Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9C0C2

- TB182_HUMAN

UniProt

Q9C0C2 - TB182_HUMAN

Protein

182 kDa tankyrase-1-binding protein

Gene

TNKS1BP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 4 (11 Jan 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. ankyrin binding Source: UniProtKB
    2. enzyme binding Source: UniProtKB

    GO - Biological processi

    1. gene expression Source: Reactome
    2. mRNA metabolic process Source: Reactome
    3. nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: Reactome
    4. nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
    5. RNA metabolic process Source: Reactome
    6. telomere maintenance via telomerase Source: UniProtKB

    Enzyme and pathway databases

    ReactomeiREACT_20514. Deadenylation of mRNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    182 kDa tankyrase-1-binding protein
    Gene namesi
    Name:TNKS1BP1
    Synonyms:KIAA1741, TAB182
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:19081. TNKS1BP1.

    Subcellular locationi

    Nucleus. Cytoplasmcytoskeleton. Chromosome
    Note: Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.

    GO - Cellular componenti

    1. CCR4-NOT complex Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. cytoskeleton Source: UniProtKB-SubCell
    4. cytosol Source: Reactome
    5. nuclear telomeric heterochromatin Source: UniProtKB
    6. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Chromosome, Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38789.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17291729182 kDa tankyrase-1-binding proteinPRO_0000072437Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei178 – 1781Phosphoserine2 Publications
    Modified residuei221 – 2211Phosphoserine1 Publication
    Modified residuei239 – 2391Phosphothreonine1 Publication
    Modified residuei429 – 4291Phosphoserine4 Publications
    Modified residuei435 – 4351Phosphoserine2 Publications
    Modified residuei437 – 4371Phosphoserine1 Publication
    Modified residuei494 – 4941Phosphoserine2 Publications
    Modified residuei498 – 4981Phosphoserine1 Publication
    Modified residuei601 – 6011Phosphoserine4 Publications
    Modified residuei672 – 6721Phosphoserine4 Publications
    Modified residuei691 – 6911Phosphoserine6 Publications
    Modified residuei695 – 6951Phosphoserine1 Publication
    Modified residuei712 – 7121Phosphoserine1 Publication
    Modified residuei744 – 7441Phosphoserine1 Publication
    Modified residuei762 – 7621Phosphoserine2 Publications
    Modified residuei833 – 8331Phosphothreonine1 Publication
    Modified residuei836 – 8361Phosphoserine7 Publications
    Modified residuei851 – 8511Phosphoserine1 Publication
    Modified residuei872 – 8721Phosphoserine3 Publications
    Modified residuei877 – 8771Phosphoserine1 Publication
    Modified residuei882 – 8821Phosphoserine1 Publication
    Modified residuei893 – 8931Phosphoserine3 Publications
    Modified residuei899 – 8991Phosphoserine1 Publication
    Modified residuei920 – 9201Phosphoserine1 Publication
    Modified residuei936 – 9361Phosphoserine1 Publication
    Modified residuei979 – 9791Phosphothreonine1 Publication
    Modified residuei983 – 9831Phosphoserine1 Publication
    Modified residuei987 – 9871Phosphoserine2 Publications
    Modified residuei1008 – 10081Phosphoserine2 Publications
    Modified residuei1024 – 10241Phosphoserine1 Publication
    Modified residuei1029 – 10291Phosphoserine1 Publication
    Modified residuei1054 – 10541Phosphoserine1 Publication
    Modified residuei1103 – 11031Phosphoserine4 Publications
    Modified residuei1133 – 11331Phosphoserine2 Publications
    Modified residuei1138 – 11381Phosphoserine4 Publications
    Modified residuei1178 – 11781Phosphoserine1 Publication
    Modified residuei1248 – 12481Phosphoserine2 Publications
    Modified residuei1253 – 12531Phosphoserine1 Publication
    Modified residuei1282 – 12821Phosphothreonine1 Publication
    Modified residuei1297 – 12971Phosphoserine2 Publications
    Modified residuei1328 – 13281Phosphoserine1 Publication
    Modified residuei1331 – 13311Phosphoserine2 Publications
    Modified residuei1383 – 13831Phosphoserine2 Publications
    Modified residuei1385 – 13851Phosphoserine3 Publications
    Modified residuei1439 – 14391Phosphoserine1 Publication
    Modified residuei1533 – 15331Phosphoserine3 Publications
    Modified residuei1545 – 15451Phosphoserine2 Publications
    Modified residuei1558 – 15581Phosphoserine1 Publication
    Modified residuei1563 – 15631Phosphothreonine1 Publication
    Modified residuei1620 – 16201Phosphoserine5 Publications
    Modified residuei1621 – 16211Phosphoserine5 Publications
    Modified residuei1631 – 16311Phosphoserine1 Publication
    Modified residuei1652 – 16521Phosphoserine2 Publications
    Modified residuei1666 – 16661Phosphoserine6 Publications
    Modified residuei1715 – 17151Phosphoserine1 Publication

    Post-translational modificationi

    ADP-ribosylated by TNKS1 (in vitro).

