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Protein

Zinc finger CCHC domain-containing protein 2

Gene

ZCCHC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1131 – 114818CCHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. phosphatidylinositol binding Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 2
Gene namesi
Name:ZCCHC2
Synonyms:KIAA1744
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:22916. ZCCHC2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: LIFEdb
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134861180.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11781178Zinc finger CCHC domain-containing protein 2PRO_0000150949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9C0B9.
PaxDbiQ9C0B9.
PRIDEiQ9C0B9.

PTM databases

PhosphoSiteiQ9C0B9.

Expressioni

Gene expression databases

BgeeiQ9C0B9.
CleanExiHS_ZCCHC2.
ExpressionAtlasiQ9C0B9. baseline and differential.
GenevestigatoriQ9C0B9.

Organism-specific databases

HPAiHPA040943.

Interactioni

Protein-protein interaction databases

BioGridi120225. 1 interaction.
MINTiMINT-4717754.
STRINGi9606.ENSP00000269499.

Structurei

3D structure databases

ProteinModelPortaliQ9C0B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 7064Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1131 – 114818CCHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG84807.
GeneTreeiENSGT00520000055637.
HOGENOMiHOG000155766.
HOVERGENiHBG108762.
InParanoidiQ9C0B9.
OMAiSGPCGSC.
OrthoDBiEOG7966GG.
PhylomeDBiQ9C0B9.
TreeFamiTF335574.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR001683. Phox.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0B9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRMKLPLKP THPAEPPPEA EEPEADARPG AKAPSRRRRD CRPPPPPPPP
60 70 80 90 100
AGPSRGPLPP PPPPRGLGPP VAGGAAAGAG MPGGGGGPSA ALREQERVYE
110 120 130 140 150
WFGLVLGSAQ RLEFMCGLLD LCNPLELRFL GSCLEDLARK DYHYLRDSEA
160 170 180 190 200
KANGLSDPGP LADFREPAVR SRLIVYLALL GSENREAAGR LHRLLPQVDS
210 220 230 240 250
VLKSLRAARG EGSRGGAEDE RGEDGDGEQD AEKDGSGPEG GIVEPRVGGG
260 270 280 290 300
LGSRAQEELL LLFTMASLHP AFSFHQRVTL REHLERLRAA LRGGPEDAEV
310 320 330 340 350
EVEPCKFAGP RAQNNSAHGD YMQNNESSLI EQAPIPQDGL TVAPHRAQRE
360 370 380 390 400
AVHIEKIMLK GVQRKRADKY WEYTFKVNWS DLSVTTVTKT HQELQEFLLK
410 420 430 440 450
LPKELSSETF DKTILRALNQ GSLKREERRH PDLEPILRQL FSSSSQAFLQ
460 470 480 490 500
SQKVHSFFQS ISSDSLHSIN NLQSSLKTSK ILEHLKEDSS EASSQEEDVL
510 520 530 540 550
QHAIIHKKHT GKSPIVNNIG TSCSPLDGLT MQYSEQNGIV DWRKQSCTTI
560 570 580 590 600
QHPEHCVTSA DQHSAEKRSL SSINKKKGKP QTEKEKIKKT DNRLNSRING
610 620 630 640 650
IRLSTPQHAH GGTVKDVNLD IGSGHDTCGE TSSESYSSPS SPRHDGRESF
660 670 680 690 700
ESEEEKDRDT DSNSEDSGNP STTRFTGYGS VNQTVTVKPP VQIASLGNEN
710 720 730 740 750
GNLLEDPLNS PKYQHISFMP TLHCVMHNGA QKSEVVVPAP KPADGKTIGM
760 770 780 790 800
LVPSPVAISA IRESANSTPV GILGPTACTG ESEKHLELLA SPLPIPSTFL
810 820 830 840 850
PHSSTPALHL TVQRLKLPPP QGSSESCTVN IPQQPPGSLS IASPNTAFIP
860 870 880 890 900
IHNPGSFPGS PVATTDPITK SASQVVGLNQ MVPQIEGNTG TVPQPTNVKV
910 920 930 940 950
VLPAAGLSAA QPPASYPLPG SPLAAGVLPS QNSSVLSTAA TSPQPASAGI
960 970 980 990 1000
SQAQATVPPA VPTHTPGPAP SPSPALTHST AQSDSTSYIS AVGNTNANGT
1010 1020 1030 1040 1050
VVPPQQMGSG PCGSCGRRCS CGTNGNLQLN SYYYPNPMPG PMYRVPSFFT
1060 1070 1080 1090 1100
LPSICNGSYL NQAHQSNGNQ LPFFLPQTPY ANGLVHDPVM GSQANYGMQQ
1110 1120 1130 1140 1150
MAGFGRFYPV YPAPNVVANT SGSGPKKNGN VSCYNCGVSG HYAQDCKQSS
1160 1170
MEANQQGTYR LRYAPPLPPS NDTLDSAD
Length:1,178
Mass (Da):125,936
Last modified:April 8, 2008 - v6
Checksum:iB93600F7D6B9A484
GO
Isoform 2 (identifier: Q9C0B9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-321: Missing.

