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Q9C0B9

- ZCHC2_HUMAN

UniProt

Q9C0B9 - ZCHC2_HUMAN

Protein

Zinc finger CCHC domain-containing protein 2

Gene

ZCCHC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 6 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1131 – 114818CCHC-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. phosphatidylinositol binding Source: InterPro
    3. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger CCHC domain-containing protein 2
    Gene namesi
    Name:ZCCHC2
    Synonyms:KIAA1744
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:22916. ZCCHC2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: LIFEdb

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134861180.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11781178Zinc finger CCHC domain-containing protein 2PRO_0000150949Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei236 – 2361Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9C0B9.
    PaxDbiQ9C0B9.
    PRIDEiQ9C0B9.

    PTM databases

    PhosphoSiteiQ9C0B9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9C0B9.
    BgeeiQ9C0B9.
    CleanExiHS_ZCCHC2.
    GenevestigatoriQ9C0B9.

    Organism-specific databases

    HPAiHPA040943.

    Interactioni

    Protein-protein interaction databases

    BioGridi120225. 1 interaction.
    MINTiMINT-4717754.
    STRINGi9606.ENSP00000269499.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C0B9.
    SMRiQ9C0B9. Positions 351-464.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi7 – 7064Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1131 – 114818CCHC-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG84807.
    HOGENOMiHOG000155766.
    HOVERGENiHBG108762.
    InParanoidiQ9C0B9.
    OMAiSGPCGSC.
    OrthoDBiEOG7966GG.
    PhylomeDBiQ9C0B9.
    TreeFamiTF335574.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    4.10.60.10. 1 hit.
    InterProiIPR001683. Phox.
    IPR001878. Znf_CCHC.
    [Graphical view]
    PfamiPF00098. zf-CCHC. 1 hit.
    [Graphical view]
    SMARTiSM00343. ZnF_C2HC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57756. SSF57756. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEiPS50158. ZF_CCHC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9C0B9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLRMKLPLKP THPAEPPPEA EEPEADARPG AKAPSRRRRD CRPPPPPPPP     50
    AGPSRGPLPP PPPPRGLGPP VAGGAAAGAG MPGGGGGPSA ALREQERVYE 100
    WFGLVLGSAQ RLEFMCGLLD LCNPLELRFL GSCLEDLARK DYHYLRDSEA 150
    KANGLSDPGP LADFREPAVR SRLIVYLALL GSENREAAGR LHRLLPQVDS 200
    VLKSLRAARG EGSRGGAEDE RGEDGDGEQD AEKDGSGPEG GIVEPRVGGG 250
    LGSRAQEELL LLFTMASLHP AFSFHQRVTL REHLERLRAA LRGGPEDAEV 300
    EVEPCKFAGP RAQNNSAHGD YMQNNESSLI EQAPIPQDGL TVAPHRAQRE 350
    AVHIEKIMLK GVQRKRADKY WEYTFKVNWS DLSVTTVTKT HQELQEFLLK 400
    LPKELSSETF DKTILRALNQ GSLKREERRH PDLEPILRQL FSSSSQAFLQ 450
    SQKVHSFFQS ISSDSLHSIN NLQSSLKTSK ILEHLKEDSS EASSQEEDVL 500
    QHAIIHKKHT GKSPIVNNIG TSCSPLDGLT MQYSEQNGIV DWRKQSCTTI 550
    QHPEHCVTSA DQHSAEKRSL SSINKKKGKP QTEKEKIKKT DNRLNSRING 600
    IRLSTPQHAH GGTVKDVNLD IGSGHDTCGE TSSESYSSPS SPRHDGRESF 650
    ESEEEKDRDT DSNSEDSGNP STTRFTGYGS VNQTVTVKPP VQIASLGNEN 700
    GNLLEDPLNS PKYQHISFMP TLHCVMHNGA QKSEVVVPAP KPADGKTIGM 750
    LVPSPVAISA IRESANSTPV GILGPTACTG ESEKHLELLA SPLPIPSTFL 800
    PHSSTPALHL TVQRLKLPPP QGSSESCTVN IPQQPPGSLS IASPNTAFIP 850
    IHNPGSFPGS PVATTDPITK SASQVVGLNQ MVPQIEGNTG TVPQPTNVKV 900
    VLPAAGLSAA QPPASYPLPG SPLAAGVLPS QNSSVLSTAA TSPQPASAGI 950
    SQAQATVPPA VPTHTPGPAP SPSPALTHST AQSDSTSYIS AVGNTNANGT 1000
    VVPPQQMGSG PCGSCGRRCS CGTNGNLQLN SYYYPNPMPG PMYRVPSFFT 1050
    LPSICNGSYL NQAHQSNGNQ LPFFLPQTPY ANGLVHDPVM GSQANYGMQQ 1100
    MAGFGRFYPV YPAPNVVANT SGSGPKKNGN VSCYNCGVSG HYAQDCKQSS 1150
    MEANQQGTYR LRYAPPLPPS NDTLDSAD 1178
    Length:1,178
    Mass (Da):125,936
    Last modified:April 8, 2008 - v6
    Checksum:iB93600F7D6B9A484
    GO
    Isoform 2 (identifier: Q9C0B9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-321: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:857
    Mass (Da):91,738
    Checksum:i95C7A36B05B0B2F1
    GO