    Keywords - PTMi

    ADP-ribosylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9C0C2.
    PaxDbiQ9C0C2.
    PRIDEiQ9C0C2.

    PTM databases

    PhosphoSiteiQ9C0C2.

    Expressioni

    Tissue specificityi

    Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very low levels in brain and peripheral blood leukocytes.

    Gene expression databases

    ArrayExpressiQ9C0C2.
    BgeeiQ9C0C2.
    CleanExiHS_TNKS1BP1.
    GenevestigatoriQ9C0C2.

    Organism-specific databases

    HPAiHPA037929.
    HPA037930.

    Interactioni

    Subunit structurei

    Binds to the ANK repeat domain of TNKS1 and TNKS2.

    Protein-protein interaction databases

    BioGridi124540. 20 interactions.
    IntActiQ9C0C2. 12 interactions.
    MINTiMINT-4538987.
    STRINGi9606.ENSP00000350990.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C0C2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni210 – 15721363AcidicAdd
    BLAST
    Regioni1450 – 154293Tankyrase-bindingAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1629 – 16357Nuclear localization signalSequence Analysis
    Motifi1723 – 17297Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 103102Arg/Glu/Lys/Pro-rich (charged)Add
    BLAST
    Compositional biasi127 – 767641Pro-richAdd
    BLAST
    Compositional biasi1010 – 1340331Gly-richAdd
    BLAST
    Compositional biasi1572 – 1729158Arg/Glu/Lys-rich (charged)Add
    BLAST

    Phylogenomic databases

    eggNOGiNOG46995.
    HOGENOMiHOG000001569.
    HOVERGENiHBG080593.
    InParanoidiQ9C0C2.
    OMAiQDQEKLG.
    OrthoDBiEOG7DC23N.
    PhylomeDBiQ9C0C2.
    TreeFamiTF336029.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9C0C2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKVSTLRESS AMASPLPREM EEELVPTGSE PGDTRAKPPV KPKPRALPAK     50
    PALPAKPSLL VPVGPRPPRG PLAELPSARK MNMLAGPQPY GGSKRPLPFA 100
    PRPAVEASTG GEATQETGKE EAGKEEPPPL TPPARCAAPG GVRKAPAPFR 150
    PASERFAATT VEEILAKMEQ PRKEVLASPD RLWGSRLTFN HDGSSRYGPR 200
    TYGTTTAPRD EDGSTLFRGW SQEGPVKSPA ECREEHSKTP EERSLPSDLA 250
    FNGDLAKAAS SELPADISKP WIPSSPAPSS ENGGPASPGL PAEASGSGPG 300
    SPHLHPPDKS SPCHSQLLEA QTPEASQASP CPAVTPSAPS AALPDEGSRH 350
    TPSPGLPAEG APEAPRPSSP PPEVLEPHSL DQPPATSPRP LIEVGELLDL 400
    TRTFPSGGEE EAKGDAHLRP TSLVQRRFSE GVLQSPSQDQ EKLGGSLAAL 450
    PQGQGSQLAL DRPFGAESNW SLSQSFEWTF PTRPSGLGVW RLDSPPPSPI 500
    TEASEAAEAA EAGNLAVSSR EEGVSQQGQG AGSAPSGSGS SWVQGDDPSM 550
    SLTQKGDGES QPQFPAVPLE PLPTTEGTPG LPLQQAEERY ESQEPLAGQE 600
    SPLPLATREA ALPILEPVLG QEQPAAPDQP CVLFADAPEP GQALPVEEEA 650
    VTLARAETTQ ARTEAQDLCR ASPEPPGPES SSRWLDDLLA SPPPSGGGAR 700
    RGAGAELKDT QSPSTCSEGL LGWSQKDLQS EFGITGDPQP SSFSPSSWCQ 750
    GASQDYGLGG ASPRGDPGLG ERDWTSKYGQ GAGEGSTREW ASRCGIGQEE 800
    MEASSSQDQS KVSAPGVLTA QDRVVGKPAQ LGTQRSQEAD VQDWEFRKRD 850
    SQGTYSSRDA ELQDQEFGKR DSLGTYSSRD VSLGDWEFGK RDSLGAYASQ 900
    DANEQGQDLG KRDHHGRYSS QDADEQDWEF QKRDVSLGTY GSRAAEPQEQ 950
    EFGKSAWIRD YSSGGSSRTL DAQDRSFGTR PLSSGFSPEE AQQQDEEFEK 1000
    KIPSVEDSLG EGSRDAGRPG ERGSGGLFSP STAHVPDGAL GQRDQSSWQN 1050
    SDASQEVGGH QERQQAGAQG PGSADLEDGE MGKRGWVGEF SLSVGPQREA 1100
    AFSPGQQDWS RDFCIEASER SYQFGIIGND RVSGAGFSPS SKMEGGHFVP 1150
    PGKTTAGSVD WTDQLGLRNL EVSSCVGSGG SSEARESAVG QMGWSGGLSL 1200
    RDMNLTGCLE SGGSEEPGGI GVGEKDWTSD VNVKSKDLAE VGEGGGHSQA 1250
    RESGVGQTDW SGVEAGEFLK SRERGVGQAD WTPDLGLRNM APGAVCSPGE 1300
    SKELGVGQMD WGNNLGLRDL EVTCDPDSGG SQGLRGCGVG QMDWTQDLAP 1350
    QNVELFGAPS EAREHGVGGV SQCPEPGLRH NGSLSPGLEA RDPLEARELG 1400
    VGETSGPETQ GEDYSSSSLE PHPADPGMET GEALSFGASP GRCPARPPPS 1450
    GSQGLLEEML AASSSKAVAR RESAASGLGG LLEEEGAGAG AAQEEVLEPG 1500
    RDSPPSWRPQ PDGEASQTED VDGTWGSSAA RWSDQGPAQT SRRPSQGPPA 1550
    RSPSQDFSFI EDTEILDSAM YRSRANLGRK RGHRAPVIRP GGTLGLSEAA 1600
    DSDAHLFQDS TEPRASRVPS SDEEVVEEPQ SRRTRMSLGT KGLKVNLFPG 1650
    LSPSALKAKL RPRNRSAEEG ELAESKSSQK ESAVQRSKSC KVPGLGKPLT 1700
    LPPKPEKSSG SEGSSPNWLQ ALKLKKKKV 1729
    Length:1,729
    Mass (Da):181,796
    Last modified:January 11, 2011 - v4
    Checksum:i561FA5C27C923036
    GO
    Isoform 2 (identifier: Q9C0C2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-549: Missing.
         1275-1327: GVGQADWTPD...RDLEVTCDPD → LGRHIYALCI...SSSSLPWVFF
         1328-1729: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:778
    Mass (Da):82,677
    Checksum:iA08CC80D7372B25D
    GO