Note: No experimental confirmation available.

Show »
Length:857
Mass (Da):91,738
Checksum:i95C7A36B05B0B2F1
GO

Sequence cautioni

The sequence BAA91057.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti508 – 5081K → R in CAD38618 (PubMed:17974005).Curated
Sequence conflicti802 – 8021H → Y in CAD38618 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti941 – 9411T → A.
Corresponds to variant rs35643152 [ dbSNP | Ensembl ].
VAR_060121

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 321321Missing in isoform 2. 1 PublicationVSP_055995Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC064801 Genomic DNA. No translation available.
BC137435 mRNA. Translation: AAI37436.1.
AL832323 mRNA. Translation: CAD38618.1.
AB051531 mRNA. Translation: BAB21835.1.
AK000288 mRNA. Translation: BAA91057.1. Different initiation.
CCDSiCCDS45880.1. [Q9C0B9-1]
RefSeqiNP_060212.4. NM_017742.5. [Q9C0B9-1]
UniGeneiHs.114191.
Hs.714637.
Hs.733355.

Genome annotation databases

EnsembliENST00000269499; ENSP00000269499; ENSG00000141664. [Q9C0B9-1]
ENST00000586834; ENSP00000464791; ENSG00000141664. [Q9C0B9-2]
GeneIDi54877.
KEGGihsa:54877.
UCSCiuc002lip.4. human. [Q9C0B9-1]

Polymorphism databases

DMDMi182676458.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC064801 Genomic DNA. No translation available.
BC137435 mRNA. Translation: AAI37436.1.
AL832323 mRNA. Translation: CAD38618.1.
AB051531 mRNA. Translation: BAB21835.1.
AK000288 mRNA. Translation: BAA91057.1. Different initiation.
CCDSiCCDS45880.1. [Q9C0B9-1]
RefSeqiNP_060212.4. NM_017742.5. [Q9C0B9-1]
UniGeneiHs.114191.
Hs.714637.
Hs.733355.

3D structure databases

ProteinModelPortaliQ9C0B9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120225. 1 interaction.
MINTiMINT-4717754.
STRINGi9606.ENSP00000269499.

PTM databases

PhosphoSiteiQ9C0B9.

Polymorphism databases

DMDMi182676458.

Proteomic databases

MaxQBiQ9C0B9.
PaxDbiQ9C0B9.
PRIDEiQ9C0B9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269499; ENSP00000269499; ENSG00000141664. [Q9C0B9-1]
ENST00000586834; ENSP00000464791; ENSG00000141664. [Q9C0B9-2]
GeneIDi54877.
KEGGihsa:54877.
UCSCiuc002lip.4. human. [Q9C0B9-1]

Organism-specific databases

CTDi54877.
GeneCardsiGC18P060190.
H-InvDBHIX0014493.
HGNCiHGNC:22916. ZCCHC2.
HPAiHPA040943.
neXtProtiNX_Q9C0B9.
PharmGKBiPA134861180.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG84807.
GeneTreeiENSGT00520000055637.
HOGENOMiHOG000155766.
HOVERGENiHBG108762.
InParanoidiQ9C0B9.
OMAiSGPCGSC.
OrthoDBiEOG7966GG.
PhylomeDBiQ9C0B9.
TreeFamiTF335574.

Miscellaneous databases

ChiTaRSiZCCHC2. human.
GeneWikiiZCCHC2.
GenomeRNAii54877.
NextBioi35468383.
PROiQ9C0B9.

Gene expression databases

BgeeiQ9C0B9.
CleanExiHS_ZCCHC2.
ExpressionAtlasiQ9C0B9. baseline and differential.
GenevestigatoriQ9C0B9.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR001683. Phox.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 280-1178 (ISOFORM 1).
    Tissue: Skeletal muscle.
  4. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 324-1178 (ISOFORM 1/2).
    Tissue: Brain.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 782-1178 (ISOFORM 1/2).
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZCHC2_HUMAN
AccessioniPrimary (citable) accession number: Q9C0B9
Secondary accession number(s): B2RPG6, Q8N3S1, Q9NXF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: April 8, 2008
Last modified: March 4, 2015
This is version 112 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.