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Protein

Transport and Golgi organization protein 6 homolog

Gene

TANGO6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103047-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transport and Golgi organization protein 6 homolog
Alternative name(s):
Transmembrane and coiled-coil domain-containing protein 7
Gene namesi
Name:TANGO6
Synonyms:KIAA1746, TMCO7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25749. TANGO6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei468 – 488HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000103047.
PharmGKBiPA162405811.

Polymorphism and mutation databases

BioMutaiTANGO6.
DMDMi158706353.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050591 – 1094Transport and Golgi organization protein 6 homologAdd BLAST1094

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei556PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9C0B7.
MaxQBiQ9C0B7.
PaxDbiQ9C0B7.
PeptideAtlasiQ9C0B7.
PRIDEiQ9C0B7.

PTM databases

iPTMnetiQ9C0B7.
PhosphoSitePlusiQ9C0B7.

Expressioni

Gene expression databases

BgeeiENSG00000103047.
CleanExiHS_TMCO7.
ExpressionAtlasiQ9C0B7. baseline and differential.
GenevisibleiQ9C0B7. HS.

Organism-specific databases

HPAiHPA041312.

Interactioni

Protein-protein interaction databases

BioGridi122747. 4 interactors.
IntActiQ9C0B7. 3 interactors.
STRINGi9606.ENSP00000261778.

Structurei

3D structure databases

ProteinModelPortaliQ9C0B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati873 – 909HEAT 1Add BLAST37
Repeati952 – 988HEAT 2Add BLAST37

Sequence similaritiesi

Belongs to the Tango6 family.Curated
Contains 2 HEAT repeats.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4653. Eukaryota.
ENOG410XS2I. LUCA.
GeneTreeiENSGT00390000010938.
HOGENOMiHOG000154637.
HOVERGENiHBG057050.
InParanoidiQ9C0B7.
OMAiRLYTSCK.
OrthoDBiEOG091G02MW.
PhylomeDBiQ9C0B7.
TreeFamiTF330876.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019451. Rtp1_C1.
IPR019414. Rtp1_C2.
[Graphical view]
PfamiPF10363. RTP1_C1. 1 hit.
PF10304. RTP1_C2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9C0B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARQAVGSG AQETCGLDRI LEALKLLLSP GGSGSSSLQV TKHDVLLATL
60 70 80 90 100
KSNLSALEDK FLKDPQWKNL KLLRDEIADK AEWPQNSVDV TWSFTSQTLL
110 120 130 140 150
LLLCLKETMI RLAANFNPGK PNPRTPEVAP ALSPDALSIS QQKTVQFVLQ
160 170 180 190 200
FVVTLGICPY LMPGVGVPLR YRTEFGAVVQ DVVCFDAAPD ATRRLYTSCK
210 220 230 240 250
ALLNVAQHTS LGSLIFCHHF GDIAAGLCQL GFCPTKRKLL TPAEEVLTEE
260 270 280 290 300
ERTLSRGALR DMLDQVYQPL AVRELLILQG GPPQSCTDVK TQMRCRAPAW
310 320 330 340 350
LRRLCGQLLS ERLMRPNGVQ AVVRGILEGA GAGAAGGSDA EVTAADWKKC
360 370 380 390 400
DLIAKILASC PQQSLSPENY YRDICPQVLD LFHFQDKLTA RQFQRVATTT
410 420 430 440 450
FITLSRERPH LAAKYLLQPV LAPLHRCLNT AELSESDMVP GTILVTEEEL
460 470 480 490 500
SRCIEDVFKV YVVGNEPLTV LMDSLLPVLG VLFLLYCFTK QSVSHIRSLC
510 520 530 540 550
QEILLWILGK LERKKAIASL KGFAGLDKAV PSLHSLCQFR VATQGGIMIT
560 570 580 590 600
IKEAISDEDE DEALYQKVSS EQGRVEHLGD LLSHCQECGL AGDFFIFCLK
610 620 630 640 650
ELTHVASENE TELKTEPFSS KSLLELEQHQ TLLVEGQERK LLVLQLMAVL
660 670 680 690 700
CERMSEQIFT NVTQVVDFVA ATLQRACASL AHQAESTVES QTLSMSMGLV
710 720 730 740 750
AVMLGGAVQL KSSDFAVLKQ LLPLLEKVSN TYPDPVIQEL AVDLRITIST
760 770 780 790 800
HGAFATEAVS MAAQSTLNRK DLEGKIEEQQ QTSHERPTDV AHSHLEQQQS
810 820 830 840 850
HETAPQTGLQ SNAPIIPQGV NEPSTTTSQK SGSVTTEQLQ EVLLSAYDPQ
860 870 880 890 900
IPTRAAALRT LSHWIEQREA KALEMQEKLL KIFLENLEHE DTFVYLSAIQ
910 920 930 940 950
GVALLSDVYP EKILPDLLAQ YDSSKDKHTP ETRMKVGEVL MRIVRALGDM
960 970 980 990 1000
VSKYREPLIH TFLRGVRDPD GAHRASSLAN LGELCQRLDF LLGSVVHEVT
1010 1020 1030 1040 1050
ACLIAVAKTD GEVQVRRAAI HVVVLLLRGL SQKATEVLSA VLKDLYHLLK
1060 1070 1080 1090
HVVCLEPDDV AKLHAQLALE ELDDIMKNFL FPPQKLEKKI MVLP
Length:1,094
Mass (Da):120,748
Last modified:October 2, 2007 - v2
Checksum:i48E9BBD05E6902CE
GO