    Sequence cautioni

    The sequence BAB84939.1 differs from that shown. Reason: Frameshift at positions 1070, 1098 and 1466.
    The sequence BAB84939.1 differs from that shown. Reason: Frameshift at positions 1071, 1097 and 1467.
    The sequence BAB21832.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti84 – 841L → P in AAM15531. (PubMed:11854288)Curated
    Sequence conflicti388 – 3881P → S in AAM15531. (PubMed:11854288)Curated
    Sequence conflicti554 – 5541Q → H in BAB84939. (PubMed:15489334)Curated
    Sequence conflicti604 – 6041P → S in AAM15531. (PubMed:11854288)Curated
    Sequence conflicti1450 – 14501S → F in AAM15531. (PubMed:11854288)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti322 – 3221T → S.1 Publication
    Corresponds to variant rs4939134 [ dbSNP | Ensembl ].
    VAR_028141
    Natural varianti714 – 7141S → N.
    Corresponds to variant rs34203865 [ dbSNP | Ensembl ].
    VAR_032615

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 549549Missing in isoform 2. 1 PublicationVSP_026000Add
    BLAST
    Alternative sequencei1275 – 132753GVGQA…TCDPD → LGRHIYALCITLRTPPTPSL PWISSLVVEGFVPSSPPSLS LSASSSSLPWVFF in isoform 2. 1 PublicationVSP_026001Add
    BLAST
    Alternative sequencei1328 – 1729402Missing in isoform 2. 1 PublicationVSP_026002Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF441771 mRNA. Translation: AAM15531.1.
    AB051528 mRNA. Translation: BAB21832.2. Different initiation.
    AK124903 mRNA. Translation: BAC85989.1.
    AP000781 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW73731.1.
    BC023622 mRNA. Translation: AAH23622.1.
    BC150333 mRNA. Translation: AAI50334.1.
    AK074113 mRNA. Translation: BAB84939.1. Frameshift.
    CCDSiCCDS7951.1. [Q9C0C2-1]
    RefSeqiNP_203754.2. NM_033396.2. [Q9C0C2-1]
    XP_006718788.1. XM_006718725.1. [Q9C0C2-1]
    UniGeneiHs.530730.

