S in AAM15531 (PubMed:11854288).Curated1
Sequence conflicti1450S → F in AAM15531 (PubMed:11854288).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028141322T → S.1 PublicationCorresponds to variant rs4939134dbSNPEnsembl.1
Natural variantiVAR_032615714S → N.Corresponds to variant rs34203865dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0260001 – 549Missing in isoform 2. 1 PublicationAdd BLAST549
Alternative sequenceiVSP_0260011275 – 1327GVGQA…TCDPD → LGRHIYALCITLRTPPTPSL PWISSLVVEGFVPSSPPSLS LSASSSSLPWVFF in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_0260021328 – 1729Missing in isoform 2. 1 PublicationAdd BLAST402

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441771 mRNA. Translation: AAM15531.1.
AB051528 mRNA. Translation: BAB21832.2. Different initiation.
AK124903 mRNA. Translation: BAC85989.1.
AP000781 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73731.1.
BC023622 mRNA. Translation: AAH23622.1.
BC150333 mRNA. Translation: AAI50334.1.
AK074113 mRNA. Translation: BAB84939.1. Frameshift.
CCDSiCCDS7951.1. [Q9C0C2-1]
RefSeqiNP_203754.2. NM_033396.2. [Q9C0C2-1]
XP_006718788.1. XM_006718725.3. [Q9C0C2-1]
UniGeneiHs.530730.

Genome annotation databases

EnsembliENST00000358252; ENSP00000350990; ENSG00000149115. [Q9C0C2-1]
ENST00000532437; ENSP00000437271; ENSG00000149115. [Q9C0C2-1]
GeneIDi85456.
KEGGihsa:85456.
UCSCiuc001njr.4. human. [Q9C0C2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441771 mRNA. Translation: AAM15531.1.
AB051528 mRNA. Translation: BAB21832.2. Different initiation.
AK124903 mRNA. Translation: BAC85989.1.
AP000781 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73731.1.
BC023622 mRNA. Translation: AAH23622.1.
BC150333 mRNA. Translation: AAI50334.1.
AK074113 mRNA. Translation: BAB84939.1. Frameshift.
CCDSiCCDS7951.1. [Q9C0C2-1]
RefSeqiNP_203754.2. NM_033396.2. [Q9C0C2-1]
XP_006718788.1. XM_006718725.3. [Q9C0C2-1]
UniGeneiHs.530730.

3D structure databases

ProteinModelPortaliQ9C0C2.
SMRiQ9C0C2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124540. 43 interactors.
IntActiQ9C0C2. 22 interactors.
MINTiMINT-4538987.
STRINGi9606.ENSP00000350990.

PTM databases

iPTMnetiQ9C0C2.
PhosphoSitePlusiQ9C0C2.

Polymorphism and mutation databases

BioMutaiTNKS1BP1.
DMDMi317373547.

Proteomic databases

EPDiQ9C0C2.
MaxQBiQ9C0C2.
PaxDbiQ9C0C2.
PeptideAtlasiQ9C0C2.
PRIDEiQ9C0C2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358252; ENSP00000350990; ENSG00000149115. [Q9C0C2-1]
ENST00000532437; ENSP00000437271; ENSG00000149115. [Q9C0C2-1]
GeneIDi85456.
KEGGihsa:85456.
UCSCiuc001njr.4. human. [Q9C0C2-1]

Organism-specific databases

CTDi85456.
GeneCardsiTNKS1BP1.
HGNCiHGNC:19081. TNKS1BP1.
HPAiHPA037929.
HPA037930.
MIMi607104. gene.
neXtProtiNX_Q9C0C2.
OpenTargetsiENSG00000149115.
PharmGKBiPA38789.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK8U. Eukaryota.
ENOG410ZTHW. LUCA.
GeneTreeiENSGT00730000111391.
HOGENOMiHOG000001569.
HOVERGENiHBG080593.
InParanoidiQ9C0C2.
OMAiPDQPCVL.
OrthoDBiEOG091G01HQ.
PhylomeDBiQ9C0C2.
TreeFamiTF336029.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149115-MONOMER.
ReactomeiR-HSA-429947. Deadenylation of mRNA.
R-HSA-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Miscellaneous databases

ChiTaRSiTNKS1BP1. human.
GeneWikiiTNKS1BP1.
GenomeRNAii85456.
PROiQ9C0C2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149115.
CleanExiHS_TNKS1BP1.
ExpressionAtlasiQ9C0C2. baseline and differential.
GenevisibleiQ9C0C2. HS.

Family and domain databases

InterProiIPR032764. Tankyrase-bd_C.
[Graphical view]
PfamiPF15327. Tankyrase_bdg_C. 1 hit.
[Graphical view]
SMARTiSM01319. Tankyrase_bdg_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTB182_HUMAN
AccessioniPrimary (citable) accession number: Q9C0C2
Secondary accession number(s): A7E2F8, Q6PJ35, Q6ZV74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 141 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.