    Sequence cautioni

    The sequence BAA91057.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti508 – 5081K → R in CAD38618. (PubMed:17974005)Curated
    Sequence conflicti802 – 8021H → Y in CAD38618. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti941 – 9411T → A.
    Corresponds to variant rs35643152 [ dbSNP | Ensembl ].
    VAR_060121

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 321321Missing in isoform 2. 1 PublicationVSP_055995Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC064801 Genomic DNA. No translation available.
    BC137435 mRNA. Translation: AAI37436.1.
    AL832323 mRNA. Translation: CAD38618.1.
    AB051531 mRNA. Translation: BAB21835.1.
    AK000288 mRNA. Translation: BAA91057.1. Different initiation.
    CCDSiCCDS45880.1.
    RefSeqiNP_060212.4. NM_017742.4.
    UniGeneiHs.114191.
    Hs.714637.

    Genome annotation databases

    EnsembliENST00000269499; ENSP00000269499; ENSG00000141664.
    ENST00000586834; ENSP00000464791; ENSG00000141664.
    GeneIDi54877.
    KEGGihsa:54877.
    UCSCiuc002lip.4. human.

    Polymorphism databases

    DMDMi182676458.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC064801 Genomic DNA. No translation available.
    BC137435 mRNA. Translation: AAI37436.1 .
    AL832323 mRNA. Translation: CAD38618.1 .
    AB051531 mRNA. Translation: BAB21835.1 .
    AK000288 mRNA. Translation: BAA91057.1 . Different initiation.
    CCDSi CCDS45880.1.
    RefSeqi NP_060212.4. NM_017742.4.
    UniGenei Hs.114191.
    Hs.714637.

    3D structure databases

    ProteinModelPortali Q9C0B9.
    SMRi Q9C0B9. Positions 351-464.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120225. 1 interaction.
    MINTi MINT-4717754.
    STRINGi 9606.ENSP00000269499.

    PTM databases

    PhosphoSitei Q9C0B9.

    Polymorphism databases

    DMDMi 182676458.

    Proteomic databases

    MaxQBi Q9C0B9.
    PaxDbi Q9C0B9.
    PRIDEi Q9C0B9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000269499 ; ENSP00000269499 ; ENSG00000141664 .
    ENST00000586834 ; ENSP00000464791 ; ENSG00000141664 .
    GeneIDi 54877.
    KEGGi hsa:54877.
    UCSCi uc002lip.4. human.

    Organism-specific databases

    CTDi 54877.
    GeneCardsi GC18P060190.
    H-InvDB HIX0014493.
    HGNCi HGNC:22916. ZCCHC2.
    HPAi HPA040943.
    neXtProti NX_Q9C0B9.
    PharmGKBi PA134861180.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84807.
    HOGENOMi HOG000155766.
    HOVERGENi HBG108762.
    InParanoidi Q9C0B9.
    OMAi SGPCGSC.
    OrthoDBi EOG7966GG.
    PhylomeDBi Q9C0B9.
    TreeFami TF335574.

    Miscellaneous databases

    GeneWikii ZCCHC2.
    GenomeRNAii 54877.
    NextBioi 57813.
    PROi Q9C0B9.

    Gene expression databases

    ArrayExpressi Q9C0B9.
    Bgeei Q9C0B9.
    CleanExi HS_ZCCHC2.
    Genevestigatori Q9C0B9.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    4.10.60.10. 1 hit.
    InterProi IPR001683. Phox.
    IPR001878. Znf_CCHC.
    [Graphical view ]
    Pfami PF00098. zf-CCHC. 1 hit.
    [Graphical view ]
    SMARTi SM00343. ZnF_C2HC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57756. SSF57756. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEi PS50158. ZF_CCHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 280-1178 (ISOFORM 1).
      Tissue: Skeletal muscle.
    4. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 324-1178 (ISOFORM 1/2).
      Tissue: Brain.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 782-1178 (ISOFORM 1/2).
    6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZCHC2_HUMAN
    AccessioniPrimary (citable) accession number: Q9C0B9
    Secondary accession number(s): B2RPG6, Q8N3S1, Q9NXF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2003
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 107 of the entry and version 6 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3