    Genome annotation databases

    EnsembliENST00000358252; ENSP00000350990; ENSG00000149115. [Q9C0C2-1]
    ENST00000532437; ENSP00000437271; ENSG00000149115. [Q9C0C2-1]
    GeneIDi85456.
    KEGGihsa:85456.
    UCSCiuc001njr.3. human. [Q9C0C2-1]

    Polymorphism databases

    DMDMi317373547.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF441771 mRNA. Translation: AAM15531.1 .
    AB051528 mRNA. Translation: BAB21832.2 . Different initiation.
    AK124903 mRNA. Translation: BAC85989.1 .
    AP000781 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW73731.1 .
    BC023622 mRNA. Translation: AAH23622.1 .
    BC150333 mRNA. Translation: AAI50334.1 .
    AK074113 mRNA. Translation: BAB84939.1 . Frameshift.
    CCDSi CCDS7951.1. [Q9C0C2-1 ]
    RefSeqi NP_203754.2. NM_033396.2. [Q9C0C2-1 ]
    XP_006718788.1. XM_006718725.1. [Q9C0C2-1 ]
    UniGenei Hs.530730.

    3D structure databases

    ProteinModelPortali Q9C0C2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124540. 20 interactions.
    IntActi Q9C0C2. 12 interactions.
    MINTi MINT-4538987.
    STRINGi 9606.ENSP00000350990.

    PTM databases

    PhosphoSitei Q9C0C2.

    Polymorphism databases

    DMDMi 317373547.

    Proteomic databases

    MaxQBi Q9C0C2.
    PaxDbi Q9C0C2.
    PRIDEi Q9C0C2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358252 ; ENSP00000350990 ; ENSG00000149115 . [Q9C0C2-1 ]
    ENST00000532437 ; ENSP00000437271 ; ENSG00000149115 . [Q9C0C2-1 ]
    GeneIDi 85456.
    KEGGi hsa:85456.
    UCSCi uc001njr.3. human. [Q9C0C2-1 ]

    Organism-specific databases

    CTDi 85456.
    GeneCardsi GC11M057067.
    HGNCi HGNC:19081. TNKS1BP1.
    HPAi HPA037929.
    HPA037930.
    MIMi 607104. gene.
    neXtProti NX_Q9C0C2.
    PharmGKBi PA38789.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46995.
    HOGENOMi HOG000001569.
    HOVERGENi HBG080593.
    InParanoidi Q9C0C2.
    OMAi QDQEKLG.
    OrthoDBi EOG7DC23N.
    PhylomeDBi Q9C0C2.
    TreeFami TF336029.

    Enzyme and pathway databases

    Reactomei REACT_20514. Deadenylation of mRNA.

    Miscellaneous databases

    ChiTaRSi TNKS1BP1. human.
    GeneWikii TNKS1BP1.
    GenomeRNAii 85456.
    NextBioi 76085.
    PROi Q9C0C2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9C0C2.
    Bgeei Q9C0C2.
    CleanExi HS_TNKS1BP1.
    Genevestigatori Q9C0C2.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)."
      Seimiya H., Smith S.
      J. Biol. Chem. 277:14116-14126(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-322.
      Tissue: Placenta and Testis.
    2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Hippocampus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    8. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
      Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
      DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 495-1729 (ISOFORM 1).
      Tissue: Spleen.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-672; THR-833; SER-836; SER-1383; SER-1385 AND SER-1666, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-691; SER-695; SER-836; SER-1103; SER-1138; SER-1620; SER-1621 AND SER-1666, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."
      Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.
      Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Prostate cancer.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-836; SER-1248 AND SER-1331, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601; SER-691; SER-836 AND SER-1103, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; THR-239; SER-429; SER-435; SER-494; SER-498; SER-601; SER-672; SER-712; SER-744; SER-762; SER-872; SER-877; SER-893; SER-920; SER-936; THR-979; SER-983; SER-987; SER-1008; SER-1029; SER-1103; SER-1133; SER-1138; SER-1178; SER-1297; SER-1328; SER-1331; SER-1439; SER-1533; SER-1545; SER-1558; THR-1563; SER-1620; SER-1621; SER-1652 AND SER-1666, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
      Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    17. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-691, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-429; SER-494; SER-691; SER-836; SER-1620; SER-1621 AND SER-1666, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; SER-221; SER-429; SER-435; SER-437; SER-601; SER-672; SER-691; SER-762; SER-836; SER-872; SER-882; SER-893; SER-987; SER-1008; SER-1024; SER-1103; SER-1133; SER-1138; SER-1248; SER-1253; THR-1282; SER-1297; SER-1383; SER-1385; SER-1533; SER-1620; SER-1621; SER-1652; SER-1666 AND SER-1715, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-429; SER-601; SER-672; SER-691; SER-836; SER-851; SER-872; SER-893; SER-899; SER-1054; SER-1138; SER-1385; SER-1533; SER-1545; SER-1620; SER-1621; SER-1631 AND SER-1666, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    23. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTB182_HUMAN
    AccessioniPrimary (citable) accession number: Q9C0C2
    Secondary accession number(s): A7E2F8, Q6PJ35, Q6ZV74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 120 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3