Sequence cautioni

The sequence BAB14224 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB21837 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051533 mRNA. Translation: BAB21837.1. Different initiation.
AC009027 Genomic DNA. No translation available.
AC009082 Genomic DNA. No translation available.
AC009137 Genomic DNA. No translation available.
AK022750 mRNA. Translation: BAB14224.1. Different initiation.
CCDSiCCDS45516.1.
RefSeqiNP_078838.1. NM_024562.1.
UniGeneiHs.13526.

Genome annotation databases

EnsembliENST00000261778; ENSP00000261778; ENSG00000103047.
GeneIDi79613.
KEGGihsa:79613.
UCSCiuc002ewi.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051533 mRNA. Translation: BAB21837.1. Different initiation.
AC009027 Genomic DNA. No translation available.
AC009082 Genomic DNA. No translation available.
AC009137 Genomic DNA. No translation available.
AK022750 mRNA. Translation: BAB14224.1. Different initiation.
CCDSiCCDS45516.1.
RefSeqiNP_078838.1. NM_024562.1.
UniGeneiHs.13526.

3D structure databases

ProteinModelPortaliQ9C0B7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122747. 4 interactors.
IntActiQ9C0B7. 3 interactors.
STRINGi9606.ENSP00000261778.

PTM databases

iPTMnetiQ9C0B7.
PhosphoSitePlusiQ9C0B7.

Polymorphism and mutation databases

BioMutaiTANGO6.
DMDMi158706353.

Proteomic databases

EPDiQ9C0B7.
MaxQBiQ9C0B7.
PaxDbiQ9C0B7.
PeptideAtlasiQ9C0B7.
PRIDEiQ9C0B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261778; ENSP00000261778; ENSG00000103047.
GeneIDi79613.
KEGGihsa:79613.
UCSCiuc002ewi.5. human.

Organism-specific databases

CTDi79613.
GeneCardsiTANGO6.
H-InvDBHIX0013178.
HGNCiHGNC:25749. TANGO6.
HPAiHPA041312.
neXtProtiNX_Q9C0B7.
OpenTargetsiENSG00000103047.
PharmGKBiPA162405811.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4653. Eukaryota.
ENOG410XS2I. LUCA.
GeneTreeiENSGT00390000010938.
HOGENOMiHOG000154637.
HOVERGENiHBG057050.
InParanoidiQ9C0B7.
OMAiRLYTSCK.
OrthoDBiEOG091G02MW.
PhylomeDBiQ9C0B7.
TreeFamiTF330876.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103047-MONOMER.

Miscellaneous databases

GenomeRNAii79613.
PROiQ9C0B7.

Gene expression databases

BgeeiENSG00000103047.
CleanExiHS_TMCO7.
ExpressionAtlasiQ9C0B7. baseline and differential.
GenevisibleiQ9C0B7. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019451. Rtp1_C1.
IPR019414. Rtp1_C2.
[Graphical view]
PfamiPF10363. RTP1_C1. 1 hit.
PF10304. RTP1_C2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiTNG6_HUMAN
AccessioniPrimary (citable) accession number: Q9C0B7
Secondary accession number(s): Q569F9, Q9H9K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.